{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T19:36:08Z","timestamp":1781897768969,"version":"3.54.5"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2024,9]]},"DOI":"10.1016\/j.bbrc.2024.150216","type":"journal-article","created":{"date-parts":[[2024,6,4]],"date-time":"2024-06-04T00:36:22Z","timestamp":1717461382000},"page":"150216","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Protection of blood-brain barrier by endothelial DAPK1 deletion after stroke"],"prefix":"10.1016","volume":"724","author":[{"given":"Zhijiang","family":"Gu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaoxun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiyu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaotian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cong","family":"Pang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lianshu","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changchun","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2024.150216_bib1","doi-asserted-by":"crossref","first-page":"e347","DOI":"10.1161\/CIR.0000000000001209","article-title":"Heart disease and stroke statistics: a report of US and global data from the American heart association","volume":"149","author":"Martin","year":"2024","journal-title":"Circulation"},{"key":"10.1016\/j.bbrc.2024.150216_bib2","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1161\/STROKEAHA.123.044174","article-title":"Current and future treatments of vascular cognitive impairment","volume":"55","author":"Ip","year":"2024","journal-title":"Stroke"},{"key":"10.1016\/j.bbrc.2024.150216_bib3","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1056\/NEJMoa1813046","article-title":"Thrombolysis guided by perfusion imaging up to 9 hours after onset of stroke","volume":"380","author":"Ma","year":"2019","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bbrc.2024.150216_bib4","doi-asserted-by":"crossref","first-page":"2690","DOI":"10.1161\/STROKEAHA.120.030173","article-title":"Symptomatic intracranial hemorrhage after mechanical thrombectomy in Chinese ischemic stroke patients: the ASIAN score","volume":"51","author":"Zhang","year":"2020","journal-title":"Stroke"},{"key":"10.1016\/j.bbrc.2024.150216_bib5","doi-asserted-by":"crossref","first-page":"2688","DOI":"10.1161\/STROKEAHA.123.044123","article-title":"Neurovascular inflammation and complications of thrombolysis therapy in stroke","volume":"54","author":"Liu","year":"2023","journal-title":"Stroke"},{"key":"10.1016\/j.bbrc.2024.150216_bib6","article-title":"The next step in the treatment of stroke","volume":"11","author":"Matei","year":"2020","journal-title":"Front. Neurol."},{"key":"10.1016\/j.bbrc.2024.150216_bib7","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1016\/S0140-6736(20)30258-0","article-title":"Efficacy and safety of nerinetide for the treatment of acute ischaemic stroke (ESCAPE-NA1): a multicentre, double-blind, randomised controlled trial","volume":"395","author":"Hill","year":"2020","journal-title":"Lancet"},{"key":"10.1016\/j.bbrc.2024.150216_bib8","doi-asserted-by":"crossref","DOI":"10.1111\/cns.14634","article-title":"Advancing stroke therapy: a deep dive into early phase of ischemic stroke and recanalization","volume":"30","author":"He","year":"2024","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.bbrc.2024.150216_bib9","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1002\/ana.25383","volume":"85","author":"Lyden","year":"2019","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.bbrc.2024.150216_bib10","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.cellsig.2018.09.019","article-title":"S1PR2 antagonist alleviates oxidative stress-enhanced brain endothelial permeability by attenuating p38 and Erk1\/2-dependent cPLA2 phosphorylation","volume":"53","author":"Cao","year":"2019","journal-title":"Cell. Signal."},{"key":"10.1016\/j.bbrc.2024.150216_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellsig.2019.109467","article-title":"Activation of CRHR1 contributes to cerebral endothelial barrier impairment via cPLA2 phosphorylation in experimental ischemic stroke","volume":"66","author":"Cao","year":"2020","journal-title":"Cell. Signal."},{"key":"10.1016\/j.bbrc.2024.150216_bib12","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1021\/acs.jmedchem.2c01606","article-title":"Targeting death-associated protein kinases for treatment of human diseases: recent advances and future directions","volume":"66","author":"Zhang","year":"2023","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bbrc.2024.150216_bib13","doi-asserted-by":"crossref","first-page":"42290","DOI":"10.1074\/jbc.M505804200","article-title":"Death-associated protein kinase is activated by dephosphorylation in response to cerebral ischemia","volume":"280","author":"Shamloo","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2024.150216_bib14","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.cell.2009.12.055","article-title":"DAPK1 interaction with NMDA receptor NR2B subunits mediates brain damage in stroke","volume":"140","author":"Tu","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.bbrc.2024.150216_bib15","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.jns.2018.01.003","article-title":"DAPK1-ERK signal mediates oxygen glucose deprivation reperfusion induced apoptosis in mouse N2a cells","volume":"387","author":"Xiong","year":"2018","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.bbrc.2024.150216_bib16","doi-asserted-by":"crossref","first-page":"4904","DOI":"10.1007\/s12035-018-1415-z","article-title":"Expression and functional relevance of death-associated protein kinase in human drug-resistant epileptic brain: focusing on the neurovascular interface","volume":"56","author":"Williams","year":"2019","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.bbrc.2024.150216_bib17","doi-asserted-by":"crossref","first-page":"9062","DOI":"10.1096\/fj.201802052RRR","article-title":"ZIPK mediates endothelial cell contraction through myosin light chain phosphorylation and is required for ischemic-reperfusion injury","volume":"33","author":"Zhang","year":"2019","journal-title":"Faseb. J."},{"key":"10.1016\/j.bbrc.2024.150216_bib18","doi-asserted-by":"crossref","first-page":"8611","DOI":"10.1128\/MCB.24.19.8611-8626.2004","article-title":"Death-associated protein kinase phosphorylates ZIP kinase, forming a unique kinase hierarchy to activate its cell death functions","volume":"24","author":"Shani","year":"2004","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.bbrc.2024.150216_bib19","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.molcel.2008.09.019","article-title":"DAPK-ZIPK-L13a axis constitutes a negative-feedback module regulating inflammatory gene expression","volume":"32","author":"Mukhopadhyay","year":"2008","journal-title":"Mol. Cell"},{"key":"10.1016\/j.bbrc.2024.150216_bib20","doi-asserted-by":"crossref","first-page":"3760","DOI":"10.7150\/thno.53316","article-title":"Environmental enrichment implies GAT-1 as a potential therapeutic target for stroke recovery","volume":"11","author":"Lin","year":"2021","journal-title":"Theranostics"},{"key":"10.1016\/j.bbrc.2024.150216_bib21","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0226302","article-title":"Isolation of endothelial cells, pericytes and astrocytes from mouse brain","volume":"14","author":"Bernard-Patrzynski","year":"2019","journal-title":"PLoS One"},{"key":"10.1016\/j.bbrc.2024.150216_bib22","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.jneumeth.2010.12.013","article-title":"Comparison Evans Blue injection routes: intravenous versus intraperitoneal, for measurement of blood-brain barrier in a mice hemorrhage model","volume":"195","author":"Manaenko","year":"2011","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.bbrc.2024.150216_bib23","doi-asserted-by":"crossref","first-page":"13535","DOI":"10.1523\/JNEUROSCI.1305-14.2014","article-title":"Interaction of nNOS with PSD-95 negatively controls regenerative repair after stroke","volume":"34","author":"Luo","year":"2014","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbrc.2024.150216_bib24","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms10180","article-title":"Nuclear AURKA acquires kinase-independent transactivating function to enhance breast cancer stem cell phenotype","volume":"7","author":"Zheng","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbrc.2024.150216_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellsig.2021.110062","article-title":"ITPRIP promotes glioma progression by linking MYL9 to DAPK1 inhibition","volume":"85","author":"Cao","year":"2021","journal-title":"Cell. Signal."},{"key":"10.1016\/j.bbrc.2024.150216_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.111693","article-title":"Nrf 2 activation by neferine mitigates microglial neuroinflammation after subarachnoid hemorrhage through inhibiting TAK1-NF-kappaB signaling","volume":"130","author":"Zhang","year":"2024","journal-title":"Int. Immunopharm."},{"key":"10.1016\/j.bbrc.2024.150216_bib27","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1002\/path.4999","article-title":"Dissociation of nNOS from PSD-95 promotes functional recovery after cerebral ischaemia in mice through reducing excessive tonic GABA release from reactive astrocytes","volume":"244","author":"Lin","year":"2018","journal-title":"J. Pathol."},{"key":"10.1016\/j.bbrc.2024.150216_bib28","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1186\/s12883-023-03159-w","article-title":"Cerebrolysin as an early add-on to reperfusion therapy: risk of hemorrhagic transformation after ischemic stroke (CEREHETIS), a prospective, randomized, multicenter pilot study","volume":"23","author":"Khasanova","year":"2023","journal-title":"BMC Neurol."},{"key":"10.1016\/j.bbrc.2024.150216_bib29","doi-asserted-by":"crossref","first-page":"4716","DOI":"10.1007\/s12035-016-0008-y","article-title":"DAPK1 signaling pathways in stroke: from mechanisms to therapies","volume":"54","author":"Wang","year":"2017","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.bbrc.2024.150216_bib30","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23126370","article-title":"Blocking ERK-DAPK1 Axis attenuates glutamate excitotoxicity in epilepsy","volume":"23","author":"Gan","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbrc.2024.150216_bib31","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.neuroscience.2013.11.024","article-title":"The role of DAPK-BimEL pathway in neuronal death induced by oxygen-glucose deprivation","volume":"258","author":"He","year":"2014","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbrc.2024.150216_bib32","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.cellsig.2010.09.016","article-title":"Phosphorylation-dependent control of ZIPK nuclear import is species specific","volume":"23","author":"Weitzel","year":"2011","journal-title":"Cell. Signal."},{"key":"10.1016\/j.bbrc.2024.150216_bib33","doi-asserted-by":"crossref","first-page":"1884","DOI":"10.1371\/journal.pgen.0030180","article-title":"ZIPK: a unique case of murine-specific divergence of a conserved vertebrate gene","volume":"3","author":"Shoval","year":"2007","journal-title":"PLoS Genet."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X24007526?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X24007526?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,22]],"date-time":"2024-06-22T11:08:21Z","timestamp":1719054501000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X24007526"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9]]},"references-count":33,"alternative-id":["S0006291X24007526"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2024.150216","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2024,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Protection of blood-brain barrier by endothelial DAPK1 deletion after stroke","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2024.150216","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"150216"}}