{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T10:10:40Z","timestamp":1768558240648,"version":"3.49.0"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1016\/j.bbrc.2024.151265","type":"journal-article","created":{"date-parts":[[2024,12,31]],"date-time":"2024-12-31T23:54:14Z","timestamp":1735689254000},"page":"151265","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Bradykinin attenuates NiSO4-induced autophagy in MIN6 cells and protects islet function in mice by regulating the PI3K\/AKT\/mTOR signaling pathway"],"prefix":"10.1016","volume":"746","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-6663-4223","authenticated-orcid":false,"given":"Zhuanping","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"12","key":"10.1016\/j.bbrc.2024.151265_bib1","doi-asserted-by":"crossref","first-page":"29592","DOI":"10.3390\/ijms161226183","article-title":"Heavy metals and human health: mechanistic insight into toxicity and counter defense system of antioxidants","volume":"16","author":"Jan","year":"2015","journal-title":"Int. J. Mol. Sci."},{"issue":"Suppl 4","key":"10.1016\/j.bbrc.2024.151265_bib2","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1289\/ehp.96104s4715","article-title":"Research needs for the risk assessment of health and environmental effects of endocrine disruptors: a report of the U.S. EPA-sponsored workshop","volume":"104","author":"Kavlock","year":"1996","journal-title":"Environ. Health Perspect."},{"issue":"3","key":"10.1016\/j.bbrc.2024.151265_bib3","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1111\/cen.12704","article-title":"Cadmium delays puberty onset and testis growth in adolescents","volume":"83","author":"Interdonato","year":"2015","journal-title":"Clin. Endocrinol."},{"issue":"1","key":"10.1016\/j.bbrc.2024.151265_bib4","first-page":"125","article-title":"The relationship between exposure to lead-containing welding fumes and the levels of reproductive hormones","volume":"85","author":"Dehghan","year":"2019","journal-title":"Ann. Global HGlob.Access Sci. Sour.ealth"},{"key":"10.1016\/j.bbrc.2024.151265_bib5","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s12940-015-0004-0","article-title":"A nested case-control study indicating heavy metal residues in meconium associate with maternal gestational diabetes mellitus risk","volume":"14","author":"Peng","year":"2015","journal-title":"Environ. Health : a global access science source"},{"issue":"18","key":"10.1016\/j.bbrc.2024.151265_bib6","doi-asserted-by":"crossref","first-page":"18714","DOI":"10.1007\/s11356-016-7078-2","article-title":"Blood cadmium in Chinese adults and its relationships with diabetes and obesity","volume":"23","author":"Nie","year":"2016","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"10.1016\/j.bbrc.2024.151265_bib7","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.envres.2019.03.023","article-title":"Heavy metals, welding fumes, and other occupational exposures, and the risk of kidney cancer: a population-based nested case-control study in three Nordic countries","volume":"173","author":"Michalek","year":"2019","journal-title":"Environ. Res."},{"issue":"9","key":"10.1016\/j.bbrc.2024.151265_bib8","doi-asserted-by":"crossref","first-page":"22989","DOI":"10.3390\/ijms160922989","article-title":"Modulation of the PI3K\/akt pathway and bcl-2 family proteins involved in chicken's tubular apoptosis induced by nickel chloride (NiCl\u2082)","volume":"16","author":"Guo","year":"2015","journal-title":"Int. J. Mol. Sci."},{"issue":"8","key":"10.1016\/j.bbrc.2024.151265_bib9","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1002\/tox.22768","article-title":"Nano-selenium attenuates nickel-induced testosterone synthesis disturbance through inhibition of MAPK pathways in Sprague-Dawley rats","volume":"34","author":"Gan","year":"2019","journal-title":"Environ. Toxicol."},{"issue":"6","key":"10.1016\/j.bbrc.2024.151265_bib10","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1210\/er.2015-1093","article-title":"Executive summary to EDC-2: the endocrine society's second scientific statement on endocrine-disrupting chemicals","volume":"36","author":"Gore","year":"2015","journal-title":"Endocr. Rev."},{"issue":"1","key":"10.1016\/j.bbrc.2024.151265_bib11","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.etap.2015.06.009","article-title":"A review on endocrine disruptors and their possible impacts on human health","volume":"40","author":"Kabir","year":"2015","journal-title":"Environ. Toxicol. Pharmacol."},{"issue":"3","key":"10.1016\/j.bbrc.2024.151265_bib12","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1007\/s12020-015-0581-2","article-title":"Systemic nickel allergic syndrome as an immune-mediated disease with an increased risk for thyroid autoimmunity","volume":"50","author":"Andrioli","year":"2015","journal-title":"Endocrine"},{"issue":"8","key":"10.1016\/j.bbrc.2024.151265_bib13","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0202683","article-title":"Overweight and obese patients with nickel allergy have a worse metabolic profile compared to weight matched non-allergic individuals","volume":"13","author":"Watanabe","year":"2018","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.bbrc.2024.151265_bib14","first-page":"97","article-title":"Occupational exposure to heavy metals, alcohol intake, and risk of type 2 diabetes and prediabetes among Chinese male workers","volume":"5","author":"Yang","year":"2019","journal-title":"Chron. Dis. Translat. Med."},{"key":"10.1016\/j.bbrc.2024.151265_bib15","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.envint.2019.03.037","article-title":"Toenail concentrations of trace elements and occupational history in pancreatic cancer","volume":"127","author":"Camargo","year":"2019","journal-title":"Environ. Int."},{"issue":"1","key":"10.1016\/j.bbrc.2024.151265_bib16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/15548627.2015.1100356","article-title":"Guidelines for the use and interpretation of assays for monitoring autophagy","volume":"12","author":"Klionsky","year":"2016","journal-title":"Autophagy"},{"issue":"3","key":"10.1016\/j.bbrc.2024.151265_bib17","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.cell.2010.01.028","article-title":"Methods in mammalian autophagy research","volume":"140","author":"Mizushima","year":"2010","journal-title":"Cell"},{"issue":"40","key":"10.1016\/j.bbrc.2024.151265_bib18","doi-asserted-by":"crossref","first-page":"5105","DOI":"10.1038\/onc.2014.458","article-title":"Cell death by autophagy: emerging molecular mechanisms and implications for cancer therapy","volume":"34","author":"Fulda","year":"2015","journal-title":"Oncogene"},{"issue":"9","key":"10.1016\/j.bbrc.2024.151265_bib19","doi-asserted-by":"crossref","DOI":"10.3390\/ijms18091865","article-title":"Monitoring and measuring autophagy","volume":"18","author":"Yoshii","year":"2017","journal-title":"Int. J. Mol. Sci."},{"issue":"20","key":"10.1016\/j.bbrc.2024.151265_bib20","doi-asserted-by":"crossref","first-page":"8315","DOI":"10.1074\/jbc.M116.773986","article-title":"Nuclear factor erythroid 2-related factor 2 enhances carcinogenesis by suppressing apoptosis and promoting autophagy in nickel-transformed cells","volume":"292","author":"Son","year":"2017","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.bbrc.2024.151265_bib21","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1007\/s12011-021-02643-z","article-title":"Nickel sulfate induces autophagy in human thyroid follicular epithelial cells","volume":"200","author":"Zhang","year":"2022","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.bbrc.2024.151265_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2021.112954","article-title":"Oxidative stress-mediated apoptosis and autophagy involved in Ni-induced nephrotoxicity in the mice","volume":"228","author":"Guo","year":"2021","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"6","key":"10.1016\/j.bbrc.2024.151265_bib23","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.tice.2011.07.001","article-title":"Bradykinin potentiating factor isolated from Buthus occitanus venom has a protective effect against cadmium-induced rat liver and kidney damage","volume":"43","author":"Bekheet","year":"2011","journal-title":"Tissue Cell"},{"issue":"4","key":"10.1016\/j.bbrc.2024.151265_bib24","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1038\/s41418-018-0252-y","article-title":"Autophagy-dependent cell death","volume":"26","author":"Denton","year":"2019","journal-title":"Cell Death Differ."},{"issue":"1","key":"10.1016\/j.bbrc.2024.151265_bib25","doi-asserted-by":"crossref","first-page":"H202","DOI":"10.1152\/ajpheart.01287.2004","article-title":"Age-related changes of bradykinin B1 and B2 receptors in rat heart","volume":"289","author":"Kintsurashvili","year":"2005","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"8","key":"10.1016\/j.bbrc.2024.151265_bib26","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1038\/hr.2010.82","article-title":"Cardioprotective properties of bradykinin: role of the B(2) receptor","volume":"33","author":"Manolis","year":"2010","journal-title":"Hypertens. Res."},{"key":"10.1016\/j.bbrc.2024.151265_bib27","article-title":"Exposure to nickel chloride induces epigenetic modification on detoxification enzyme glutathione S-transferase M2","author":"Kang","year":"2023","journal-title":"Environ. Toxicol."},{"issue":"1","key":"10.1016\/j.bbrc.2024.151265_bib28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s12011-007-8062-y","article-title":"Copper, chromium, manganese, iron, nickel, and zinc levels in biological samples of diabetes mellitus patients","volume":"122","author":"Kazi","year":"2008","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.bbrc.2024.151265_bib29","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1007\/978-3-7643-8340-4_6","article-title":"Heavy metal toxicity and the environment","volume":"101","author":"Tchounwou","year":"2012","journal-title":"Experientia Suppl."},{"key":"10.1016\/j.bbrc.2024.151265_bib30","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/640754","article-title":"Biomedical implications of heavy metals induced imbalances in redox systems","volume":"2014","author":"Sharma","year":"2014","journal-title":"BioMed Res. Int."},{"key":"10.1016\/j.bbrc.2024.151265_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.pdpdt.2020.102137","article-title":"Crosstalk between oxidative stress, autophagy and apoptosis in hemoporfin photodynamic therapy treated human umbilical vein endothelial cells","volume":"33","author":"Xue","year":"2021","journal-title":"Photodiagnosis Photodyn. Ther."},{"issue":"1","key":"10.1016\/j.bbrc.2024.151265_bib32","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1124\/pr.57.1.2","article-title":"International union of pharmacology. XLV. Classification of the kinin receptor family: from molecular mechanisms to pathophysiological consequences","volume":"57","author":"Leeb-Lundberg","year":"2005","journal-title":"Pharmacol. Rev."},{"issue":"4","key":"10.1016\/j.bbrc.2024.151265_bib33","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1515\/bc.2010.042","article-title":"Tissue kallikrein in cardiovascular, cerebrovascular and renal diseases and skin wound healing","volume":"391","author":"Chao","year":"2010","journal-title":"Biol. Chem."},{"key":"10.1016\/j.bbrc.2024.151265_bib34","doi-asserted-by":"crossref","first-page":"300","DOI":"10.3389\/fphar.2019.00300","article-title":"Bradykinin type 1 receptor - inducible nitric oxide synthase: a new Axis implicated in diabetic retinopathy","volume":"10","author":"Othman","year":"2019","journal-title":"Front. Pharmacol."},{"issue":"2","key":"10.1016\/j.bbrc.2024.151265_bib35","doi-asserted-by":"crossref","first-page":"188","DOI":"10.15690\/vramn.v70i2.1312","article-title":"[Role of bradikynin in the mechanism of ischemic preconditioning of the heart. Prospects of bradykinin application in cardiosurgical praxis]","author":"Maslov","year":"2015","journal-title":"Vestn. Ross. Akad. Med. Nauk"},{"issue":"2","key":"10.1016\/j.bbrc.2024.151265_bib36","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/S0168-8227(00)00222-9","article-title":"The effect of bradykinin on the oxidative state of rats with acute hyperglycaemia","volume":"51","author":"Mikrut","year":"2001","journal-title":"Diabetes Res. Clin. Pract."},{"issue":"2","key":"10.1016\/j.bbrc.2024.151265_bib37","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1093\/toxsci\/kfn008","article-title":"Role of tissue kallikrein in prevention and recovery of gentamicin-induced renal injury","volume":"102","author":"Bledsoe","year":"2008","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.bbrc.2024.151265_bib38","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/161020","article-title":"PI3K\/AKT\/mTOR\/p70S6K pathway is involved in a\u03b225-35-induced autophagy","volume":"2015","author":"Fan","year":"2015","journal-title":"BioMed Res. Int."},{"issue":"3","key":"10.1016\/j.bbrc.2024.151265_bib39","doi-asserted-by":"crossref","DOI":"10.1002\/jbt.22683","article-title":"Natural compounds against cytotoxic drug-induced cardiotoxicity: a review on the involvement of PI3K\/Akt signaling pathway","volume":"35","author":"Yarmohammadi","year":"2021","journal-title":"J. Biochem. Mol. Toxicol."},{"issue":"1\u20132","key":"10.1016\/j.bbrc.2024.151265_bib40","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1007\/s11010-016-2853-4","article-title":"Akt\/AMPK\/mTOR pathway was involved in the autophagy induced by vitamin E succinate in human gastric cancer SGC-7901 cells","volume":"424","author":"Yu","year":"2017","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.bbrc.2024.151265_bib41","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.bbrc.2023.04.005","article-title":"Bradykinin-(1-9) mitigates autophagy through upregulating PI3K\/Akt in rats with myocardial infarction","volume":"660","author":"Lu","year":"2023","journal-title":"Biochem. Biophys. Res. Commun."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X24018011?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X24018011?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,23]],"date-time":"2025-02-23T18:24:18Z","timestamp":1740335058000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X24018011"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":41,"alternative-id":["S0006291X24018011"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2024.151265","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Bradykinin attenuates NiSO4-induced autophagy in MIN6 cells and protects islet function in mice by regulating the PI3K\/AKT\/mTOR signaling pathway","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2024.151265","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"151265"}}