{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T08:26:43Z","timestamp":1774859203665,"version":"3.50.1"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2024,4]]},"DOI":"10.1016\/j.bbrc.2024.149661","type":"journal-article","created":{"date-parts":[[2024,2,15]],"date-time":"2024-02-15T11:12:34Z","timestamp":1707995554000},"page":"149661","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Sequential administration of delta-tocotrienol ameliorates radiation-induced myelosuppression in mice and non-human primates through inducing G-CSF production"],"prefix":"10.1016","volume":"704","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8220-1161","authenticated-orcid":false,"given":"Shaozheng","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zongchao","family":"Zuo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhangyi","family":"Ouyang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinyu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junke","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yajun","family":"Shan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruoxi","family":"Meng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenhu","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaolan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3528-1397","authenticated-orcid":false,"given":"Yiguang","family":"Jin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhongtang","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-2062-5554","authenticated-orcid":false,"given":"Limei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuwen","family":"Cong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.bbrc.2024.149661_bib1","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1097\/MOH.0000000000000380","article-title":"Medical and policy considerations for nuclear and radiation accidents, incidents and terrorism","volume":"24","author":"Gale","year":"2017","journal-title":"Curr. Opin. Hematol."},{"issue":"3","key":"10.1016\/j.bbrc.2024.149661_bib2","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1093\/rpd\/ncn173","article-title":"Estimation of health hazards resulting from a radiological terrorist attack in a city","volume":"131","author":"Andersson","year":"2008","journal-title":"Radiat. Protect. Dosim."},{"issue":"9","key":"10.1016\/j.bbrc.2024.149661_bib3","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1089\/ars.2013.5635","article-title":"Hematopoietic stem cell injury induced by ionizing radiation","volume":"20","author":"Shao","year":"2014","journal-title":"Antioxidants Redox Signal."},{"issue":"6","key":"10.1016\/j.bbrc.2024.149661_bib4","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1097\/HP.0000000000000279","article-title":"Medical countermeasures for radiation exposure and related injuries: characterization of medicines, FDA-approval status and inclusion into the strategic national stockpile","volume":"108","author":"Singh","year":"2015","journal-title":"Health Phys."},{"key":"10.1016\/j.bbrc.2024.149661_bib5","first-page":"36","article-title":"Medical countermeasures for the hematopoietic-subsyndrome of acute radiation syndrome in space","volume":"35","author":"Kernagis","year":"2022","journal-title":"Life Sci. Space Res."},{"key":"10.1016\/j.bbrc.2024.149661_bib6","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1007\/0-306-47452-2_7","article-title":"Characterization, formulation, and stability of Neupogen (Filgrastim), a recombinant human granulocyte-colony stimulating factor","volume":"9","author":"Herman","year":"1996","journal-title":"Pharmaceut. Biotechnol."},{"issue":"1","key":"10.1016\/j.bbrc.2024.149661_bib7","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.addr.2007.04.017","article-title":"Formulation of neulasta (pegfilgrastim)","volume":"60","author":"Piedmonte","year":"2008","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"3","key":"10.1016\/j.bbrc.2024.149661_bib8","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.cyto.2008.03.002","article-title":"Granulocyte colony-stimulating factor: molecular mechanisms of action during steady state and 'emergency' hematopoiesis","volume":"42","author":"Panopoulos","year":"2008","journal-title":"Cytokine"},{"issue":"1","key":"10.1016\/j.bbrc.2024.149661_bib9","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1182\/blood.V73.1.117.117","article-title":"Serum granulocyte colony-stimulating factor levels in healthy volunteers and patients with various disorders as estimated by enzyme immunoassay","volume":"73","author":"Watari","year":"1989","journal-title":"Blood"},{"issue":"10","key":"10.1016\/j.bbrc.2024.149661_bib10","doi-asserted-by":"crossref","first-page":"1962","DOI":"10.1182\/blood.V76.10.1962.1962","article-title":"Levels of serum granulocyte colony-stimulating factor in patients with infections","volume":"76","author":"Kawakami","year":"1990","journal-title":"Blood"},{"issue":"4","key":"10.1016\/j.bbrc.2024.149661_bib11","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/j.intimp.2012.09.001","article-title":"Gamma-tocotrienol, a radiation prophylaxis agent, induces high levels of granulocyte colony-stimulating factor","volume":"14","author":"Kulkarni","year":"2012","journal-title":"Int. Immunopharm."},{"issue":"2","key":"10.1016\/j.bbrc.2024.149661_bib12","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.lfs.2014.01.065","article-title":"Radioprotective efficacy of delta-tocotrienol, a vitamin E isoform, is mediated through granulocyte colony-stimulating factor","volume":"98","author":"Singh","year":"2014","journal-title":"Life Sci."},{"issue":"2","key":"10.1016\/j.bbrc.2024.149661_bib13","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.cyto.2013.03.009","article-title":"Granulocyte colony-stimulating factor antibody abrogates radioprotective efficacy of gamma-tocotrienol, a promising radiation countermeasure","volume":"62","author":"Kulkarni","year":"2013","journal-title":"Cytokine"},{"issue":"9","key":"10.1016\/j.bbrc.2024.149661_bib14","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1111\/j.1753-4887.2012.00512.x","article-title":"Tocotrienol research: past into present","volume":"70","author":"Wong","year":"2012","journal-title":"Nutr. Rev."},{"issue":"24","key":"10.1016\/j.bbrc.2024.149661_bib15","doi-asserted-by":"crossref","DOI":"10.3390\/ijms232416170","article-title":"Gamma-tocotrienol modulates total-body irradiation-induced hematopoietic injury in a nonhuman primate model","volume":"23","author":"Garg","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbrc.2024.149661_bib16","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1146\/annurev.immunol.20.083001.084359","article-title":"Innate immune recognition","volume":"20","author":"Jr","year":"2002","journal-title":"Annu. Rev. Immunol."},{"issue":"2","key":"10.1016\/j.bbrc.2024.149661_bib17","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1038\/nri1004","article-title":"Innate immune sensing and its roots: the story of endotoxin","volume":"3","author":"Beutler","year":"2003","journal-title":"Nat. Rev. Immunol."},{"issue":"4","key":"10.1016\/j.bbrc.2024.149661_bib18","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1097\/MOH.0000000000000511","article-title":"Toll-like receptor signaling in hematopoietic stem and progenitor cells","volume":"26","author":"Capitano","year":"2019","journal-title":"Curr. Opin. Hematol."},{"issue":"2","key":"10.1016\/j.bbrc.2024.149661_bib19","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1124\/jpet.112.196071","article-title":"Identification of granulocyte colony-stimulating factor and interleukin-6 as candidate biomarkers of CBLB502 efficacy as a medical radiation countermeasure","volume":"343","author":"Krivokrysenko","year":"2012","journal-title":"J. Pharmacol. Exp. Therapeut."},{"issue":"5873","key":"10.1016\/j.bbrc.2024.149661_bib20","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1126\/science.1154986","article-title":"An agonist of toll-like receptor 5 has radioprotective activity in mouse and primate models","volume":"320","author":"Burdelya","year":"2008","journal-title":"Science"},{"issue":"5","key":"10.1016\/j.bbrc.2024.149661_bib21","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1667\/RR2657.1","article-title":"CBLB613: a TLR 2\/6 agonist, natural lipopeptide of Mycoplasma arginini , as a novel radiation countermeasure","volume":"177","author":"Singh","year":"2012","journal-title":"Radiat. Res."},{"issue":"23","key":"10.1016\/j.bbrc.2024.149661_bib22","doi-asserted-by":"crossref","first-page":"3353","DOI":"10.1182\/blood.2022015879","article-title":"Extramedullary hematopoietic stem cells","volume":"139","author":"Gallagher","year":"2022","journal-title":"Blood"},{"issue":"14","key":"10.1016\/j.bbrc.2024.149661_bib23","doi-asserted-by":"crossref","first-page":"2723","DOI":"10.1007\/s00018-020-03450-w","article-title":"The mechanisms of pathological extramedullary hematopoiesis in diseases","volume":"77","author":"Yang","year":"2020","journal-title":"Cell. Mol. Life Sci."},{"issue":"7579","key":"10.1016\/j.bbrc.2024.149661_bib24","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1038\/nature15530","article-title":"A perisinusoidal niche for extramedullary haematopoiesis in the spleen","volume":"527","author":"Inra","year":"2015","journal-title":"Nature"},{"issue":"12","key":"10.1016\/j.bbrc.2024.149661_bib25","doi-asserted-by":"crossref","first-page":"2501","DOI":"10.1182\/blood-2011-11-394304","article-title":"EPO-mediated expansion of late-stage erythroid progenitors in the bone marrow initiates recovery from sublethal radiation stress","volume":"120","author":"Peslak","year":"2012","journal-title":"Blood"},{"issue":"7213","key":"10.1016\/j.bbrc.2024.149661_bib26","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1038\/nature07317","article-title":"STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling","volume":"455","author":"Ishikawa","year":"2008","journal-title":"Nature"},{"issue":"7370","key":"10.1016\/j.bbrc.2024.149661_bib27","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1038\/nature10429","article-title":"STING is a direct innate immune sensor of cyclic di-GMP","volume":"478","author":"Burdette","year":"2011","journal-title":"Nature"},{"issue":"3 Pt 2","key":"10.1016\/j.bbrc.2024.149661_bib28","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/0091-6749(94)90142-2","article-title":"Hematopoiesis","volume":"94","author":"Ogawa","year":"1994","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.bbrc.2024.149661_bib29","series-title":"Animal Rule Summary","year":"2020"},{"issue":"4","key":"10.1016\/j.bbrc.2024.149661_bib30","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.4049\/jimmunol.1500861","article-title":"G-CSF and GM-CSF in neutropenia","volume":"195","author":"Mehta","year":"2015","journal-title":"J. Immunol."},{"key":"10.1016\/j.bbrc.2024.149661_bib31","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.ijbiomac.2015.10.033","article-title":"CBLB502, an agonist of Toll-like receptor 5, has antioxidant and scavenging free radicals activities in vitro","volume":"82","author":"Li","year":"2016","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.bbrc.2024.149661_bib32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.freeradbiomed.2020.03.021","article-title":"Dimethyl sulfoxide, a potent oral radioprotective agent, confers radioprotection of hematopoietic stem and progenitor cells independent of apoptosis","volume":"153","author":"Peng","year":"2020","journal-title":"Free Radic. Biol. Med."},{"issue":"1","key":"10.1016\/j.bbrc.2024.149661_bib33","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.ijrobp.2018.08.002","article-title":"17a-Ethinyl-androst-5-ene-3b, 17b-diol, a novel potent oral radioprotective agent, confers radioprotection of hematopoietic stem and progenitor cells in a granulocyte colony-stimulating factor-independent manner","volume":"103","author":"Bai","year":"2019","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X24001979?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X24001979?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T12:40:38Z","timestamp":1757767238000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X24001979"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4]]},"references-count":33,"alternative-id":["S0006291X24001979"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2024.149661","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2024,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sequential administration of delta-tocotrienol ameliorates radiation-induced myelosuppression in mice and non-human primates through inducing G-CSF production","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2024.149661","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"149661"}}