{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T22:36:30Z","timestamp":1772836590787,"version":"3.50.1"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,12,27]],"date-time":"2024-12-27T00:00:00Z","timestamp":1735257600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008866","name":"Changhai Hospital of Shanghai","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008866","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82172390"],"award-info":[{"award-number":["82172390"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1016\/j.bbrc.2024.151255","type":"journal-article","created":{"date-parts":[[2024,12,27]],"date-time":"2024-12-27T16:12:20Z","timestamp":1735315940000},"page":"151255","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Excessive accumulation of thioredoxin promotes osteogenic differentiation of mesenchymal stem cells of ligament in ankylosing spondylitis by upregulating autophagy levels"],"prefix":"10.1016","volume":"745","author":[{"given":"Junjie","family":"Qiao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bole","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5444-7375","authenticated-orcid":false,"given":"Changhao","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qianqian","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinzhe","family":"Feng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6477-9461","authenticated-orcid":false,"given":"Weidong","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.bbrc.2024.151255_bib1","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1186\/s13287-019-1306-x","article-title":"lncRNA-mRNA expression profiles and functional networks of mesenchymal stromal cells involved in monocyte regulation","volume":"10","author":"Li","year":"2019","journal-title":"Stem Cell Res. Ther."},{"issue":"3","key":"10.1016\/j.bbrc.2024.151255_bib2","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1002\/art.41156","article-title":"Polyfunctional, proinflammatory, tissue-resident memory phenotype and function of synovial interleukin-17A+CD8+ T cells in psoriatic arthritis","volume":"72","author":"Steel","year":"2020","journal-title":"Arthritis Rheumatol."},{"key":"10.1016\/j.bbrc.2024.151255_bib3","article-title":"FOXO3a alleviates the inflammation and oxidative stress via regulating TGF-\u03b2 and HO-1 in ankylosing spondylitis","volume":"13","author":"Xu","year":"2022","journal-title":"Front. Immunol."},{"issue":"6","key":"10.1016\/j.bbrc.2024.151255_bib4","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1136\/annrheumdis-2013-204963","article-title":"Sarilumab for the treatment of ankylosing spondylitis: results of a Phase II, randomised, double-blind, placebo-controlled study (ALIGN)","volume":"74","author":"Sieper","year":"2015","journal-title":"Ann. Rheum. Dis."},{"issue":"1","key":"10.1016\/j.bbrc.2024.151255_bib5","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1136\/annrheumdis-2013-203460","article-title":"Maintenance of biologic-free remission with naproxen or no treatment in patients with early, active axial spondyloarthritis: results from a 6-month, randomised, open-label follow-up study, INFAST Part 2","volume":"73","author":"Sieper","year":"2014","journal-title":"Ann. Rheum. Dis."},{"issue":"3","key":"10.1016\/j.bbrc.2024.151255_bib6","doi-asserted-by":"crossref","DOI":"10.1136\/rmdopen-2020-001391","article-title":"No relationship between bone mineral density and syndesmophyte formation at the same level in the lumbar spine of patients with radiographic axial Spondyloarthritis","volume":"6","author":"Marques","year":"2020","journal-title":"RMD Open"},{"key":"10.1016\/j.bbrc.2024.151255_bib7","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1016\/j.omtn.2019.10.003","article-title":"miR-17-5p regulates heterotopic ossification by targeting ANKH in ankylosing spondylitis","volume":"18","author":"Qin","year":"2019","journal-title":"Mol. Ther. Nucleic Acids"},{"issue":"1","key":"10.1016\/j.bbrc.2024.151255_bib8","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1038\/s41413-021-00140-6","article-title":"Chondrogenesis mediates progression of ankylosing spondylitis through heterotopic ossification","volume":"9","author":"Yu","year":"2021","journal-title":"Bone research"},{"key":"10.1016\/j.bbrc.2024.151255_bib9","doi-asserted-by":"crossref","first-page":"231","DOI":"10.3389\/fphar.2020.00231","article-title":"Circulating retinol-binding protein 4 as a possible biomarker of treatment response for ankylosing spondylitis: an array-based comparative study","volume":"11","author":"Wu","year":"2020","journal-title":"Front. Pharmacol."},{"issue":"9","key":"10.1016\/j.bbrc.2024.151255_bib10","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/s11926-017-0681-5","article-title":"Mechanism of new bone formation in axial spondyloarthritis","volume":"19","author":"Poddubnyy","year":"2017","journal-title":"Curr. Rheumatol. Rep."},{"key":"10.1016\/j.bbrc.2024.151255_bib11","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/6873197","article-title":"Pathway-driven approaches of interaction between oxidative balance and genetic polymorphism on metabolic syndrome","volume":"2017","author":"Lee","year":"2017","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.bbrc.2024.151255_bib12","doi-asserted-by":"crossref","DOI":"10.1038\/cddiscovery.2016.57","article-title":"The pro-oxidative drug WF-10 inhibits serial killing by primary human cytotoxic T-cells","volume":"2","author":"Wabnitz","year":"2016","journal-title":"Cell death discovery"},{"issue":"4","key":"10.1016\/j.bbrc.2024.151255_bib13","doi-asserted-by":"crossref","DOI":"10.3390\/nu10040503","article-title":"Taiwanese green propolis ethanol extract delays the progression of type 2 diabetes mellitus in rats treated with streptozotocin\/high-fat diet","volume":"10","author":"Chen","year":"2018","journal-title":"Nutrients"},{"issue":"20","key":"10.1016\/j.bbrc.2024.151255_bib14","doi-asserted-by":"crossref","first-page":"4598","DOI":"10.1111\/febs.12964","article-title":"Molecular characterization of the thioredoxin system from Methanosarcina acetivorans","volume":"281","author":"McCarver","year":"2014","journal-title":"FEBS J."},{"issue":"4","key":"10.1016\/j.bbrc.2024.151255_bib15","article-title":"Immunoproteomic analysis reveals novel candidate antigens for the diagnosis of paracoccidioidomycosis due to paracoccidioides lutzii","volume":"6","author":"Rodrigues","year":"2020","journal-title":"Journal of fungi (Basel, Switzerland)"},{"key":"10.1016\/j.bbrc.2024.151255_bib16","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.redox.2017.03.001","article-title":"Xanthohumol ameliorates lipopolysaccharide (LPS)-induced acute lung injury via induction of AMPK\/GSK3\u03b2-Nrf2 signal axis","volume":"12","author":"Lv","year":"2017","journal-title":"Redox Biol."},{"issue":"1","key":"10.1016\/j.bbrc.2024.151255_bib17","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1186\/s40164-022-00329-3","article-title":"Thioredoxin-1 regulates self-renewal and differentiation of murine hematopoietic stem cells through p53 tumor suppressor","volume":"11","author":"Jabbar","year":"2022","journal-title":"Exp. Hematol. Oncol."},{"key":"10.1016\/j.bbrc.2024.151255_bib18","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.biocel.2015.05.014","article-title":"Apoptosis of cholangiocytes modulated by thioredoxin of carcinogenic liver fluke","volume":"65","author":"Matchimakul","year":"2015","journal-title":"Int. J. Biochem. Cell Biol."},{"issue":"12","key":"10.1016\/j.bbrc.2024.151255_bib19","doi-asserted-by":"crossref","first-page":"640","DOI":"10.5483\/BMBRep.2020.53.12.161","article-title":"Anti-inflammatory mechanisms of suppressors of cytokine signaling target ROS via NRF-2\/thioredoxin induction and inflammasome activation in macrophages","volume":"53","author":"Kim","year":"2020","journal-title":"BMB reports"},{"issue":"1","key":"10.1016\/j.bbrc.2024.151255_bib20","first-page":"186","article-title":"Honokiol antagonizes doxorubicin-induced cardiomyocyte senescence by inhibiting TXNIP-mediated NLRP3 inflammasome activation","volume":"45","author":"Huang","year":"2020","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.bbrc.2024.151255_bib21","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/4904696","article-title":"Transient receptor potential canonical channels 4 and 5 mediate Escherichia coli-derived thioredoxin effects in lipopolysaccharide-injected mice","volume":"2018","author":"Pereira","year":"2018","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"6","key":"10.1016\/j.bbrc.2024.151255_bib22","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1007\/s00253-007-0949-1","article-title":"Release of thioredoxin from Saccharomyces cerevisiae with environmental stimuli: solubilization of thioredoxin with ethanol","volume":"75","author":"Takeuchi","year":"2007","journal-title":"Appl. Microbiol. Biotechnol."},{"issue":"4","key":"10.1016\/j.bbrc.2024.151255_bib23","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.cytogfr.2013.01.001","article-title":"Extracellular thioredoxin: a therapeutic tool to combat inflammation","volume":"24","author":"Matsuo","year":"2013","journal-title":"Cytokine Growth Factor Rev."},{"issue":"9","key":"10.1016\/j.bbrc.2024.151255_bib24","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21093298","article-title":"Disruption of placental homeostasis leads to preeclampsia","volume":"21","author":"Nakashima","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbrc.2024.151255_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2020.101748","article-title":"Redox homeostasis and cell cycle activation mediate beta-cell mass expansion in aged, diabetes-prone mice under metabolic stress conditions: role of thioredoxin-interacting protein (TXNIP)","volume":"37","author":"Kehm","year":"2020","journal-title":"Redox Biol."},{"issue":"1","key":"10.1016\/j.bbrc.2024.151255_bib26","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1002\/hep.24690","article-title":"Activation of autophagy protects against acetaminophen-induced hepatotoxicity","volume":"55","author":"Ni","year":"2012","journal-title":"Hepatology"},{"issue":"1","key":"10.1016\/j.bbrc.2024.151255_bib27","doi-asserted-by":"crossref","first-page":"5373","DOI":"10.1038\/s41467-021-25710-4","article-title":"TNF-\u03b1-mediated m(6)A modification of ELMO1 triggers directional migration of mesenchymal stem cell in ankylosing spondylitis","volume":"12","author":"Xie","year":"2021","journal-title":"Nat. Commun."},{"issue":"3","key":"10.1016\/j.bbrc.2024.151255_bib28","doi-asserted-by":"crossref","first-page":"4658","DOI":"10.1080\/21655979.2021.2024956","article-title":"microRNA-135a-5p regulates NOD-like receptor family pyrin domain containing 3 inflammasome-mediated hypertensive cardiac inflammation and fibrosis via thioredoxin-interacting protein","volume":"13","author":"Chen","year":"2022","journal-title":"Bioengineered"},{"issue":"1","key":"10.1016\/j.bbrc.2024.151255_bib29","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/s13045-016-0383-x","article-title":"Novel roles of DC-SIGNR in colon cancer cell adhesion, migration, invasion, and liver metastasis","volume":"10","author":"Na","year":"2017","journal-title":"J. Hematol. Oncol."},{"issue":"5","key":"10.1016\/j.bbrc.2024.151255_bib30","doi-asserted-by":"crossref","DOI":"10.1186\/ar2496","article-title":"The relationship between inflammation and new bone formation in patients with ankylosing spondylitis","volume":"10","author":"Baraliakos","year":"2008","journal-title":"Arthritis Res. Ther."},{"issue":"11","key":"10.1016\/j.bbrc.2024.151255_bib31","doi-asserted-by":"crossref","first-page":"2731","DOI":"10.1038\/s41591-023-02613-z","article-title":"Targeted depletion of TRBV9(+) T cells as immunotherapy in a patient with ankylosing spondylitis","volume":"29","author":"Britanova","year":"2023","journal-title":"Nat. Med."},{"issue":"3","key":"10.1016\/j.bbrc.2024.151255_bib32","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.berh.2010.01.005","article-title":"Can we stop progression of ankylosing spondylitis?","volume":"24","author":"Schett","year":"2010","journal-title":"Best Pract. Res. Clin. Rheumatol."},{"issue":"12","key":"10.1016\/j.bbrc.2024.151255_bib33","doi-asserted-by":"crossref","first-page":"5086","DOI":"10.18632\/aging.204130","article-title":"Galectin-3 induces vascular smooth muscle cells calcification via AMPK\/TXNIP pathway","volume":"14","author":"Tian","year":"2022","journal-title":"Aging"},{"key":"10.1016\/j.bbrc.2024.151255_bib34","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/8729398","article-title":"Activation of LRP1 ameliorates cerebral ischemia\/reperfusion injury and cognitive decline by suppressing neuroinflammation and oxidative stress through TXNIP\/NLRP3 signaling pathway in mice","volume":"2022","author":"Yang","year":"2022","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.bbrc.2024.151255_bib35","article-title":"Transfer of microRNA-22-3p by M2 macrophage-derived extracellular vesicles facilitates the development of ankylosing spondylitis through the PER2-mediated Wnt\/\u03b2-catenin axis","author":"Chong","year":"2022","journal-title":"Cell Death Discovery"},{"issue":"12","key":"10.1016\/j.bbrc.2024.151255_bib36","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1111\/apm.12757","article-title":"M2 polarization of monocytes in ankylosing spondylitis and relationship with inflammation and structural damage","volume":"125","author":"Zhao","year":"2017","journal-title":"APMIS : acta pathologica, microbiologica, et immunologica Scandinavica"},{"key":"10.1016\/j.bbrc.2024.151255_bib37","first-page":"1","article-title":"TXNIP mediated by EZH2 regulated osteogenic differentiation in hBmscs and MC3T3-E1 cells through the modulation of oxidative stress and PI3K\/AKT\/Nrf2 pathway","author":"Zhou","year":"2024","journal-title":"Connect. Tissue Res."},{"issue":"48","key":"10.1016\/j.bbrc.2024.151255_bib38","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.1808609115","article-title":"Klotho controls the brain-immune system interface in the choroid plexus","volume":"115","author":"Zhu","year":"2018","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"1","key":"10.1016\/j.bbrc.2024.151255_bib39","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1186\/s12974-017-0878-6","article-title":"Thioredoxin-interacting protein links endoplasmic reticulum stress to inflammatory brain injury and apoptosis after subarachnoid haemorrhage","volume":"14","author":"Zhao","year":"2017","journal-title":"J. Neuroinflammation"}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X24017911?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X24017911?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T01:41:11Z","timestamp":1736300471000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X24017911"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":39,"alternative-id":["S0006291X24017911"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2024.151255","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Excessive accumulation of thioredoxin promotes osteogenic differentiation of mesenchymal stem cells of ligament in ankylosing spondylitis by upregulating autophagy levels","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2024.151255","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"151255"}}