{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T16:44:18Z","timestamp":1786985058233,"version":"build-2736575974"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2019A1515010077"],"award-info":[{"award-number":["2019A1515010077"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1016\/j.bbrc.2024.150490","type":"journal-article","created":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T19:23:28Z","timestamp":1722972208000},"page":"150490","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["Form-deprivation myopia promotes sclera M2-type macrophages polarization in mice"],"prefix":"10.1016","volume":"737","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6528-3369","authenticated-orcid":false,"given":"Bingru","family":"Zheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongmei","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baodi","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6979-4756","authenticated-orcid":false,"given":"Wen","family":"Long","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guitong","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaochong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junwen","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2024.150490_bib1","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1016\/j.ophtha.2016.01.006","article-title":"Global prevalence of myopia and high myopia and temporal trends from 2000 through 2050","volume":"123","author":"Holden","year":"2016","journal-title":"Ophthalmology"},{"key":"10.1016\/j.bbrc.2024.150490_bib2","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.exer.2014.07.015","article-title":"The dynamic sclera: extracellular matrix remodeling in normal ocular growth and myopia development","volume":"133","author":"Harper","year":"2015","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.bbrc.2024.150490_bib3","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/bs.pmbts.2015.05.005","article-title":"Scleral mechanisms underlying ocular growth and myopia","volume":"134","author":"Metlapally","year":"2015","journal-title":"Prog Mol Biol Transl Sci"},{"key":"10.1016\/j.bbrc.2024.150490_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.preteyeres.2019.100773","article-title":"Scleral structure and biomechanics","volume":"74","author":"Boote","year":"2020","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.bbrc.2024.150490_bib5","doi-asserted-by":"crossref","first-page":"1850","DOI":"10.1038\/s41467-019-09709-6","article-title":"Dynamic fibroblast contractions attract remote macrophages in fibrillar collagen matrix","volume":"10","author":"Pakshir","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbrc.2024.150490_bib6","article-title":"Tissue-resident macrophages promote extracellular matrix homeostasis in the mammary gland stroma of nulliparous mice","volume":"9","author":"Wang","year":"2020","journal-title":"Elife"},{"key":"10.1016\/j.bbrc.2024.150490_bib7","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1111\/imcb.12236","article-title":"Macrophages in wound healing: activation and plasticity","volume":"97","author":"Kim","year":"2019","journal-title":"Immunol. Cell Biol."},{"key":"10.1016\/j.bbrc.2024.150490_bib8","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1080\/02713683.2018.1540704","article-title":"Detection of pro- and antiangiogenic factors in the human sclera","volume":"44","author":"Schlereth","year":"2018","journal-title":"Curr. Eye Res."},{"key":"10.1016\/j.bbrc.2024.150490_bib9","article-title":"Characterization of antigen-presenting macrophages and dendritic cells in the healthy human sclera","volume":"57","author":"Schlereth","year":"2016","journal-title":"Investigative Opthalmology & Visual Science"},{"key":"10.1016\/j.bbrc.2024.150490_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.aanat.2020.151485","article-title":"The lymphangiogenic and hemangiogenic privilege of the human sclera","volume":"230","author":"Atta","year":"2020","journal-title":"Annals of Anatomy - Anatomischer Anzeiger"},{"key":"10.1016\/j.bbrc.2024.150490_bib11","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.1016\/j.ajpath.2020.06.002","article-title":"Up-regulation of matrix metalloproteinase-2 by scleral monocyte-derived macrophages contributes to myopia development","volume":"190","author":"Zhao","year":"2020","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.bbrc.2024.150490_bib12","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1038\/nri3671","article-title":"Monocytes and macrophages: developmental pathways and tissue homeostasis","volume":"14","author":"Ginhoux","year":"2014","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.bbrc.2024.150490_bib13","doi-asserted-by":"crossref","first-page":"e110","DOI":"10.1182\/blood-2013-08-520619","article-title":"Alternatively activated macrophages derived from monocytes and tissue macrophages are phenotypically and functionally distinct","volume":"123","author":"Gundra","year":"2014","journal-title":"Blood"},{"key":"10.1016\/j.bbrc.2024.150490_bib14","doi-asserted-by":"crossref","first-page":"3964","DOI":"10.4049\/jimmunol.0903356","article-title":"Differential roles of macrophages in diverse phases of skin repair","volume":"184","author":"Lucas","year":"2010","journal-title":"J. Immunol."},{"key":"10.1016\/j.bbrc.2024.150490_bib15","doi-asserted-by":"crossref","DOI":"10.1126\/science.aau0964","article-title":"Two distinct interstitial macrophage populations coexist across tissues in specific subtissular niches","volume":"363","author":"Chakarov","year":"2019","journal-title":"Science"},{"key":"10.1016\/j.bbrc.2024.150490_bib16","first-page":"269","article-title":"Regulation of extracellular matrix assembly and structure by hybrid M1\/M2 macrophages","author":"Witherel","year":"2021","journal-title":"Biomaterials"},{"key":"10.1016\/j.bbrc.2024.150490_bib17","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1111\/imcb.12236","article-title":"Macrophages in wound healing: activation and plasticity","volume":"97","author":"Kim","year":"2019","journal-title":"Immunol. Cell Biol."},{"key":"10.1016\/j.bbrc.2024.150490_bib18","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.matbio.2018.01.019","article-title":"The big five in fibrosis: macrophages, myofibroblasts, matrix, mechanics, and miscommunication","volume":"68\u201369","author":"Pakshir","year":"2018","journal-title":"Matrix Biol."},{"key":"10.1016\/j.bbrc.2024.150490_bib19","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.semcdb.2016.08.006","article-title":"Tissue-specific contribution of macrophages to wound healing","volume":"61","author":"Minutti","year":"2017","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.bbrc.2024.150490_bib20","article-title":"Refractive changes induced by form deprivation in the mouse eye","volume":"44","author":"Tejedor","year":"2003","journal-title":"Investigative Opthalmology & Visual Science"},{"key":"10.1016\/j.bbrc.2024.150490_bib21","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1016\/j.visres.2008.01.004","article-title":"Two models of experimental myopia in the mouse","volume":"48","author":"Barathi","year":"2008","journal-title":"Vis. Res."},{"key":"10.1016\/j.bbrc.2024.150490_bib22","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1080\/02713680903003492","article-title":"Sonic hedgehog expression and its role in form-deprivation myopia in mice","volume":"34","author":"Qian","year":"2009","journal-title":"Curr. Eye Res."},{"key":"10.1016\/j.bbrc.2024.150490_bib23","first-page":"1","article-title":"In vivo structural assessments of ocular disease in rodent models using optical coherence tomography","volume":"161","author":"Pardue","year":"2020","journal-title":"JoVE"},{"key":"10.1016\/j.bbrc.2024.150490_bib24","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/s10549-012-2332-x","article-title":"Inhibition of the proliferation of acquired aromatase inhibitor-resistant breast cancer cells by histone deacetylase inhibitor LBH589 (panobinostat)","volume":"137","author":"Kubo","year":"2012","journal-title":"Breast Cancer Res. Treat."},{"key":"10.1016\/j.bbrc.2024.150490_bib25","first-page":"523","article-title":"Distribution of adenosine receptors in human sclera fibroblasts","volume":"14","author":"Cui","year":"2008","journal-title":"Mol. Vis."},{"key":"10.1016\/j.bbrc.2024.150490_bib26","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/nmeth.3317","article-title":"HISAT: a fast spliced aligner with low memory requirements","volume":"12","author":"Kim","year":"2015","journal-title":"Nat. Methods"},{"key":"10.1016\/j.bbrc.2024.150490_bib27","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/nmeth.1923","article-title":"Fast gapped-read alignment with Bowtie 2","volume":"9","author":"Langmead","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.bbrc.2024.150490_bib28","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1186\/1471-2105-12-323","article-title":"RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome","volume":"12","author":"Li","year":"2011","journal-title":"BMC Bioinf."},{"key":"10.1016\/j.bbrc.2024.150490_bib29","doi-asserted-by":"crossref","first-page":"D561","DOI":"10.1093\/nar\/gkq973","article-title":"The STRING database in 2011: functional interaction networks of proteins, globally integrated and scored","volume":"39","author":"Szklarczyk","year":"2011","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bbrc.2024.150490_bib30","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1101\/gr.1239303","article-title":"Cytoscape: a software environment for integrated models of biomolecular interaction networks","volume":"13","author":"Shannon","year":"2003","journal-title":"Genome Res."},{"key":"10.1016\/j.bbrc.2024.150490_bib31","doi-asserted-by":"crossref","first-page":"S11","DOI":"10.1186\/1752-0509-8-S4-S11","article-title":"cytoHubba: identifying hub objects and sub-networks from complex interactome","author":"Chin","year":"2014","journal-title":"BMC Syst. Biol."},{"key":"10.1016\/j.bbrc.2024.150490_bib32","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.exer.2014.06.010","article-title":"Absence of lymphatic vessels in the developing human sclera","volume":"125","author":"Schlereth","year":"2014","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.bbrc.2024.150490_bib33","article-title":"Enrichment of lymphatic vessel endothelial hyaluronan receptor 1 (LYVE1)-Positive macrophages around blood vessels in the normal human sclera","volume":"55","author":"Schlereth","year":"2014","journal-title":"Investigative Opthalmology & Visual Science"},{"key":"10.1016\/j.bbrc.2024.150490_bib34","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.exer.2014.06.010","article-title":"Absence of lymphatic vessels in the developing human sclera","volume":"125","author":"Schlereth","year":"2014","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.bbrc.2024.150490_bib35","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1136\/bjo.2006.102046","article-title":"Identification of resident and inflammatory bone marrow derived cells in the sclera by bone marrow and haematopoietic stem cell transplantation","volume":"91","author":"Hisatomi","year":"2007","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.bbrc.2024.150490_bib36","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1167\/iovs.13-13453","article-title":"Enrichment of lymphatic vessel endothelial hyaluronan receptor 1 (LYVE1)-positive macrophages around blood vessels in the normal human sclera","volume":"55","author":"Schlereth","year":"2014","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.bbrc.2024.150490_bib37","doi-asserted-by":"crossref","first-page":"4878","DOI":"10.1167\/iovs.15-18552","article-title":"Characterization of antigen-presenting macrophages and dendritic cells in the healthy human sclera","volume":"57","author":"Schlereth","year":"2016","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.bbrc.2024.150490_bib38","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.1016\/j.ajpath.2020.06.002","article-title":"Up-regulation of matrix metalloproteinase-2 by scleral monocyte\u2013derived macrophages contributes to myopia development","volume":"190","author":"Zhao","year":"2020","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.bbrc.2024.150490_bib39","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.immuni.2016.02.015","article-title":"Macrophages in tissue repair, regeneration, and fibrosis","volume":"44","author":"Wynn","year":"2016","journal-title":"Immunity"},{"key":"10.1016\/j.bbrc.2024.150490_bib40","article-title":"Function of macrophages in disease: current understanding on molecular mechanisms","volume":"12","author":"Zhang","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bbrc.2024.150490_bib41","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20205086","article-title":"Gene expression profiling of the extracellular matrix signature in macrophages of different activation status: relevance for skin wound healing","volume":"20","author":"Etich","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbrc.2024.150490_bib42","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1055\/s-0030-1255354","article-title":"Macrophages: master regulators of inflammation and fibrosis","volume":"30","author":"Wynn","year":"2010","journal-title":"Semin. Liver Dis."},{"key":"10.1016\/j.bbrc.2024.150490_bib43","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1038\/nri3073","article-title":"Protective and pathogenic functions of macrophage subsets","volume":"11","author":"Murray","year":"2011","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.bbrc.2024.150490_bib44","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/S8756-3282(03)00229-1","article-title":"Long-term analgesic effect of clodronate in rodents","volume":"33","author":"Bonabello","year":"2003","journal-title":"Bone"},{"key":"10.1016\/j.bbrc.2024.150490_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.109955","article-title":"Global characterization of macrophage polarization mechanisms and identification of M2-type polarization inhibitors","volume":"37","author":"He","year":"2021","journal-title":"Cell Rep."},{"key":"10.1016\/j.bbrc.2024.150490_bib46","doi-asserted-by":"crossref","first-page":"9382","DOI":"10.1016\/j.biomaterials.2010.07.101","article-title":"Cell-cell signaling in co-cultures of macrophages and fibroblasts","volume":"31","author":"Holt","year":"2010","journal-title":"Biomaterials"},{"key":"10.1016\/j.bbrc.2024.150490_bib47","doi-asserted-by":"crossref","DOI":"10.1016\/j.aanat.2020.151485","article-title":"The lymphangiogenic and hemangiogenic privilege of the human sclera","volume":"230","author":"Atta","year":"2020","journal-title":"Ann. Anat."},{"key":"10.1016\/j.bbrc.2024.150490_bib48","article-title":"Uncovering mediators of collagen degradation in the tumor microenvironment","volume":"13","author":"Thorseth","year":"2022","journal-title":"Matrix Biol."},{"key":"10.1016\/j.bbrc.2024.150490_bib49","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.aao3469","article-title":"Cadherin-11-mediated adhesion of macrophages to myofibroblasts establishes a profibrotic niche of active TGF-\u03b2","volume":"12","author":"Lodyga","year":"2019","journal-title":"Sci. Signal."},{"key":"10.1016\/j.bbrc.2024.150490_bib50","doi-asserted-by":"crossref","first-page":"231e","DOI":"10.1097\/PRS.0000000000007563","article-title":"Human CD206+ macrophages show antifibrotic effects on human fibroblasts through an IL-6-dependent mechanism in vitro","volume":"147","author":"Kurachi","year":"2021","journal-title":"Plast. Reconstr. Surg."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X2401026X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X2401026X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,10]],"date-time":"2025-02-10T16:08:54Z","timestamp":1739203734000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X2401026X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":50,"alternative-id":["S0006291X2401026X"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2024.150490","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Form-deprivation myopia promotes sclera M2-type macrophages polarization in mice","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2024.150490","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"150490"}}