{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T00:52:22Z","timestamp":1780361542894,"version":"3.54.1"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2024,8]]},"DOI":"10.1016\/j.bbrc.2024.150130","type":"journal-article","created":{"date-parts":[[2024,5,16]],"date-time":"2024-05-16T06:56:05Z","timestamp":1715842565000},"page":"150130","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["Apigenin intervenes in liver fibrosis by regulating PKM2-HIF-1\u03b1 mediated oxidative stress"],"prefix":"10.1016","volume":"721","author":[{"given":"Tao","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saifei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoying","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanfei","family":"Lei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baoying","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianghua","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanfa","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ningning","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2024.150130_bib1","doi-asserted-by":"crossref","DOI":"10.3390\/cells10051097","article-title":"Pathophysiology and treatment options for hepatic fibrosis: can it Be completely cured?","volume":"10","author":"Khanam","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.bbrc.2024.150130_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2021.108051","article-title":"Crosstalk between hepatic stellate cells and surrounding cells in hepatic fibrosis","volume":"99","author":"Yang","year":"2021","journal-title":"Int. Immunopharm."},{"key":"10.1016\/j.bbrc.2024.150130_bib3","doi-asserted-by":"crossref","first-page":"709","DOI":"10.3389\/fcell.2020.00709","article-title":"Hepatic stellate cells and hepatocarcinogenesis","volume":"8","author":"Barry","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.bbrc.2024.150130_bib4","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1016\/j.cell.2011.03.054","article-title":"Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1","volume":"145","author":"Luo","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.bbrc.2024.150130_bib5","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/6114132","article-title":"Contribution of oxidative stress to HIF-1-Mediated profibrotic changes during the kidney damage","volume":"2021","author":"Zhang","year":"2021","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.bbrc.2024.150130_bib6","doi-asserted-by":"crossref","first-page":"2267","DOI":"10.1016\/j.ajpath.2020.08.002","article-title":"Pyruvate kinase M2 tetramerization protects against hepatic stellate cell activation and liver fibrosis","volume":"190","author":"Zheng","year":"2020","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.bbrc.2024.150130_bib7","doi-asserted-by":"crossref","first-page":"26087","DOI":"10.3390\/ijms161125942","article-title":"The role of oxidative stress and antioxidants in liver diseases","volume":"16","author":"Li","year":"2015","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbrc.2024.150130_bib8","doi-asserted-by":"crossref","DOI":"10.3390\/antiox12091653","article-title":"Oxidative stress in liver pathophysiology and disease","volume":"12","author":"Allameh","year":"2023","journal-title":"Antioxidants"},{"key":"10.1016\/j.bbrc.2024.150130_bib9","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24044004","article-title":"Fibrosis: types, effects, markers, mechanisms for disease progression, and its relation with oxidative stress, immunity, and inflammation","volume":"24","author":"Antar","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbrc.2024.150130_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.111398","article-title":"Isobavachalcone attenuates liver fibrosis via activation of the Nrf2\/HO-1 pathway in rats","volume":"128","author":"Wang","year":"2024","journal-title":"Int. Immunopharm."},{"key":"10.1016\/j.bbrc.2024.150130_bib11","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1038\/s41401-020-00545-9","article-title":"\u03b2-Arrestin2 deficiency attenuates oxidative stress in mouse hepatic fibrosis through modulation of NOX4","volume":"42","author":"Du","year":"2021","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.bbrc.2024.150130_bib12","article-title":"Recent advances in research on active compounds against hepatic fibrosis","author":"Liu","year":"2023","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.bbrc.2024.150130_bib13","article-title":"Liver fibrosis: pathophysiology and clinical implications","volume":"13","author":"Berumen","year":"2021","journal-title":"WIREs Mech. Dis."},{"key":"10.1016\/j.bbrc.2024.150130_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2021.173982","article-title":"Carvacrol alleviates liver fibrosis by inhibiting TRPM7 and modulating the MAPK signaling pathway","volume":"898","author":"Cai","year":"2021","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.bbrc.2024.150130_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2019.105765","article-title":"Research progress on the anti-hepatic fibrosis action and mechanism of natural products","volume":"75","author":"Shan","year":"2019","journal-title":"Int. Immunopharm."},{"key":"10.1016\/j.bbrc.2024.150130_bib16","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1007\/s11064-021-03473-0","article-title":"Neuroprotective effect of apigenin on depressive-like behavior: mechanistic approach","volume":"47","author":"Bijani","year":"2022","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.bbrc.2024.150130_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2021.119641","article-title":"Protective effect of apigenin on ethylene glycol-induced urolithiasis via attenuating oxidative stress and inflammatory parameters in adult male Wistar rats","volume":"279","author":"Azimi","year":"2021","journal-title":"Life Sci."},{"key":"10.1016\/j.bbrc.2024.150130_bib18","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/6651839","article-title":"Apigenin alleviates liver fibrosis by inhibiting hepatic stellate cell activation and autophagy via TGF-\u03b21\/smad3 and p38\/PPAR\u03b1 pathways","volume":"2021","author":"Ji","year":"2021","journal-title":"PPAR Res."},{"key":"10.1016\/j.bbrc.2024.150130_bib19","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.2174\/1389201021666200320140908","article-title":"Apigenin alleviates renal fibroblast activation through AMPK and ERK signaling pathways in vitro","volume":"21","author":"Li","year":"2020","journal-title":"Curr. Pharmaceut. Biotechnol."},{"key":"10.1016\/j.bbrc.2024.150130_bib20","doi-asserted-by":"crossref","first-page":"2616","DOI":"10.3748\/wjg.v29.i17.2616","article-title":"Cryptotanshinone induces apoptosis of activated hepatic stellate cells via modulating endoplasmic reticulum stress","volume":"29","author":"Hou","year":"2023","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.bbrc.2024.150130_bib21","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1186\/s12986-021-00589-6","article-title":"Dihydromyricetin ameliorates liver fibrosis via inhibition of hepatic stellate cells by inducing autophagy and natural killer cell-mediated killing effect","volume":"18","author":"Zhou","year":"2021","journal-title":"Nutr. Metabol."},{"key":"10.1016\/j.bbrc.2024.150130_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2022.109433","article-title":"Glabridin inhibits liver fibrosis and hepatic stellate cells activation through suppression of inflammation and oxidative stress by activating PPAR\u03b3 in carbon tetrachloride-treated mice","volume":"113","author":"Zhang","year":"2022","journal-title":"Int. Immunopharm."},{"key":"10.1016\/j.bbrc.2024.150130_bib23","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1002\/hep.31437","article-title":"Attenuating the epidermal growth factor receptor-extracellular signal-regulated kinase-sex-determining region Y-box 9 Axis promotes liver progenitor cell-mediated liver regeneration in Zebrafish","volume":"73","author":"So","year":"2021","journal-title":"Hepatology (Baltimore, Md"},{"key":"10.1016\/j.bbrc.2024.150130_bib24","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1002\/jcp.30582","article-title":"Hepatic stellate cells in the injured liver: perspectives beyond hepatic fibrosis","volume":"237","author":"Ezhilarasan","year":"2022","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.bbrc.2024.150130_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2020.104720","article-title":"Intercellular crosstalk of hepatic stellate cells in liver fibrosis: new insights into therapy","volume":"155","author":"Cai","year":"2020","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.bbrc.2024.150130_bib26","doi-asserted-by":"crossref","DOI":"10.3389\/fmolb.2023.1183808","article-title":"Mechanical homeostasis imbalance in hepatic stellate cells activation and hepatic fibrosis","volume":"10","author":"Zhao","year":"2023","journal-title":"Front. Mol. Biosci."},{"key":"10.1016\/j.bbrc.2024.150130_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154466","article-title":"TKF, a mexicanolide-type limonoid derivative, suppressed hepatic stellate cells activation and liver fibrosis through inhibition of the YAP\/Notch3 pathway","volume":"107","author":"Yang","year":"2022","journal-title":"Phytomedicine : Int. J. Phytother. Phytopharm."},{"key":"10.1016\/j.bbrc.2024.150130_bib28","doi-asserted-by":"crossref","first-page":"2774","DOI":"10.1002\/hep.31987","article-title":"Single-cell transcriptomic analysis reveals a hepatic stellate cell-activation roadmap and myofibroblast origin during liver fibrosis in mice","volume":"74","author":"Yang","year":"2021","journal-title":"Hepatology"},{"key":"10.1016\/j.bbrc.2024.150130_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2020.107151","article-title":"Amygdalin inhibits TGF\u03b21-induced activation of hepatic stellate cells (HSCs) in vitro and CCl(4)-induced hepatic fibrosis in rats in vivo","volume":"90","author":"Wang","year":"2021","journal-title":"Int. Immunopharm."},{"key":"10.1016\/j.bbrc.2024.150130_bib30","doi-asserted-by":"crossref","DOI":"10.3390\/cells9020281","article-title":"Glycochenodeoxycholate promotes liver fibrosis in mice with hepatocellular cholestasis","volume":"9","author":"Hohenester","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.bbrc.2024.150130_bib31","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.immuni.2024.01.009","article-title":"Amphiregulin from regulatory T cells promotes liver fibrosis and insulin resistance in non-alcoholic steatohepatitis","volume":"57","author":"Savage","year":"2024","journal-title":"Immunity"},{"key":"10.1016\/j.bbrc.2024.150130_bib32","doi-asserted-by":"crossref","DOI":"10.3390\/cells12151930","article-title":"Glycolysis in chronic liver diseases: mechanistic insights and therapeutic opportunities","volume":"12","author":"Qu","year":"2023","journal-title":"Cells"}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X24006661?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X24006661?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,5]],"date-time":"2024-06-05T11:59:54Z","timestamp":1717588794000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X24006661"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8]]},"references-count":32,"alternative-id":["S0006291X24006661"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2024.150130","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2024,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Apigenin intervenes in liver fibrosis by regulating PKM2-HIF-1\u03b1 mediated oxidative stress","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2024.150130","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"150130"}}