{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T00:11:10Z","timestamp":1767139870632,"version":"3.37.3"},"reference-count":24,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81971197"],"award-info":[{"award-number":["81971197"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014718","name":"Innovative Research Group Project of the National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014718","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2021YFC2700803"],"award-info":[{"award-number":["2021YFC2700803"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2024,11]]},"DOI":"10.1016\/j.bbrc.2024.150640","type":"journal-article","created":{"date-parts":[[2024,9,2]],"date-time":"2024-09-02T16:31:20Z","timestamp":1725294680000},"page":"150640","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Upregulation of NFE2L1 reduces ROS levels and \u03b1-synuclein aggregation caused by GBA1 knockdown"],"prefix":"10.1016","volume":"734","author":[{"given":"Yajun","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuxia","family":"Wen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wanqing","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fei","family":"Shen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nan","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Duan","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2024.150640_bib1","doi-asserted-by":"crossref","DOI":"10.3390\/ijms18020441","article-title":"A review of gaucher disease pathophysiology, clinical presentation and treatments","volume":"18","author":"Stirnemann","year":"2017","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.bbrc.2024.150640_bib2","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.ymgme.2016.11.006","article-title":"Gaucher disease: progress and ongoing challenges","volume":"120","author":"Mistry","year":"2017","journal-title":"Mol Genet Metab"},{"key":"10.1016\/j.bbrc.2024.150640_bib3","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1002\/ana.23614","article-title":"Glucocerebrosidase deficiency in substantia nigra of Parkinson disease brains","volume":"72","author":"Gegg","year":"2012","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.bbrc.2024.150640_bib4","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1006\/mgme.2001.3201","article-title":"Gaucher disease and parkinsonism: a phenotypic and genotypic characterization","volume":"73","author":"Tayebi","year":"2001","journal-title":"Mol Genet Metab"},{"key":"10.1016\/j.bbrc.2024.150640_bib5","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.beem.2014.08.007","article-title":"The emergence of Parkinson disease among patients with Gaucher disease","volume":"29","author":"Elstein","year":"2015","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"key":"10.1016\/j.bbrc.2024.150640_bib6","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1212\/01.wnl.0000230215.41296.18","article-title":"Glucocerebrosidase mutations are an important risk factor for Lewy body disorders","volume":"67","author":"Goker-Alpan","year":"2006","journal-title":"Neurology"},{"key":"10.1016\/j.bbrc.2024.150640_bib7","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1056\/NEJMoa0901281","article-title":"Multicenter analysis of glucocerebrosidase mutations in Parkinson's disease","volume":"361","author":"Sidransky","year":"2009","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bbrc.2024.150640_bib8","doi-asserted-by":"crossref","DOI":"10.3389\/fgene.2022.892457","article-title":"Establishment and phenotypic analysis of the novel gaucher disease mouse model with the partially humanized Gba1 gene and F213I mutation","volume":"13","author":"Guo","year":"2022","journal-title":"Front. Genet."},{"key":"10.1016\/j.bbrc.2024.150640_bib9","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1038\/s41531-022-00397-6","article-title":"Lysosomal lipid alterations caused by glucocerebrosidase deficiency promote lysosomal dysfunction, chaperone-mediated-autophagy deficiency, and alpha-synuclein pathology","volume":"8","author":"Navarro-Romero","year":"2022","journal-title":"NPJ Parkinsons Dis"},{"issue":"Suppl 1","key":"10.1016\/j.bbrc.2024.150640_bib10","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1111\/jnc.13385","article-title":"The relationship between glucocerebrosidase mutations and Parkinson disease","volume":"139","author":"Migdalska-Richards","year":"2016","journal-title":"J. Neurochem."},{"key":"10.1016\/j.bbrc.2024.150640_bib11","doi-asserted-by":"crossref","first-page":"4755","DOI":"10.1038\/ncomms5755","article-title":"Glucocerebrosidase depletion enhances cell-to-cell transmission of \u03b1-synuclein","volume":"5","author":"Bae","year":"2014","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbrc.2024.150640_bib12","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1038\/nrm3270","article-title":"The unfolded protein response: controlling cell fate decisions under ER stress and beyond","volume":"13","author":"Hetz","year":"2012","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.bbrc.2024.150640_bib13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neuint.2012.10.010","article-title":"Glucocerebrosidase inhibition causes mitochondrial dysfunction and free radical damage","volume":"62","author":"Cleeter","year":"2013","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.bbrc.2024.150640_bib14","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1007\/s00109-021-02174-z","article-title":"Gaucher disease - more than just a rare lipid storage disease","volume":"100","author":"Roh","year":"2022","journal-title":"J. Mol. Med. (Berl.)"},{"key":"10.1016\/j.bbrc.2024.150640_bib15","doi-asserted-by":"crossref","first-page":"2387","DOI":"10.1093\/hmg\/ddi240","article-title":"ER retention and degradation as the molecular basis underlying Gaucher disease heterogeneity","volume":"14","author":"Ron","year":"2005","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.bbrc.2024.150640_bib16","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.taap.2018.09.037","article-title":"Nrf1 is paved as a new strategic avenue to prevent and treat cancer, neurodegenerative and other diseases","volume":"360","author":"Yuan","year":"2018","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.bbrc.2024.150640_bib17","doi-asserted-by":"crossref","first-page":"19958","DOI":"10.1074\/jbc.M113.545582","article-title":"Amigo adhesion protein regulates development of neural circuits in zebrafish brain","volume":"289","author":"Zhao","year":"2014","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2024.150640_bib18","doi-asserted-by":"crossref","first-page":"2138","DOI":"10.1038\/s41436-021-01260-4","article-title":"Biallelic variants in PCDHGC4 cause a novel neurodevelopmental syndrome with progressive microcephaly, seizures, and joint anomalies","volume":"23","author":"Iqbal","year":"2021","journal-title":"Genet. Med."},{"key":"10.1016\/j.bbrc.2024.150640_bib19","doi-asserted-by":"crossref","DOI":"10.1098\/rstb.2022.0381","article-title":"Lysosomal storage, impaired autophagy and innate immunity in Gaucher and Parkinson's diseases: insights for drug discovery","volume":"379","author":"Hull","year":"2024","journal-title":"Philos. Trans. R. Soc. Lond. B Biol. Sci."},{"key":"10.1016\/j.bbrc.2024.150640_bib20","doi-asserted-by":"crossref","first-page":"2158","DOI":"10.1091\/mbc.E20-04-0238","article-title":"Regulation of NRF1, a master transcription factor of proteasome genes: implications for cancer and neurodegeneration","volume":"31","author":"Northrop","year":"2020","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.bbrc.2024.150640_bib21","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.gene.2016.03.002","article-title":"Nuclear factor erythroid-2 like 1 (NFE2L1): structure, function and regulation","volume":"584","author":"Kim","year":"2016","journal-title":"Gene"},{"key":"10.1016\/j.bbrc.2024.150640_bib22","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1111\/j.1365-2443.2011.01522.x","article-title":"Central nervous system-specific deletion of transcription factor Nrf1 causes progressive motor neuronal dysfunction","volume":"16","author":"Kobayashi","year":"2011","journal-title":"Gene Cell."},{"key":"10.1016\/j.bbrc.2024.150640_bib23","doi-asserted-by":"crossref","first-page":"1963","DOI":"10.15252\/embj.201593725","article-title":"A PBX1 transcriptional network controls dopaminergic neuron development and is impaired in Parkinson's disease","volume":"35","author":"Villaescusa","year":"2016","journal-title":"Embo j"},{"key":"10.1016\/j.bbrc.2024.150640_bib24","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1089\/ars.2015.6539","article-title":"TCF11\/Nrf1-Mediated induction of proteasome expression prevents cytotoxicity by rotenone","volume":"25","author":"Sotzny","year":"2016","journal-title":"Antioxid Redox Signal"}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X24011768?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X24011768?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,11,26]],"date-time":"2024-11-26T19:32:17Z","timestamp":1732649537000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X24011768"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":24,"alternative-id":["S0006291X24011768"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2024.150640","relation":{},"ISSN":["0006-291X"],"issn-type":[{"type":"print","value":"0006-291X"}],"subject":[],"published":{"date-parts":[[2024,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Upregulation of NFE2L1 reduces ROS levels and \u03b1-synuclein aggregation caused by GBA1 knockdown","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2024.150640","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"150640"}}