{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T20:17:45Z","timestamp":1790713065952,"version":"4.1.0"},"reference-count":24,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1016\/j.bbrc.2024.151202","type":"journal-article","created":{"date-parts":[[2024,12,18]],"date-time":"2024-12-18T02:49:23Z","timestamp":1734490163000},"page":"151202","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Verapamil inhibits ferroptosis in septic acute lung injury by blocking L-type calcium channels"],"prefix":"10.1016","volume":"744","author":[{"given":"Hongru","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangyang","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meiqi","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haixia","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zixin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yushan","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jihong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cuiqing","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2024.151202_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2020.105224","article-title":"Natural product derived phytochemicals in managing acute lung injury by multiple mechanisms","volume":"163","author":"He","year":"2021","journal-title":"Pharmacol. Res."},{"issue":"10358","key":"10.1016\/j.bbrc.2024.151202_bib2","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1016\/S0140-6736(22)01485-4","article-title":"Acute respiratory distress syndrome: causes, pathophysiology, and phenotypes","volume":"400","author":"Bos","year":"2022","journal-title":"Lancet"},{"issue":"5","key":"10.1016\/j.bbrc.2024.151202_bib3","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1097\/SHK.0000000000001303","article-title":"Activation of AMP-activated protein kinase by A769662 ameliorates sepsis-induced acute lung injury in adult mice","volume":"52","author":"Kitzmiller","year":"2019","journal-title":"Shock"},{"issue":"4","key":"10.1016\/j.bbrc.2024.151202_bib4","doi-asserted-by":"crossref","first-page":"345","DOI":"10.5858\/arpa.2015-0519-RA","article-title":"Acute lung injury: a clinical and molecular review","volume":"140","author":"Butt","year":"2016","journal-title":"Arch. Pathol. Lab Med."},{"issue":"8","key":"10.1016\/j.bbrc.2024.151202_bib5","doi-asserted-by":"crossref","first-page":"3337","DOI":"10.7150\/ijbs.69141","article-title":"Neutrophil extracellular traps mediate m6A modification and regulates sepsis-associated acute lung injury by activating ferroptosis in alveolar epithelial cells","volume":"18","author":"Zhang","year":"2022","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.bbrc.2024.151202_bib6","doi-asserted-by":"crossref","first-page":"1722","DOI":"10.3389\/fimmu.2020.01722","article-title":"Pulmonary innate immune response determines the outcome of inflammation during pneumonia and sepsis-associated acute lung injury","volume":"11","author":"Kumar","year":"2020","journal-title":"Front. Immunol."},{"issue":"4","key":"10.1016\/j.bbrc.2024.151202_bib7","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1038\/s41580-020-00324-8","article-title":"Ferroptosis: mechanisms, biology and role in disease","volume":"22","author":"Jiang","year":"2021","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"3","key":"10.1016\/j.bbrc.2024.151202_bib8","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.cell.2017.11.048","article-title":"Selenium utilization by GPX4 is required to prevent hydroperoxide-induced ferroptosis","volume":"172","author":"Ingold","year":"2018","journal-title":"Cell"},{"issue":"19","key":"10.1016\/j.bbrc.2024.151202_bib9","doi-asserted-by":"crossref","first-page":"2119","DOI":"10.1080\/15384101.2023.2278328","article-title":"Role and mechanism of ferroptosis in acute lung injury","volume":"22","author":"Yu","year":"2023","journal-title":"Cell Cycle"},{"key":"10.1016\/j.bbrc.2024.151202_bib10","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.709538","article-title":"Ferroptosis, a new insight into acute lung injury","volume":"12","author":"Yin","year":"2021","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.bbrc.2024.151202_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.ceca.2023.102778","article-title":"Calcium as a master regulator of ferroptosis and other types of regulated necrosis","volume":"114","author":"Pedrera","year":"2023","journal-title":"Cell Calcium"},{"key":"10.1016\/j.bbrc.2024.151202_bib12","doi-asserted-by":"crossref","DOI":"10.3389\/fmed.2024.1457882","article-title":"Focus on the role of calcium signaling in ferroptosis: a potential therapeutic strategy for sepsis-induced acute lung injury","volume":"11","author":"Xu","year":"2024","journal-title":"Front. Med."},{"key":"10.1016\/j.bbrc.2024.151202_bib13","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.freeradbiomed.2018.05.074","article-title":"The tumor suppressor protein p53 and the ferroptosis network","volume":"133","author":"Kang","year":"2019","journal-title":"Free Radic. Biol. Med."},{"issue":"6","key":"10.1016\/j.bbrc.2024.151202_bib14","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1016\/j.cmet.2020.10.011","article-title":"The metabolic underpinnings of ferroptosis","volume":"32","author":"Zheng","year":"2020","journal-title":"Cell Metabol."},{"issue":"5","key":"10.1016\/j.bbrc.2024.151202_bib15","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.1038\/s41418-020-00691-x","article-title":"Ferroptotic pores induce Ca2+ fluxes and ESCRT-III activation to modulate cell death kinetics","volume":"28","author":"Pedrera","year":"2021","journal-title":"Cell Death Differ."},{"issue":"22","key":"10.1016\/j.bbrc.2024.151202_bib16","doi-asserted-by":"crossref","first-page":"9913","DOI":"10.7150\/thno.46417","article-title":"Inhibition of pendrin by a small molecule reduces lipopolysaccharide-induced acute lung injury","volume":"10","author":"Lee","year":"2020","journal-title":"Theranostics"},{"issue":"2","key":"10.1016\/j.bbrc.2024.151202_bib17","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.chembiol.2023.10.012","article-title":"Ferroptosis inhibition by oleic acid mitigates iron-overload-induced injury","volume":"31","author":"Mann","year":"2024","journal-title":"Cell Chem. Biol."},{"issue":"9","key":"10.1016\/j.bbrc.2024.151202_bib18","doi-asserted-by":"crossref","first-page":"2635","DOI":"10.1038\/s41418-020-0528-x","article-title":"Inhibitor of apoptosis-stimulating protein of p53 inhibits ferroptosis and alleviates intestinal ischemia\/reperfusion-induced acute lung injury","volume":"27","author":"Li","year":"2020","journal-title":"Cell Death Differ."},{"issue":"1","key":"10.1016\/j.bbrc.2024.151202_bib19","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1038\/s41392-020-0149-3","article-title":"Erianin, a novel dibenzyl compound in Dendrobium extract, inhibits lung cancer cell growth and migration via calcium\/calmodulin-dependent ferroptosis","volume":"5","author":"Chen","year":"2020","journal-title":"Signal Transduct. Targeted Ther."},{"key":"10.1016\/j.bbrc.2024.151202_bib20","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.jare.2022.01.004","article-title":"Mechanical overloading induces GPX4-regulated chondrocyte ferroptosis in osteoarthritis via Piezo1 channel facilitated calcium influx","volume":"41","author":"Wang","year":"2022","journal-title":"J. Adv. Res."},{"issue":"6","key":"10.1016\/j.bbrc.2024.151202_bib21","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1016\/j.kint.2022.07.034","article-title":"Repression of the antiporter SLC7A11\/glutathione\/glutathione peroxidase 4 axis drives ferroptosis of vascular smooth muscle cells to facilitate vascular calcification","volume":"102","author":"Ye","year":"2022","journal-title":"Kidney Int."},{"key":"10.1016\/j.bbrc.2024.151202_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.116729","article-title":"Saikosaponin B2 ameliorates depression-induced microglia activation by inhibiting ferroptosis-mediated neuroinflammation and ER stress","volume":"316","author":"Wang","year":"2023","journal-title":"J. Ethnopharmacol."},{"issue":"3","key":"10.1016\/j.bbrc.2024.151202_bib23","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.tem.2023.10.010","article-title":"Regulated cell death in myocardial ischemia-reperfusion injury","volume":"35","author":"Xiang","year":"2024","journal-title":"Trends Endocrinol Metab"},{"key":"10.1016\/j.bbrc.2024.151202_bib24","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.phrs.2018.11.017","article-title":"How CaV1.2-bound verapamil blocks Ca2+ influx into cardiomyocyte: atomic level views","volume":"139","author":"Li","year":"2019","journal-title":"Pharmacol. Res."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X24017388?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X24017388?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,12,31]],"date-time":"2024-12-31T10:59:15Z","timestamp":1735642755000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X24017388"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":24,"alternative-id":["S0006291X24017388"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2024.151202","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Verapamil inhibits ferroptosis in septic acute lung injury by blocking L-type calcium channels","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2024.151202","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"151202"}}