{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T10:34:21Z","timestamp":1788431661299,"version":"build-2803163510"},"reference-count":23,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100007449","name":"Takeda Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007449","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["20H03644"],"award-info":[{"award-number":["20H03644"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["21K07756"],"award-info":[{"award-number":["21K07756"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2024,3]]},"DOI":"10.1016\/j.bbrc.2024.149551","type":"journal-article","created":{"date-parts":[[2024,1,19]],"date-time":"2024-01-19T21:09:30Z","timestamp":1705698570000},"page":"149551","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["A pH imbalance is linked to autophagic dysregulation of inner ear hair cells in Atp6v1ba-deficient zebrafish"],"prefix":"10.1016","volume":"699","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3147-5618","authenticated-orcid":false,"given":"Mayo","family":"Ikeuchi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masanori","family":"Inoue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0723-0047","authenticated-orcid":false,"given":"Hiroaki","family":"Miyahara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7762-4298","authenticated-orcid":false,"given":"Wulan Apridita","family":"Sebastian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuya","family":"Miyazaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Takeno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyoko","family":"Kiyota","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinji","family":"Yano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Shiraishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuyuki","family":"Shimizu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reiko","family":"Hanada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5676-8949","authenticated-orcid":false,"given":"Akihiko","family":"Yoshimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8831-1991","authenticated-orcid":false,"given":"Kenji","family":"Ihara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3317-6366","authenticated-orcid":false,"given":"Toshikatsu","family":"Hanada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2024.149551_bib1","doi-asserted-by":"crossref","first-page":"2232","DOI":"10.2215\/CJN.07400715","article-title":"Acid-base homeostasis","volume":"10","author":"Hamm","year":"2015","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"10.1016\/j.bbrc.2024.149551_bib2","doi-asserted-by":"crossref","first-page":"2073","DOI":"10.1007\/s40620-021-01032-y","article-title":"Distal renal tubular acidosis: a systematic approach from diagnosis to treatment","volume":"34","author":"Giglio","year":"2021","journal-title":"J. Nephrol."},{"key":"10.1016\/j.bbrc.2024.149551_bib3","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1038\/nrm2272","article-title":"Vacuolar ATPases: rotary proton pumps in physiology and pathophysiology","volume":"8","author":"Forgac","year":"2007","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.bbrc.2024.149551_bib4","doi-asserted-by":"crossref","first-page":"1762","DOI":"10.1242\/jeb.028803","article-title":"Regulation of the V-ATPase in kidney epithelial cells: dual role in acid-base homeostasis and vesicle trafficking","volume":"212","author":"Brown","year":"2009","journal-title":"J. Exp. Biol."},{"key":"10.1016\/j.bbrc.2024.149551_bib5","doi-asserted-by":"crossref","first-page":"3691","DOI":"10.1093\/ndt\/gfs442","article-title":"Genetic causes and mechanisms of distal renal tubular acidosis","volume":"27","author":"Batlle","year":"2012","journal-title":"Nephrol. Dial. Transplant."},{"key":"10.1016\/j.bbrc.2024.149551_bib6","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1016\/j.kint.2016.12.017","article-title":"The genetic and clinical spectrum of a large cohort of patients with distal renal tubular acidosis","volume":"91","author":"Palazzo","year":"2017","journal-title":"Kidney Int."},{"key":"10.1016\/j.bbrc.2024.149551_bib7","doi-asserted-by":"crossref","first-page":"13616","DOI":"10.1073\/pnas.0506769102","article-title":"The B1-subunit of the H ATPase is required for maximal urinary acidification","volume":"102","author":"Karin E Finberg","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbrc.2024.149551_bib8","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/S0378-5955(03)00108-4","article-title":"Mice lacking the B1 subunit of H+ -ATPase have normal hearing","volume":"180","author":"Dou","year":"2003","journal-title":"Hear. Res."},{"key":"10.1016\/j.bbrc.2024.149551_bib9","doi-asserted-by":"crossref","first-page":"3722","DOI":"10.1093\/hmg\/ddx257","article-title":"Hearing loss without overt metabolic acidosis in ATP6V1B1 deficient MRL mice, a new genetic model for non-syndromic deafness with enlarged vestibular aqueducts","volume":"26","author":"Tian","year":"2017","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.bbrc.2024.149551_bib10","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1038\/79951","article-title":"Effective targeted gene 'knockdown' in zebrafish","volume":"26","author":"Nasevicius","year":"2000","journal-title":"Nat. Genet."},{"key":"10.1016\/j.bbrc.2024.149551_bib11","doi-asserted-by":"crossref","first-page":"4982","DOI":"10.1242\/dev.099085","article-title":"Efficient CRISPR\/Cas9 genome editing with low off-target effects in zebrafish","volume":"140","author":"Hruscha","year":"2013","journal-title":"Development"},{"key":"10.1016\/j.bbrc.2024.149551_bib12","doi-asserted-by":"crossref","first-page":"132","DOI":"10.4236\/abb.2011.23021","article-title":"pHluorin2: an enhanced, ratiometric, pH-sensitive green florescent protein","volume":"2","author":"Mahon","year":"2011","journal-title":"Adv. Biosci. Biotechnol."},{"key":"10.1016\/j.bbrc.2024.149551_bib13","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1242\/dmm.016576","article-title":"The zebrafish merovingian mutant reveals a role for pH regulation in hair cell toxicity and function","volume":"7","author":"Stawicki","year":"2014","journal-title":"Dis Model Mech"},{"key":"10.1016\/j.bbrc.2024.149551_bib14","doi-asserted-by":"crossref","first-page":"3088","DOI":"10.1002\/dvdy.21343","article-title":"The Tol2kit: a multisite gateway-based construction kit for Tol2 transposon transgenesis constructs","volume":"236","author":"Kwan","year":"2007","journal-title":"Dev. Dynam."},{"key":"10.1016\/j.bbrc.2024.149551_bib15","doi-asserted-by":"crossref","DOI":"10.1242\/dmm.034165","article-title":"Modeling Niemann-Pick disease type C1 in zebrafish: a robust platform for in vivo screening of candidate therapeutic compounds","volume":"11","author":"Tseng","year":"2018","journal-title":"Dis Model Mech"},{"key":"10.1016\/j.bbrc.2024.149551_bib16","doi-asserted-by":"crossref","first-page":"8392","DOI":"10.1038\/s41598-021-87879-4","article-title":"Leucyl-tRNA synthetase deficiency systemically induces excessive autophagy in zebrafish","volume":"11","author":"Inoue","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbrc.2024.149551_bib17","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1002\/dvdy.20074","article-title":"Isoforms vatB1 and vatB2 of the vacuolar type ATPase subunit B are differentially expressed in embryos of the zebrafish (Danio rerio)","volume":"230","author":"Schredelseker","year":"2004","journal-title":"Dev. Dynam."},{"key":"10.1016\/j.bbrc.2024.149551_bib18","doi-asserted-by":"crossref","DOI":"10.1098\/rstb.2019.0163","article-title":"Cilia in the developing zebrafish ear","volume":"375","author":"Whitfield","year":"2020","journal-title":"Philos. Trans. R. Soc. Lond. B Biol. Sci."},{"key":"10.1016\/j.bbrc.2024.149551_bib19","doi-asserted-by":"crossref","first-page":"12","DOI":"10.3892\/ol.2023.14146","article-title":"In vitro anticancer effect of azithromycin targeting hypoxic lung cancer cells via the inhibition of mitophagy","volume":"27","author":"Toriyama","year":"2024","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.bbrc.2024.149551_bib20","doi-asserted-by":"crossref","DOI":"10.1242\/dmm.048997","article-title":"Loss of vacuolar-type H+-ATPase induces caspase-independent necrosis-like death of hair cells in zebrafish neuromasts","volume":"14","author":"Santra","year":"2021","journal-title":"Dis Model Mech"},{"key":"10.1016\/j.bbrc.2024.149551_bib21","doi-asserted-by":"crossref","first-page":"2297","DOI":"10.1007\/s00467-020-04685-2","article-title":"Evaluation of phenotypic and genotypic features of children with distal kidney tubular acidosis","volume":"35","author":"Atmis","year":"2020","journal-title":"Pediatr. Nephrol."},{"key":"10.1016\/j.bbrc.2024.149551_bib22","doi-asserted-by":"crossref","first-page":"3691","DOI":"10.1093\/hmg\/ddaa240","article-title":"NCOA3 identified as a new candidate to explain autosomal dominant progressive hearing loss","volume":"29","author":"Salazar-Silva","year":"2021","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.bbrc.2024.149551_bib23","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1002\/ar.24115","article-title":"Zebrafish model for nonsyndromic X-linked sensorineural deafness, DFNX1","volume":"303","author":"DeSmidt","year":"2020","journal-title":"Anat. Rec."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X2400086X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X2400086X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T14:50:03Z","timestamp":1762095003000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X2400086X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3]]},"references-count":23,"alternative-id":["S0006291X2400086X"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2024.149551","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2024,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A pH imbalance is linked to autophagic dysregulation of inner ear hair cells in Atp6v1ba-deficient zebrafish","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2024.149551","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"149551"}}