{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T20:06:25Z","timestamp":1773345985553,"version":"3.50.1"},"reference-count":20,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,12,19]],"date-time":"2023-12-19T00:00:00Z","timestamp":1702944000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006400","name":"Alnylam Pharmaceuticals","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006400","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["JP20K09774"],"award-info":[{"award-number":["JP20K09774"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","award":["JP21K09703"],"award-info":[{"award-number":["JP21K09703"]}],"id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2024,1]]},"DOI":"10.1016\/j.bbrc.2023.149397","type":"journal-article","created":{"date-parts":[[2023,12,16]],"date-time":"2023-12-16T11:00:42Z","timestamp":1702724442000},"page":"149397","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Silencing of ocular transthyretin, a gene responsible for hereditary transthyretin amyloidosis, by intravitreal injection of an siRNA conjugate into rabbit eyes"],"prefix":"10.1016","volume":"694","author":[{"given":"Takahiro","family":"Watanabe","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0374-4174","authenticated-orcid":false,"given":"Yuji","family":"Takihara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirofumi","family":"Jono","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomokazu","family":"Fujimoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masayoshi","family":"Tasaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aito","family":"Isoguchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yui","family":"Urahashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takefumi","family":"Shimoda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eri","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukio","family":"Ando","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinji","family":"Ueno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6814-0582","authenticated-orcid":false,"given":"Mitsuharu","family":"Ueda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3769-7609","authenticated-orcid":false,"given":"Toshihiro","family":"Inoue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2023.149397_bib1","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1016\/S0006-291X(83)80224-1","article-title":"Identification of amyloid prealbumin variant in familial amyloidotic polyneuropathy (Japanese type)","volume":"116","author":"Tawara","year":"1983","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbrc.2023.149397_bib2","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1007\/s40120-021-00258-z","article-title":"Characteristics of patients with late- vs. early-onset Val30Met transthyretin amyloidosis from the transthyretin amyloidosis outcomes survey (THAOS)","volume":"10","author":"Waddington-Cruz","year":"2021","journal-title":"Neurol. Ther."},{"key":"10.1016\/j.bbrc.2023.149397_bib3","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1001\/archneur.62.7.1057","article-title":"Transthyretin-related familial amyloidotic polyneuropathy","volume":"62","author":"Ando","year":"2005","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.bbrc.2023.149397_bib4","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1016\/0140-6736(93)93127-M","article-title":"Clinical improvement and amyloid regression after liver transplantation in hereditary transthyretin amyloidosis","volume":"341","author":"Holmgren","year":"1993","journal-title":"Lancet"},{"key":"10.1016\/j.bbrc.2023.149397_bib5","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/2047-9158-3-19","article-title":"Recent advances in transthyretin amyloidosis therapy","volume":"3","author":"Ueda","year":"2014","journal-title":"Transl. Neurodegener."},{"key":"10.1016\/j.bbrc.2023.149397_bib6","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1212\/WNL.0b013e318248df18","article-title":"Long-term survival after liver transplantation in patients with familial amyloid polyneuropathy","volume":"78","author":"Yamashita","year":"2012","journal-title":"Neurology"},{"key":"10.1016\/j.bbrc.2023.149397_bib7","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1056\/NEJMoa1716153","article-title":"Patisiran, an RNAi therapeutic, for hereditary transthyretin amyloidosis","volume":"379","author":"Adams","year":"2018","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bbrc.2023.149397_bib8","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1001\/archophthalmol.2009.390","article-title":"Impact of liver transplantation on transthyretin-related ocular amyloidosis in Japanese patients","volume":"128","author":"Hara","year":"2010","journal-title":"Arch. Ophthalmol."},{"key":"10.1016\/j.bbrc.2023.149397_bib9","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/s10633-022-09872-0","article-title":"ISCEV Standard for full-field clinical electroretinography (2022 update)","volume":"144","author":"Robson","year":"2022","journal-title":"Doc. Ophthalmol."},{"key":"10.1016\/j.bbrc.2023.149397_bib10","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1038\/s41587-022-01334-x","article-title":"Expanding RNAi therapeutics to extrahepatic tissues with lipophilic conjugates","volume":"40","author":"Brown","year":"2022","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.bbrc.2023.149397_bib11","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1056\/NEJMoa1414264","article-title":"Aflibercept, bevacizumab, or ranibizumab for diabetic macular edema","volume":"372","author":"Wells","year":"2015","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bbrc.2023.149397_bib12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/13506129.2022.2091985","article-title":"Efficacy and safety of vutrisiran for patients with hereditary transthyretin-mediated amyloidosis with polyneuropathy: a randomized clinical trial","volume":"30","author":"Adams","year":"2023","journal-title":"Amyloid"},{"key":"10.1016\/j.bbrc.2023.149397_bib13","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1016\/j.ophtha.2009.07.042","article-title":"Novel therapy for transthyretin-related ocular amyloidosis: a pilot study of retinal laser photocoagulation","volume":"117","author":"Kawaji","year":"2010","journal-title":"Ophthalmology"},{"key":"10.1016\/j.bbrc.2023.149397_bib14","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/BF00920934","article-title":"Aqueous outflow system in familial amyloidotic polyneuropathy, Portuguese type","volume":"231","author":"Silva-Ara\u00fajo","year":"1993","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."},{"key":"10.1016\/j.bbrc.2023.149397_bib15","first-page":"289","article-title":"Familial amyloidotic polyneuropathy: ocular manifestations with clinicopathological observation","volume":"28","author":"Futa","year":"1984","journal-title":"Jpn. J. Ophthalmol."},{"key":"10.1016\/j.bbrc.2023.149397_bib16","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1038\/s12276-023-00998-y","article-title":"J. Han, where should siRNAs go: applicable organs for siRNA drugs","volume":"55","author":"Ahn","year":"2023","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.bbrc.2023.149397_bib17","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.ajo.2010.02.006","article-title":"RNAi-based treatment for neovascular age-related macular degeneration by Sirna-027","volume":"150","author":"Kaiser","year":"2010","journal-title":"Am. J. Ophthalmol."},{"key":"10.1016\/j.bbrc.2023.149397_bib18","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1089\/nat.2014.0489","article-title":"Toxicological and pharmacokinetic properties of QPI-1007, a chemically modified synthetic siRNA targeting caspase 2 mRNA, following intravitreal injection","volume":"24","author":"Solano","year":"2014","journal-title":"Nucleic Acid Therapeut."},{"key":"10.1016\/j.bbrc.2023.149397_bib19","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1111\/j.1463-5224.2008.00619.x","article-title":"Experimental determination and allometric prediction of vitreous volume, and retina and lens weights in G\u00f6ttingen minipigs","volume":"11","author":"Shafiee","year":"2008","journal-title":"Vet. Ophthalmol."},{"key":"10.1016\/j.bbrc.2023.149397_bib20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10633-017-9621-y","article-title":"ISCEV guide to visual electrodiagnostic procedures","volume":"136","author":"Robson","year":"2018","journal-title":"Doc. Ophthalmol."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X23014912?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X23014912?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T12:38:57Z","timestamp":1757767137000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X23014912"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":20,"alternative-id":["S0006291X23014912"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2023.149397","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Silencing of ocular transthyretin, a gene responsible for hereditary transthyretin amyloidosis, by intravitreal injection of an siRNA conjugate into rabbit eyes","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2023.149397","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"149397"}}