{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T16:01:07Z","timestamp":1792512067737,"version":"4.5.0"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001503","name":"Indian Council of Agricultural Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001503","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1016\/j.bbrc.2024.150578","type":"journal-article","created":{"date-parts":[[2024,8,22]],"date-time":"2024-08-22T13:06:15Z","timestamp":1724331975000},"page":"150578","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Effect of bovine beta-casomorphins on rat pancreatic beta cells (RIN-5F) under glucotoxic stress"],"prefix":"10.1016","volume":"739","author":[{"given":"Shivam Kumar","family":"Dubey","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhishek","family":"Thakur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manoj Kumar","family":"Jena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sudarshan","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Sodhi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manishi","family":"Mukesh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jai Kumar","family":"Kaushik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashok Kumar","family":"Mohanty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2024.150578_bib1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1476-511X-6-25","article-title":"Bovine milk in human nutrition\u2013a review","volume":"6","author":"Haug","year":"2007","journal-title":"Lipids Health Dis."},{"key":"10.1016\/j.bbrc.2024.150578_bib2","doi-asserted-by":"crossref","first-page":"1955","DOI":"10.1080\/10408398.2012.740102","article-title":"Formation and degradation of beta-casomorphins in dairy processing","volume":"55","author":"Nguyen","year":"2015","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"10.1016\/j.bbrc.2024.150578_bib3","doi-asserted-by":"crossref","first-page":"1905","DOI":"10.2174\/0929867054546618","article-title":"Biochemical properties of peptides encrypted in bovine milk proteins","volume":"12","author":"Meisel","year":"2005","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.bbrc.2024.150578_bib4","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1007\/BF03195213","article-title":"Polymorphism of bovine beta-casein and it potential effect on human health","volume":"48","author":"Kaminski","year":"2007","journal-title":"J. Appl. Genet."},{"key":"10.1016\/j.bbrc.2024.150578_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2022.134617","article-title":"Impact of in vitro static digestion method on the release of \u03b2-casomorphin-7 from bovine milk and cheeses with A1 or A2 \u03b2-casein phenotypes","volume":"404","author":"Cattaneo","year":"2023","journal-title":"Food Chem."},{"key":"10.1016\/j.bbrc.2024.150578_bib6","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1016\/j.foodchem.2008.02.077","article-title":"Release of \u03b2-casomorphins 5 and 7 during simulated gastro-intestinal digestion of bovine \u03b2-casein variants and milk-based infant formulas","volume":"110","author":"De Noni","year":"2008","journal-title":"Food Chem."},{"key":"10.1016\/j.bbrc.2024.150578_bib7","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.foodchem.2014.07.024","article-title":"Release of \u03b2-casomorphin-7\/5 during simulated gastrointestinal digestion of milk \u03b2-casein variants from Indian crossbred cattle(KaranFries)","volume":"168","author":"Haq","year":"2015","journal-title":"Food Chem."},{"key":"10.1016\/j.bbrc.2024.150578_bib8","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.3945\/ajcn.112.055202","article-title":"Sequential release of milk protein\u2013derived bioactive peptides in the jejunum in healthy humans","volume":"97","author":"Boutrou","year":"2013","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.bbrc.2024.150578_bib9","doi-asserted-by":"crossref","first-page":"2161","DOI":"10.3390\/molecules29092161","article-title":"BCM-7: opioid-like peptide with potential role in disease mechanisms","volume":"29","author":"Bolat","year":"2024","journal-title":"Molecules"},{"key":"10.1016\/j.bbrc.2024.150578_bib10","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1038\/253563a0","article-title":"Identification of novel high affinity opiate receptor binding in rat brain","volume":"253","author":"Pasternak","year":"1975","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2024.150578_bib11","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1124\/pr.112.007138","article-title":"Mu opioids and their receptors: evolution of a concept","volume":"65","author":"Pasternak","year":"2013","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.bbrc.2024.150578_bib12","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1007\/BF00318454","article-title":"Immunohistochemistry of opioid peptides in the Guinea pig endocrine pancreas","volume":"259","author":"Cetin","year":"1990","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.bbrc.2024.150578_bib13","doi-asserted-by":"crossref","first-page":"22","DOI":"10.20510\/ukjpb\/2\/i6\/91165","article-title":"Opioid receptor-dependent modulation of insulin-release in pancreatic beta-cells","volume":"2","author":"Paul","year":"2014","journal-title":"UK Journal of Pharmaceutical and Biosciences"},{"key":"10.1016\/j.bbrc.2024.150578_bib14","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1017\/S0022029900028788","article-title":"Chemical characterization of bioactive peptides from in vivo digests of casein","volume":"56","author":"Meisel","year":"1989","journal-title":"J. Dairy Res."},{"key":"10.1016\/j.bbrc.2024.150578_bib15","doi-asserted-by":"crossref","first-page":"e274","DOI":"10.1038\/nutd.2017.16","article-title":"A1 beta-casein milk protein and other environmental pre-disposing factors for type 1 diabetes","volume":"7","author":"Chia","year":"2017","journal-title":"Nutr. Diabetes"},{"key":"10.1016\/j.bbrc.2024.150578_bib16","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.3390\/nu10091291","article-title":"Dietary cows' milk protein A1 beta-casein increases the incidence of T1D in NOD mice","volume":"10","author":"Chia","year":"2018","journal-title":"Nutrients"},{"key":"10.1016\/j.bbrc.2024.150578_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.jff.2020.104272","article-title":"Comparative evaluation of feeding effects of A1 and A2 cow milk derived casein hydrolysates in diabetic model of rats","volume":"75","author":"Thakur","year":"2020","journal-title":"J. Funct.Foods"},{"key":"10.1016\/j.bbrc.2024.150578_bib18","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.1016\/j.peptides.2010.05.016","article-title":"Protective effect of beta-casomorphin-7 on type 1 diabetes rats induced with streptozotocin","volume":"31","author":"Yin","year":"2010","journal-title":"Peptides"},{"key":"10.1016\/j.bbrc.2024.150578_bib19","doi-asserted-by":"crossref","first-page":"C278","DOI":"10.1111\/j.1750-3841.2011.02577.x","article-title":"\u03b2\u2010Casomorphin\u20107 cause decreasing in oxidative stress and inhibiting NF\u2010\u03baB\u2010iNOS\u2010NO signal pathway in pancreas of diabetes rats","volume":"77","author":"Yin","year":"2012","journal-title":"J. Food Sci."},{"key":"10.1016\/j.bbrc.2024.150578_bib20","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.peptides.2012.05.022","article-title":"Beta-Casomorphin-7 attenuates the development of nephropathy in type I diabetes via inhibition of epithelial-mesenchymal transition of renal tubular epithelial cells","volume":"36","author":"Zhang","year":"2012","journal-title":"Peptides (N. Y., NY, U. S.)"},{"key":"10.1016\/j.bbrc.2024.150578_bib21","article-title":"The protective effects of beta-casomorphin-7 against glucose-induced renal oxidative stress in vivo and vitro","volume":"8","author":"Zhang","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.bbrc.2024.150578_bib22","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.peptides.2015.04.002","article-title":"Beta-casomorphin-7 prevents epithelial-mesenchymal transdifferentiation of NRK-52E cells at high glucose level: involvement of AngII-TGF-\u03b21 pathway","volume":"70","author":"Zhang","year":"2015","journal-title":"Peptides"},{"key":"10.1016\/j.bbrc.2024.150578_bib23","doi-asserted-by":"crossref","first-page":"49","DOI":"10.4062\/biomolther.2015.056","article-title":"Aloe-emodin protects RIN-5F (pancreatic \u03b2-cell) cell from glucotoxicity via regulation of pro-inflammatory cytokine and downregulation of Bax and caspase 3","volume":"24","author":"Alshatwi","year":"2016","journal-title":"Biomolecules & Therapeutics"},{"key":"10.1016\/j.bbrc.2024.150578_bib24","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/0003-2697(90)90310-6","article-title":"An enzyme-linked immunosorbent assay for bromodeoxyuridine incorporation using fixed microcultures","volume":"185","author":"Muir","year":"1990","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.bbrc.2024.150578_bib25","first-page":"3345","article-title":"Nicotinamide-functionalized multiwalled carbon nanotubes increase insulin production in pancreatic beta cells via MIF pathway","volume":"8","author":"Ilie","year":"2013","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.bbrc.2024.150578_bib26","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1016\/j.cellsig.2016.06.011","article-title":"The protein phosphatase 4-PEA15 axis regulates the survival of breast cancer cells","volume":"28","author":"Mohammed","year":"2016","journal-title":"Cell. Signal."},{"key":"10.1016\/j.bbrc.2024.150578_bib27","doi-asserted-by":"crossref","first-page":"75","DOI":"10.2144\/05391RV01","article-title":"Real-time PCR for mRNA quantitation","volume":"39","author":"Wong","year":"2005","journal-title":"Biotechniques"},{"key":"10.1016\/j.bbrc.2024.150578_bib28","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2\u2212 \u0394\u0394CT method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.bbrc.2024.150578_bib29","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1042\/bj2560205","article-title":"Hydroxyl radical production and autoxidative glycosylation. Glucose autoxidation as the cause of protein damage in the experimental glycation model of diabetes mellitus and ageing","volume":"256","author":"Hunt","year":"1988","journal-title":"Biochem. J."},{"key":"10.1016\/j.bbrc.2024.150578_bib30","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1002\/jbt.10058","article-title":"Diabetes, oxidative stress, and antioxidants: a review","volume":"17","author":"Maritim","year":"2003","journal-title":"J. Biochem. Mol. Toxicol."},{"key":"10.1016\/j.bbrc.2024.150578_bib31","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.ejphar.2007.12.011","article-title":"Antioxidant and pancreas-protective effect of aucubin on rats with streptozotocin-induced diabetes","volume":"582","author":"Jin","year":"2008","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.bbrc.2024.150578_bib32","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.cbi.2007.11.012","article-title":"The antidiabetic effects of cysteinyl metformin, a newly synthesized agent, in alloxan-and streptozocin-induced diabetic rats","volume":"173","author":"Liu","year":"2008","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.bbrc.2024.150578_bib33","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.ejphar.2007.09.002","article-title":"Curcumin prevents streptozotocin-induced islet damage by scavenging free radicals: a prophylactic and protective role","volume":"577","author":"Meghana","year":"2007","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.bbrc.2024.150578_bib34","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.freeradbiomed.2010.03.016","article-title":"Lutein protects HT-29 cells against Deoxynivalenol-induced oxidative stress and apoptosis: prevention of NF-\u03baB nuclear localization and down regulation of NF-\u03baB and Cyclo-Oxygenase\u20132 expression","volume":"49","author":"Krishnaswamy","year":"2010","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bbrc.2024.150578_bib35","doi-asserted-by":"crossref","first-page":"1684","DOI":"10.1111\/j.1523-1755.2005.00265.x","article-title":"Epidemic of end-stage renal disease in people with diabetes in the United States population: do we know the cause?","volume":"67","author":"Jones","year":"2005","journal-title":"Kidney Int."},{"key":"10.1016\/j.bbrc.2024.150578_bib36","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1210\/me.2008-0345","article-title":"The MOR-1 opioid receptor regulates glucose homeostasis by modulating insulin secretion","volume":"23","author":"Wen","year":"2009","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.bbrc.2024.150578_bib37","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.pharmthera.2013.05.002","article-title":"Opioid \u03bc\u2010receptors as new target for insulin resistance","volume":"139","author":"Cheng","year":"2013","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.bbrc.2024.150578_bib38","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1002\/jcb.24962","article-title":"Activation of \u03ba\u2010opioid receptor exerts the glucose\u2010homeostatic effect in streptozotocin\u2010induced diabetic mice","volume":"116","author":"Shang","year":"2015","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.bbrc.2024.150578_bib39","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1091\/mbc.e08-07-0681","article-title":"The OGF\u2013OGFr axis utilizes the p16INK4a and p21WAF1\/CIP1 pathways to restrict normal cell proliferation","volume":"20","author":"Cheng","year":"2009","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.bbrc.2024.150578_bib40","doi-asserted-by":"crossref","first-page":"R1154","DOI":"10.1152\/ajpregu.00414.2009","article-title":"Opioid growth factor-opioid growth factor receptor axis is a physiological determinant of cell proliferation in diverse human cancers","volume":"297","author":"Zagon","year":"2009","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.bbrc.2024.150578_bib41","doi-asserted-by":"crossref","first-page":"R459","DOI":"10.1152\/ajpregu.00646.2009","article-title":"The opioid growth factor-opioid growth factor receptor axis regulates cell proliferation of human hepatocellular cancer","volume":"298","author":"Avella","year":"2010","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X24011148?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X24011148?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,30]],"date-time":"2025-01-30T22:55:37Z","timestamp":1738277737000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X24011148"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":41,"alternative-id":["S0006291X24011148"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2024.150578","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effect of bovine beta-casomorphins on rat pancreatic beta cells (RIN-5F) under glucotoxic stress","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2024.150578","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"150578"}}