{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T16:59:02Z","timestamp":1774025942623,"version":"3.50.1"},"reference-count":72,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,12,24]],"date-time":"2024-12-24T00:00:00Z","timestamp":1734998400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002873","name":"Chulalongkorn University","doi-asserted-by":"publisher","award":["RCU_H_64_009_30"],"award-info":[{"award-number":["RCU_H_64_009_30"]}],"id":[{"id":"10.13039\/501100002873","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004156","name":"Mahidol University","doi-asserted-by":"publisher","award":["A21\/2562"],"award-info":[{"award-number":["A21\/2562"]}],"id":[{"id":"10.13039\/501100004156","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1016\/j.bbrc.2024.151229","type":"journal-article","created":{"date-parts":[[2024,12,20]],"date-time":"2024-12-20T17:41:02Z","timestamp":1734716462000},"page":"151229","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["In silico prediction and experimental evaluation of LIP3228 of pathogenic Leptospira as a potential subunit vaccine target against leptospirosis"],"prefix":"10.1016","volume":"745","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9013-3998","authenticated-orcid":false,"given":"Yaowarin","family":"Nakornpakdee","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8188-9934","authenticated-orcid":false,"given":"Teerasit","family":"Techawiwattanaboon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saowaros","family":"Prasai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pat","family":"Komanee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nuttapone","family":"Sangkanjanavanich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sukon","family":"Boonkea","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1781-7012","authenticated-orcid":false,"given":"Kanitha","family":"Patarakul","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2024.151229_bib1","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.vetmic.2009.03.012","article-title":"Leptospira and leptospirosis","volume":"140","author":"Adler","year":"2010","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.bbrc.2024.151229_bib2","first-page":"139","article-title":"The molecular basis of leptospiral pathogenesis","volume":"387","author":"Murray","year":"2015","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"10.1016\/j.bbrc.2024.151229_bib3","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0003898","article-title":"Global morbidity and mortality of leptospirosis: a systematic review","volume":"9","author":"Costa","year":"2015","journal-title":"PLoS Neglected Trop. Dis."},{"key":"10.1016\/j.bbrc.2024.151229_bib4","article-title":"A systematic review of the mortality from untreated leptospirosis","volume":"9","author":"Taylor","year":"2015","journal-title":"PLoS Neglected Trop. Dis."},{"key":"10.1016\/j.bbrc.2024.151229_bib5","first-page":"251","article-title":"Vaccines against leptospirosis","volume":"387","author":"Adler","year":"2015","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"10.1016\/j.bbrc.2024.151229_bib6","doi-asserted-by":"crossref","first-page":"256","DOI":"10.3389\/fimmu.2017.00256","article-title":"A universal vaccine against leptospirosis: are we going in the right direction?","volume":"8","author":"Grassmann","year":"2017","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bbrc.2024.151229_bib7","doi-asserted-by":"crossref","DOI":"10.1111\/sji.13316","article-title":"Human leptospirosis: in search for a better vaccine","volume":"98","author":"Azevedo","year":"2023","journal-title":"Scand. J. Immunol."},{"key":"10.1016\/j.bbrc.2024.151229_bib8","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2021.777709","article-title":"A review on host-leptospira interactions: what we know and future expectations","volume":"11","author":"Daroz","year":"2021","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.bbrc.2024.151229_bib9","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1111\/1574-6968.12349","article-title":"Leptospiral extracellular matrix adhesins as mediators of pathogen-host interactions","volume":"352","author":"Vieira","year":"2014","journal-title":"FEMS Microbiol. Lett."},{"key":"10.1016\/j.bbrc.2024.151229_bib10","doi-asserted-by":"crossref","DOI":"10.3390\/ijms18010158","article-title":"Reverse vaccinology: an approach for identifying leptospiral vaccine candidates","volume":"18","author":"Dellagostin","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbrc.2024.151229_bib11","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2022.940966","article-title":"Challenges for the development of a universal vaccine against leptospirosis revealed by the evaluation of 22 vaccine candidates","volume":"12","author":"Maia","year":"2022","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.bbrc.2024.151229_bib12","doi-asserted-by":"crossref","first-page":"463","DOI":"10.3389\/fimmu.2017.00463","article-title":"Discovery of novel leptospirosis vaccine candidates using reverse and structural vaccinology","volume":"8","author":"Grassmann","year":"2017","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bbrc.2024.151229_bib13","doi-asserted-by":"crossref","first-page":"6935","DOI":"10.1038\/s41598-018-25281-3","article-title":"Exploring Leptospiral proteomes to identify potential candidates for vaccine design against Leptospirosis using an immunoinformatics approach","volume":"8","author":"Lata","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbrc.2024.151229_bib14","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.735373","article-title":"Immunoinformatics-based designing of a multi-epitope chimeric vaccine from multi-domain outer surface antigens of Leptospira","volume":"12","author":"Kumar","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bbrc.2024.151229_bib15","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2022.1047306","article-title":"Evaluation of the consistence between the results of immunoinformatics predictions and real-world animal experiments of a new tuberculosis vaccine MP3RT","volume":"12","author":"Cheng","year":"2022","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.bbrc.2024.151229_bib16","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1007\/s10142-023-01031-1","article-title":"Immunoinformatic prediction of potential immunodominant epitopes from cagW in order to investigate protection against Helicobacter pylori infection based on experimental consequences","volume":"23","author":"Chehelgerdi","year":"2023","journal-title":"Funct. Integr. Genomics"},{"key":"10.1016\/j.bbrc.2024.151229_bib17","doi-asserted-by":"crossref","first-page":"3374","DOI":"10.1016\/j.ygeno.2020.06.022","article-title":"Identification of novel vaccine candidate against Salmonella enterica serovar Typhi by reverse vaccinology method and evaluation of its immunization","volume":"112","author":"Esmailnia","year":"2020","journal-title":"Genomics"},{"key":"10.1016\/j.bbrc.2024.151229_bib18","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0009983","article-title":"Surface proteomics and label-free quantification of Leptospira interrogans serovar Pomona","volume":"15","author":"Techawiwattanaboon","year":"2021","journal-title":"PLoS Neglected Trop. Dis."},{"key":"10.1016\/j.bbrc.2024.151229_bib19","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1038\/nmeth.1701","article-title":"SignalP 4.0: discriminating signal peptides from transmembrane regions","volume":"8","author":"Petersen","year":"2011","journal-title":"Nat. Methods"},{"key":"10.1016\/j.bbrc.2024.151229_bib20","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1038\/nprot.2010.5","article-title":"I-TASSER: a unified platform for automated protein structure and function prediction","volume":"5","author":"Roy","year":"2010","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.bbrc.2024.151229_bib21","doi-asserted-by":"crossref","first-page":"W384","DOI":"10.1093\/nar\/gkt458","article-title":"GalaxyRefine: protein structure refinement driven by side-chain repacking","volume":"41","author":"Heo","year":"2013","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bbrc.2024.151229_bib22","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1007\/BF00228148","article-title":"AQUA and PROCHECK-NMR: programs for checking the quality of protein structures solved by NMR","volume":"8","author":"Laskowski","year":"1996","journal-title":"J. Biomol. NMR"},{"key":"10.1016\/j.bbrc.2024.151229_bib23","doi-asserted-by":"crossref","first-page":"W407","DOI":"10.1093\/nar\/gkm290","article-title":"ProSA-web: interactive web service for the recognition of errors in three-dimensional structures of proteins","volume":"35","author":"Wiederstein","year":"2007","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bbrc.2024.151229_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.jmb.2024.168531","article-title":"ModFOLD9: a web server for independent estimates of 3D protein model quality","author":"McGuffin","year":"2024","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.bbrc.2024.151229_bib25","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1002\/pro.3781","article-title":"Shortcuts for faster image creation in PyMOL","volume":"29","author":"Mooers","year":"2020","journal-title":"Protein Sci."},{"key":"10.1016\/j.bbrc.2024.151229_bib26","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1471-2105-8-4","article-title":"VaxiJen: a server for prediction of protective antigens, tumour antigens and subunit vaccines","volume":"8","author":"Doytchinova","year":"2007","journal-title":"BMC Bioinf."},{"key":"10.1016\/j.bbrc.2024.151229_bib27","doi-asserted-by":"crossref","first-page":"2278","DOI":"10.1007\/s00894-014-2278-5","article-title":"AllerTOP v.2--a server for in silico prediction of allergens","volume":"20","author":"Dimitrov","year":"2014","journal-title":"J. Mol. Model."},{"key":"10.1016\/j.bbrc.2024.151229_bib28","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0073957","article-title":"In silico approach for predicting toxicity of peptides and proteins","volume":"8","author":"Gupta","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.bbrc.2024.151229_bib29","doi-asserted-by":"crossref","first-page":"W24","DOI":"10.1093\/nar\/gkx346","article-title":"BepiPred-2.0: improving sequence-based B-cell epitope prediction using conformational epitopes","volume":"45","author":"Jespersen","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bbrc.2024.151229_bib30","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1186\/1471-2105-9-514","article-title":"ElliPro: a new structure-based tool for the prediction of antibody epitopes","volume":"9","author":"Ponomarenko","year":"2008","journal-title":"BMC Bioinf."},{"key":"10.1016\/j.bbrc.2024.151229_bib31","doi-asserted-by":"crossref","first-page":"W449","DOI":"10.1093\/nar\/gkaa379","article-title":"NetMHCpan-4.1 and NetMHCIIpan-4.0: improved predictions of MHC antigen presentation by concurrent motif deconvolution and integration of MS MHC eluted ligand data","volume":"48","author":"Reynisson","year":"2020","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bbrc.2024.151229_bib32","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1093\/bioinformatics\/btg371","article-title":"ClusPro: an automated docking and discrimination method for the prediction of protein complexes","volume":"20","author":"Comeau","year":"2004","journal-title":"Bioinformatics"},{"key":"10.1016\/j.bbrc.2024.151229_bib33","doi-asserted-by":"crossref","DOI":"10.1038\/s41596-024-01011-0","article-title":"The HADDOCK2.4 web server for integrative modeling of biomolecular complexes","author":"Honorato","year":"2024","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.bbrc.2024.151229_bib34","doi-asserted-by":"crossref","first-page":"2938","DOI":"10.1021\/acs.jmedchem.8b01583","article-title":"Structural basis of TLR2\/TLR1 activation by the synthetic agonist diprovocim","volume":"62","author":"Su","year":"2019","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bbrc.2024.151229_bib35","doi-asserted-by":"crossref","first-page":"40611","DOI":"10.1074\/jbc.M112.404608","article-title":"Structural analyses of human Toll-like receptor 4 polymorphisms D299G and T399I","volume":"287","author":"Ohto","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2024.151229_bib36","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1093\/nar\/28.1.235","article-title":"The protein Data Bank","volume":"28","author":"Berman","year":"2000","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bbrc.2024.151229_bib37","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1002\/pro.3289","article-title":"PDBsum: structural summaries of PDB entries","volume":"27","author":"Laskowski","year":"2018","journal-title":"Protein Sci."},{"key":"10.1016\/j.bbrc.2024.151229_bib38","doi-asserted-by":"crossref","first-page":"W271","DOI":"10.1093\/nar\/gku339","article-title":"iMODS: internal coordinates normal mode analysis server","volume":"42","author":"Lopez-Blanco","year":"2014","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bbrc.2024.151229_bib39","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1093\/bioinformatics\/btm044","article-title":"Simulating Epstein-Barr virus infection with C-ImmSim","volume":"23","author":"Castiglione","year":"2007","journal-title":"Bioinformatics"},{"key":"10.1016\/j.bbrc.2024.151229_bib40","article-title":"Laboratory maintenance of pathogenic Leptospira","volume":"12","author":"Zuerner","year":"2005","journal-title":"Curr Protoc Microbiol Chapter"},{"key":"10.1016\/j.bbrc.2024.151229_bib41","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2022.918629","article-title":"Designing adjuvant formulations to promote immunogenicity and protective efficacy of Leptospira immunoglobulin-like protein A subunit vaccine","volume":"12","author":"Techawiwattanaboon","year":"2022","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.bbrc.2024.151229_bib42","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0001422","article-title":"A LigA three-domain region protects hamsters from lethal infection by Leptospira interrogans","volume":"5","author":"Coutinho","year":"2011","journal-title":"PLoS Neglected Trop. Dis."},{"key":"10.1016\/j.bbrc.2024.151229_bib43","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.diagmicrobio.2009.03.014","article-title":"Detection of pathogenic Leptospira spp. through TaqMan polymerase chain reaction targeting the LipL32 gene","volume":"64","author":"Stoddard","year":"2009","journal-title":"Diagn. Microbiol. Infect. Dis."},{"key":"10.1016\/j.bbrc.2024.151229_bib44","doi-asserted-by":"crossref","DOI":"10.1002\/cpmc.127","article-title":"A mouse model of sublethal leptospirosis: protocols for infection with Leptospira through natural transmission routes, for monitoring clinical and molecular scores of disease, and for evaluation of the host immune response","volume":"59","author":"Nair","year":"2020","journal-title":"Curr Protoc Microbiol"},{"key":"10.1016\/j.bbrc.2024.151229_bib45","doi-asserted-by":"crossref","first-page":"4480","DOI":"10.1128\/IAI.05727-11","article-title":"Gene expression profiles of immune mediators and histopathological findings in animal models of leptospirosis: comparison between susceptible hamsters and resistant mice","volume":"79","author":"Matsui","year":"2011","journal-title":"Infect. Immun."},{"key":"10.1016\/j.bbrc.2024.151229_bib46","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1099\/mic.0.072439-0","article-title":"High virulence in hamsters of four dominant Leptospira serovars isolated from rats in the Philippines","volume":"160","author":"Villanueva","year":"2014","journal-title":"Microbiology (Read.)"},{"key":"10.1016\/j.bbrc.2024.151229_bib47","doi-asserted-by":"crossref","first-page":"832","DOI":"10.4269\/ajtmh.2009.80.832","article-title":"Pulmonary disease in hamsters infected with Leptospira interrogans: histopathologic findings and cytokine mRNA expressions","volume":"80","author":"Marinho","year":"2009","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.bbrc.2024.151229_bib48","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0010409","article-title":"Pulmonary haemorrhage as the earliest sign of severe leptospirosis in hamster model challenged with Leptospira interrogans strain HP358","volume":"16","author":"Philip","year":"2022","journal-title":"PLoS Neglected Trop. Dis."},{"key":"10.1016\/j.bbrc.2024.151229_bib49","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1128\/CVI.00719-13","article-title":"Vaccination with leptospiral outer membrane lipoprotein LipL32 reduces kidney invasion of Leptospira interrogans serovar canicola in hamsters","volume":"21","author":"Humphryes","year":"2014","journal-title":"Clin. Vaccine Immunol."},{"key":"10.1016\/j.bbrc.2024.151229_bib50","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1007\/978-1-0716-1884-4_16","article-title":"Development of human recombinant leptospirosis vaccines","volume":"2410","author":"de Oliveira","year":"2022","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.bbrc.2024.151229_bib51","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1038\/s41578-021-00372-2","article-title":"Designing spatial and temporal control of vaccine responses","volume":"7","author":"Roth","year":"2022","journal-title":"Nat. Rev. Mater."},{"key":"10.1016\/j.bbrc.2024.151229_bib52","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2022.936931","article-title":"Alive pathogenic and saprophytic leptospires enter and exit human and mouse macrophages with No intracellular replication","volume":"12","author":"Santecchia","year":"2022","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.bbrc.2024.151229_bib53","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.1111\/j.1462-5822.2011.01660.x","article-title":"Characteristic features of intracellular pathogenic Leptospira in infected murine macrophages","volume":"13","author":"Toma","year":"2011","journal-title":"Cell Microbiol."},{"key":"10.1016\/j.bbrc.2024.151229_bib54","doi-asserted-by":"crossref","first-page":"2669","DOI":"10.4049\/jimmunol.0900506","article-title":"TLR4- and TLR2-mediated B cell responses control the clearance of the bacterial pathogen, Leptospira interrogans","volume":"183","author":"Chassin","year":"2009","journal-title":"J. Immunol."},{"key":"10.1016\/j.bbrc.2024.151229_bib55","first-page":"187","article-title":"The leptospiral outer membrane","volume":"387","author":"Haake","year":"2015","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"10.1016\/j.bbrc.2024.151229_bib56","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1038\/86354","article-title":"Leptospiral lipopolysaccharide activates cells through a TLR2-dependent mechanism","volume":"2","author":"Werts","year":"2001","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.bbrc.2024.151229_bib57","doi-asserted-by":"crossref","first-page":"6022","DOI":"10.4049\/jimmunol.175.9.6022","article-title":"Differential TLR recognition of leptospiral lipid A and lipopolysaccharide in murine and human cells","volume":"175","author":"Nahori","year":"2005","journal-title":"J. Immunol."},{"key":"10.1016\/j.bbrc.2024.151229_bib58","article-title":"Leptospiral hemolysins induce proinflammatory cytokines through Toll-like receptor 2-and 4-mediated JNK and NF-kappaB signaling pathways","volume":"7","author":"Wang","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.bbrc.2024.151229_bib59","doi-asserted-by":"crossref","DOI":"10.1038\/srep39530","article-title":"Leptospira surface adhesin (Lsa21) induces Toll like receptor 2 and 4 mediated inflammatory responses in macrophages","volume":"6","author":"Faisal","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbrc.2024.151229_bib60","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1093\/abbs\/gmp109","article-title":"OmpA-like protein Loa22 from Leptospira interrogans serovar Lai is cytotoxic to cultured rat renal cells and promotes inflammatory responses","volume":"42","author":"Zhang","year":"2010","journal-title":"Acta Biochim. Biophys. Sin."},{"key":"10.1016\/j.bbrc.2024.151229_bib61","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.807775","article-title":"Deciphering the role of Leptospira surface protein LigA in modulating the host innate immune response","volume":"12","author":"Kumar","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bbrc.2024.151229_bib62","article-title":"Leptospiral outer membrane protein LipL32 induces inflammation and kidney injury in zebrafish larvae","volume":"6","author":"Chang","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbrc.2024.151229_bib63","doi-asserted-by":"crossref","DOI":"10.3390\/vaccines8030494","article-title":"A comparison of intramuscular and subcutaneous administration of LigA subunit vaccine adjuvanted with neutral liposomal formulation containing monophosphoryl lipid A and QS21","volume":"8","author":"Techawiwattanaboon","year":"2020","journal-title":"Vaccines"},{"key":"10.1016\/j.bbrc.2024.151229_bib64","doi-asserted-by":"crossref","first-page":"79","DOI":"10.2174\/1874285801206010079","article-title":"Evaluation of immunoprotective activity of six leptospiral proteins in the hamster model of leptospirosis","volume":"6","author":"Atzingen","year":"2012","journal-title":"Open Microbiol. J."},{"key":"10.1016\/j.bbrc.2024.151229_bib65","doi-asserted-by":"crossref","first-page":"2574","DOI":"10.1016\/j.vaccine.2018.03.078","article-title":"LemA and Erp Y-like recombinant proteins from Leptospira interrogans protect hamsters from challenge using AddaVax as adjuvant","volume":"36","author":"Oliveira","year":"2018","journal-title":"Vaccine"},{"key":"10.1016\/j.bbrc.2024.151229_bib66","doi-asserted-by":"crossref","first-page":"3363","DOI":"10.1016\/j.vaccine.2013.05.007","article-title":"The adjuvant effect of MF59 is due to the oil-in-water emulsion formulation, none of the individual components induce a comparable adjuvant effect","volume":"31","author":"Calabro","year":"2013","journal-title":"Vaccine"},{"key":"10.1016\/j.bbrc.2024.151229_bib67","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/978-1-4615-1823-5_10","article-title":"Design and evaluation of a safe and potent adjuvant for human vaccines","volume":"6","author":"Ott","year":"1995","journal-title":"Pharmaceut. Biotechnol."},{"key":"10.1016\/j.bbrc.2024.151229_bib68","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.vaccine.2009.09.089","article-title":"Protein typing of major outer membrane lipoproteins from Chinese pathogenic Leptospira spp. and characterization of their immunogenicity","volume":"28","author":"Luo","year":"2009","journal-title":"Vaccine"},{"key":"10.1016\/j.bbrc.2024.151229_bib69","doi-asserted-by":"crossref","first-page":"6572","DOI":"10.1128\/IAI.67.12.6572-6582.1999","article-title":"Leptospiral outer membrane proteins OmpL1 and LipL41 exhibit synergistic immunoprotection","volume":"67","author":"Haake","year":"1999","journal-title":"Infect. Immun."},{"key":"10.1016\/j.bbrc.2024.151229_bib70","doi-asserted-by":"crossref","DOI":"10.3390\/vaccines7030095","article-title":"Reduced renal colonization and enhanced protection by leptospiral factor H binding proteins as a multisubunit vaccine against leptospirosis in hamsters","volume":"7","author":"Techawiwattanaboon","year":"2019","journal-title":"Vaccines"},{"key":"10.1016\/j.bbrc.2024.151229_bib71","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.micres.2017.11.015","article-title":"Leptospirosis in human: biomarkers in host immune responses","volume":"207","author":"Vk","year":"2018","journal-title":"Microbiol. Res."},{"key":"10.1016\/j.bbrc.2024.151229_bib72","doi-asserted-by":"crossref","first-page":"204","DOI":"10.3389\/fcimb.2018.00204","article-title":"Leptospirosis pathophysiology: into the storm of cytokines","volume":"8","author":"Cagliero","year":"2018","journal-title":"Front. Cell. Infect. Microbiol."}],"updated-by":[{"DOI":"10.1016\/j.bbrc.2025.152268","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2025,8,30]],"date-time":"2025-08-30T00:00:00Z","timestamp":1756512000000}}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X24017650?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X24017650?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,7,24]],"date-time":"2025-07-24T01:22:34Z","timestamp":1753320154000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X24017650"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":72,"alternative-id":["S0006291X24017650"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2024.151229","relation":{"erratum":[{"id-type":"doi","id":"10.1016\/j.bbrc.2025.152268","asserted-by":"object"}]},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"In silico prediction and experimental evaluation of LIP3228 of pathogenic Leptospira as a potential subunit vaccine target against leptospirosis","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2024.151229","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"151229"}}