{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T04:50:04Z","timestamp":1777265404982,"version":"3.51.4"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T00:00:00Z","timestamp":1736726400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["5R01HL139887"],"award-info":[{"award-number":["5R01HL139887"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["5P20GM139745"],"award-info":[{"award-number":["5P20GM139745"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["3U54GM115516"],"award-info":[{"award-number":["3U54GM115516"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["2P20GM121301"],"award-info":[{"award-number":["2P20GM121301"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1016\/j.bbrc.2025.151300","type":"journal-article","created":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T23:34:59Z","timestamp":1736379299000},"page":"151300","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Vitamin A deficiency and male-specific effects on heart function in mice"],"prefix":"10.1016","volume":"748","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3827-6494","authenticated-orcid":false,"given":"Ian M.","family":"Gans","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Chepurko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vadim","family":"Chepurko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grazina A.","family":"Mangoba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary Ann","family":"Asson-Batres","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8793-0128","authenticated-orcid":false,"given":"Calvin P.","family":"Vary","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-7584-0700","authenticated-orcid":false,"given":"Douglas B.","family":"Sawyer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2025.151300_bib1","series-title":"Vitamins & Hormones","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S0083-6729(06)75010-5","article-title":"Retinoic acid and the heart","author":"Pan","year":"2007"},{"issue":"3","key":"10.1016\/j.bbrc.2025.151300_bib2","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1002\/dvdy.24232","article-title":"Input overload: contributions of retinoic acid signaling feedback mechanisms to heart development and teratogenesis","volume":"244","author":"D'Aniello","year":"2015","journal-title":"Dev. Dynam."},{"issue":"2","key":"10.1016\/j.bbrc.2025.151300_bib3","doi-asserted-by":"crossref","first-page":"11","DOI":"10.3390\/jdb7020011","article-title":"Reiterative mechanisms of retinoic acid signaling during vertebrate heart development","volume":"7","author":"Perl","year":"2019","journal-title":"J. Dev. Biol."},{"issue":"6114","key":"10.1016\/j.bbrc.2025.151300_bib4","first-page":"338","article-title":"C\/EBP transcription factors mediate epicardial activation during heart development and injury","volume":"12","author":"Huang","year":"2012","journal-title":"Science"},{"issue":"11","key":"10.1016\/j.bbrc.2025.151300_bib5","doi-asserted-by":"crossref","first-page":"H1773","DOI":"10.1152\/ajpheart.00887.2015","article-title":"Effects of vitamin A deficiency in the postnatal mouse heart: role of hepatic retinoid stores","volume":"310","author":"Asson-Batres","year":"2016","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.bbrc.2025.151300_bib6","article-title":"Retinoic acid signaling is directly activated in cardiomyocytes and protects mouse hearts from apoptosis after myocardial infarction","volume":"10","author":"Fabio Da Silva","year":"2021","journal-title":"Elife"},{"issue":"7","key":"10.1016\/j.bbrc.2025.151300_bib7","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0133414","article-title":"All-trans retinoic acid ameliorates myocardial ischemia\/reperfusion injury by reducing cardiomyocyte apoptosis","volume":"10","author":"Zhu","year":"2015","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.bbrc.2025.151300_bib8","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.devcel.2011.01.010","article-title":"Retinoic acid production by endocardium and epicardium is an injury response essential for zebrafish heart regeneration","volume":"20","author":"Kikuchi","year":"2011","journal-title":"Dev. Cell"},{"key":"10.1016\/j.bbrc.2025.151300_bib9","article-title":"Association of ischemic cardiovascular disease with inadequacy of liver store of retinol in elderly individuals","volume":"9785231","author":"Lima","year":"2018","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"8","key":"10.1016\/j.bbrc.2025.151300_bib10","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.137593","article-title":"Cardiac retinoic acid levels decline in heart failure","volume":"6","author":"Yang","year":"2021","journal-title":"JCI Insight"},{"key":"10.1016\/j.bbrc.2025.151300_bib11","first-page":"10","article-title":"Frontiers | Association of nonalcoholic fatty liver disease and liver fibrosis detected by transient elastography with serum retinol in American adults","author":"Niu","year":"2023","journal-title":"Front. Nutr."},{"issue":"2","key":"10.1016\/j.bbrc.2025.151300_bib12","doi-asserted-by":"crossref","DOI":"10.1039\/D2FO02204D","article-title":"The association between serum vitamin A and NAFLD among US adults varied in different BMI groups: a cross-sectional study","volume":"14","author":"Zhang","year":"2023","journal-title":"Food Funct."},{"key":"10.1016\/j.bbrc.2025.151300_bib13","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2021.740435","article-title":"Metabolomic profiles of plasma retinol-associated dyslipidemia in men and women","volume":"8","author":"Wang","year":"2021","journal-title":"Front. Nutr."},{"key":"10.1016\/j.bbrc.2025.151300_bib14","series-title":"The Eye and in the Liver","first-page":"10422","article-title":"Lecithin-retinol acyltransferase is essential for accumulation of all-trans-retinyl esters","author":"Batten","year":"2004"},{"key":"10.1016\/j.bbrc.2025.151300_bib15","series-title":"Disruption of the Lecithin:retinol Acyltransferase Gene Makes Mice More Susceptible to Vitamin A Deficiency","first-page":"40226","author":"Liu","year":"2005"},{"key":"10.1016\/j.bbrc.2025.151300_bib16","series-title":"Retinoid Absorption and Storage Is Impaired in Mice Lacking Lecithin:retinol Acyltransferase (LRAT)","first-page":"35647","author":"O'Byrne","year":"2005"},{"issue":"17","key":"10.1016\/j.bbrc.2025.151300_bib17","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCULATIONAHA.108.780999","article-title":"Metabolic management of acute myocardial infarction comes to the fore and extends beyond control of hyperglycemia","volume":"117","author":"Opie","year":"2008","journal-title":"Circulation"},{"issue":"2","key":"10.1016\/j.bbrc.2025.151300_bib18","doi-asserted-by":"crossref","DOI":"10.1017\/S0007114507182659","article-title":"Vitamin A deficiency modifies lipid metabolism in rat liver | British Journal of Nutrition | Cambridge Core","volume":"97","author":"Oliveros","year":"2007","journal-title":"Br. J. Nutr."},{"issue":"7\u20138","key":"10.1016\/j.bbrc.2025.151300_bib19","article-title":"Effect of nutritional vitamin A deficiency on lipid metabolism in the rat heart: its relation to PPAR gene expression","volume":"25","author":"Vega","year":"2009","journal-title":"Nutrition"},{"issue":"10","key":"10.1016\/j.bbrc.2025.151300_bib20","article-title":"The role of CD36 in the regulation of myocardial lipid metabolism","volume":"1861","author":"Kim Tt","year":"2016","journal-title":"Biochim. Biophys. Acta Mol. Cell Biol. Lipids"},{"issue":"1","key":"10.1016\/j.bbrc.2025.151300_bib21","doi-asserted-by":"crossref","DOI":"10.12997\/jla.2020.9.1.66","article-title":"CD36 (SR-B2) as a target to treat lipid overload-induced cardiac dysfunction","volume":"9","author":"Glatz","year":"2020","journal-title":"Journal of Lipid and Atherosclerosis"},{"issue":"10","key":"10.1016\/j.bbrc.2025.151300_bib22","doi-asserted-by":"crossref","first-page":"2791","DOI":"10.1172\/JCI30335","article-title":"Cardiomyocyte expression of PPAR\u03b3 leads to cardiac dysfunction in mice","volume":"117","author":"Son","year":"2007","journal-title":"J. Clin. Invest."},{"issue":"1","key":"10.1016\/j.bbrc.2025.151300_bib23","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.ydbio.2015.06.008","article-title":"Excessive feedback of Cyp26a1 promotes cell non-autonomous loss of retinoic acid signaling","volume":"405","author":"Rydeen","year":"2015","journal-title":"Dev. Biol."},{"issue":"5","key":"10.1016\/j.bbrc.2025.151300_bib24","doi-asserted-by":"crossref","DOI":"10.1210\/me.2010-0465","article-title":"Concerted action of aldehyde dehydrogenases influences depot-specific fat formation","volume":"25","author":"Reichert","year":"2011","journal-title":"Mol. Endocrinol."},{"issue":"6","key":"10.1016\/j.bbrc.2025.151300_bib25","doi-asserted-by":"crossref","first-page":"2061","DOI":"10.3390\/ijms21062061","article-title":"PPARs as metabolic regulators in the liver: lessons from liver-specific PPAR-null mice","volume":"21","author":"Wang","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.bbrc.2025.151300_bib26","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1161\/01.CIR.99.1.121","article-title":"Mobilization of antioxidant vitamin pools and hemodynamic function after myocardial infarction","volume":"99","author":"Palace","year":"1999","journal-title":"Circulation"},{"issue":"7","key":"10.1016\/j.bbrc.2025.151300_bib27","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1006\/jmcc.2002.2015","article-title":"Maintenance of myocardial levels of vitamin A in heart failure due to adriamycin","volume":"34","author":"Danelisen","year":"2002","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.bbrc.2025.151300_bib28","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.66921","article-title":"Integrative transcriptomic analysis of tissue-specific metabolic crosstalk after myocardial infarction","volume":"10","author":"Arif","year":"2021","journal-title":"Elife"},{"issue":"2","key":"10.1016\/j.bbrc.2025.151300_bib29","doi-asserted-by":"crossref","DOI":"10.1093\/ajcn\/83.2.191","article-title":"The acute and chronic toxic effects of vitamin A","volume":"83","author":"Penniston","year":"2006","journal-title":"Am. J. Clin. Nutr."},{"issue":"2","key":"10.1016\/j.bbrc.2025.151300_bib30","doi-asserted-by":"crossref","DOI":"10.1093\/ajcn\/52.2.183","article-title":"Evaluation of vitamin A toxicity","volume":"52","author":"Hathcock","year":"1990","journal-title":"Am. J. Clin. Nutr."},{"issue":"18","key":"10.1016\/j.bbrc.2025.151300_bib31","doi-asserted-by":"crossref","DOI":"10.1056\/NEJM199605023341802","article-title":"Effects of a combination of beta carotene and vitamin A on lung cancer and cardiovascular disease - PubMed","volume":"334","author":"Omenn","year":"1996","journal-title":"N. Engl. J. Med."},{"issue":"15","key":"10.1016\/j.bbrc.2025.151300_bib32","article-title":"The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers - PubMed","volume":"330","year":"1994","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bbrc.2025.151300_bib33","first-page":"99","article-title":"Loss of myocardial retinoic acid receptor \u03b1 induces diastolic dysfunction by promoting intracellular oxidative stress and calcium mishandling in adult mice","volume":"10","author":"Zhu","year":"2016","journal-title":"J. Mol. Cell. Cardiol."},{"issue":"1","key":"10.1016\/j.bbrc.2025.151300_bib34","article-title":"Retinol dehydrogenase 10 reduction mediated retinol metabolism disorder promotes diabetic cardiomyopathy in male mice","volume":"14","author":"Wu","year":"2023","journal-title":"Nat. Commun."},{"issue":"6","key":"10.1016\/j.bbrc.2025.151300_bib35","doi-asserted-by":"crossref","DOI":"10.1152\/ajpheart.00514.2022","article-title":"Vitamin A preserves cardiac energetic gene expression in a murine model of diet-induced obesity","volume":"323","author":"Naasner","year":"2022","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"10","key":"10.1016\/j.bbrc.2025.151300_bib36","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1161\/CIRCRESAHA.121.318241","article-title":"Cardiac energy metabolism in heart failure","volume":"128","author":"Lopaschuk","year":"2021","journal-title":"Circ. Res."},{"key":"10.1016\/j.bbrc.2025.151300_bib37","doi-asserted-by":"crossref","first-page":"7983","DOI":"10.1038\/s41586-023-06585-5","article-title":"Inhibition of fatty acid oxidation enables heart regeneration in adult mice","volume":"622","author":"Li","year":"2023","journal-title":"Nature"},{"issue":"11","key":"10.1016\/j.bbrc.2025.151300_bib38","doi-asserted-by":"crossref","DOI":"10.1093\/jn\/130.11.2691","article-title":"Supplemental vitamin A improves anemia and growth in anemic school children in Tanzania","volume":"130","author":"Mwanri","year":"2000","journal-title":"J. Nutr."},{"issue":"2","key":"10.1016\/j.bbrc.2025.151300_bib39","doi-asserted-by":"crossref","DOI":"10.1093\/ajcn\/71.2.507","article-title":"Vitamin A supplementation selectively improves the linear growth of Indonesian preschool children: results from a randomized controlled trial","volume":"71","author":"Hadi","year":"2000","journal-title":"Am. J. Clin. Nutr."},{"issue":"6","key":"10.1016\/j.bbrc.2025.151300_bib40","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1038\/nm1587","article-title":"Retinaldehyde represses adipogenesis and diet-induced obesity","volume":"13","author":"Ziouzenkova","year":"2007","journal-title":"Nat. Med."},{"issue":"2","key":"10.1016\/j.bbrc.2025.151300_bib41","doi-asserted-by":"crossref","DOI":"10.2337\/db22-0192","article-title":"Sex differences in adipose tissue distribution determine susceptibility to neuroinflammation in mice with dietary obesity","volume":"72","author":"Stranahan","year":"2023","journal-title":"Diabetes"},{"issue":"2","key":"10.1016\/j.bbrc.2025.151300_bib42","article-title":"Cooperative interaction between retinoic acid receptor-alpha and estrogen receptor in breast cancer - PubMed","volume":"24","author":"Caryn","year":"2010","journal-title":"Gene Dev."},{"issue":"10","key":"10.1016\/j.bbrc.2025.151300_bib43","doi-asserted-by":"crossref","DOI":"10.1210\/en.2004-0514","article-title":"Estrogen directly induces expression of retinoic acid biosynthetic enzymes, compartmentalized between the epithelium and underlying stromal cells in rat uterus","volume":"145","author":"Li","year":"2004","journal-title":"Endocrinology"},{"key":"10.1016\/j.bbrc.2025.151300_bib44","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.3390\/nu14081553","article-title":"Retinoic acid: sexually dimorphic, anti-insulin and concentration-dependent effects on energy","volume":"14","author":"Napoli","year":"2022","journal-title":"Nutrients"},{"key":"10.1016\/j.bbrc.2025.151300_bib45","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.jchromb.2016.06.043","article-title":"An HPLC-MS\/MS method for the separation of alpha-retinyl esters from retinyl esters","volume":"1029\u20131030","author":"Goetz","year":"2016","journal-title":"J. Chromatogr., B: Anal. Technol. Biomed. Life Sci."},{"issue":"7","key":"10.1016\/j.bbrc.2025.151300_bib46","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1194\/jlr.D200012-JLR200","article-title":"Retinoid quantification by HPLC\/MS(n)","volume":"43","author":"McCaffery","year":"2002","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.bbrc.2025.151300_bib47","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1186\/1471-2105-10-48","article-title":"GOrilla: a tool for discovery and visualization of enriched GO terms in ranked gene lists","volume":"10","author":"Eden","year":"2009","journal-title":"BMC Bioinf."},{"issue":"D1","key":"10.1016\/j.bbrc.2025.151300_bib48","doi-asserted-by":"crossref","first-page":"D638","DOI":"10.1093\/nar\/gkac1000","article-title":"The STRING database in 2023: protein-protein association networks and functional enrichment analyses for any sequenced genome of interest","volume":"51","author":"Szklarczyk","year":"2023","journal-title":"Nucleic Acids Res."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X25000142?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X25000142?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T04:29:44Z","timestamp":1777264184000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X25000142"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":48,"alternative-id":["S0006291X25000142"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2025.151300","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Vitamin A deficiency and male-specific effects on heart function in mice","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2025.151300","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"151300"}}