{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T09:59:09Z","timestamp":1792835949527,"version":"4.5.0"},"reference-count":18,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82372991"],"award-info":[{"award-number":["82372991"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2024,5]]},"DOI":"10.1016\/j.bbrc.2024.149862","type":"journal-article","created":{"date-parts":[[2024,4,7]],"date-time":"2024-04-07T22:20:51Z","timestamp":1712528451000},"page":"149862","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["A dynamic regulatory switch for phase separation of FUS protein: Zinc ions and zinc finger domain"],"prefix":"10.1016","volume":"710","author":[{"given":"Yatao","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoying","family":"Pei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Long","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7782-9824","authenticated-orcid":false,"given":"Liming","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2024.149862_bib1","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.cell.2020.03.046","article-title":"G3BP1 is a Tunable switch that Triggers phase separation to Assemble stress granules","volume":"181","author":"Yang","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.bbrc.2024.149862_bib2","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1038\/nchem.1110","article-title":"Peptide-nucleotide microdroplets as a step towards a membrane-free protocell model","volume":"3","author":"Koga","year":"2011","journal-title":"Nat. Chem."},{"key":"10.1016\/j.bbrc.2024.149862_bib3","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1038\/nrm.2017.7","article-title":"Biomolecular condensates: organizers of cellular biochemistry","volume":"18","author":"Banani","year":"2017","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.bbrc.2024.149862_bib4","doi-asserted-by":"crossref","first-page":"4334","DOI":"10.1073\/pnas.1017150108","article-title":"Active liquid-like behavior of nucleoli determines their size and shape in Xenopus laevis oocytes","volume":"108","author":"Brangwynne","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.bbrc.2024.149862_bib5","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1083\/jcb.201504117","article-title":"Prion-like domains in RNA binding proteins are essential for building subnuclear paraspeckles","volume":"210","author":"Hennig","year":"2015","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.bbrc.2024.149862_bib6","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.cell.2015.09.015","article-title":"Phase separation by low complexity domains promotes stress granule assembly and drives pathological fibrillization","volume":"163","author":"Molliex","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.bbrc.2024.149862_bib7","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1038\/s41577-021-00572-5","article-title":"Phase separation in immune signalling","volume":"22","author":"Xiao","year":"2022","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.bbrc.2024.149862_bib8","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.devcel.2020.09.014","article-title":"Phase separation and neurodegenerative diseases: a Disturbance in the Force","volume":"55","author":"Zbinden","year":"2020","journal-title":"Dev. Cell"},{"key":"10.1016\/j.bbrc.2024.149862_bib9","doi-asserted-by":"crossref","first-page":"7713","DOI":"10.1093\/nar\/gkab582","article-title":"The phase separation-dependent FUS interactome reveals nuclear and cytoplasmic function of liquid-liquid phase separation","volume":"49","author":"Reber","year":"2021","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bbrc.2024.149862_bib10","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.tips.2009.05.002","article-title":"Alzheimer's disease, metal ions and metal homeostatic therapy","volume":"30","author":"Zatta","year":"2009","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.bbrc.2024.149862_bib11","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1038\/nrn2734","article-title":"Zinc in the physiology and pathology of the CNS","volume":"10","author":"Sensi","year":"2009","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.bbrc.2024.149862_bib12","first-page":"1361","article-title":"Dietary intake and zinc status in amyotrophic lateral sclerosis patients","volume":"34","author":"Lopes da Silva","year":"2017","journal-title":"Nutr. Hosp."},{"key":"10.1016\/j.bbrc.2024.149862_bib13","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19030886","article-title":"The role of Post-Translational modifications on prion-like aggregation and liquid-phase separation of FUS","volume":"19","author":"Rhoads","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbrc.2024.149862_bib14","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1038\/s41594-021-00677-4","article-title":"Molecular interactions contributing to FUS SYGQ LC-RGG phase separation and co-partitioning with RNA polymerase II heptads","volume":"28","author":"Murthy","year":"2021","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.bbrc.2024.149862_bib15","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1038\/s41598-017-01281-7","article-title":"RRM domain of ALS\/FTD-causing FUS characteristic of irreversible unfolding spontaneously self-assembles into amyloid fibrils","volume":"7","author":"Lu","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbrc.2024.149862_bib16","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/j.molcel.2018.11.012","article-title":"The solution structure of FUS bound to RNA reveals a bipartite mode of RNA recognition with both sequence and shape specificity","volume":"73","author":"Loughlin","year":"2019","journal-title":"Mol. Cell"},{"key":"10.1016\/j.bbrc.2024.149862_bib17","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1038\/nsmb.2163","article-title":"RNA targets of wild-type and mutant FET family proteins","volume":"18","author":"Hoell","year":"2011","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.bbrc.2024.149862_bib18","doi-asserted-by":"crossref","first-page":"3754","DOI":"10.1038\/s41598-021-83196-y","article-title":"Mechanism of karyopherin-\u03b22 binding and nuclear import of ALS variants FUS(P525L) and FUS(R495X)","volume":"11","author":"Gonzalez","year":"2021","journal-title":"Sci. Rep."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X2400398X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X2400398X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,4,26]],"date-time":"2024-04-26T23:27:05Z","timestamp":1714174025000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X2400398X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5]]},"references-count":18,"alternative-id":["S0006291X2400398X"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2024.149862","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2024,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A dynamic regulatory switch for phase separation of FUS protein: Zinc ions and zinc finger domain","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2024.149862","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"149862"}}