{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T15:16:24Z","timestamp":1786979784275,"version":"build-2736575974"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100010814","name":"Anhui Province Department of Education","doi-asserted-by":"publisher","award":["gxgwfx2020024"],"award-info":[{"award-number":["gxgwfx2020024"]}],"id":[{"id":"10.13039\/501100010814","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010814","name":"Anhui Province Department of Education","doi-asserted-by":"publisher","award":["KJ2020A0180"],"award-info":[{"award-number":["KJ2020A0180"]}],"id":[{"id":"10.13039\/501100010814","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002947","name":"Anhui Medical University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002947","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013066","name":"Key Scientific Research Project of Colleges and Universities in Henan Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013066","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2019GQFY04"],"award-info":[{"award-number":["2019GQFY04"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["gxgwfx2020024"],"award-info":[{"award-number":["gxgwfx2020024"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2024,2]]},"DOI":"10.1016\/j.bbrc.2024.149526","type":"journal-article","created":{"date-parts":[[2024,1,14]],"date-time":"2024-01-14T05:55:46Z","timestamp":1705211746000},"page":"149526","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["ER-1 deficiency induces inflammation and lipid deposition in meibomian gland and lacrimal gland"],"prefix":"10.1016","volume":"696","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1021-9511","authenticated-orcid":false,"given":"Xiaoxuan","family":"Qi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-3633-5334","authenticated-orcid":false,"given":"Yachun","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danyu","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sainan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoqiang","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7389-4402","authenticated-orcid":false,"given":"Qing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2024.149526_bib1","doi-asserted-by":"crossref","first-page":"2212","DOI":"10.1056\/NEJMra1407936","article-title":"Dry eye","volume":"378","author":"Clayton","year":"2018","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bbrc.2024.149526_bib2","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1097\/ICO.0b013e318165b1b7","article-title":"Dry eye syndrome in elderly Tibetans at high altitude: a population-based study in China","volume":"27","author":"Lu","year":"2008","journal-title":"Cornea"},{"key":"10.1016\/j.bbrc.2024.149526_bib3","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1038\/sj.eye.6703101","article-title":"Prevalence of dry eye among adult Chinese in the Beijing Eye Study","volume":"23","author":"Jie","year":"2009","journal-title":"Eye (Lond)"},{"key":"10.1016\/j.bbrc.2024.149526_bib4","doi-asserted-by":"crossref","first-page":"234","DOI":"10.3109\/09286586.2010.498659","article-title":"Prevalence of dry eye disease in Mongolians at high altitude in China: the Henan eye study","volume":"17","author":"Guo","year":"2010","journal-title":"Ophthalmic Epidemiol."},{"key":"10.1016\/j.bbrc.2024.149526_bib5","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1001\/archophthalmol.2011.78","article-title":"Prevalence of dry eye disease in an elderly Korean population","volume":"129","author":"Han","year":"2011","journal-title":"Arch. Ophthalmol."},{"key":"10.1016\/j.bbrc.2024.149526_bib6","doi-asserted-by":"crossref","first-page":"e429","DOI":"10.1111\/aos.12174","article-title":"Dry eye disease in French elderly subjects: the Alienor Study","volume":"92","author":"Malet","year":"2014","journal-title":"Acta Ophthalmol."},{"key":"10.1016\/j.bbrc.2024.149526_bib7","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.jtos.2020.04.005","article-title":"Prevalence and risk factors of dry eye in 79,866 participants of the population-based Lifelines cohort study in The Netherlands","volume":"19","author":"Vehof","year":"2021","journal-title":"Ocul. Surf."},{"key":"10.1016\/j.bbrc.2024.149526_bib8","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.jtos.2017.05.008","article-title":"TFOS DEWS II definition and classification report","volume":"15","author":"Craig","year":"2017","journal-title":"Ocul. Surf."},{"key":"10.1016\/j.bbrc.2024.149526_bib9","first-page":"299","article-title":"Conjunctival goblet cell density in normal subjects and in dry eye syndromes","volume":"14","author":"Ralph","year":"1975","journal-title":"Invest. Ophthalmol."},{"key":"10.1016\/j.bbrc.2024.149526_bib10","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.jtos.2017.05.003","article-title":"TFOS DEWS II epidemiology report","volume":"15","author":"Stapleton","year":"2017","journal-title":"Ocul. Surf."},{"key":"10.1016\/j.bbrc.2024.149526_bib11","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.jtos.2017.04.001","article-title":"TFOS DEWS II sex, gender, and hormones report","volume":"15","author":"Sullivan","year":"2017","journal-title":"Ocul. Surf."},{"key":"10.1016\/j.bbrc.2024.149526_bib12","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1001\/archopht.122.2.151","article-title":"Dry eye signs and symptoms in women with premature ovarian failure","volume":"122","author":"Smith","year":"2004","journal-title":"Arch. Ophthalmol."},{"key":"10.1016\/j.bbrc.2024.149526_bib13","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1136\/bjophthalmol-2012-302705","article-title":"Low levels of 17-\u03b2-oestradiol, oestrone and testosterone correlate with severe evaporative dysfunctional tear syndrome in postmenopausal women: a case-control study","volume":"98","author":"Gagliano","year":"2014","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.bbrc.2024.149526_bib14","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1136\/bjophthalmol-2016-309498","article-title":"The effects of transdermal testosterone and oestrogen therapy on dry eye in postmenopausal women: a randomised, placebo-controlled, pilot study","volume":"101","author":"Golebiowski","year":"2017","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.bbrc.2024.149526_bib15","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.jtos.2020.02.009","article-title":"High-fat diet induces dry eye-like ocular surface damages in murine","volume":"18","author":"Wu","year":"2020","journal-title":"Ocul. Surf."},{"key":"10.1016\/j.bbrc.2024.149526_bib16","doi-asserted-by":"crossref","first-page":"5473","DOI":"10.1167\/iovs.06-0728","article-title":"New tools for the evaluation of toxic ocular surface changes in the rat","volume":"48","author":"Pauly","year":"2007","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.bbrc.2024.149526_bib17","doi-asserted-by":"crossref","first-page":"11162","DOI":"10.1073\/pnas.90.23.11162","article-title":"Alteration of reproductive function but not prenatal sexual development after insertional disruption of the mouse estrogen receptor gene","volume":"90","author":"Lubahn","year":"1993","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.bbrc.2024.149526_bib18","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1016\/j.cell.2020.07.027","article-title":"SnapShot: FABP functions","volume":"182","author":"Li","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.bbrc.2024.149526_bib19","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/j.jtos.2016.08.001","article-title":"PPAR\u03b3 regulates mouse meibocyte differentiation and lipid synthesis","volume":"14","author":"Jester","year":"2016","journal-title":"Ocul. Surf."},{"key":"10.1016\/j.bbrc.2024.149526_bib20","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.jtos.2018.07.004","article-title":"PPAR\u03b3 regulates meibocyte differentiation and lipid synthesis of cultured human meibomian gland epithelial cells (hMGEC)","volume":"16","author":"Kim","year":"2018","journal-title":"Ocul. Surf."},{"key":"10.1016\/j.bbrc.2024.149526_bib21","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1172\/JCI0215593","article-title":"SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver","volume":"109","author":"Horton","year":"2002","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbrc.2024.149526_bib22","doi-asserted-by":"crossref","first-page":"65","DOI":"10.2527\/jas.2015-9456","article-title":"Critical role of miR-125b in lipogenesis by targeting stearoyl-CoA desaturase-1 (SCD-1)","volume":"94","author":"Cheng","year":"2016","journal-title":"J. Anim. Sci."},{"key":"10.1016\/j.bbrc.2024.149526_bib23","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.biochi.2004.10.018","article-title":"The role of MAPKs in adipocyte differentiation and obesity","volume":"87","author":"Bost","year":"2005","journal-title":"Biochimie"},{"key":"10.1016\/j.bbrc.2024.149526_bib24","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1359\/jbmr.2001.16.6.1045","article-title":"Mechanical strain and estrogen activate estrogen receptor alpha in bone cells","volume":"16","author":"Jessop","year":"2001","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bbrc.2024.149526_bib25","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.jsbmb.2014.06.010","article-title":"Estrogen receptor \u03b1 promotes non-amyloidogenic processing of platelet amyloid precursor protein via the MAPK\/ERK pathway","volume":"144","author":"Shi","year":"2014","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.bbrc.2024.149526_bib26","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/j.jtos.2017.05.011","article-title":"TFOS DEWS II pathophysiology report","volume":"15","author":"Bron","year":"2017","journal-title":"Ocul. Surf."},{"key":"10.1016\/j.bbrc.2024.149526_bib27","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1002\/jcb.22141","article-title":"NF-kappaB and estrogen receptor alpha interactions: differential function in estrogen receptor-negative and -positive hormone-independent breast cancer cells","volume":"107","author":"Gionet","year":"2009","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.bbrc.2024.149526_bib28","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.ajog.2006.12.033","article-title":"Identification of proteins within the nuclear factor-kappa B transcriptional complex including estrogen receptor-alpha","volume":"196","author":"Feldman","year":"2007","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.bbrc.2024.149526_bib29","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1006\/bbrc.2001.5519","article-title":"Estrogen effects in the myocardium: inhibition of NF-kappaB DNA binding by estrogen receptor-alpha and -beta","volume":"286","author":"Pelzer","year":"2001","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbrc.2024.149526_bib30","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1016\/j.bbalip.2018.06.010","article-title":"Fatty acid-binding protein 5 (FABP5) promotes lipolysis of lipid droplets, de novo fatty acid (FA) synthesis and activation of nuclear factor-kappa B (NF-\u03baB) signaling in cancer cells","volume":"1863","author":"Senga","year":"2018","journal-title":"Biochim. Biophys. Acta Mol. Cell Biol. Lipids"},{"key":"10.1016\/j.bbrc.2024.149526_bib31","article-title":"Aberrant DNA methylation-mediated NF-\u03baB\/fatty acid-binding protein 5 (FABP5) feed-forward loop promotes malignancy of colorectal cancer cells","volume":"1868","author":"Kawaguchi","year":"2023","journal-title":"Biochim. Biophys. Acta Mol. Cell Biol. Lipids"},{"key":"10.1016\/j.bbrc.2024.149526_bib32","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1159\/000374103","article-title":"Biocompatibility reduces inflammation-induced apoptosis in mesothelial cells exposed to peritoneal dialysis fluid","volume":"39","author":"Santamar\u00eda","year":"2015","journal-title":"Blood Purif."},{"key":"10.1016\/j.bbrc.2024.149526_bib33","first-page":"1731","article-title":"Transcription factors Nrf2 and NF-\u03baB contribute to inflammation and apoptosis induced by intestinal ischemia-reperfusion in mice","volume":"40","author":"Meng","year":"2017","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.bbrc.2024.149526_bib34","first-page":"679","article-title":"Lacrimal gland homeostasis is maintained by the AQP5 pathway by attenuating endoplasmic reticulum stress inflammation in the lacrimal gland of AQP5 knockout mice","volume":"27","author":"Hu","year":"2021","journal-title":"Mol. Vis."},{"key":"10.1016\/j.bbrc.2024.149526_bib35","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2020.01010","article-title":"Expression profiles of CircRNA and mRNA in lacrimal glands of AQP5(-\/-) mice with primary dry eye","volume":"11","author":"Liu","year":"2020","journal-title":"Front. Physiol."},{"key":"10.1016\/j.bbrc.2024.149526_bib36","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1111\/j.1365-2443.2006.01009.x","article-title":"Chromatin immunoprecipitation-mediated target identification proved aquaporin 5 is regulated directly by estrogen in the uterus","volume":"11","author":"Kobayashi","year":"2006","journal-title":"Gene Cell."},{"key":"10.1016\/j.bbrc.2024.149526_bib37","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.exer.2009.03.020","article-title":"Altered expression of genes functioning in lipid homeostasis is associated with lipid deposition in NOD mouse lacrimal gland","volume":"89","author":"Wu","year":"2009","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.bbrc.2024.149526_bib38","doi-asserted-by":"crossref","first-page":"e451","DOI":"10.1038\/emm.2017.285","article-title":"Sleep deprivation disrupts the lacrimal system and induces dry eye disease","volume":"50","author":"Li","year":"2018","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.bbrc.2024.149526_bib39","doi-asserted-by":"crossref","first-page":"1814","DOI":"10.1074\/jbc.274.3.1814","article-title":"Molecular cloning and expression of lipid transfer inhibitor protein reveals its identity with apolipoprotein F","volume":"274","author":"Wang","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2024.149526_bib40","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1016\/j.psyneuen.2008.03.007","article-title":"Functional alterations of the nigrostriatal dopamine system in estrogen receptor-alpha knockout (ERKO) mice","volume":"33","author":"K\u00fcppers","year":"2008","journal-title":"Psychoneuroendocrinology"}],"updated-by":[{"DOI":"10.1016\/j.bbrc.2025.152358","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000}}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X24000615?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X24000615?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T14:50:01Z","timestamp":1762095001000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X24000615"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2]]},"references-count":40,"alternative-id":["S0006291X24000615"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2024.149526","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2024,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"ER-1 deficiency induces inflammation and lipid deposition in meibomian gland and lacrimal gland","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2024.149526","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"149526"}}