{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T05:46:06Z","timestamp":1793339166432,"version":"4.5.0"},"reference-count":28,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T00:00:00Z","timestamp":1736726400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1016\/j.bbrc.2025.151317","type":"journal-article","created":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T20:11:30Z","timestamp":1736453490000},"page":"151317","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Heat-inactivated Lactobacillus casei strain GKC1 Mitigates osteoporosis development in vivo via enhanced osteogenesis"],"prefix":"10.1016","volume":"748","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-2372-1136","authenticated-orcid":false,"given":"Li-Chan","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8613-344X","authenticated-orcid":false,"given":"Tsung-Ju","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Fang","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9585-2219","authenticated-orcid":false,"given":"You-Shan","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ci-Sian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shih-Wei","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yen-Lien","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chin-Chu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2025.151317_bib1","doi-asserted-by":"crossref","first-page":"2137","DOI":"10.1007\/s00198-022-06454-3","article-title":"Global, regional prevalence, and risk factors of osteoporosis according to the World Health Organization diagnostic criteria: a systematic review and meta-analysis","volume":"33","author":"Xiao","year":"2022","journal-title":"Osteoporos. Int."},{"key":"10.1016\/j.bbrc.2025.151317_bib2","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1007\/s00198-016-3865-3","article-title":"The impact of the new National Bone Health Alliance (NBHA) diagnostic criteria on the prevalence of osteoporosis in the USA","volume":"28","author":"Wright","year":"2017","journal-title":"Osteoporos. Int."},{"key":"10.1016\/j.bbrc.2025.151317_bib3","doi-asserted-by":"crossref","first-page":"46","DOI":"10.5152\/eurjrheum.2016.048","article-title":"An overview and management of osteoporosis","volume":"4","author":"Sozen","year":"2017","journal-title":"Eur J Rheumatol"},{"key":"10.1016\/j.bbrc.2025.151317_bib4","doi-asserted-by":"crossref","first-page":"1842","DOI":"10.1359\/jbmr.2003.18.10.1842","article-title":"BMP-2 controls alkaline phosphatase expression and osteoblast mineralization by a Wnt autocrine loop","volume":"18","author":"Rawadi","year":"2003","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bbrc.2025.151317_bib5","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.690113","article-title":"Albiflorin promotes osteoblast differentiation and healing of Rat femoral fractures through enhancing BMP-2\/smad and wnt\/\u03b2-catenin signaling","volume":"12","author":"Kim","year":"2021","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.bbrc.2025.151317_bib6","doi-asserted-by":"crossref","first-page":"3553","DOI":"10.3390\/ijms22073553","article-title":"Skeletal aging and osteoporosis: mechanisms and therapeutics","volume":"22","author":"Chandra","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbrc.2025.151317_bib7","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1038\/nm1593","article-title":"Skeletal remodeling in health and disease","volume":"13","author":"Zaidi","year":"2007","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbrc.2025.151317_bib8","doi-asserted-by":"crossref","first-page":"253","DOI":"10.7326\/0003-4819-128-4-199802150-00001","article-title":"Alendronate prevents postmenopausal bone loss in women without osteoporosis. A double-blind, randomized, controlled trial. Alendronate Osteoporosis Prevention Study Group","volume":"128","author":"McClung","year":"1998","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.bbrc.2025.151317_bib9","article-title":"Risedronate for the primary and secondary prevention of osteoporotic fractures in postmenopausal women","volume":"5","author":"Wells","year":"2022","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.bbrc.2025.151317_bib10","doi-asserted-by":"crossref","first-page":"2139","DOI":"10.1002\/jbmr.4409","article-title":"Romosozumab improves lumbar spine bone mass and bone strength parameters relative to alendronate in postmenopausal women: results from the Active-Controlled Fracture Study in Postmenopausal Women with Osteoporosis at High Risk (ARCH) trial","volume":"36","author":"Brown","year":"2021","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bbrc.2025.151317_bib11","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.jsbmb.2013.09.008","article-title":"Prevention and treatment of postmenopausal osteoporosis","volume":"142","author":"Tella","year":"2014","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.bbrc.2025.151317_bib12","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1038\/nrgastro.2014.66","article-title":"Expert consensus document. The International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic","volume":"11","author":"Hill","year":"2014","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.bbrc.2025.151317_bib13","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/j.tem.2016.08.003","article-title":"Linking the microbiota, chronic disease, and the immune system","volume":"27","author":"Hand","year":"2016","journal-title":"Trends Endocrinol. Metabol."},{"key":"10.1016\/j.bbrc.2025.151317_bib14","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1038\/nrgastro.2017.88","article-title":"Gut microbiota and IBD: causation or correlation?","volume":"14","author":"Ni","year":"2017","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.bbrc.2025.151317_bib15","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.bonr.2018.02.001","article-title":"Lactobacillus acidophilus inhibits bone loss and increases bone heterogeneity in osteoporotic mice via modulating Treg-Th17 cell balance","volume":"8","author":"Dar","year":"2018","journal-title":"BoneKEy Rep."},{"key":"10.1016\/j.bbrc.2025.151317_bib16","doi-asserted-by":"crossref","first-page":"438","DOI":"10.14336\/AD.2019.0523","article-title":"Gut microbiome and osteoporosis","volume":"11","author":"Ding","year":"2020","journal-title":"Aging Dis"},{"key":"10.1016\/j.bbrc.2025.151317_bib17","article-title":"Are heat-killed probiotics more effective than live ones on colon length shortness, disease activity index, and the histological score of an inflammatory bowel disease-induced murine model? A meta-analysis","volume":"134","author":"Poaty Ditengou","year":"2023","journal-title":"J. Appl. Microbiol."},{"issue":"6","key":"10.1016\/j.bbrc.2025.151317_bib18","first-page":"1","article-title":"Abrupt suspension of probiotics administration may increase host pathogen susceptibility by inducing gut dysbiosis","volume":"6:1","author":"Liu","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbrc.2025.151317_bib19","doi-asserted-by":"crossref","first-page":"3318","DOI":"10.1172\/JCI27071","article-title":"Pathogenesis of osteoporosis: concepts, conflicts, and prospects","volume":"115","author":"Raisz","year":"2005","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbrc.2025.151317_bib20","first-page":"1371","article-title":"Risk factors of osteoporosis in females: a hospital-based case-control study, yazd, Iran","volume":"51","author":"Askari","year":"2022","journal-title":"Iran. J. Public Health"},{"key":"10.1016\/j.bbrc.2025.151317_bib21","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/978-3-319-66653-2_4","article-title":"Gut microbiota and bone health","volume":"1033","author":"Quach","year":"2017","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.bbrc.2025.151317_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.bone.2019.115214","article-title":"Effect of inducible bone morphogenetic protein 2 expression on the osteogenic differentiation of dental pulp stem cells in vitro","volume":"132","author":"T\u00f3th","year":"2020","journal-title":"Bone"},{"key":"10.1016\/j.bbrc.2025.151317_bib23","doi-asserted-by":"crossref","first-page":"30689","DOI":"10.1074\/jbc.M500750200","article-title":"Cooperative interactions between activating transcription factor 4 and Runx2\/Cbfa1 stimulate osteoblast-specific osteocalcin gene expression","volume":"280","author":"Xiao","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2025.151317_bib24","doi-asserted-by":"crossref","first-page":"8783","DOI":"10.1128\/MCB.20.23.8783-8792.2000","article-title":"Runx2 is a common target of transforming growth factor beta1 and bone morphogenetic protein 2, and cooperation between Runx2 and Smad5 induces osteoblast-specific gene expression in the pluripotent mesenchymal precursor cell line C2C12","volume":"20","author":"Lee","year":"2000","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.bbrc.2025.151317_bib25","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1359\/JBMR.050307","article-title":"Ovariectomy-induced bone loss varies among inbred strains of mice","volume":"20","author":"Bouxsein","year":"2005","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bbrc.2025.151317_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/8756-3282(95)00285-L","article-title":"FDA Guidelines and animal models for osteoporosis","volume":"17","author":"Thompson","year":"1995","journal-title":"Bone"},{"key":"10.1016\/j.bbrc.2025.151317_bib27","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2023.2190304","article-title":"Lactobacillus rhamnosus GG ameliorates osteoporosis in ovariectomized rats by regulating the Th17\/Treg balance and gut microbiota structure","volume":"15","author":"Guo","year":"2023","journal-title":"Gut Microb."},{"key":"10.1016\/j.bbrc.2025.151317_bib28","doi-asserted-by":"crossref","first-page":"6508","DOI":"10.1210\/jc.2005-1258","article-title":"In vivo assessment of trabecular bone microarchitecture by high-resolution peripheral quantitative computed tomography","volume":"90","author":"Boutroy","year":"2005","journal-title":"J. Clin. Endocrinol. Metab."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X25000312?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X25000312?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T04:28:06Z","timestamp":1777264086000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X25000312"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":28,"alternative-id":["S0006291X25000312"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2025.151317","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Heat-inactivated Lactobacillus casei strain GKC1 Mitigates osteoporosis development in vivo via enhanced osteogenesis","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2025.151317","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"151317"}}