{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T01:03:46Z","timestamp":1785891826980,"version":"3.56.0"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2024,11]]},"DOI":"10.1016\/j.bbrc.2024.150410","type":"journal-article","created":{"date-parts":[[2024,7,17]],"date-time":"2024-07-17T20:46:27Z","timestamp":1721249187000},"page":"150410","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["PLA plastic particles disrupt bile acid metabolism leading to hepatic inflammatory injury in male mice"],"prefix":"10.1016","volume":"732","author":[{"given":"Meiting","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruirui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisi","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huanwen","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qizhan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1433-711X","authenticated-orcid":false,"given":"Zhi","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2024.150410_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2020.124004","article-title":"Estimation of the mass of microplastics ingested - a pivotal first step towards human health risk assessment","volume":"404","author":"Senathirajah","year":"2021","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.bbrc.2024.150410_bib2","doi-asserted-by":"crossref","DOI":"10.1002\/anie.202205713","article-title":"Microplastics and their additives in the indoor environment","volume":"61","author":"Salthammer","year":"2022","journal-title":"Angew. Chem."},{"key":"10.1016\/j.bbrc.2024.150410_bib3","doi-asserted-by":"crossref","first-page":"1612","DOI":"10.1111\/jam.14290","article-title":"Polylactic acid: synthesis and biomedical applications","volume":"127","author":"Singhvi","year":"2019","journal-title":"J. Appl. Microbiol."},{"key":"10.1016\/j.bbrc.2024.150410_bib4","doi-asserted-by":"crossref","first-page":"1967","DOI":"10.3390\/molecules26071967","article-title":"Poly lactic acid (PLA) nanocomposites: effect of inorganic nanoparticles reinforcement on its performance and food packaging applications","volume":"26","author":"Mulla","year":"2021","journal-title":"Molecules"},{"key":"10.1016\/j.bbrc.2024.150410_bib5","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.3390\/ma10091008","article-title":"On the use of PLA-PHB blends for sustainable food packaging applications","volume":"10","author":"Arrieta","year":"2017","journal-title":"Materials"},{"key":"10.1016\/j.bbrc.2024.150410_bib6","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1007\/s10532-022-09993-y","article-title":"Comparison of polylactic acid biodegradation ability of Brevibacillus brevis and Bacillus amyloliquefaciens and promotion of PLA biodegradation by soytone","volume":"33","author":"Yu","year":"2022","journal-title":"Biodegradation"},{"key":"10.1016\/j.bbrc.2024.150410_bib7","doi-asserted-by":"crossref","first-page":"6876","DOI":"10.1038\/s41598-017-07028-8","article-title":"PLA(2)R binds to the annexin A2-S100A10 complex in human podocytes","volume":"7","author":"Fresquet","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbrc.2024.150410_bib8","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.addr.2016.04.003","article-title":"PLA composites: from production to properties","volume":"107","author":"Murariu","year":"2016","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.bbrc.2024.150410_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2023.131236","article-title":"Polystyrene microplastics promote liver inflammation by inducing the formation of macrophages extracellular traps","volume":"452","author":"Yin","year":"2023","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.bbrc.2024.150410_bib10","doi-asserted-by":"crossref","first-page":"6634","DOI":"10.1021\/acs.est.7b00423","article-title":"Plastic and human health: a micro Issue?","volume":"51","author":"Wright","year":"2017","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.bbrc.2024.150410_bib11","doi-asserted-by":"crossref","first-page":"378","DOI":"10.3390\/metabo13030378","article-title":"What do NAFLD, liver fibrosis, and inflammatory bowel disease have in common? Review of the current literature","volume":"13","author":"Jarmakiewicz-Czaja","year":"2023","journal-title":"Metabolites"},{"key":"10.1016\/j.bbrc.2024.150410_bib12","doi-asserted-by":"crossref","DOI":"10.1289\/EHP9620","article-title":"Exposure to outdoor particulate matter air pollution and risk of gastrointestinal cancers in adults: a systematic review and meta-analysis of epidemiologic evidence","volume":"130","author":"Pritchett","year":"2022","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.bbrc.2024.150410_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2023.165659","article-title":"The hepatotoxicity assessment of micro\/nanoplastics: a preliminary study to apply the adverse outcome pathways","volume":"902","author":"Ge","year":"2023","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.bbrc.2024.150410_bib14","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1002\/cphy.c120023","article-title":"Bile acid metabolism and signaling","volume":"3","author":"Chiang","year":"2013","journal-title":"Compr. Physiol."},{"key":"10.1016\/j.bbrc.2024.150410_bib15","doi-asserted-by":"crossref","first-page":"1955","DOI":"10.1194\/jlr.R900010-JLR200","article-title":"Bile acids: regulation of synthesis","volume":"50","author":"Chiang","year":"2009","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.bbrc.2024.150410_bib16","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1053\/gast.2001.25542","article-title":"Effects of ursodeoxycholic and cholic acid feeding on hepatocellular transporter expression in mouse liver","volume":"121","author":"Fickert","year":"2001","journal-title":"Gastroenterology"},{"key":"10.1016\/j.bbrc.2024.150410_bib17","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1038\/nrd2619","article-title":"Targeting bile-acid signalling for metabolic diseases","volume":"7","author":"Thomas","year":"2008","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.bbrc.2024.150410_bib18","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1016\/j.molmed.2015.09.001","article-title":"Bile acid-activated receptors, intestinal microbiota, and the treatment of metabolic disorders","volume":"21","author":"Fiorucci","year":"2015","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.bbrc.2024.150410_bib19","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1038\/nature04330","article-title":"Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation","volume":"439","author":"Watanabe","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2024.150410_bib20","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.1053\/j.gastro.2017.01.055","article-title":"Bile acid control of metabolism and inflammation in obesity, type 2 diabetes, dyslipidemia, and nonalcoholic fatty liver disease","volume":"152","author":"Ch\u00e1vez-Talavera","year":"2017","journal-title":"Gastroenterology"},{"key":"10.1016\/j.bbrc.2024.150410_bib21","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1146\/annurev-food-041715-033159","article-title":"Bile acid modifications at the microbe-host interface: potential for nutraceutical and pharmaceutical interventions in host health","volume":"7","author":"Joyce","year":"2016","journal-title":"Annu. Rev. Food Sci. Technol."},{"key":"10.1016\/j.bbrc.2024.150410_bib22","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1038\/s41577-018-0066-7","article-title":"Recent insights into targeting the IL-6 cytokine family in inflammatory diseases and cancer","volume":"18","author":"Jones","year":"2018","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.bbrc.2024.150410_bib23","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1038\/s41586-024-07098-5","article-title":"IL-10 constrains sphingolipid metabolism to limit inflammation","volume":"627","author":"York","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2024.150410_bib24","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1007\/s13238-020-00804-9","article-title":"Targeting the alternative bile acid synthetic pathway for metabolic diseases","volume":"12","author":"Jia","year":"2021","journal-title":"Protein & cell"},{"key":"10.1016\/j.bbrc.2024.150410_bib25","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.bcp.2019.04.008","article-title":"Advances in understanding the regulatory mechanism of cholesterol 7\u03b1-hydroxylase","volume":"164","author":"Ge","year":"2019","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.bbrc.2024.150410_bib26","doi-asserted-by":"crossref","first-page":"1594","DOI":"10.1016\/S0022-2275(20)32213-6","article-title":"Alternate pathways of bile acid synthesis in the cholesterol 7 alpha-hydroxylase knockout mouse are not upregulated by either cholesterol or cholestyramine feeding","volume":"42","author":"Schwarz","year":"2001","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.bbrc.2024.150410_bib27","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.cca.2007.03.025","article-title":"Changes in classic and alternative pathways of bile acid synthesis in chronic liver disease","volume":"382","author":"Crosignani","year":"2007","journal-title":"Clinica chimica acta; international journal of clinical chemistry"},{"key":"10.1016\/j.bbrc.2024.150410_bib28","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1111\/joim.13767","article-title":"Targeting the FGF19-FGFR4 pathway for cholestatic, metabolic, and cancerous diseases","volume":"295","author":"Li","year":"2024","journal-title":"J. Intern. Med."},{"key":"10.1016\/j.bbrc.2024.150410_bib29","doi-asserted-by":"crossref","first-page":"2576","DOI":"10.7150\/ijbs.58776","article-title":"Aberrant FGFR4 signaling worsens nonalcoholic steatohepatitis in FGF21KO mice","volume":"17","author":"Yu","year":"2021","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.bbrc.2024.150410_bib30","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1002\/hep.21183","article-title":"Bile acids and cytokines inhibit the human cholesterol 7 alpha-hydroxylase gene via the JNK\/c-jun pathway in human liver cells","volume":"43","author":"Li","year":"2006","journal-title":"Hepatology (Baltimore, Md"}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X2400946X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X2400946X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,9,7]],"date-time":"2024-09-07T19:34:51Z","timestamp":1725737691000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X2400946X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":30,"alternative-id":["S0006291X2400946X"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2024.150410","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2024,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"PLA plastic particles disrupt bile acid metabolism leading to hepatic inflammatory injury in male mice","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2024.150410","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"150410"}}