{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T03:18:19Z","timestamp":1783567099063,"version":"3.55.0"},"reference-count":27,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2024,5]]},"DOI":"10.1016\/j.bbrc.2024.149709","type":"journal-article","created":{"date-parts":[[2024,2,22]],"date-time":"2024-02-22T04:14:55Z","timestamp":1708575295000},"page":"149709","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Renoprotective effects of laxative linaclotide: Inhibition of acute kidney injury and fibrosis in a rat model of renal ischemia-reperfusion"],"prefix":"10.1016","volume":"709","author":[{"given":"Yukihiro","family":"Hitaka","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naohito","family":"Isoyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunya","family":"Tsuji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9737-0937","authenticated-orcid":false,"given":"Takeshi","family":"Honda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Nakayama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuhiro","family":"Yamaguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimihiko","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Hirata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Shiraishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masataka","family":"Asagiri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2024.149709_bib1","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1681\/ASN.2010050546","article-title":"Where is the epidemic in kidney disease?","volume":"21","author":"Hsu","year":"2010","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.bbrc.2024.149709_bib2","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1007\/s40620-016-0291-8","article-title":"ReNe (Renal Lombardy Network), Additional contributors from ReNe Network, Healthcare costs of the progression of chronic kidney disease and different dialysis techniques estimated through administrative database analysis","volume":"30","author":"Roggeri","year":"2017","journal-title":"J. Nephrol."},{"key":"10.1016\/j.bbrc.2024.149709_bib3","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1053\/j.ajkd.2015.05.015","article-title":"Functional status, time to transplantation, and survival benefit of kidney transplantation among wait-listed candidates","volume":"66","author":"Reese","year":"2015","journal-title":"Am. J. Kidney Dis."},{"key":"10.1016\/j.bbrc.2024.149709_bib4","doi-asserted-by":"crossref","first-page":"2093","DOI":"10.1111\/j.1600-6143.2011.03686.x","article-title":"Systematic review: kidney transplantation compared with dialysis in clinically relevant outcomes","volume":"11","author":"Tonelli","year":"2011","journal-title":"Am. J. Transplant."},{"key":"10.1016\/j.bbrc.2024.149709_bib5","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.2215\/CJN.12921216","article-title":"A systematic review of the prevalence and associations of limited Health literacy in CKD","volume":"12","author":"Taylor","year":"2017","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"10.1016\/j.bbrc.2024.149709_bib6","doi-asserted-by":"crossref","first-page":"2824","DOI":"10.1111\/ajt.16463","article-title":"Long-term kidney transplant graft survival\u2014making progress when most needed","volume":"21","author":"Poggio","year":"2021","journal-title":"Am. J. Transplant."},{"key":"10.1016\/j.bbrc.2024.149709_bib7","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.ebiom.2018.01.025","article-title":"Ischemia-reperfusion injury reduces long term renal graft survival: mechanism and beyond","volume":"28","author":"Zhao","year":"2018","journal-title":"EBioMedicine"},{"key":"10.1016\/j.bbrc.2024.149709_bib8","doi-asserted-by":"crossref","DOI":"10.1038\/nm.2507","article-title":"Ischemia and reperfusion\u2014from mechanism to translation","volume":"17","author":"Eltzschig","year":"2011","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbrc.2024.149709_bib9","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1681\/ASN.2012060560","article-title":"Renal ischemia-reperfusion injury amplifies the humoral immune response","volume":"24","author":"Fuquay","year":"2013","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.bbrc.2024.149709_bib10","doi-asserted-by":"crossref","unstructured":"S. Chung, J.M. Overstreet, Y. Li, Y. Wang, A. Niu, S. Wang, X. Fan, K. Sasaki, G.-N. Jin, S.N. Khodo, L. Gewin, M.-Z. Zhang, R.C. Harris, TGF-\u03b2 promotes fibrosis after severe acute kidney injury by enhancing renal macrophage infiltration, JCI Insight. 3 (n.d.) e123563. https:\/\/doi.org\/10.1172\/jci.insight.123563..","DOI":"10.1172\/jci.insight.123563"},{"key":"10.1016\/j.bbrc.2024.149709_bib11","unstructured":"Macrophages: versatile players in renal inflammation and fibrosis | Nat. Rev. Nephrol., (n.d.). https:\/\/www.nature.com\/articles\/s41581-019-0110-2 (accessed October 25, 2023)."},{"key":"10.1016\/j.bbrc.2024.149709_bib12","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.kint.2018.10.009","article-title":"Ischemia-reperfusion injury in renal transplantation: 3 key signaling pathways in tubular epithelial cells","volume":"95","author":"Smith","year":"2019","journal-title":"Kidney Int."},{"key":"10.1016\/j.bbrc.2024.149709_bib13","first-page":"250","article-title":"The guanylate cyclase C agonist linaclotide ameliorates the gut\u2013cardio\u2013renal axis in an adenine-induced mouse model of chronic kidney disease","volume":"35","author":"Nanto-Hara","year":"2020","journal-title":"Nephrol. Dial. Transplant."},{"key":"10.1016\/j.bbrc.2024.149709_bib14","doi-asserted-by":"crossref","first-page":"2018","DOI":"10.1093\/ndt\/gfaa205","article-title":"Laxative use in patients with advanced chronic kidney disease transitioning to dialysis","volume":"36","author":"Sumida","year":"2020","journal-title":"Nephrol. Dial. Transplant."},{"key":"10.1016\/j.bbrc.2024.149709_bib15","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1111\/ajt.15794","article-title":"Targeting of intragraft reactive oxygen species by APP-103, a novel polymer product, mitigates ischemia\/reperfusion injury and promotes the survival of renal transplants","volume":"20","author":"Minami","year":"2020","journal-title":"Am. J. Transplant."},{"key":"10.1016\/j.bbrc.2024.149709_bib16","doi-asserted-by":"crossref","DOI":"10.1093\/rb\/rbac029","article-title":"Specific bFGF targeting of KIM-1 in ischemic kidneys protects against renal ischemia-reperfusion injury in rats","volume":"9","author":"Song","year":"2022","journal-title":"Regen. Biomater."},{"key":"10.1016\/j.bbrc.2024.149709_bib17","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1681\/ASN.2014060530","article-title":"Alteration of the intestinal environment by lubiprostone is associated with amelioration of adenine-induced CKD","volume":"26","author":"Mishima","year":"2015","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.bbrc.2024.149709_bib18","doi-asserted-by":"crossref","first-page":"8026","DOI":"10.3390\/ijms22158026","article-title":"Organ specific differences in alteration of aquaporin expression in rats treated with sennoside A, Senna anthraquinones and rhubarb anthraquinones","volume":"22","author":"Wang","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbrc.2024.149709_bib19","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1681\/ASN.2015010006","article-title":"Failed tubule recovery, AKI-CKD transition, and kidney disease progression","volume":"26","author":"Venkatachalam","year":"2015","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.bbrc.2024.149709_bib20","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1016\/j.kint.2020.04.048","article-title":"Intestinal microbiota control acute kidney injury severity by immune modulation","volume":"98","author":"Yang","year":"2020","journal-title":"Kidney Int."},{"key":"10.1016\/j.bbrc.2024.149709_bib21","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1186\/s12906-023-04323-y","article-title":"Berberine alleviates ischemia reperfusion injury induced AKI by regulation of intestinal microbiota and reducing intestinal inflammation","volume":"24","author":"Huo","year":"2024","journal-title":"BMC Compl. Med. Ther."},{"key":"10.1016\/j.bbrc.2024.149709_bib22","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1038\/nrneph.2015.3","article-title":"Mechanisms of maladaptive repair after AKI leading to accelerated kidney ageing and CKD","volume":"11","author":"Ferenbach","year":"2015","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.bbrc.2024.149709_bib23","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.1053\/j.gastro.2013.08.017","article-title":"Linaclotide inhibits colonic nociceptors and relieves abdominal pain via guanylate cyclase-C and extracellular cyclic guanosine 3\u2032,5\u2032-monophosphate","volume":"145","author":"Castro","year":"2013","journal-title":"Gastroenterology"},{"key":"10.1016\/j.bbrc.2024.149709_bib24","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1093\/ndt\/gfu259","article-title":"Plasma S100A12 and soluble receptor of advanced glycation end product levels and mortality in chronic kidney disease Stage 5 patients","volume":"30","author":"Isoyama","year":"2015","journal-title":"Nephrol. Dial. Transplant."},{"key":"10.1016\/j.bbrc.2024.149709_bib25","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1097\/TP.0000000000001222","article-title":"Anti-TNF-\u03b1 agent infliximab and splenectomy are protective against renal ischemia-reperfusion injury","volume":"100","author":"Nagata","year":"2016","journal-title":"Transplantation"},{"key":"10.1016\/j.bbrc.2024.149709_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.trim.2020.101263","article-title":"Receptor activator of the NF\u03baB ligand system protects renal function during experimental renal ischemia-reperfusion in mice","volume":"58","author":"Nakayama","year":"2020","journal-title":"Transpl. Immunol."},{"key":"10.1016\/j.bbrc.2024.149709_bib27","doi-asserted-by":"crossref","first-page":"183","DOI":"10.2174\/1574888X11666161024143640","article-title":"Mesenchymal stem cells in renal ischemia-reperfusion injury: biological and therapeutic perspectives","volume":"12","author":"Hu","year":"2017","journal-title":"Curr. Stem Cell Res. Ther."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X24002456?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X24002456?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,10,8]],"date-time":"2024-10-08T13:40:51Z","timestamp":1728394851000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X24002456"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5]]},"references-count":27,"alternative-id":["S0006291X24002456"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2024.149709","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2024,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Renoprotective effects of laxative linaclotide: Inhibition of acute kidney injury and fibrosis in a rat model of renal ischemia-reperfusion","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2024.149709","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"149709"}}