{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T03:35:38Z","timestamp":1783740938926,"version":"3.55.0"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2024,8]]},"DOI":"10.1016\/j.bbrc.2024.150145","type":"journal-article","created":{"date-parts":[[2024,5,20]],"date-time":"2024-05-20T05:47:23Z","timestamp":1716184043000},"page":"150145","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["A regulatory role of the medial septum in the chloroquine-induced acute itch through local GABAergic system and GABAergic pathway to the anterior cingulate cortex"],"prefix":"10.1016","volume":"721","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0846-8359","authenticated-orcid":false,"given":"Jianyu","family":"Zhu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yayue","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lixia","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3308-3100","authenticated-orcid":false,"given":"Wei","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yachen","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7117-6386","authenticated-orcid":false,"given":"Ting","family":"Yi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiliang","family":"Maoying","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxia","family":"Chu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanqing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8324-0007","authenticated-orcid":false,"given":"Wenli","family":"Mi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2024.150145_bib1","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1038\/nrn1950","article-title":"The neurobiology of itch","volume":"7","author":"Ikoma","year":"2006","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.bbrc.2024.150145_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2023.113304","article-title":"An atlas of itch-associated neural dynamics in the mouse brain","volume":"42","author":"Chen","year":"2023","journal-title":"Cell Rep."},{"key":"10.1016\/j.bbrc.2024.150145_bib3","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1126\/science.aaf4918","article-title":"A central neural circuit for itch sensation","volume":"357","author":"Mu","year":"2017","journal-title":"Science"},{"key":"10.1016\/j.bbrc.2024.150145_bib4","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.neuroscience.2020.07.048","article-title":"Posterior thalamic nucleus mediates facial histaminergic itch","volume":"444","author":"Zhu","year":"2020","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbrc.2024.150145_bib5","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.neuron.2018.11.010","article-title":"Tac1-Expressing neurons in the periaqueductal gray facilitate the itch-scratching cycle via descending regulation","volume":"101","author":"Gao","year":"2019","journal-title":"Neuron"},{"key":"10.1016\/j.bbrc.2024.150145_bib6","doi-asserted-by":"crossref","first-page":"4356","DOI":"10.1038\/s41467-019-12316-0","article-title":"Cell type-specific modulation of sensory and affective components of itch in the periaqueductal gray","volume":"10","author":"Samineni","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbrc.2024.150145_bib7","doi-asserted-by":"crossref","first-page":"10330","DOI":"10.1523\/JNEUROSCI.1445-21.2021","article-title":"Multiplexed representation of itch and mechanical and thermal sensation in the primary somatosensory cortex","volume":"41","author":"Chen","year":"2021","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbrc.2024.150145_bib8","doi-asserted-by":"crossref","first-page":"3823","DOI":"10.1523\/JNEUROSCI.3466-17.2018","article-title":"ACC to dorsal medial striatum inputs modulate histaminergic itch sensation","volume":"38","author":"Lu","year":"2018","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbrc.2024.150145_bib9","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1007\/s12264-023-01093-y","article-title":"The anterior insula and its projection to the prelimbic cortex are involved in the regulation of 5-HT-induced itch","volume":"39","author":"Yao","year":"2023","journal-title":"Neurosci. Bull."},{"key":"10.1016\/j.bbrc.2024.150145_bib10","article-title":"The medial septum as a potential target for treating brain disorders associated with oscillopathies","volume":"15","author":"Takeuchi","year":"2021","journal-title":"Front. Neural Circ."},{"key":"10.1016\/j.bbrc.2024.150145_bib11","doi-asserted-by":"crossref","first-page":"11185","DOI":"10.1523\/JNEUROSCI.2042-16.2016","article-title":"An inhibitory septum to lateral hypothalamus circuit that suppresses feeding","volume":"36","author":"Sweeney","year":"2016","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbrc.2024.150145_bib12","doi-asserted-by":"crossref","first-page":"13816","DOI":"10.1073\/pnas.1707228114","article-title":"Appetite suppressive role of medial septal glutamatergic neurons","volume":"114","author":"Sweeney","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbrc.2024.150145_bib13","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1038\/s41586-021-03956-8","article-title":"5-HT modulation of a medial septal circuit tunes social memory stability","volume":"599","author":"Wu","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2024.150145_bib14","doi-asserted-by":"crossref","first-page":"11741","DOI":"10.1096\/fj.202000398R","article-title":"Dorsal hippocampus- and ACC-projecting medial septum neurons differentially contribute to the recollection of episodic-like memory","volume":"34","author":"Jin","year":"2020","journal-title":"Faseb. J."},{"key":"10.1016\/j.bbrc.2024.150145_bib15","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1016\/j.cub.2021.01.019","article-title":"Medial septum glutamatergic neurons control wakefulness through a septo-hypothalamic circuit","volume":"31","author":"An","year":"2021","journal-title":"Curr. Biol."},{"key":"10.1016\/j.bbrc.2024.150145_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.physbeh.2021.113448","article-title":"Changes in sleep-wake cycle after microinjection of agonist and antagonist of endocannabinoid receptors at the medial septum of rats","volume":"237","author":"Puskar","year":"2021","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.bbrc.2024.150145_bib17","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/j.biopsych.2019.11.014","article-title":"Direct septum-Hippocampus cholinergic circuit attenuates seizure through driving somatostatin inhibition","volume":"87","author":"Wang","year":"2020","journal-title":"Biol. Psychiatr."},{"key":"10.1016\/j.bbrc.2024.150145_bib18","doi-asserted-by":"crossref","DOI":"10.1038\/srep15419","article-title":"GABAergic neurons of the medial septum play a nodal role in facilitation of nociception-induced affect","volume":"5","author":"Ang","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbrc.2024.150145_bib19","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.neulet.2018.01.041","article-title":"Cholinergic neurons in medial septum maintain anxiety-like behaviors induced by chronic inflammatory pain","volume":"671","author":"Jiang","year":"2018","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.bbrc.2024.150145_bib20","doi-asserted-by":"crossref","first-page":"2528","DOI":"10.1016\/j.pain.2011.07.019","article-title":"Forebrain medial septum region facilitates nociception in a rat formalin model of inflammatory pain","volume":"152","author":"Lee","year":"2011","journal-title":"Pain"},{"key":"10.1016\/j.bbrc.2024.150145_bib21","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1016\/S0306-4522(01)00006-9","article-title":"Selective destruction of medial septal cholinergic neurons attenuates pyramidal cell suppression, but not excitation in dorsal hippocampus field CA1 induced by subcutaneous injection of formalin","volume":"103","author":"Zheng","year":"2001","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbrc.2024.150145_bib22","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.1097\/j.pain.0000000000001240","article-title":"Neural pathways in medial septal cholinergic modulation of chronic pain: distinct contribution of the anterior cingulate cortex and ventral hippocampus","volume":"159","author":"Jiang","year":"2018","journal-title":"Pain"},{"key":"10.1016\/j.bbrc.2024.150145_bib23","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1002\/(SICI)1096-9861(19970224)378:4<508::AID-CNE6>3.0.CO;2-6","article-title":"Distribution of trigeminohypothalamic and spinohypothalamic tract neurons displaying substance P receptor-like immunoreactivity in the rat","volume":"378","author":"Li","year":"1997","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.bbrc.2024.150145_bib24","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1038\/s41467-022-28854-z","article-title":"A bottom-up reward pathway mediated by somatostatin neurons in the medial septum complex underlying appetitive learning","volume":"13","author":"Shen","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbrc.2024.150145_bib25","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1016\/j.neuron.2019.03.030","article-title":"Central processing of itch in the midbrain reward center","volume":"102","author":"Su","year":"2019","journal-title":"Neuron"},{"key":"10.1016\/j.bbrc.2024.150145_bib26","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1126\/science.aar5703","article-title":"Piezo2 channel-Merkel cell signaling modulates the conversion of touch to itch","volume":"360","author":"Feng","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.bbrc.2024.150145_bib27","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1146\/annurev.pa.20.040180.002301","article-title":"Efficient analysis of experimental observations","volume":"20","author":"Dixon","year":"1980","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.bbrc.2024.150145_bib28","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0301-0082(96)00021-4","article-title":"Activation of c-fos in the brain","volume":"50","author":"Herrera","year":"1996","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.bbrc.2024.150145_bib29","doi-asserted-by":"crossref","first-page":"7025","DOI":"10.1523\/JNEUROSCI.1954-08.2008","article-title":"A FLEX switch targets Channelrhodopsin-2 to multiple cell types for imaging and long-range circuit mapping","volume":"28","author":"Atasoy","year":"2008","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbrc.2024.150145_bib30","doi-asserted-by":"crossref","first-page":"2501","DOI":"10.1038\/s41467-020-16198-5","article-title":"nNOS-expressing neurons in the vmPFC transform pPVT-derived chronic pain signals into anxiety behaviors","volume":"11","author":"Liang","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbrc.2024.150145_bib31","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2202536119","article-title":"Dissection of the long-range projections of specific neurons at the synaptic level in the whole mouse brain","volume":"119","author":"Tian","year":"2022","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbrc.2024.150145_bib32","doi-asserted-by":"crossref","first-page":"27011","DOI":"10.1073\/pnas.1905658116","article-title":"Synaptic control of spinal GRPR(+) neurons by local and long-range inhibitory inputs","volume":"116","author":"Liu","year":"2019","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbrc.2024.150145_bib33","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1152\/physrev.1995.75.2.393","article-title":"The septohippocampal pathway: structure and function of a central cholinergic system","volume":"75","author":"Dutar","year":"1995","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.bbrc.2024.150145_bib34","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1152\/jn.00367.2014","article-title":"Interconnection and synchronization of neuronal populations in the mouse medial septum\/diagonal band of Broca","volume":"113","author":"Leao","year":"2015","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.bbrc.2024.150145_bib35","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1093\/ijnp\/pyad019","article-title":"Medial prefrontal cortex to medial septum pathway activation improves cognitive flexibility in rats","volume":"26","author":"Bortz","year":"2023","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.bbrc.2024.150145_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2020.108028","article-title":"Anteromedial thalamic nucleus to anterior cingulate cortex inputs modulate histaminergic itch sensation","volume":"168","author":"Deng","year":"2020","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.bbrc.2024.150145_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbr.2021.113388","article-title":"Differential roles of prelimbic and anterior cingulate cortical region in the modulation of histaminergic and non-histaminergic itch","volume":"411","author":"Li","year":"2021","journal-title":"Behav. Brain Res."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X24006818?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X24006818?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,5]],"date-time":"2024-06-05T12:01:41Z","timestamp":1717588901000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X24006818"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8]]},"references-count":37,"alternative-id":["S0006291X24006818"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2024.150145","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2024,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A regulatory role of the medial septum in the chloroquine-induced acute itch through local GABAergic system and GABAergic pathway to the anterior cingulate cortex","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2024.150145","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"150145"}}