{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T08:14:41Z","timestamp":1781597681973,"version":"3.54.5"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,9,8]],"date-time":"2024-09-08T00:00:00Z","timestamp":1725753600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003093","name":"Ministry of Higher Education, Malaysia","doi-asserted-by":"publisher","award":["FP103-2019"],"award-info":[{"award-number":["FP103-2019"]}],"id":[{"id":"10.13039\/501100003093","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003093","name":"Ministry of Higher Education, Malaysia","doi-asserted-by":"publisher","award":["FRGS\/1\/2019\/SKK10\/UM\/02\/3"],"award-info":[{"award-number":["FRGS\/1\/2019\/SKK10\/UM\/02\/3"]}],"id":[{"id":"10.13039\/501100003093","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2024,11]]},"DOI":"10.1016\/j.bbrc.2024.150677","type":"journal-article","created":{"date-parts":[[2024,9,7]],"date-time":"2024-09-07T22:26:05Z","timestamp":1725747965000},"page":"150677","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Synergistic anti-tumorigenic effect of diosmetin in combination with 5-fluorouracil on human colon cancer xenografts in nude mice"],"prefix":"10.1016","volume":"735","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4299-291X","authenticated-orcid":false,"given":"Sareh","family":"Kamran","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7572-9926","authenticated-orcid":false,"given":"Ajantha","family":"Sinniah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zamri","family":"Chik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giribabu","family":"Nelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8342-5183","authenticated-orcid":false,"given":"Mohammed Abdullah","family":"Alshawsh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2024.150677_bib1","doi-asserted-by":"crossref","DOI":"10.3322\/caac.21492","article-title":"Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","author":"Bray","year":"2018","journal-title":"CA. Cancer J. Clin."},{"key":"10.1016\/j.bbrc.2024.150677_bib2","article-title":"Colorectal cancer incidence and mortality: the current status, temporal trends and their attributable risk factors in 60 countries in 2000-2019","author":"Lu","year":"2021","journal-title":"Chin. Med. J. (Engl)."},{"issue":"2","key":"10.1016\/j.bbrc.2024.150677_bib3","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1136\/gutjnl-2022-327736","article-title":"Global burden of colorectal cancer in 2020 and 2040: incidence and mortality estimates from GLOBOCAN","volume":"72","author":"Eileen Morgan","year":"2023","journal-title":"Gut"},{"issue":"3","key":"10.1016\/j.bbrc.2024.150677_bib4","doi-asserted-by":"crossref","first-page":"531","DOI":"10.3390\/biomedicines10030531","article-title":"Diosmetin exerts synergistic effects in combination with 5-fluorouracil in colorectal cancer cells","volume":"10","author":"Kamran","year":"2022","journal-title":"Biomedicines"},{"key":"10.1016\/j.bbrc.2024.150677_bib5","doi-asserted-by":"crossref","DOI":"10.1038\/s12276-018-0128-8","article-title":"Wnt pathway is involved in 5-FU drug resistance of colorectal cancer cells","author":"He","year":"2018","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.bbrc.2024.150677_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2019.108855","article-title":"Methylglyoxal in combination with 5-Fluorouracil elicits improved chemosensitivity in breast cancer through apoptosis and cell cycle inhibition","author":"Ghosh","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.bbrc.2024.150677_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2018.05.023","article-title":"Pharmacoinformatics approach for the identification of Polo-like kinase-1 inhibitors from natural sources as anti-cancer agents","author":"AlAjmi","year":"2018","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.bbrc.2024.150677_bib8","article-title":"Anticancer effects of the flavonoid diosmetin on cell cycle progression and proliferation of MDA-MB 468 breast cancer cells due to CYP1 activation","author":"Androutsopoulos","year":"2009","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.bbrc.2024.150677_bib9","doi-asserted-by":"crossref","DOI":"10.3892\/ijo.2018.4407","article-title":"Diosmetin suppresses human prostate cancer cell proliferation through the induction of apoptosis and cell cycle arrest","author":"Oak","year":"2018","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.bbrc.2024.150677_bib10","article-title":"Radiosensitizing effect of diosmetin on radioresistant lung cancer cells via Akt signaling pathway","author":"Xu","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.bbrc.2024.150677_bib11","doi-asserted-by":"crossref","DOI":"10.1021\/acs.molpharmaceut.7b01151","article-title":"Diosmetin induces apoptosis of acute myeloid leukemia cells","author":"Roma","year":"2018","journal-title":"Mol. Pharm."},{"issue":"14","key":"10.1016\/j.bbrc.2024.150677_bib12","first-page":"1","article-title":"Evaluation of anti-tumorigenic effects of diosmetin against human colon cancer xenografts in athymic nude mice","volume":"24","author":"Sanaz Koosha","year":"2019","journal-title":"Molecules"},{"key":"10.1016\/j.bbrc.2024.150677_bib13","author":"Nih"},{"key":"10.1016\/j.bbrc.2024.150677_bib14","article-title":"Esculetin suppresses proliferation of human colon cancer cells by directly targeting \u03b2-catenin","author":"Lee","year":"2013","journal-title":"Cancer Prev. Res."},{"key":"10.1016\/j.bbrc.2024.150677_bib15","doi-asserted-by":"crossref","DOI":"10.1177\/1758835920937428","article-title":"Synergistic antitumor effect of 5-fluorouracil with the novel LSD1 inhibitor ZY0511 in colorectal cancer","author":"Peng","year":"2020","journal-title":"Ther. Adv. Med. Oncol."},{"key":"10.1016\/j.bbrc.2024.150677_bib16","doi-asserted-by":"crossref","DOI":"10.1186\/s13046-017-0661-7","article-title":"Curcumin synergizes with 5-fluorouracil by impairing AMPK\/ULK1-dependent autophagy, AKT activity and enhancing apoptosis in colon cancer cells with tumor growth inhibition in xenograft mice","author":"Zhang","year":"2017","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.bbrc.2024.150677_bib17","doi-asserted-by":"crossref","DOI":"10.1007\/s002800100359","article-title":"Comparative study between daily and 5-days-a-week administration of oral 5-fluorouracil chemotherapy in mice: determining the superior regimen","author":"Makino","year":"2001","journal-title":"Cancer Chemother. Pharmacol."},{"issue":"3","key":"10.1016\/j.bbrc.2024.150677_bib18","first-page":"1","article-title":"Interpretation of animal dose and human equivalent dose for drug development","volume":"31","author":"Shin","year":"2010","journal-title":"J. Korean Orient. Med."},{"key":"10.1016\/j.bbrc.2024.150677_bib19","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0142190","article-title":"Tumor volume estimation and quasi- continuous administration for most effective bevacizumab therapy","author":"S\u00e1pi","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.bbrc.2024.150677_bib20","doi-asserted-by":"crossref","DOI":"10.4137\/CIN.S13974","article-title":"Growth rate analysis and efficient experimental Design for tumor xenograft studies","author":"Hather","year":"2014","journal-title":"Cancer Inform"},{"key":"10.1016\/j.bbrc.2024.150677_bib21","doi-asserted-by":"crossref","DOI":"10.1309\/LM1WIPCCVS9JMDZA","article-title":"Biomarkers of myocardial infarction in patients undergoing gastrointestinal cancer surgery","author":"Lippi","year":"2009","journal-title":"Lab. Med."},{"key":"10.1016\/j.bbrc.2024.150677_bib22","doi-asserted-by":"crossref","DOI":"10.1002\/ijc.33351","article-title":"Circulating liver function markers and colorectal cancer risk: a prospective cohort study in the UK Biobank","author":"He","year":"2021","journal-title":"Int. J. Cancer"},{"issue":"4","key":"10.1016\/j.bbrc.2024.150677_bib23","first-page":"a628","article-title":"Effects on hepatic and renal biomarkers in patients of colorectal carcinoma treated with two different schedules of 5FU\/LV","volume":"6","author":"Bano","year":"2013","journal-title":"Br. J. Med. Pract."},{"key":"10.1016\/j.bbrc.2024.150677_bib24","doi-asserted-by":"crossref","DOI":"10.1186\/s12929-016-0261-4","article-title":"Characterization of a murine xenograft model for contrast agent development in breast lesion malignancy assessment","author":"Yen","year":"2016","journal-title":"J. Biomed. Sci."},{"key":"10.1016\/j.bbrc.2024.150677_bib25","series-title":"Methods in Molecular Biology","doi-asserted-by":"crossref","DOI":"10.1007\/978-1-4939-8935-5_25","article-title":"An introduction to the performance of immunohistochemistry","author":"Magaki","year":"2019"},{"key":"10.1016\/j.bbrc.2024.150677_bib26","series-title":"Methods in Molecular Biology","doi-asserted-by":"crossref","DOI":"10.1007\/978-1-4939-8935-5_26","article-title":"An introduction to performing immunofluorescence staining","author":"Im","year":"2019"},{"key":"10.1016\/j.bbrc.2024.150677_bib27","doi-asserted-by":"crossref","DOI":"10.1177\/1758835918780140","article-title":"5-fluorouracil and cardiotoxicity: a review","author":"Sara","year":"2018","journal-title":"Therapeutic Advances in Medical Oncology"},{"issue":"10","key":"10.1016\/j.bbrc.2024.150677_bib28","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1111\/1440-1681.13309","article-title":"Diosmetin exerts cardioprotective effect on myocardial ischaemia injury in neonatal rats by decreasing oxidative stress and myocardial apoptosis","volume":"47","author":"Mo","year":"2020","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"issue":"1","key":"10.1016\/j.bbrc.2024.150677_bib29","first-page":"1","article-title":"The effect of propolis on 5-fluorouracil-induced cardiac toxicity in rats","volume":"12","author":"Barary","year":"2022","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbrc.2024.150677_bib30","series-title":"Robbins and Cotran Pathologic Basis of Disease","article-title":"Inflammation and repair: tissue repair","author":"Kumar","year":"2015"},{"key":"10.1016\/j.bbrc.2024.150677_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.cell.2011.10.033","article-title":"Programmed cell death in animal development and disease","author":"Fuchs","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.bbrc.2024.150677_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.111285","article-title":"5-Fluorouracil (5-FU) resistance and the new strategy to enhance the sensitivity against cancer: Implication of DNA repair inhibition","author":"Sethy","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.bbrc.2024.150677_bib33","article-title":"5-Fluorouracil: mechanisms of resistance and reversal strategies","author":"Zhang","year":"2008","journal-title":"Molecules"},{"issue":"1","key":"10.1016\/j.bbrc.2024.150677_bib34","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12906-021-03301-6","article-title":"A plant-based medicinal food inhibits the growth of human gastric carcinoma by reversing epithelial\u2013mesenchymal transition via the canonical Wnt\/\u03b2-catenin signaling pathway","volume":"21","author":"Chen","year":"2021","journal-title":"BMC Complement. Med. Ther."},{"key":"10.1016\/j.bbrc.2024.150677_bib35","doi-asserted-by":"crossref","DOI":"10.1186\/s40659-021-00363-1","article-title":"Diosmetin inhibits cell proliferation and promotes apoptosis through STAT3\/c-Myc signaling pathway in human osteosarcoma cells","author":"Ning","year":"2021","journal-title":"Biol. Res."},{"key":"10.1016\/j.bbrc.2024.150677_bib36","doi-asserted-by":"crossref","DOI":"10.15171\/apb.2019.024","article-title":"Understanding apoptosis and apoptotic pathways targeted cancer therapeutics","author":"Jan","year":"2019","journal-title":"Adv. Pharmaceut. Bull."},{"key":"10.1016\/j.bbrc.2024.150677_bib37","article-title":"The molecular mechanism of G2\/M cell cycle arrest induced by AFB1 in the jejunum","author":"Yin","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.bbrc.2024.150677_bib38","doi-asserted-by":"crossref","DOI":"10.12659\/MSMBR.903910","article-title":"TNF-Alpha promotes Invasion and metastasis via NF-Kappa B pathway in oral Squamous cell carcinoma","author":"Tang","year":"2017","journal-title":"Med. Sci. Monit. Basic Res."},{"issue":"1","key":"10.1016\/j.bbrc.2024.150677_bib39","doi-asserted-by":"crossref","DOI":"10.3390\/cells5010012","article-title":"The regulation of NF-\u043aB Subunits by phosphorylation","volume":"5","author":"Christian","year":"2016","journal-title":"Cells"},{"key":"10.1016\/j.bbrc.2024.150677_bib40","doi-asserted-by":"crossref","DOI":"10.2147\/OTT.S118272","article-title":"Curcumin sensitizes human gastric cancer cells to 5-fluorouracil through inhibition of the NF\u03baB survival-signaling pathway","author":"Kang","year":"2016","journal-title":"OncoTargets Ther."},{"issue":"1","key":"10.1016\/j.bbrc.2024.150677_bib41","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12935-022-02561-7","article-title":"A systematic review of the therapeutic effects of resveratrol in combination with 5-fluorouracil during colorectal cancer treatment: with a special focus on the oxidant, apoptotic, and anti-inflammatory activities","volume":"22","author":"Moutabian","year":"2022","journal-title":"Cancer Cell Int."},{"key":"10.1016\/j.bbrc.2024.150677_bib42","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0186511","article-title":"Protective effect of dexamethasone on 5-FUinduced oral mucositis in hamsters","author":"Ribeiro","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.bbrc.2024.150677_bib43","doi-asserted-by":"crossref","DOI":"10.2147\/OTT.S60114","article-title":"Chemotherapy-enhanced inflammation may lead to the failure of therapy and metastasis","author":"Vyas","year":"2014","journal-title":"OncoTargets Ther."},{"key":"10.1016\/j.bbrc.2024.150677_bib44","doi-asserted-by":"crossref","DOI":"10.1172\/JCI26322","article-title":"IKK\/NF-\u03baB signaling: Balancing life and death - a new approach to cancer therapy","author":"Luo","year":"2005","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbrc.2024.150677_bib45","doi-asserted-by":"crossref","DOI":"10.1093\/alcalc\/agw098","article-title":"The role of NFkB in drug addiction: beyond inflammation","author":"Nennig","year":"2017","journal-title":"Alcohol Alcohol"},{"key":"10.1016\/j.bbrc.2024.150677_bib46","doi-asserted-by":"crossref","DOI":"10.1016\/j.toxlet.2016.11.018","article-title":"Diosmin-induced senescence, apoptosis and autophagy in breast cancer cells of different p53 status and ERK activity","author":"Lewinska","year":"2017","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.bbrc.2024.150677_bib47","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines12040827","article-title":"Decoding tumor angiogenesis for therapeutic advancements: Mechanistic Insights","author":"Kaur","year":"2024","journal-title":"Biomedicines"},{"key":"10.1016\/j.bbrc.2024.150677_bib48","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2019.109091","article-title":"Diosmetin inhibits tumor development and block tumor angiogenesis in skin cancer","author":"Choi","year":"2019","journal-title":"Biomed. Pharmacother."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X24012130?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X24012130?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,12,20]],"date-time":"2024-12-20T09:03:05Z","timestamp":1734685385000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X24012130"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":48,"alternative-id":["S0006291X24012130"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2024.150677","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2024,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Synergistic anti-tumorigenic effect of diosmetin in combination with 5-fluorouracil on human colon cancer xenografts in nude mice","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2024.150677","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"150677"}}