{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T00:55:53Z","timestamp":1794012953771,"version":"4.8.0"},"reference-count":169,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003093","name":"Malaysia Ministry of Higher Education","doi-asserted-by":"publisher","award":["FRGS\/1\/2022\/SKK10\/UPM\/02\/4"],"award-info":[{"award-number":["FRGS\/1\/2022\/SKK10\/UPM\/02\/4"]}],"id":[{"id":"10.13039\/501100003093","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2024,11]]},"DOI":"10.1016\/j.bbrc.2024.150713","type":"journal-article","created":{"date-parts":[[2024,9,17]],"date-time":"2024-09-17T17:48:09Z","timestamp":1726595289000},"page":"150713","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["Brain insulin resistance in Down syndrome: Involvement of PI3K-Akt\/mTOR axis in early-onset of Alzheimer's disease and its potential as a therapeutic target"],"prefix":"10.1016","volume":"733","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1694-9491","authenticated-orcid":false,"given":"Mansour","family":"Azimzadeh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pike-See","family":"Cheah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3968-7263","authenticated-orcid":false,"given":"King-Hwa","family":"Ling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2024.150713_bib1","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2021.636633","volume":"11","author":"Grimm","year":"2021","journal-title":"Front. Oncol."},{"issue":"7","key":"10.1016\/j.bbrc.2024.150713_bib2","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1002\/alz.12112","volume":"16","author":"Snyder","year":"2020","journal-title":"Alzheimers Dement"},{"issue":"7","key":"10.1016\/j.bbrc.2024.150713_bib3","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1212\/WNL.35.7.957","volume":"35","author":"Wisniewski","year":"1985","journal-title":"Neurology"},{"issue":"3","key":"10.1016\/j.bbrc.2024.150713_bib4","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1002\/ana.410170310","volume":"17","author":"Wisniewski","year":"1985","journal-title":"Ann. Neurol."},{"issue":"3","key":"10.1016\/j.bbrc.2024.150713_bib5","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1038\/s41582-018-0132-6","volume":"15","author":"Lott","year":"2019","journal-title":"Nat. Rev. Neurol."},{"issue":"10242","key":"10.1016\/j.bbrc.2024.150713_bib6","doi-asserted-by":"crossref","first-page":"1988","DOI":"10.1016\/S0140-6736(20)30689-9","volume":"395","author":"Fortea","year":"2020","journal-title":"Lancet"},{"key":"10.1016\/j.bbrc.2024.150713_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2020.104772","volume":"137","author":"Tramutola","year":"2020","journal-title":"Neurobiol. Dis."},{"issue":"46","key":"10.1016\/j.bbrc.2024.150713_bib8","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2212954119","volume":"119","author":"Condello","year":"2022","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"9","key":"10.1016\/j.bbrc.2024.150713_bib9","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1038\/s41580-019-0129-z","volume":"20","author":"Bilanges","year":"2019","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.bbrc.2024.150713_bib10","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.semcancer.2019.04.001","volume":"59","author":"Yang","year":"2019","journal-title":"Semin. Cancer Biol."},{"issue":"12","key":"10.1016\/j.bbrc.2024.150713_bib11","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19123725","volume":"19","author":"S\u00e1nchez-Alegr\u00eda","year":"2018","journal-title":"Int. J. Mol. Sci."},{"issue":"14","key":"10.1016\/j.bbrc.2024.150713_bib12","doi-asserted-by":"crossref","first-page":"2762","DOI":"10.1523\/JNEUROSCI.2260-18.2019","volume":"39","author":"Nguyen","year":"2019","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbrc.2024.150713_bib13","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.brainresbull.2016.06.007","volume":"125","author":"Zhang","year":"2016","journal-title":"Brain Res. Bull."},{"issue":"80","key":"10.1016\/j.bbrc.2024.150713_bib14","doi-asserted-by":"crossref","first-page":"ra36","DOI":"10.1126\/scisignal.2000308","volume":"2","author":"Santini","year":"2009","journal-title":"Sci. Signal."},{"key":"10.1016\/j.bbrc.2024.150713_bib15","doi-asserted-by":"crossref","DOI":"10.1038\/npjamd.2015.8","volume":"1","author":"Talboom","year":"2015","journal-title":"NPJ Aging Mech Dis"},{"issue":"7","key":"10.1016\/j.bbrc.2024.150713_bib16","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/j.exger.2013.02.025","volume":"48","author":"O' Neill","year":"2013","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.bbrc.2024.150713_bib17","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.freeradbiomed.2021.01.042","volume":"165","author":"Lanzillotta","year":"2021","journal-title":"Free Radic. Biol. Med."},{"issue":"8","key":"10.1016\/j.bbrc.2024.150713_bib18","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1111\/dmcn.14260","volume":"61","author":"Baburamani","year":"2019","journal-title":"Dev. Med. Child Neurol."},{"key":"10.1016\/j.bbrc.2024.150713_bib19","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1186\/1742-2094-10-84","volume":"10","author":"Wilcock","year":"2013","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.bbrc.2024.150713_bib20","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.3389\/fnins.2019.01081","volume":"13","author":"Chiotto","year":"2019","journal-title":"Front. Neurosci."},{"issue":"2","key":"10.1016\/j.bbrc.2024.150713_bib21","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1006\/exnr.1997.6777","volume":"150","author":"Leverenz","year":"1998","journal-title":"Exp. Neurol."},{"issue":"2","key":"10.1016\/j.bbrc.2024.150713_bib22","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.bbadis.2011.10.001","volume":"1822","author":"Cenini","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"issue":"19","key":"10.1016\/j.bbrc.2024.150713_bib23","doi-asserted-by":"crossref","first-page":"3882","DOI":"10.1091\/mbc.e12-05-0337","volume":"23","author":"Gupta","year":"2012","journal-title":"Mol. Biol. Cell"},{"issue":"4","key":"10.1016\/j.bbrc.2024.150713_bib24","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1042\/BST20120080","volume":"40","author":"O'Neill","year":"2012","journal-title":"Biochem. Soc. Trans."},{"issue":"4","key":"10.1016\/j.bbrc.2024.150713_bib25","doi-asserted-by":"crossref","first-page":"E581","DOI":"10.1152\/ajpendo.90437.2008","volume":"296","author":"Boura-Halfon","year":"2009","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"issue":"1","key":"10.1016\/j.bbrc.2024.150713_bib26","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1001\/archneurol.2011.233","volume":"69","author":"Craft","year":"2012","journal-title":"Arch. Neurol."},{"issue":"4","key":"10.1016\/j.bbrc.2024.150713_bib27","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1172\/JCI59903","volume":"122","author":"Talbot","year":"2012","journal-title":"J. Clin. Invest."},{"issue":"7","key":"10.1016\/j.bbrc.2024.150713_bib28","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1089\/ars.2016.6686","volume":"26","author":"Tramutola","year":"2017","journal-title":"Antioxidants Redox Signal."},{"key":"10.1016\/j.bbrc.2024.150713_bib29","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.nbd.2018.07.006","volume":"118","author":"Tramutola","year":"2018","journal-title":"Neurobiol. Dis."},{"issue":"2","key":"10.1016\/j.bbrc.2024.150713_bib30","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1042\/BJ20140772","volume":"463","author":"Butterfield","year":"2014","journal-title":"Biochem. J."},{"key":"10.1016\/j.bbrc.2024.150713_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2024.106523","volume":"196","author":"Lanzillotta","year":"2024","journal-title":"Neurobiol. Dis."},{"issue":"5","key":"10.1016\/j.bbrc.2024.150713_bib32","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/S1081-1206(10)60516-9","volume":"102","author":"Cruz","year":"2009","journal-title":"Ann. Allergy Asthma Immunol."},{"issue":"1","key":"10.1016\/j.bbrc.2024.150713_bib33","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.cmet.2012.12.005","volume":"17","author":"Helguera","year":"2013","journal-title":"Cell Metabol."},{"key":"10.1016\/j.bbrc.2024.150713_bib34","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/1472-6823-5-6","volume":"5","author":"Fonseca","year":"2005","journal-title":"BMC Endocr. Disord."},{"issue":"2","key":"10.1016\/j.bbrc.2024.150713_bib35","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1136\/adc.77.2.183g","volume":"77","author":"Van Goor","year":"1997","journal-title":"Arch. Dis. Child."},{"key":"10.1016\/j.bbrc.2024.150713_bib36","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1007\/s00125-006-0231-6","volume":"49","author":"Bergholdt","year":"2006","journal-title":"Diabetologia"},{"issue":"2","key":"10.1016\/j.bbrc.2024.150713_bib37","volume":"9","author":"Moreau","year":"2021","journal-title":"Biomedicines"},{"issue":"4","key":"10.1016\/j.bbrc.2024.150713_bib38","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1038\/nm.3820","volume":"21","author":"Wang","year":"2015","journal-title":"Nat. Med."},{"issue":"11","key":"10.1016\/j.bbrc.2024.150713_bib39","doi-asserted-by":"crossref","first-page":"5212","DOI":"10.1210\/en.2011-2149","volume":"153","author":"Peiris","year":"2012","journal-title":"Endocrinology"},{"issue":"12","key":"10.1016\/j.bbrc.2024.150713_bib40","doi-asserted-by":"crossref","first-page":"2892","DOI":"10.2337\/dc22-0482","volume":"45","author":"Aslam","year":"2022","journal-title":"Diabetes Care"},{"issue":"7","key":"10.1016\/j.bbrc.2024.150713_bib41","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1038\/jcbfm.2012.35","volume":"32","author":"Howarth","year":"2012","journal-title":"J. Cerebr. Blood Flow Metabol."},{"issue":"1","key":"10.1016\/j.bbrc.2024.150713_bib42","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.expneurol.2005.10.035","volume":"198","author":"Uemura","year":"2006","journal-title":"Exp. Neurol."},{"issue":"6","key":"10.1016\/j.bbrc.2024.150713_bib43","first-page":"611","article-title":"Arch psychiatr nervenkr Z gesamte neurol psychiatr","volume":"196","author":"Erbsloh","year":"1958"},{"key":"10.1016\/j.bbrc.2024.150713_bib44","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.3389\/fnins.2019.01301","volume":"13","author":"Deitmer","year":"2019","journal-title":"Front. Neurosci."},{"issue":"1","key":"10.1016\/j.bbrc.2024.150713_bib45","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0006-8993(98)00103-6","volume":"797","author":"Vannucci","year":"1998","journal-title":"Brain Res."},{"issue":"5","key":"10.1016\/j.bbrc.2024.150713_bib46","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1002\/(SICI)1097-4547(19990901)57:5<693::AID-JNR11>3.0.CO;2-X","volume":"57","author":"Apelt","year":"1999","journal-title":"J. Neurosci. Res."},{"issue":"3","key":"10.1016\/j.bbrc.2024.150713_bib47","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1038\/nrneurol.2017.185","volume":"14","author":"Arnold","year":"2018","journal-title":"Nat. Rev. Neurol."},{"issue":"10","key":"10.1016\/j.bbrc.2024.150713_bib48","doi-asserted-by":"crossref","first-page":"2565","DOI":"10.1007\/s00125-012-2644-8","volume":"55","author":"Copps","year":"2012","journal-title":"Diabetologia"},{"key":"10.1016\/j.bbrc.2024.150713_bib49","volume":"12","author":"Long","year":"2021","journal-title":"Front. Pharmacol."},{"issue":"10","key":"10.1016\/j.bbrc.2024.150713_bib50","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1080\/15548627.2015.1043076","volume":"11","author":"Yu","year":"2015","journal-title":"Autophagy"},{"key":"10.1016\/j.bbrc.2024.150713_bib51","first-page":"6","author":"Levenga","year":"2017","journal-title":"Elife"},{"issue":"2","key":"10.1016\/j.bbrc.2024.150713_bib52","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1042\/BJ20150041","volume":"468","author":"Risso","year":"2015","journal-title":"Biochem. J."},{"issue":"10","key":"10.1016\/j.bbrc.2024.150713_bib53","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1016\/j.cellsig.2011.05.004","volume":"23","author":"Hers","year":"2011","journal-title":"Cell. Signal."},{"issue":"50","key":"10.1016\/j.bbrc.2024.150713_bib54","doi-asserted-by":"crossref","first-page":"6473","DOI":"10.1038\/onc.2008.313","volume":"27","author":"Franke","year":"2008","journal-title":"Oncogene"},{"issue":"3","key":"10.1016\/j.bbrc.2024.150713_bib55","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.tem.2011.12.004","volume":"23","author":"Kim","year":"2012","journal-title":"Trends Endocrinol. Metabol."},{"issue":"2","key":"10.1016\/j.bbrc.2024.150713_bib56","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.neuron.2014.09.034","volume":"84","author":"Lipton","year":"2014","journal-title":"Neuron"},{"issue":"9","key":"10.1016\/j.bbrc.2024.150713_bib57","volume":"8","author":"Wei","year":"2019","journal-title":"Cells"},{"issue":"2\u20133","key":"10.1016\/j.bbrc.2024.150713_bib58","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.exger.2010.08.030","volume":"46","author":"Garelick","year":"2011","journal-title":"Exp. Gerontol."},{"issue":"6","key":"10.1016\/j.bbrc.2024.150713_bib59","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1042\/EBC20170027","volume":"61","author":"Rabanal-Ruiz","year":"2017","journal-title":"Essays Biochem."},{"issue":"9","key":"10.1016\/j.bbrc.2024.150713_bib60","doi-asserted-by":"crossref","first-page":"3791","DOI":"10.1073\/pnas.1014715108","volume":"108","author":"Stoica","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"2","key":"10.1016\/j.bbrc.2024.150713_bib61","doi-asserted-by":"crossref","first-page":"89","DOI":"10.3858\/emm.2012.44.2.031","volume":"44","author":"Son","year":"2012","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.bbrc.2024.150713_bib62","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.rvsc.2018.11.006","volume":"122","author":"Rivera-Calder\u00f3n","year":"2019","journal-title":"Res. Vet. Sci."},{"key":"10.1016\/j.bbrc.2024.150713_bib63","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.16807","volume":"5","author":"Mahoney","year":"2016","journal-title":"Elife"},{"issue":"8","key":"10.1016\/j.bbrc.2024.150713_bib64","doi-asserted-by":"crossref","first-page":"2825","DOI":"10.1021\/acs.jproteome.7b00140","volume":"16","author":"Zhang","year":"2017","journal-title":"J. Proteome Res."},{"issue":"5","key":"10.1016\/j.bbrc.2024.150713_bib65","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1111\/jnc.13037","volume":"133","author":"Tramutola","year":"2015","journal-title":"J. Neurochem."},{"issue":"11","key":"10.1016\/j.bbrc.2024.150713_bib66","doi-asserted-by":"crossref","first-page":"1926","DOI":"10.1016\/j.bbamcr.2011.04.003","volume":"1813","author":"Kloet","year":"2011","journal-title":"Biochimica et Biophysica Acta (BBA) - Mol Cell Res"},{"issue":"4","key":"10.1016\/j.bbrc.2024.150713_bib67","doi-asserted-by":"crossref","DOI":"10.1111\/cns.14463","volume":"30","author":"Davoody","year":"2024","journal-title":"CNS Neurosci. Ther."},{"issue":"6791","key":"10.1016\/j.bbrc.2024.150713_bib68","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1038\/35017574","volume":"406","author":"Hoeflich","year":"2000","journal-title":"Nature"},{"issue":"6","key":"10.1016\/j.bbrc.2024.150713_bib69","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1002\/jcb.22881","volume":"111","author":"Kai","year":"2010","journal-title":"J. Cell. Biochem."},{"issue":"10","key":"10.1016\/j.bbrc.2024.150713_bib70","doi-asserted-by":"crossref","first-page":"2116","DOI":"10.1038\/sj.emboj.7600217","volume":"23","author":"Yada","year":"2004","journal-title":"Embo j"},{"issue":"1","key":"10.1016\/j.bbrc.2024.150713_bib71","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1083\/jcb.200409067","volume":"168","author":"Bachelder","year":"2005","journal-title":"J. Cell Biol."},{"issue":"12","key":"10.1016\/j.bbrc.2024.150713_bib72","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1038\/ncb1508","volume":"8","author":"Yook","year":"2006","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.bbrc.2024.150713_bib73","first-page":"2011","author":"Salcedo-Tello","year":"2011","journal-title":"Int. J. Alzheimer's Dis."},{"issue":"6","key":"10.1016\/j.bbrc.2024.150713_bib74","doi-asserted-by":"crossref","first-page":"E1188","DOI":"10.1152\/ajpendo.00547.2004","volume":"288","author":"Dokken","year":"2005","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"issue":"7","key":"10.1016\/j.bbrc.2024.150713_bib75","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1016\/j.bbadis.2014.04.007","volume":"1842","author":"Perluigi","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbrc.2024.150713_bib76","volume":"2011","author":"Hanger","year":"2011","journal-title":"Int. J. Alzheimer's Dis."},{"issue":"2","key":"10.1016\/j.bbrc.2024.150713_bib77","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.expneurol.2009.09.011","volume":"223","author":"Hern\u00e1ndez","year":"2010","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.bbrc.2024.150713_bib78","volume":"2011","author":"Mines","year":"2011","journal-title":"Int. J. Alzheimer's Dis."},{"issue":"6","key":"10.1016\/j.bbrc.2024.150713_bib79","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1111\/j.1471-4159.2004.02422.x","volume":"89","author":"Bhat","year":"2004","journal-title":"J. Neurochem."},{"issue":"13","key":"10.1016\/j.bbrc.2024.150713_bib80","doi-asserted-by":"crossref","first-page":"2586","DOI":"10.1038\/sj.emboj.7600251","volume":"23","author":"Baki","year":"2004","journal-title":"Embo j"},{"issue":"4","key":"10.1016\/j.bbrc.2024.150713_bib81","doi-asserted-by":"crossref","first-page":"828.e31","DOI":"10.1016\/j.neurobiolaging.2011.06.025","volume":"33","author":"Sheppard","year":"2012","journal-title":"Neurobiol. Aging"},{"issue":"1","key":"10.1016\/j.bbrc.2024.150713_bib82","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1111\/j.1471-4159.2004.02949.x","volume":"93","author":"Griffin","year":"2005","journal-title":"J. Neurochem."},{"key":"10.1016\/j.bbrc.2024.150713_bib83","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.freeradbiomed.2013.01.016","volume":"62","author":"Ermak","year":"2013","journal-title":"Free Radic. Biol. Med."},{"issue":"7","key":"10.1016\/j.bbrc.2024.150713_bib84","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1093\/hmg\/ddm374","volume":"17","author":"Keating","year":"2008","journal-title":"Hum. Mol. Genet."},{"issue":"4","key":"10.1016\/j.bbrc.2024.150713_bib85","doi-asserted-by":"crossref","first-page":"701","DOI":"10.3233\/JAD-2011-110890","volume":"27","author":"Lloret","year":"2011","journal-title":"J Alzheimers Dis"},{"issue":"4","key":"10.1016\/j.bbrc.2024.150713_bib86","doi-asserted-by":"crossref","first-page":"415","DOI":"10.2174\/1567202614666171116102911","volume":"14","author":"Maiese","year":"2017","journal-title":"Curr. Neurovascular Res."},{"issue":"8","key":"10.1016\/j.bbrc.2024.150713_bib87","doi-asserted-by":"crossref","first-page":"723","DOI":"10.2174\/1567205012666150710115506","volume":"12","author":"Nuzzo","year":"2015","journal-title":"Curr. Alzheimer Res."},{"key":"10.1016\/j.bbrc.2024.150713_bib88","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.mcn.2015.08.002","volume":"68","author":"Saha","year":"2015","journal-title":"Mol. Cell. Neurosci."},{"issue":"4","key":"10.1016\/j.bbrc.2024.150713_bib89","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.3233\/JAD-160149","volume":"52","author":"Fernandez","year":"2016","journal-title":"J Alzheimers Dis"},{"issue":"11","key":"10.1016\/j.bbrc.2024.150713_bib90","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1038\/mp.2010.17","volume":"15","author":"Manolopoulos","year":"2010","journal-title":"Mol. Psychiatr."},{"key":"10.1016\/j.bbrc.2024.150713_bib91","first-page":"340","author":"Zemva","year":"2011","journal-title":"Exp. Clin. Endocrinol. Diabetes"},{"key":"10.1016\/j.bbrc.2024.150713_bib92","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1196\/annals.1427.024","volume":"1147","author":"Qin","year":"2008","journal-title":"Ann. N. Y. Acad. Sci."},{"issue":"4","key":"10.1016\/j.bbrc.2024.150713_bib93","doi-asserted-by":"crossref","first-page":"3539","DOI":"10.3892\/mmr.2016.4957","volume":"13","author":"Guo","year":"2016","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.bbrc.2024.150713_bib94","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.cbi.2015.07.013","volume":"240","author":"Lin","year":"2015","journal-title":"Chem. Biol. Interact."},{"issue":"7","key":"10.1016\/j.bbrc.2024.150713_bib95","doi-asserted-by":"crossref","first-page":"1892","DOI":"10.2337\/db15-1428","volume":"65","author":"Sajan","year":"2016","journal-title":"Diabetes"},{"issue":"9","key":"10.1016\/j.bbrc.2024.150713_bib96","doi-asserted-by":"crossref","first-page":"1815","DOI":"10.1242\/jcs.185009","volume":"129","author":"Shi","year":"2016","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.bbrc.2024.150713_bib97","volume":"17","author":"Liu","year":"2024","journal-title":"Front. Mol. Neurosci."},{"issue":"1","key":"10.1016\/j.bbrc.2024.150713_bib98","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/s12943-018-0803-3","volume":"17","author":"Haddadi","year":"2018","journal-title":"Mol. Cancer"},{"issue":"8","key":"10.1016\/j.bbrc.2024.150713_bib99","doi-asserted-by":"crossref","DOI":"10.3390\/cancers11081076","volume":"11","author":"Luongo","year":"2019","journal-title":"Cancers"},{"issue":"6","key":"10.1016\/j.bbrc.2024.150713_bib100","doi-asserted-by":"crossref","first-page":"2869","DOI":"10.1007\/s11033-018-4321-6","volume":"45","author":"Naderali","year":"2018","journal-title":"Mol. Biol. Rep."},{"issue":"2","key":"10.1016\/j.bbrc.2024.150713_bib101","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.neurobiolaging.2008.04.002","volume":"31","author":"Moloney","year":"2010","journal-title":"Neurobiol. Aging"},{"issue":"1","key":"10.1016\/j.bbrc.2024.150713_bib102","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.biochi.2004.10.019","volume":"87","author":"Gual","year":"2005","journal-title":"Biochimie"},{"issue":"6","key":"10.1016\/j.bbrc.2024.150713_bib103","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/j.coph.2009.07.004","volume":"9","author":"Tanti","year":"2009","journal-title":"Curr. Opin. Pharmacol."},{"issue":"1","key":"10.1016\/j.bbrc.2024.150713_bib104","doi-asserted-by":"crossref","first-page":"35","DOI":"10.2174\/156720512799015037","volume":"9","author":"de la Monte","year":"2012","journal-title":"Curr. Alzheimer Res."},{"key":"10.1016\/j.bbrc.2024.150713_bib105","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.pneurobio.2013.06.004","volume":"108","author":"Chen","year":"2013","journal-title":"Prog. Neurobiol."},{"issue":"4","key":"10.1016\/j.bbrc.2024.150713_bib106","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1172\/JCI57256","volume":"122","author":"Bomfim","year":"2012","journal-title":"J. Clin. Invest."},{"issue":"6","key":"10.1016\/j.bbrc.2024.150713_bib107","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.phrs.2012.09.003","volume":"66","author":"Lavallard","year":"2012","journal-title":"Pharmacol. Res."},{"issue":"16","key":"10.1016\/j.bbrc.2024.150713_bib108","doi-asserted-by":"crossref","first-page":"14190","DOI":"10.1074\/jbc.M111.219923","volume":"286","author":"Wu","year":"2011","journal-title":"J. Biol. Chem."},{"issue":"6","key":"10.1016\/j.bbrc.2024.150713_bib109","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1007\/s12192-021-01231-3","volume":"26","author":"Razani","year":"2021","journal-title":"Cell Stress Chaperones"},{"issue":"53","key":"10.1016\/j.bbrc.2024.150713_bib110","doi-asserted-by":"crossref","first-page":"41740","DOI":"10.1074\/jbc.M110.156489","volume":"285","author":"Akiyama","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2024.150713_bib111","first-page":"9","author":"Andrews","year":"2020","journal-title":"Elife"},{"key":"10.1016\/j.bbrc.2024.150713_bib112","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.bbr.2017.01.033","volume":"323","author":"Lloyd","year":"2017","journal-title":"Behav. Brain Res."},{"issue":"5","key":"10.1016\/j.bbrc.2024.150713_bib113","doi-asserted-by":"crossref","first-page":"1626","DOI":"10.1016\/j.celrep.2014.04.048","volume":"7","author":"Kassai","year":"2014","journal-title":"Cell Rep."},{"issue":"4","key":"10.1016\/j.bbrc.2024.150713_bib114","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1152\/physrev.00038.2014","volume":"95","author":"Bockaert","year":"2015","journal-title":"Physiol. Rev."},{"issue":"7","key":"10.1016\/j.bbrc.2024.150713_bib115","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.1073\/pnas.1523645113","volume":"113","author":"Li","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"40","key":"10.1016\/j.bbrc.2024.150713_bib116","doi-asserted-by":"crossref","first-page":"27734","DOI":"10.1074\/jbc.M109.008177","volume":"284","author":"Morita","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2024.150713_bib117","doi-asserted-by":"crossref","first-page":"13","DOI":"10.3389\/fnmol.2012.00013","volume":"5","author":"Bradley","year":"2012","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.bbrc.2024.150713_bib118","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.freeradbiomed.2014.06.023","volume":"74","author":"Ribeiro","year":"2014","journal-title":"Free Radic. Biol. Med."},{"issue":"11","key":"10.1016\/j.bbrc.2024.150713_bib119","doi-asserted-by":"crossref","first-page":"2682","DOI":"10.1002\/ijc.27935","volume":"132","author":"Seitz","year":"2013","journal-title":"Int. J. Cancer"},{"issue":"1","key":"10.1016\/j.bbrc.2024.150713_bib120","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.18632\/aging.202459","volume":"13","author":"Duggan","year":"2021","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.bbrc.2024.150713_bib121","volume":"13","author":"Su","year":"2022","journal-title":"Front. Neurol."},{"issue":"5","key":"10.1016\/j.bbrc.2024.150713_bib122","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23052814","volume":"23","author":"Villa-Gonz\u00e1lez","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.bbrc.2024.150713_bib123","doi-asserted-by":"crossref","DOI":"10.3390\/biom10010137","volume":"10","author":"Cianciulli","year":"2020","journal-title":"Biomolecules"},{"issue":"2","key":"10.1016\/j.bbrc.2024.150713_bib124","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1021\/pr2011582","volume":"11","author":"Ahmed","year":"2012","journal-title":"J. Proteome Res."},{"issue":"7","key":"10.1016\/j.bbrc.2024.150713_bib125","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1111\/j.1601-183X.2008.00428.x","volume":"7","author":"Siddiqui","year":"2008","journal-title":"Gene Brain Behav."},{"issue":"4","key":"10.1016\/j.bbrc.2024.150713_bib126","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1111\/j.1471-4159.2006.03971.x","volume":"98","author":"Siarey","year":"2006","journal-title":"J. Neurochem."},{"issue":"1","key":"10.1016\/j.bbrc.2024.150713_bib127","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/nrm3025","volume":"12","author":"Zoncu","year":"2011","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"2","key":"10.1016\/j.bbrc.2024.150713_bib128","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1042\/BJ20080281","volume":"412","author":"Huang","year":"2008","journal-title":"Biochem. J."},{"key":"10.1016\/j.bbrc.2024.150713_bib129","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/s40035-018-0133-9","volume":"7","author":"Tramutola","year":"2018","journal-title":"Transl. Neurodegener."},{"issue":"3","key":"10.1016\/j.bbrc.2024.150713_bib130","doi-asserted-by":"crossref","first-page":"967","DOI":"10.3233\/JAD-2010-091726","volume":"21","author":"de la Monte","year":"2010","journal-title":"J Alzheimers Dis"},{"issue":"1","key":"10.1016\/j.bbrc.2024.150713_bib131","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.neulet.2009.12.078","volume":"471","author":"Sonoda","year":"2010","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.bbrc.2024.150713_bib132","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/1750-1326-5-49","volume":"5","author":"Kwak","year":"2010","journal-title":"Mol. Neurodegener."},{"issue":"4","key":"10.1016\/j.bbrc.2024.150713_bib133","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1007\/s00401-002-0657-y","volume":"105","author":"Pei","year":"2003","journal-title":"Acta Neuropathol."},{"issue":"6b","key":"10.1016\/j.bbrc.2024.150713_bib134","doi-asserted-by":"crossref","first-page":"2525","DOI":"10.1111\/j.1582-4934.2008.00509.x","volume":"12","author":"Pei","year":"2008","journal-title":"J. Cell Mol. Med."},{"issue":"1","key":"10.1016\/j.bbrc.2024.150713_bib135","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1096\/fj.06-7703com","volume":"22","author":"Zhao","year":"2008","journal-title":"Faseb j"},{"issue":"9","key":"10.1016\/j.bbrc.2024.150713_bib136","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1016\/j.bbadis.2014.06.010","volume":"1842","author":"Butterfield","year":"2014","journal-title":"Biochim. Biophys. Acta (BBA) - Mol. Basis Dis."},{"issue":"2","key":"10.1016\/j.bbrc.2024.150713_bib137","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1111\/j.1474-9726.2011.00791.x","volume":"11","author":"Majumder","year":"2012","journal-title":"Aging Cell"},{"issue":"18","key":"10.1016\/j.bbrc.2024.150713_bib138","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1016\/j.cub.2004.08.026","volume":"14","author":"Shah","year":"2004","journal-title":"Curr. Biol."},{"issue":"11","key":"10.1016\/j.bbrc.2024.150713_bib139","doi-asserted-by":"crossref","first-page":"8924","DOI":"10.1074\/jbc.M110.180638","volume":"286","author":"Caccamo","year":"2011","journal-title":"J. Biol. Chem."},{"issue":"2","key":"10.1016\/j.bbrc.2024.150713_bib140","doi-asserted-by":"crossref","first-page":"437","DOI":"10.3233\/JAD-131124","volume":"38","author":"Sun","year":"2014","journal-title":"J Alzheimers Dis"},{"issue":"Pt 23","key":"10.1016\/j.bbrc.2024.150713_bib141","doi-asserted-by":"crossref","first-page":"4081","DOI":"10.1242\/jcs.019265","volume":"120","author":"Nixon","year":"2007","journal-title":"J. Cell Sci."},{"issue":"6","key":"10.1016\/j.bbrc.2024.150713_bib142","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1111\/j.1471-4159.2011.07262.x","volume":"117","author":"Santos","year":"2011","journal-title":"J. Neurochem."},{"issue":"16","key":"10.1016\/j.bbrc.2024.150713_bib143","doi-asserted-by":"crossref","first-page":"4211","DOI":"10.1111\/j.1742-4658.2005.04833.x","volume":"272","author":"Li","year":"2005","journal-title":"FEBS J."},{"issue":"1","key":"10.1016\/j.bbrc.2024.150713_bib144","doi-asserted-by":"crossref","first-page":"a011460","DOI":"10.1101\/cshperspect.a011460","volume":"2","author":"Selkoe","year":"2012","journal-title":"Cold Spring Harb Perspect Med"},{"issue":"3","key":"10.1016\/j.bbrc.2024.150713_bib145","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/j.neuron.2011.04.009","volume":"70","author":"Morris","year":"2011","journal-title":"Neuron"},{"issue":"2","key":"10.1016\/j.bbrc.2024.150713_bib146","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1038\/nrn2967","volume":"12","author":"Ittner","year":"2011","journal-title":"Nat. Rev. Neurosci."},{"issue":"17","key":"10.1016\/j.bbrc.2024.150713_bib147","doi-asserted-by":"crossref","first-page":"13107","DOI":"10.1074\/jbc.M110.100420","volume":"285","author":"Caccamo","year":"2010","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.bbrc.2024.150713_bib148","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1111\/acel.12057","volume":"12","author":"Caccamo","year":"2013","journal-title":"Aging Cell"},{"issue":"11","key":"10.1016\/j.bbrc.2024.150713_bib149","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0142340","volume":"10","author":"Siman","year":"2015","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.bbrc.2024.150713_bib150","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.0050052","volume":"5","author":"Westmark","year":"2007","journal-title":"PLoS Biol."},{"issue":"10","key":"10.1016\/j.bbrc.2024.150713_bib151","doi-asserted-by":"crossref","first-page":"3181","DOI":"10.1016\/j.bbadis.2018.07.005","volume":"1864","author":"Triani","year":"2018","journal-title":"Biochim. Biophys. Acta, Mol. Basis Dis."},{"issue":"6","key":"10.1016\/j.bbrc.2024.150713_bib152","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/j.cmet.2013.11.002","volume":"18","author":"Lourenco","year":"2013","journal-title":"Cell Metabol."},{"key":"10.1016\/j.bbrc.2024.150713_bib153","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2019.101162","volume":"23","author":"Di Domenico","year":"2019","journal-title":"Redox Biol."},{"key":"10.1016\/j.bbrc.2024.150713_bib154","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/4712053","volume":"2016","author":"Gibbs","year":"2016","journal-title":"J. Diabetes Res."},{"issue":"1","key":"10.1016\/j.bbrc.2024.150713_bib155","doi-asserted-by":"crossref","DOI":"10.3390\/antiox12010111","volume":"12","author":"Tramutola","year":"2023","journal-title":"Antioxidants"},{"issue":"5","key":"10.1016\/j.bbrc.2024.150713_bib156","first-page":"4059","volume":"20","author":"Liu","year":"2019","journal-title":"Mol. Med. Rep."},{"issue":"12","key":"10.1016\/j.bbrc.2024.150713_bib160","doi-asserted-by":"crossref","first-page":"3311","DOI":"10.1002\/ptr.6780","volume":"34","author":"Borges","year":"2020","journal-title":"Phytother Res."},{"key":"10.1016\/j.bbrc.2024.150713_bib161","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.intimp.2016.05.007","volume":"36","author":"Cianciulli","year":"2016","journal-title":"Int. Immunopharm."},{"issue":"3","key":"10.1016\/j.bbrc.2024.150713_bib162","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1016\/j.jep.2012.05.056","volume":"142","author":"Wu","year":"2012","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.bbrc.2024.150713_bib163","volume":"2015","author":"Zhang","year":"2015","journal-title":"Evid Based Complement Alternat Med"},{"key":"10.1016\/j.bbrc.2024.150713_bib164","first-page":"1335","volume":"10","author":"Zhang","year":"2016","journal-title":"Drug Des. Dev. Ther."},{"issue":"1\u201302","key":"10.1016\/j.bbrc.2024.150713_bib165","first-page":"51","volume":"83","author":"Qi","year":"2017","journal-title":"Planta Med."},{"key":"10.1016\/j.bbrc.2024.150713_bib166","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2020.113466","volume":"266","author":"Cui","year":"2021","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.bbrc.2024.150713_bib167","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.jep.2015.12.020","volume":"179","author":"Li","year":"2016","journal-title":"J. Ethnopharmacol."},{"issue":"3\u20134","key":"10.1016\/j.bbrc.2024.150713_bib169","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.brainresbull.2011.03.024","volume":"85","author":"Xing","year":"2011","journal-title":"Brain Res. Bull."},{"issue":"3","key":"10.1016\/j.bbrc.2024.150713_bib157","doi-asserted-by":"crossref","first-page":"264","DOI":"10.3390\/molecules21030264","volume":"21","author":"Pulido-Moran","year":"2016","journal-title":"Molecules"},{"key":"10.1016\/j.bbrc.2024.150713_bib158","series-title":"Parkinson's Disease Therapeutics","first-page":"51","author":"Obulesu","year":"2020"},{"issue":"12","key":"10.1016\/j.bbrc.2024.150713_bib159","doi-asserted-by":"crossref","first-page":"6506","DOI":"10.4049\/jimmunol.168.12.6506","volume":"168","author":"Natarajan","year":"2002","journal-title":"J. Immunol."},{"issue":"4","key":"10.1016\/j.bbrc.2024.150713_bib168","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.14336\/AD.2021.1205","volume":"13","author":"Yu","year":"2022","journal-title":"Aging Dis"}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X2401249X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X2401249X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,12,4]],"date-time":"2024-12-04T13:55:18Z","timestamp":1733320518000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X2401249X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":169,"alternative-id":["S0006291X2401249X"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2024.150713","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2024,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Brain insulin resistance in Down syndrome: Involvement of PI3K-Akt\/mTOR axis in early-onset of Alzheimer's disease and its potential as a therapeutic target","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2024.150713","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"150713"}}