{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T06:26:08Z","timestamp":1773901568182,"version":"3.50.1"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012154","name":"Graduate Research and Innovation Projects of Jiangsu Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012154","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2024,11]]},"DOI":"10.1016\/j.bbrc.2024.150678","type":"journal-article","created":{"date-parts":[[2024,9,10]],"date-time":"2024-09-10T06:10:28Z","timestamp":1725948628000},"page":"150678","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Salidroside promotes liver regeneration after partial hepatectomy in mice by modulating NLRP3 inflammasome-mediated pyroptosis pathway"],"prefix":"10.1016","volume":"735","author":[{"given":"Saiya","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meilu","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sha","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuefei","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7108-1491","authenticated-orcid":false,"given":"Hongyu","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiangpeng","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7474-4203","authenticated-orcid":false,"given":"Weiqian","family":"Tian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2024.150678_bib1","doi-asserted-by":"crossref","first-page":"E144","DOI":"10.1055\/a-0588-4653","article-title":"Magnetic compression anastomosis for biliary obstruction after partial hepatectomy","volume":"50","author":"Jiang","year":"2018","journal-title":"Endoscopy"},{"key":"10.1016\/j.bbrc.2024.150678_bib2","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1002\/hep.28912","article-title":"Nicotinamide adenine dinucleotide biosynthesis promotes liver regeneration","volume":"65","author":"Mukherjee","year":"2017","journal-title":"Hepatology (Baltimore, Md"},{"key":"10.1016\/j.bbrc.2024.150678_bib3","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.asjsur.2018.01.007","article-title":"Chinese expert consensus on enhanced recovery after hepatectomy (version 2017)","volume":"42","author":"Jia","year":"2019","journal-title":"Asian J. Surg."},{"key":"10.1016\/j.bbrc.2024.150678_bib4","first-page":"40","article-title":"Liver regeneration: biological and pathological mechanisms and implications, Nature reviews","volume":"18","author":"Michalopoulos","year":"2021","journal-title":"Gastroenterol. Hepatol."},{"key":"10.1016\/j.bbrc.2024.150678_bib5","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1002\/hep.30508","article-title":"The role of complement in liver injury, regeneration, and transplantation","volume":"70","author":"Thorgersen","year":"2019","journal-title":"Hepatology (Baltimore, Md"},{"key":"10.1016\/j.bbrc.2024.150678_bib6","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.jfda.2015.04.007","article-title":"Rhodiola plants: chemistry and biological activity","volume":"23","author":"Chiang","year":"2015","journal-title":"J. Food Drug Anal."},{"key":"10.1016\/j.bbrc.2024.150678_bib7","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1002\/ptr.6335","article-title":"Neuroprotective effect of salidroside against central nervous system inflammation-induced cognitive deficits: a pivotal role of sirtuin 1-dependent Nrf-2\/HO-1\/NF-\u03baB pathway","volume":"33","author":"Xu","year":"2019","journal-title":"Phytother Res. : PTR"},{"key":"10.1016\/j.bbrc.2024.150678_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.jare.2024.02.019","article-title":"Salidroside promotes pro-angiogenesis and repair of blood brain barrier via Notch\/ITGB1 signal path in CSVD Model","author":"Zhilan","year":"2024","journal-title":"J. Adv. Res."},{"key":"10.1016\/j.bbrc.2024.150678_bib9","article-title":"Protective effect of salidroside against bone loss via hypoxia-inducible factor-1\u03b1 pathway-induced angiogenesis","volume":"6","author":"Li","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbrc.2024.150678_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2022.102034","article-title":"Dietary supplementation of salidroside alleviates liver lipid metabolism disorder and inflammatory response to promote hepatocyte regeneration via PI3K\/AKT\/Gsk3-\u03b2 pathway","volume":"101","author":"Cui","year":"2022","journal-title":"Poultry Sci."},{"key":"10.1016\/j.bbrc.2024.150678_bib11","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/nrmicro2070","article-title":"Pyroptosis: host cell death and inflammation","volume":"7","author":"Bergsbaken","year":"2009","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.bbrc.2024.150678_bib12","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1038\/s41577-019-0228-2","article-title":"The gasdermins, a protein family executing cell death and inflammation","volume":"20","author":"Broz","year":"2020","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.bbrc.2024.150678_bib13","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1038\/s41590-021-00886-5","article-title":"NLRP3 inflammasome in cancer and metabolic diseases","volume":"22","author":"Sharma","year":"2021","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.bbrc.2024.150678_bib14","doi-asserted-by":"crossref","first-page":"2340","DOI":"10.1002\/hep4.1973","article-title":"Gasdermin D-mediated pyroptosis suppresses liver regeneration after 70% partial hepatectomy","volume":"6","author":"Lv","year":"2022","journal-title":"Hepatol. Communicat."},{"key":"10.1016\/j.bbrc.2024.150678_bib15","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.intimp.2017.10.030","article-title":"Dexmedetomidine promotes liver regeneration in mice after 70% partial hepatectomy by suppressing NLRP3 inflammasome not TLR4\/NFkappaB","volume":"54","author":"Lv","year":"2018","journal-title":"Int. Immunopharm."},{"key":"10.1016\/j.bbrc.2024.150678_bib16","first-page":"1378","article-title":"Targeting ferroptosis alleviates methionine-choline deficient (MCD)-diet induced NASH by suppressing liver lipotoxicity, Liver international","volume":"40","author":"Li","year":"2020","journal-title":"Off. J. Int. Assoc. Stud. Liver"},{"key":"10.1016\/j.bbrc.2024.150678_bib17","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1002\/(SICI)1097-4652(200003)182:3<311::AID-JCP1>3.0.CO;2-9","article-title":"The Ki-67 protein: from the known and the unknown","volume":"182","author":"Scholzen","year":"2000","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.bbrc.2024.150678_bib18","article-title":"Resina draconis reduces acute liver injury and promotes liver regeneration after 2\/3 partial hepatectomy in mice","volume":"2020","author":"He","year":"2020","journal-title":"Evid. base Compl. Alternative Med. : eCAM"},{"key":"10.1016\/j.bbrc.2024.150678_bib19","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.semcdb.2019.10.007","article-title":"Cellular and molecular mechanisms of liver regeneration: proliferation, growth, death and protection of hepatocytes","volume":"100","author":"Ozaki","year":"2020","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.bbrc.2024.150678_bib20","doi-asserted-by":"crossref","first-page":"3178","DOI":"10.1111\/jcmm.12871","article-title":"Salidroside suppressing LPS-induced myocardial injury by inhibiting ROS-mediated PI3K\/Akt\/mTOR pathway in vitro and in vivo","volume":"21","author":"Chen","year":"2017","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.bbrc.2024.150678_bib21","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.bbrc.2023.07.059","article-title":"Integrating network pharmacology and experimental verification to explore the mechanisms of salidroside against myocardial fibrosis","volume":"677","author":"Ma","year":"2023","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbrc.2024.150678_bib22","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.812362","article-title":"Salidroside ameliorates depression by suppressing NLRP3-mediated pyroptosis via P2X7\/NF-\u03baB\/NLRP3 signaling pathway","volume":"13","author":"Chai","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.bbrc.2024.150678_bib23","doi-asserted-by":"crossref","first-page":"9405","DOI":"10.18632\/aging.103215","article-title":"Salidroside ameliorates Parkinson's disease by inhibiting NLRP3-dependent pyroptosis","volume":"12","author":"Zhang","year":"2020","journal-title":"Aging"},{"key":"10.1016\/j.bbrc.2024.150678_bib24","first-page":"21","article-title":"Salidroside regulates inflammatory response in raw 264.7 macrophages via TLR4\/TAK1 and ameliorates inflammation in alcohol binge drinking-induced liver injury","author":"Sun","year":"2016","journal-title":"Molecules"},{"key":"10.1016\/j.bbrc.2024.150678_bib25","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/8597897","article-title":"Salidroside attenuates high-fat diet-induced nonalcoholic fatty liver disease via AMPK-dependent TXNIP\/NLRP3 pathway","volume":"2018","author":"Zheng","year":"2018","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.bbrc.2024.150678_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2023.121793","article-title":"Salidroside alleviates acetaminophen-induced hepatotoxicity via Sirt1-mediated activation of Akt\/Nrf2 pathway and suppression of NF-\u03baB\/NLRP3 inflammasome axis","volume":"327","author":"Gao","year":"2023","journal-title":"Life Sci."},{"key":"10.1016\/j.bbrc.2024.150678_bib27","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.677810","article-title":"Salidroside inhibits CCl(4)-induced liver fibrosis in mice by reducing activation and migration of HSC induced by liver sinusoidal endothelial cell-derived exosomal SphK1","volume":"12","author":"Ye","year":"2021","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.bbrc.2024.150678_bib28","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/314081","article-title":"Salidroside attenuates concanavalin A-induced hepatitis via modulating cytokines secretion and lymphocyte migration in mice","volume":"2014","author":"Hu","year":"2014","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.bbrc.2024.150678_bib29","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.ebiom.2018.10.069","article-title":"Salidroside improves the hypoxic tumor microenvironment and reverses the drug resistance of platinum drugs via HIF-1\u03b1 signaling pathway","volume":"38","author":"Qin","year":"2018","journal-title":"EBioMedicine"},{"key":"10.1016\/j.bbrc.2024.150678_bib30","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.intimp.2017.10.030","article-title":"Dexmedetomidine promotes liver regeneration in mice after 70% partial hepatectomy by suppressing NLRP3 inflammasome not TLR4\/NF\u03baB","volume":"54","author":"Lv","year":"2018","journal-title":"Int. Immunopharm."},{"key":"10.1016\/j.bbrc.2024.150678_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2020.120573","article-title":"A dopamine-precursor-based nanoprodrug for in-situ drug release and treatment of acute liver failure by inhibiting NLRP3 inflammasome and facilitating liver regeneration","volume":"268","author":"Zhan","year":"2021","journal-title":"Biomaterials"},{"key":"10.1016\/j.bbrc.2024.150678_bib32","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1007\/s10753-017-0613-6","article-title":"Deficiency of NALP3 signaling impairs liver regeneration after partial hepatectomy","volume":"40","author":"Ando","year":"2017","journal-title":"Inflammation"},{"key":"10.1016\/j.bbrc.2024.150678_bib33","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.freeradbiomed.2020.05.012","article-title":"Baicalin promotes liver regeneration after acetaminophen-induced liver injury by inducing NLRP3 inflammasome activation","volume":"160","author":"Shi","year":"2020","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bbrc.2024.150678_bib34","doi-asserted-by":"crossref","DOI":"10.1002\/jbt.23606","article-title":"Nanocurcumin attenuates pyroptosis and inflammation through inhibiting NF-\u03baB\/GSDMD signal in high altitude-associated acute liver injury","volume":"38","author":"Yang","year":"2024","journal-title":"J. Biochem. Mol. Toxicol."},{"key":"10.1016\/j.bbrc.2024.150678_bib35","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.jss.2005.12.011","article-title":"Prometheus' challenge: molecular, cellular and systemic aspects of liver regeneration","volume":"134","author":"Pahlavan","year":"2006","journal-title":"J. Surg. Res."},{"key":"10.1016\/j.bbrc.2024.150678_bib36","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1053\/jlts.2001.27865","article-title":"Liver regeneration: from laboratory to clinic","volume":"7","author":"Fausto","year":"2001","journal-title":"Liver Transplant. : Off. Public. Am. Assoc. Study Liver Dis. Int. Liver Transplant. Soc."},{"key":"10.1016\/j.bbrc.2024.150678_bib37","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.3389\/fphar.2020.01174","article-title":"Periplaneta americana extracts accelerate liver regeneration via a complex network of pathways","volume":"11","author":"Zou","year":"2020","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.bbrc.2024.150678_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2024.110970","article-title":"Oleanolic acid promotes liver regeneration after partial hepatectomy via regulating pregnane X receptor signaling pathway in mice","volume":"393","author":"Song","year":"2024","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.bbrc.2024.150678_bib39","series-title":"Effects of Salidroside on Keap1-Nrf2 Signal Pathway in Acetaminophen-Induced Liver Injury Model Mice","author":"Wei","year":"2018"},{"key":"10.1016\/j.bbrc.2024.150678_bib40","series-title":"Inhibitory Action of Salidrose on Hepatic Fibrosis","author":"Yi","year":"2006"},{"key":"10.1016\/j.bbrc.2024.150678_bib41","first-page":"1","article-title":"Salidroside inhibits insulin resistance and hepatic steatosis by downregulating miR-21 and subsequent activation of AMPK and upregulation of PPAR\u03b1 in the liver and muscles of high fat diet-fed rats","author":"Almohawes","year":"2022","journal-title":"Arch. Physiol. Biochem."},{"key":"10.1016\/j.bbrc.2024.150678_bib42","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1002\/micr.20271","article-title":"Regenerative capacity of individual liver lobes in the microsurgical mouse model","volume":"26","author":"Inderbitzin","year":"2006","journal-title":"Microsurgery"},{"key":"10.1016\/j.bbrc.2024.150678_bib43","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1186\/s12906-019-2536-2","article-title":"Panax notoginseng saponins promote liver regeneration through activation of the PI3K\/AKT\/mTOR cell proliferation pathway and upregulation of the AKT\/Bad cell survival pathway in mice","volume":"19","author":"Zhong","year":"2019","journal-title":"BMC Compl. Alternative Med."},{"key":"10.1016\/j.bbrc.2024.150678_bib44","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.ejphar.2017.10.044","article-title":"Schisandrol B promotes liver regeneration after partial hepatectomy in mice","volume":"818","author":"Li","year":"2018","journal-title":"Eur. J. Pharmacol."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X24012142?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X24012142?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,12,20]],"date-time":"2024-12-20T09:02:57Z","timestamp":1734685377000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X24012142"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":44,"alternative-id":["S0006291X24012142"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2024.150678","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2024,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Salidroside promotes liver regeneration after partial hepatectomy in mice by modulating NLRP3 inflammasome-mediated pyroptosis pathway","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2024.150678","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"150678"}}