{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T10:21:28Z","timestamp":1768645288833,"version":"3.49.0"},"reference-count":27,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,6,19]],"date-time":"2025-06-19T00:00:00Z","timestamp":1750291200000},"content-version":"am","delay-in-days":291,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2024,9]]},"DOI":"10.1016\/j.bbrc.2024.150254","type":"journal-article","created":{"date-parts":[[2024,6,11]],"date-time":"2024-06-11T06:19:15Z","timestamp":1718086755000},"page":"150254","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Dapagliflozin administration to a mouse model of type 2 diabetes induces DNA methylation and gene expression changes in pancreatic islets"],"prefix":"10.1016","volume":"725","author":[{"given":"Aisha","family":"Yokoi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6661-9402","authenticated-orcid":false,"given":"Shun-ichiro","family":"Asahara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Inoue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masako","family":"Seike","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nozomi","family":"Kido","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirotaka","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayumi","family":"Kanno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maki","family":"Kimura-Koyanagi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiaki","family":"Kido","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wataru","family":"Ogawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"10397","key":"10.1016\/j.bbrc.2024.150254_bib1","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/S0140-6736(23)01301-6","article-title":"Global, regional, and national burden of diabetes from 1990 to 2021, with projections of prevalence to 2050: a systematic analysis for the Global Burden of Disease Study 2021","volume":"402","year":"2023","journal-title":"Lancet"},{"issue":"22","key":"10.1016\/j.bbrc.2024.150254_bib2","doi-asserted-by":"crossref","first-page":"2117","DOI":"10.1056\/NEJMoa1504720","article-title":"EMPA-REG OUTCOME Investigators, Empagliflozin, cardiovascular outcomes, and mortality in type 2 diabete","volume":"373","author":"Zinman","year":"2015","journal-title":"N. Engl. J. Med."},{"issue":"7","key":"10.1016\/j.bbrc.2024.150254_bib3","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1056\/NEJMoa1611925","article-title":"CANVAS Program Collaborative Group, Canagliflozin and cardiovascular and renal events in type 2 diabetes","volume":"377","author":"Neal","year":"2017","journal-title":"N. Engl. J. Med."},{"issue":"4","key":"10.1016\/j.bbrc.2024.150254_bib4","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1056\/NEJMoa1812389","article-title":"DECLARE\u2013TIMI 58 Investigators, Dapagliflozin and cardiovascular outcomes in type 2 diabetes","volume":"380","author":"Wiviott","year":"2019","journal-title":"N. Engl. J. Med."},{"issue":"24","key":"10.1016\/j.bbrc.2024.150254_bib5","doi-asserted-by":"crossref","first-page":"2295","DOI":"10.1056\/NEJMoa1811744","article-title":"Canagliflozin and renal outcomes in type 2 diabetes and nephropathy","volume":"380","author":"Perkovic","year":"2019","journal-title":"N. Engl. J. Med."},{"issue":"4","key":"10.1016\/j.bbrc.2024.150254_bib6","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1007\/s00125-022-05851-x","article-title":"Empagliflozin protects mice against diet-induced obesity, insulin resistance and hepatic steatosis","volume":"66","author":"Radlinger","year":"2023","journal-title":"Diabetologia"},{"issue":"1","key":"10.1016\/j.bbrc.2024.150254_bib7","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1172\/JCI39721","article-title":"Ablation of C\/EBPbeta alleviates ER stress and pancreatic beta cell failure through the GRP78 chaperone in mice","volume":"120","author":"Matsuda","year":"2010","journal-title":"J. Clin. Invest."},{"issue":"27","key":"10.1016\/j.bbrc.2024.150254_bib8","doi-asserted-by":"crossref","first-page":"8332","DOI":"10.1073\/pnas.1422104112","article-title":"Paternal allelic mutation at the Kcnq1 locus reduces pancreatic \u03b2-cell mass by epigenetic modification of Cdkn1c","volume":"112","author":"Asahara","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"3","key":"10.1016\/j.bbrc.2024.150254_bib9","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1111\/jdi.12945","article-title":"Early administration of dapagliflozin preserves pancreatic \u03b2-cell mass through a legacy effect in a mouse model of type 2 diabetes","volume":"10","author":"Kanno","year":"2019","journal-title":"J. Diabetes Invest."},{"issue":"3","key":"10.1016\/j.bbrc.2024.150254_bib10","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1016\/j.bbrc.2015.10.109","article-title":"Protective effects of SGLT2 inhibitor luseogliflozin on pancreatic \u03b2-cells in obese type 2 diabetic db\/db mice","volume":"470","author":"Okauchi","year":"2016","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"5","key":"10.1016\/j.bbrc.2024.150254_bib11","doi-asserted-by":"crossref","first-page":"1927","DOI":"10.1210\/jc.2014-3472","article-title":"Dapagliflozin lowers plasma glucose concentration and improves \u03b2-cell function","volume":"100","author":"Merovci","year":"2015","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"7766","key":"10.1016\/j.bbrc.2024.150254_bib12","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1038\/s41586-019-1411-0","article-title":"Advances in epigenetics link genetics to the environment and disease","volume":"571","author":"Cavalli","year":"2019","journal-title":"Nature"},{"issue":"16","key":"10.1016\/j.bbrc.2024.150254_bib13","doi-asserted-by":"crossref","first-page":"5624","DOI":"10.1128\/MCB.21.16.5624-5630.2001","article-title":"Preserved pancreatic beta-cell development and function in mice lacking the insulin receptor-related receptor","volume":"21","author":"Kitamura","year":"2001","journal-title":"Mol. Cell Biol."},{"issue":"3","key":"10.1016\/j.bbrc.2024.150254_bib14","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.bbrc.2009.02.047","article-title":"Increased ribosomal biogenesis induces pancreatic beta cell failure in mice model of type 2 diabetes","volume":"381","author":"Asahara","year":"2009","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"15","key":"10.1016\/j.bbrc.2024.150254_bib15","doi-asserted-by":"crossref","first-page":"2114","DOI":"10.1093\/bioinformatics\/btu170","article-title":"Trimmomatic: a flexible trimmer for Illumina sequence data","volume":"30","author":"Bolger","year":"2014","journal-title":"Bioinformatics"},{"key":"10.1016\/j.bbrc.2024.150254_bib16","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/nmeth.1923","article-title":"Fast gapped-read alignment with Bowtie 2","volume":"9","author":"Langmead","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.bbrc.2024.150254_bib17","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1093\/bioinformatics\/btt650","article-title":"MEDIPS: genome-wide differential coverage analysis of sequencing data derived from DNA enrichment experiments","volume":"30","author":"Lienhard","year":"2014","journal-title":"Bioinformatics"},{"issue":"5895","key":"10.1016\/j.bbrc.2024.150254_bib18","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1038\/301089a0","article-title":"Hypomethylation distinguishes genes of some human cancers from their normal counterparts","volume":"301","author":"Feinberg","year":"1983","journal-title":"Nature"},{"issue":"30","key":"10.1016\/j.bbrc.2024.150254_bib19","doi-asserted-by":"crossref","first-page":"27513","DOI":"10.1074\/jbc.M304119200","article-title":"Characterization of cadherin-24, a novel alternatively spliced type II cadherin","volume":"278","author":"Katafiasz","year":"2013","journal-title":"J. Biol. Chem."},{"issue":"7","key":"10.1016\/j.bbrc.2024.150254_bib20","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.2337\/diabetes.48.7.1402","article-title":"Pancreatic beta-cell-to-beta-cell interactions are required for integrated responses to nutrient stimuli: enhanced Ca2+ and insulin secretory responses of MIN6 pseudoislets","volume":"48","author":"Hauge-Evans","year":"1999","journal-title":"Diabetes"},{"issue":"6267","key":"10.1016\/j.bbrc.2024.150254_bib21","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1038\/344665a0","article-title":"A frame-shift mutation in the cystic fibrosis gene","volume":"344","author":"White","year":"1990","journal-title":"Nature"},{"issue":"8","key":"10.1016\/j.bbrc.2024.150254_bib22","article-title":"Cystic fibrosis-related diabetes is caused by islet loss and inflammation","volume":"3","author":"Hart","year":"2018","journal-title":"J.C.I. Insight."},{"issue":"1","key":"10.1016\/j.bbrc.2024.150254_bib23","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1007\/s12253-014-9804-8","article-title":"Frameshift mutations of cadherin genes DCHS2, CDH10 and CDH24 genes in gastric and colorectal cancers with high microsatellite instability","volume":"21","author":"An, E","year":"2015","journal-title":"Pathol. Oncol. Res."},{"issue":"1","key":"10.1016\/j.bbrc.2024.150254_bib24","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1038\/ng0593-35","article-title":"Production of a severe cystic fibrosis mutation in mice by gene targeting","volume":"4","author":"Ratcliff","year":"1993","journal-title":"Nat. Genet."},{"key":"10.1016\/j.bbrc.2024.150254_bib25","doi-asserted-by":"crossref","first-page":"4420","DOI":"10.1038\/ncomms5420","article-title":"Glucose-induced electrical activities and insulin secretion in pancreatic islet \u03b2-cells are modulated by CFTR","volume":"5","author":"Guo","year":"2014","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.bbrc.2024.150254_bib26","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1038\/s41598-017-00098-8","article-title":"CFTR is involved in the regulation of glucagon secretion in human and rodent alpha cells","volume":"7","author":"Edlund","year":"2017","journal-title":"Sci. Rep."},{"issue":"2","key":"10.1016\/j.bbrc.2024.150254_bib27","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1007\/s12020-007-9026-x","article-title":"Expression and localization of cystic fibrosis transmembrane conductance regulator in the rat endocrine pancreas","volume":"32","author":"Boom","year":"2007","journal-title":"Endocrine"}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X24007903?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X24007903?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,7,12]],"date-time":"2024-07-12T12:57:50Z","timestamp":1720789070000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X24007903"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9]]},"references-count":27,"alternative-id":["S0006291X24007903"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2024.150254","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2024,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dapagliflozin administration to a mouse model of type 2 diabetes induces DNA methylation and gene expression changes in pancreatic islets","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2024.150254","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"150254"}}