{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T17:33:14Z","timestamp":1781803994747,"version":"3.54.5"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1016\/j.bbrc.2025.151291","type":"journal-article","created":{"date-parts":[[2025,1,6]],"date-time":"2025-01-06T16:16:24Z","timestamp":1736180184000},"page":"151291","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Abscisic acid improves non-alcoholic fatty liver disease in mice through the AMPK\/NRF2\/KEAP1 signaling axis"],"prefix":"10.1016","volume":"747","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5542-5183","authenticated-orcid":false,"given":"Lin","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fu Hua","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai Xiao","family":"Kun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2025.151291_bib1","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1038\/s41575-023-00800-4","article-title":"Lifestyle interventions in nonalcoholic fatty liver disease","volume":"20","author":"Younossi","year":"2023","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.bbrc.2025.151291_bib2","doi-asserted-by":"crossref","first-page":"2212","DOI":"10.1016\/S0140-6736(20)32511-3","article-title":"Non-alcoholic fatty liver disease","volume":"397","author":"Powell","year":"2021","journal-title":"Lancet"},{"key":"10.1016\/j.bbrc.2025.151291_bib3","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1056\/NEJMc1006581","article-title":"Pioglitazone, vitamin E, or placebo for nonalcoholic steatohepatitis","volume":"363","author":"Violi","year":"2010","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bbrc.2025.151291_bib4","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1002\/hep.30368","article-title":"Vitamin E improves transplant-free survival and hepatic decompensation among patients with nonalcoholic steatohepatitis and advanced fibrosis","volume":"71","author":"Vilar-Gomez","year":"2020","journal-title":"Hepatology"},{"key":"10.1016\/j.bbrc.2025.151291_bib5","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/S0140-6736(15)00803-X","article-title":"Liraglutide safety and efficacy in patients with non-alcoholic steatohepatitis (LEAN): a multicentre, double-blind, randomised, placebo-controlled phase 2 study","volume":"387","author":"Armstrong","year":"2016","journal-title":"Lancet"},{"key":"10.1016\/j.bbrc.2025.151291_bib6","doi-asserted-by":"crossref","first-page":"2168","DOI":"10.1016\/j.cgh.2020.05.021","article-title":"SGLT2 inhibitors in liver patients","volume":"18","author":"Hsiang","year":"2020","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"10.1016\/j.bbrc.2025.151291_bib7","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.2174\/0929867323666160405113129","article-title":"Abscisic acid: a phytohormone and mammalian cytokine as novel pharmacon with potential for future development into clinical applications","volume":"23","author":"Sakthivel","year":"2016","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.bbrc.2025.151291_bib8","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1080\/14786419.2019.1637874","article-title":"Abscisic acid identification in Okra, Abelmoschus esculentus L. (Moench): perspective nutraceutical use for the treatment of diabetes","volume":"34","author":"Daliu","year":"2020","journal-title":"Nat. Prod. Res."},{"key":"10.1016\/j.bbrc.2025.151291_bib9","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.clnu.2006.07.008","article-title":"Dietary abscisic acid ameliorates glucose tolerance and obesity-related inflammation in db\/db mice fed high-fat diets","volume":"26","author":"Guri","year":"2007","journal-title":"Clin. Nutr."},{"key":"10.1016\/j.bbrc.2025.151291_bib10","doi-asserted-by":"crossref","DOI":"10.3390\/metabo12060523","article-title":"Abscisic acid improves insulin action on glycemia in insulin-deficient mouse models of type 1 diabetes","volume":"12","author":"Magnone","year":"2022","journal-title":"Metabolites"},{"key":"10.1016\/j.bbrc.2025.151291_bib11","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/j.jhazmat.2007.03.018","article-title":"Abcisic acid and gibberellic acid cause increased lipid peroxidation and fluctuated antioxidant defense systems of various tissues in rats","volume":"148","author":"Celik","year":"2007","journal-title":"J. Hazard Mater."},{"key":"10.1016\/j.bbrc.2025.151291_bib12","article-title":"Abscisic acid ameliorates d-galactose -induced aging in mice by modulating AMPK-SIRT1-p53 pathway and intestinal flora","volume":"10","author":"Zheng","year":"2024","journal-title":"Heliyon"},{"key":"10.1016\/j.bbrc.2025.151291_bib13","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1016\/j.clnu.2010.02.009","article-title":"Abscisic acid ameliorates experimental IBD by downregulating cellular adhesion molecule expression and suppressing immune cell infiltration","volume":"29","author":"Guri","year":"2010","journal-title":"Clin. Nutr."},{"key":"10.1016\/j.bbrc.2025.151291_bib14","first-page":"141","article-title":"Cordycepin suppresses the migration and invasion of human liver cancer cells by downregulating the expression of CXCR4","volume":"45","author":"Guo","year":"2020","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.bbrc.2025.151291_bib15","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1172\/JCI23621","article-title":"Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease","volume":"115","author":"Donnelly","year":"2005","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbrc.2025.151291_bib16","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1172\/JCI9826","article-title":"Inhibition of ubiquitin-proteasome pathway-mediated I kappa B alpha degradation by a naturally occurring antibacterial peptide","volume":"106","author":"Gao","year":"2000","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbrc.2025.151291_bib17","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/cdd.2012.72","article-title":"Ubiquitination and selective autophagy","volume":"20","author":"Shaid","year":"2013","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.bbrc.2025.151291_bib18","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/ncb2021","article-title":"The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1","volume":"12","author":"Komatsu","year":"2010","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.bbrc.2025.151291_bib19","first-page":"1","article-title":"An overview of the molecular mechanism of autophagy","volume":"335","author":"Yang","year":"2009","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"10.1016\/j.bbrc.2025.151291_bib20","article-title":"Nonalcoholic fatty liver disease","volume":"1","author":"Brunt","year":"2015","journal-title":"Nat. Rev. Dis. Prim."},{"key":"10.1016\/j.bbrc.2025.151291_bib21","doi-asserted-by":"crossref","first-page":"210","DOI":"10.3350\/cmh.2013.19.3.210","article-title":"Nonalcoholic fatty liver disease: molecular mechanisms for the hepatic steatosis","volume":"19","author":"Koo","year":"2013","journal-title":"Clin. Mol. Hepatol."},{"key":"10.1016\/j.bbrc.2025.151291_bib22","doi-asserted-by":"crossref","first-page":"5843","DOI":"10.1007\/s00253-019-09703-4","article-title":"Lactobacillus plantarum NA136 improves the non-alcoholic fatty liver disease by modulating the AMPK\/Nrf2 pathway","volume":"103","author":"Zhao","year":"2019","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.bbrc.2025.151291_bib23","doi-asserted-by":"crossref","first-page":"2672","DOI":"10.1002\/hep.30251","article-title":"Global perspectives on nonalcoholic fatty liver disease and nonalcoholic steatohepatitis","volume":"69","author":"Younossi","year":"2019","journal-title":"Hepatology"},{"key":"10.1016\/j.bbrc.2025.151291_bib24","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1007\/s12072-022-10296-w","article-title":"Colesevelam ameliorates non-alcoholic steatohepatitis and obesity in mice","volume":"16","author":"Hartmann","year":"2022","journal-title":"Hepatol Int"},{"key":"10.1016\/j.bbrc.2025.151291_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.111045","article-title":"MMP10 alleviates non-alcoholic steatohepatitis by regulating macrophage M2 polarization","volume":"124","author":"Chang","year":"2023","journal-title":"Int. Immunopharm."},{"key":"10.1016\/j.bbrc.2025.151291_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2023.121595","article-title":"LCN2 contributes to the improvement of nonalcoholic steatohepatitis by 8-Cetylberberine","volume":"321","author":"He","year":"2023","journal-title":"Life Sci."},{"key":"10.1016\/j.bbrc.2025.151291_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.154798","article-title":"Neferine ameliorates nonalcoholic steatohepatitis through regulating AMPK pathway","volume":"114","author":"Wang","year":"2023","journal-title":"Phytomedicine"},{"key":"10.1016\/j.bbrc.2025.151291_bib28","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.redox.2016.10.003","article-title":"Nrf2 mediates redox adaptations to exercise","volume":"10","author":"Done","year":"2016","journal-title":"Redox Biol."},{"key":"10.1016\/j.bbrc.2025.151291_bib29","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1146\/annurev-pharmtox-011112-140320","article-title":"Role of nrf2 in oxidative stress and toxicity","volume":"53","author":"Ma","year":"2013","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.bbrc.2025.151291_bib30","doi-asserted-by":"crossref","first-page":"3275","DOI":"10.1128\/MCB.00248-10","article-title":"A noncanonical mechanism of Nrf2 activation by autophagy deficiency: direct interaction between Keap1 and p62","volume":"30","author":"Lau","year":"2010","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.bbrc.2025.151291_bib31","doi-asserted-by":"crossref","first-page":"2538","DOI":"10.1038\/s41467-019-10386-8","article-title":"Cordycepin prevents radiation ulcer by inhibiting cell senescence via NRF2 and AMPK in rodents","volume":"10","author":"Wang","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbrc.2025.151291_bib32","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1038\/s41598-020-58206-0","article-title":"Insulin-independent stimulation of skeletal muscle glucose uptake by low-dose abscisic acid via AMPK activation","volume":"10","author":"Magnone","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbrc.2025.151291_bib33","doi-asserted-by":"crossref","DOI":"10.3390\/nu12061724","article-title":"Abscisic acid: a conserved hormone in plants and humans and a promising aid to combat prediabetes and the metabolic syndrome","volume":"12","author":"Magnone","year":"2020","journal-title":"Nutrients"},{"key":"10.1016\/j.bbrc.2025.151291_bib34","doi-asserted-by":"crossref","first-page":"393","DOI":"10.21037\/hbsn-22-476","article-title":"Choline suppresses hepatocellular carcinoma progression by attenuating AMPK\/mTOR-mediated autophagy via choline transporter SLC5A7 activation","volume":"13","author":"Wang","year":"2024","journal-title":"Hepatobiliary Surg. Nutr."},{"key":"10.1016\/j.bbrc.2025.151291_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2018.11.024","article-title":"Chikusetsu saponin IVa attenuates isoprenaline-induced myocardial fibrosis in mice through activation autophagy mediated by AMPK\/mTOR\/ULK1 signaling","volume":"58","author":"Wang","year":"2019","journal-title":"Phytomedicine"},{"key":"10.1016\/j.bbrc.2025.151291_bib36","article-title":"Biofunctional magnesium-coated Ti6Al4V scaffolds promote autophagy-dependent apoptosis in osteosarcoma by activating the AMPK\/mTOR\/ULK1 signaling pathway","volume":"12","author":"Wei","year":"2021","journal-title":"Mater. Today Bio."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X25000051?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X25000051?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,30]],"date-time":"2025-01-30T22:57:59Z","timestamp":1738277879000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X25000051"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":36,"alternative-id":["S0006291X25000051"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2025.151291","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Abscisic acid improves non-alcoholic fatty liver disease in mice through the AMPK\/NRF2\/KEAP1 signaling axis","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2025.151291","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"151291"}}