{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T21:02:53Z","timestamp":1789765373938,"version":"4.0.1"},"reference-count":20,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100007449","name":"Takeda Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007449","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011746","name":"The NOVARTIS Foundation (Japan) for the Promotion of Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011746","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008662","name":"Murata Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008662","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007325","name":"Kobayashi International Scholarship Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007325","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007428","name":"Naito Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007428","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013236","name":"MSD Life Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013236","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007434","name":"Koeki Zaidan Hojin Suzuki Kenzo Kinen Ikagaku Oyo Kenkyu Zaidan","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007434","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2024,6]]},"DOI":"10.1016\/j.bbrc.2024.149961","type":"journal-article","created":{"date-parts":[[2024,4,16]],"date-time":"2024-04-16T19:39:57Z","timestamp":1713296397000},"page":"149961","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Nardilysin in vascular smooth muscle cells controls blood pressure via the regulation of calcium dynamics"],"prefix":"10.1016","volume":"712-713","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-7704-1593","authenticated-orcid":false,"given":"Mend Amar","family":"Batbaatar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Kinoshita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8165-8423","authenticated-orcid":false,"given":"Shinya","family":"Ikeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7404-4095","authenticated-orcid":false,"given":"Kiyoto","family":"Nishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0528-4263","authenticated-orcid":false,"given":"Hirotaka","family":"Iwasaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Narangerel","family":"Ganbaatar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikiko","family":"Ohno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8188-8026","authenticated-orcid":false,"given":"Eiichiro","family":"Nishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2024.149961_bib1","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1161\/01.CIR.64.6.1079","article-title":"The relationship of cardiac output and arterial pressure control","volume":"64","author":"Guyton","year":"1981","journal-title":"Circulation"},{"key":"10.1016\/j.bbrc.2024.149961_bib2","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1097\/01.hjh.0000209973.67746.f0","article-title":"Blood pressure and the global burden of disease 2000. Part II: estimates of attributable burden","volume":"24","author":"Lawes","year":"2006","journal-title":"J. Hypertens."},{"key":"10.1016\/j.bbrc.2024.149961_bib3","doi-asserted-by":"crossref","first-page":"e33","DOI":"10.1161\/HYPERTENSIONAHA.113.02444","article-title":"Symphony of vascular contraction: how smooth muscle cells lose harmony to signal increased vascular resistance in hypertension","volume":"63","author":"Goulopoulou","year":"2014","journal-title":"Hypertension"},{"key":"10.1016\/j.bbrc.2024.149961_bib4","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1126\/science.273.5272.245","article-title":"Regulation of myosin phosphatase by rho and rho-associated kinase (Rho-kinase)","volume":"273","author":"Kimura","year":"1996","journal-title":"Science"},{"key":"10.1016\/j.bbrc.2024.149961_bib5","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1152\/physrev.00023.2003","article-title":"Ca2+ sensitivity of smooth muscle and nonmuscle myosin II: modulated by G proteins, kinases, and myosin phosphatase","volume":"83","author":"Somlyo","year":"2003","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.bbrc.2024.149961_bib6","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1093\/cvr\/cvy023","article-title":"Vascular smooth muscle contraction in hypertension","volume":"114","author":"Touyz","year":"2018","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.bbrc.2024.149961_bib7","doi-asserted-by":"crossref","first-page":"3342","DOI":"10.1093\/emboj\/20.13.3342","article-title":"N-arginine dibasic convertase is a specific receptor for heparin-binding EGF-like growth factor that mediates cell migration","volume":"20","author":"Nishi","year":"2001","journal-title":"EMBO J."},{"key":"10.1016\/j.bbrc.2024.149961_bib8","doi-asserted-by":"crossref","first-page":"31164","DOI":"10.1074\/jbc.M601316200","article-title":"Nardilysin enhances ectodomain shedding of heparin-binding epidermal growth factor-like growth factor through activation of tumor necrosis factor-alpha-converting enzyme","volume":"281","author":"Nishi","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2024.149961_bib9","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.bbrc.2008.03.050","article-title":"Ectodomain shedding of TNF-alpha is enhanced by nardilysin via activation of ADAM proteases","volume":"370","author":"Hiraoka","year":"2008","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbrc.2024.149961_bib10","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.1038\/nn.2438","article-title":"Nardilysin regulates axonal maturation and myelination in the central and peripheral nervous system","volume":"12","author":"Ohno","year":"2009","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.bbrc.2024.149961_bib11","doi-asserted-by":"crossref","first-page":"3224","DOI":"10.1038\/ncomms4224","article-title":"Critical roles of nardilysin in the maintenance of body temperature homoeostasis","volume":"5","author":"Hiraoka","year":"2014","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbrc.2024.149961_bib12","doi-asserted-by":"crossref","first-page":"3015","DOI":"10.2337\/db16-0178","article-title":"Nardilysin is required for maintaining pancreatic beta-cell function","volume":"65","author":"Nishi","year":"2016","journal-title":"Diabetes"},{"key":"10.1016\/j.bbrc.2024.149961_bib13","doi-asserted-by":"crossref","first-page":"11624","DOI":"10.1096\/fj.202000604R","article-title":"Nardilysin controls cardiac sympathetic innervation patterning through regulation of p75 neurotrophin receptor","volume":"34","author":"Ohno","year":"2020","journal-title":"Faseb. J."},{"key":"10.1016\/j.bbrc.2024.149961_bib14","doi-asserted-by":"crossref","first-page":"7142","DOI":"10.1073\/pnas.102650499","article-title":"Smooth muscle-selective deletion of guanylyl cyclase-A prevents the acute but not chronic effects of ANP on blood pressure","volume":"99","author":"Holtwick","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbrc.2024.149961_bib15","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1002\/gene.20112","article-title":"High-efficiency somatic mutagenesis in smooth muscle cells and cardiac myocytes in SM22alpha-Cre transgenic mice","volume":"41","author":"Lepore","year":"2005","journal-title":"Genesis"},{"key":"10.1016\/j.bbrc.2024.149961_bib16","doi-asserted-by":"crossref","DOI":"10.1136\/rmdopen-2017-000436","article-title":"Nardilysin is involved in autoimmune arthritis via the regulation of tumour necrosis factor alpha secretion","volume":"3","author":"Fujii","year":"2017","journal-title":"RMD Open"},{"key":"10.1016\/j.bbrc.2024.149961_bib17","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.91316","article-title":"Nardilysin controls intestinal tumorigenesis through HDAC1\/p53-dependent transcriptional regulation","volume":"3","author":"Kanda","year":"2018","journal-title":"JCI Insight"},{"key":"10.1016\/j.bbrc.2024.149961_bib18","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1038\/s41419-021-03671-2","article-title":"Smooth muscle-specific HuR knockout induces defective autophagy and atherosclerosis","volume":"12","author":"Liu","year":"2021","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.bbrc.2024.149961_bib19","doi-asserted-by":"crossref","first-page":"2395","DOI":"10.1093\/cvr\/cvab021","article-title":"Truncated YY1 interacts with BASP1 through a 339KLK341 motif in YY1 and suppresses vascular smooth muscle cell growth and intimal hyperplasia after vascular injury","volume":"117","author":"Santiago","year":"2021","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.bbrc.2024.149961_bib20","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1042\/bj20020822","article-title":"The metalloendopeptidase nardilysin (NRDc) is potently inhibited by heparin-binding epidermal growth factor-like growth factor (HB-EGF)","volume":"367","author":"Hospital","year":"2002","journal-title":"Biochem. J."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X24004972?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X24004972?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T20:15:05Z","timestamp":1789762505000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X24004972"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6]]},"references-count":20,"alternative-id":["S0006291X24004972"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2024.149961","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2024,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Nardilysin in vascular smooth muscle cells controls blood pressure via the regulation of calcium dynamics","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2024.149961","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"149961"}}