{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T18:25:22Z","timestamp":1789583122470,"version":"build-2803163510"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015308","name":"Xinjiang Uygur Autonomous Region Department of Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100015308","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1016\/j.bbrc.2025.151365","type":"journal-article","created":{"date-parts":[[2025,1,20]],"date-time":"2025-01-20T16:55:47Z","timestamp":1737392147000},"page":"151365","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["SW033291 promotes liver regeneration after acetaminophen-induced liver injury in mice"],"prefix":"10.1016","volume":"749","author":[{"given":"Jing","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutong","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiayidanmu","family":"Tuniyazi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinlong","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyi","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guodong","family":"L\u00fc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2025.151365_bib1","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/j.ajpath.2018.12.006","article-title":"Liver regeneration after acetaminophen hepatotoxicity: mechanisms and therapeutic opportunities","volume":"189","author":"Bhushan","year":"2019","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.bbrc.2025.151365_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhepr.2024.101131","article-title":"Acute liver failure: a practical update","volume":"6","author":"Fern\u00e1ndez","year":"2024","journal-title":"JHEP reports : innovation in hepatology"},{"key":"10.1016\/j.bbrc.2025.151365_bib3","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1016\/S0140-6736(19)31894-X","article-title":"Acute liver failure","volume":"394","author":"Stravitz","year":"2019","journal-title":"Lancet (London, England)"},{"key":"10.1016\/j.bbrc.2025.151365_bib4","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1007\/s00204-021-03211-z","article-title":"Comparing N-acetylcysteine and 4-methylpyrazole as antidotes for acetaminophen overdose","volume":"96","author":"Akakpo","year":"2022","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.bbrc.2025.151365_bib5","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1016\/j.jhep.2017.07.005","article-title":"Acetaminophen (APAP) hepatotoxicity-Isn't it time for APAP to go away?","volume":"67","author":"Lee","year":"2017","journal-title":"J. Hepatol."},{"key":"10.1016\/j.bbrc.2025.151365_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.yrtph.2020.104859","article-title":"Assessment of the biochemical pathways for acetaminophen toxicity: implications for its carcinogenic hazard potential","volume":"120","author":"Jaeschke","year":"2021","journal-title":"Regul. Toxicol. Pharmacol. : RTP (Regul. Toxicol. Pharmacol.)"},{"key":"10.1016\/j.bbrc.2025.151365_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.yrtph.2020.104788","article-title":"Application of the DILIsym\u00ae Quantitative Systems Toxicology drug-induced liver injury model to evaluate the carcinogenic hazard potential of acetaminophen","volume":"118","author":"Eichenbaum","year":"2020","journal-title":"Regul. Toxicol. Pharmacol. : RTP (Regul. Toxicol. Pharmacol.)"},{"key":"10.1016\/j.bbrc.2025.151365_bib8","doi-asserted-by":"crossref","first-page":"3740","DOI":"10.1016\/j.apsb.2021.09.023","article-title":"Recommendations for the use of the acetaminophen hepatotoxicity model for mechanistic studies and how to avoid common pitfalls","volume":"11","author":"Jaeschke","year":"2021","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.bbrc.2025.151365_bib9","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1093\/toxsci\/kfaa002","article-title":"Novel therapeutic approaches against acetaminophen-induced liver injury and acute liver failure","volume":"174","author":"Jaeschke","year":"2020","journal-title":"Toxicol. Sci. : Offi J. Soc. Toxicol."},{"key":"10.1016\/j.bbrc.2025.151365_bib10","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1073\/pnas.81.5.1327","article-title":"N-acetyl-p-benzoquinone imine: a cytochrome P-450-mediated oxidation product of acetaminophen","volume":"81","author":"Dahlin","year":"1984","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.bbrc.2025.151365_bib11","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1177\/15353702221147563","article-title":"The molecular mechanisms of acetaminophen-induced hepatotoxicity and its potential therapeutic targets","volume":"248","author":"Luo","year":"2023","journal-title":"Exp. Biol. Med."},{"key":"10.1016\/j.bbrc.2025.151365_bib12","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1080\/15563650.2017.1408812","article-title":"Fewer adverse effects with a modified two-bag acetylcysteine protocol in paracetamol overdose","volume":"56","author":"McNulty","year":"2018","journal-title":"Clin. Toxicol."},{"key":"10.1016\/j.bbrc.2025.151365_bib13","doi-asserted-by":"crossref","DOI":"10.1126\/science.aaa2340","article-title":"TISSUE REGENERATION. Inhibition of the prostaglandin-degrading enzyme 15-PGDH potentiates tissue regeneration","volume":"348","author":"Zhang","year":"2015","journal-title":"Science (New York, N.Y.)"},{"key":"10.1016\/j.bbrc.2025.151365_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2023.106646","article-title":"15-Hydroxyprostaglandin dehydrogenase inhibitor SW033291 ameliorates hepatic abnormal lipid metabolism, ER stress, and inflammation through PGE(2)\/EP4 in T2DM mice","volume":"137","author":"Wang","year":"2023","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.bbrc.2025.151365_bib15","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1038\/s41467-018-08097-7","article-title":"Prostaglandin E2 mediates sensory nerve regulation of bone homeostasis","volume":"10","author":"Chen","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbrc.2025.151365_bib16","doi-asserted-by":"crossref","first-page":"F1054","DOI":"10.1152\/ajprenal.00103.2020","article-title":"Inhibition of 15-PGDH prevents ischemic renal injury by the PGE(2)\/EP(4) signaling pathway mediating vasodilation, increased renal blood flow, and increased adenosine\/A(2A) receptors","volume":"319","author":"Kim","year":"2020","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.bbrc.2025.151365_bib17","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.bbrc.2022.05.049","article-title":"Effects of small molecule inhibitor SW033291 on hepatic ischemia-reperfusion injury in mice","volume":"615","author":"Xie","year":"2022","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbrc.2025.151365_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.plefa.2024.102640","article-title":"Inhibition of 15-prostaglandin dehydrogenase attenuates acetaminophen-induced liver injury via suppression of apoptosis in liver endothelial cells","volume":"202","author":"Shimada","year":"2024","journal-title":"Prostagl. Leukot. Essent. Fat. Acids"},{"key":"10.1016\/j.bbrc.2025.151365_bib19","article-title":"Induced hepatocyte-like cells derived from adipose-derived stem cells alleviates liver injury in mice infected with Echinococcus Multilocularis","volume":"14","author":"Liu","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbrc.2025.151365_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellsig.2021.110227","article-title":"Netrin-1 promotes liver regeneration possibly by facilitating vagal nerve repair after partial hepatectomy in mice","volume":"91","author":"Wang","year":"2022","journal-title":"Cell. Signal."},{"key":"10.1016\/j.bbrc.2025.151365_bib21","doi-asserted-by":"crossref","DOI":"10.3390\/biology11071057","article-title":"The dual role of innate immune response in acetaminophen-induced liver injury","volume":"11","author":"Yang","year":"2022","journal-title":"Biology"},{"key":"10.1016\/j.bbrc.2025.151365_bib22","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1631\/jzus.B2100977","article-title":"Molecular pathogenesis of acetaminophen-induced liver injury and its treatment options","volume":"23","author":"Cai","year":"2022","journal-title":"J. Zhejiang Univ. - Sci. B"},{"key":"10.1016\/j.bbrc.2025.151365_bib23","article-title":"Acetaminophen (paracetamol) for the common cold in adults","volume":"2013","author":"Li","year":"2013","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.bbrc.2025.151365_bib24","doi-asserted-by":"crossref","first-page":"8274","DOI":"10.1080\/07391102.2021.1910570","article-title":"The in silico mechanism of hVKOR interaction with acetaminophen and its metabolite, as well as N-acetyl cysteine: caution on application in COVID-19 patients","volume":"40","author":"Hashemi","year":"2022","journal-title":"J. Biomol. Struct. Dynam."},{"key":"10.1016\/j.bbrc.2025.151365_bib25","first-page":"9","article-title":"Perceptions of Romanian physicians on lockdowns for COVID-19 prevention","author":"Dima","year":"2021","journal-title":"Healthcare"},{"key":"10.1016\/j.bbrc.2025.151365_bib26","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1002\/hep.31116","article-title":"c-Jun NH(2) -terminal protein kinase phosphorylates the nrf2-ECH homology 6 domain of nuclear factor erythroid 2-related factor 2 and downregulates cytoprotective genes in acetaminophen-induced liver injury in mice","volume":"71","author":"Chen","year":"2020","journal-title":"Hepatology"},{"key":"10.1016\/j.bbrc.2025.151365_bib27","doi-asserted-by":"crossref","first-page":"8836","DOI":"10.7150\/thno.63396","article-title":"Role of prostaglandin E2 in tissue repair and regeneration","volume":"11","author":"Cheng","year":"2021","journal-title":"Theranostics"},{"key":"10.1016\/j.bbrc.2025.151365_bib28","doi-asserted-by":"crossref","first-page":"5348","DOI":"10.7150\/thno.27385","article-title":"Prostaglandin E(2) hydrogel improves cutaneous wound healing via M2 macrophages polarization","volume":"8","author":"Zhang","year":"2018","journal-title":"Theranostics"},{"key":"10.1016\/j.bbrc.2025.151365_bib29","first-page":"371","article-title":"Inhibition of prostaglandin-degrading enzyme 15-PGDH rejuvenates aged muscle mass and strength","author":"Palla","year":"2021","journal-title":"Science"},{"key":"10.1016\/j.bbrc.2025.151365_bib30","doi-asserted-by":"crossref","first-page":"17315","DOI":"10.1073\/pnas.1008209107","article-title":"PGE2-regulated wnt signaling and N-acetylcysteine are synergistically hepatoprotective in zebrafish acetaminophen injury","volume":"107","author":"North","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.bbrc.2025.151365_bib31","doi-asserted-by":"crossref","first-page":"6675","DOI":"10.1073\/pnas.1705420114","article-title":"Prostaglandin E2 is essential for efficacious skeletal muscle stem-cell function, augmenting regeneration and strength","volume":"114","author":"Ho","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.bbrc.2025.151365_bib32","doi-asserted-by":"crossref","first-page":"15327","DOI":"10.1021\/acs.jmedchem.2c01299","article-title":"Orally bioavailable quinoxaline inhibitors of 15-prostaglandin dehydrogenase (15-PGDH) promote tissue repair and regeneration","volume":"65","author":"Hu","year":"2022","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bbrc.2025.151365_bib33","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1186\/s13287-020-1574-5","article-title":"Effects of SW033291 on the myogenesis of muscle-derived stem cells and muscle regeneration","volume":"11","author":"Dong","year":"2020","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.bbrc.2025.151365_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2020.105102","article-title":"Current etiological comprehension and therapeutic targets of acetaminophen-induced hepatotoxicity","volume":"161","author":"Chowdhury","year":"2020","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.bbrc.2025.151365_bib35","doi-asserted-by":"crossref","first-page":"138","DOI":"10.3389\/fphys.2020.00138","article-title":"Pharmacologic blockade of 15-PGDH protects against acute renal injury induced by LPS in mice","volume":"11","author":"Miao","year":"2020","journal-title":"Front. Physiol."},{"key":"10.1016\/j.bbrc.2025.151365_bib36","doi-asserted-by":"crossref","first-page":"7204","DOI":"10.18632\/oncotarget.23208","article-title":"Inflammatory responses and inflammation-associated diseases in organs","volume":"9","author":"Chen","year":"2018","journal-title":"Oncotarget"},{"key":"10.1016\/j.bbrc.2025.151365_bib37","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1016\/j.jhep.2021.06.021","article-title":"Advanced preclinical models for evaluation of drug-induced liver injury - consensus statement by the European Drug-Induced Liver Injury Network [PRO-EURO-DILI-NET]","volume":"75","author":"Fernandez-Checa","year":"2021","journal-title":"J. Hepatol."},{"key":"10.1016\/j.bbrc.2025.151365_bib38","doi-asserted-by":"crossref","first-page":"3690","DOI":"10.1002\/ptr.7066","article-title":"The effects of honey on pro- and anti-inflammatory cytokines: a narrative review","volume":"35","author":"Navaei-Alipour","year":"2021","journal-title":"Phytother Res. : PTR"},{"key":"10.1016\/j.bbrc.2025.151365_bib39","doi-asserted-by":"crossref","first-page":"3844","DOI":"10.1073\/pnas.1602023113","article-title":"PGE2 induced in and released by dying cells functions as an inhibitory DAMP","volume":"113","author":"Hangai","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.bbrc.2025.151365_bib40","first-page":"446","article-title":"Effects of prostaglandin E2, cholera toxin and 8-bromo-cyclic AMP on lipopolysaccharide-induced gene expression of cytokines in human macrophages","volume":"84","author":"Zhong","year":"1995","journal-title":"Immunology"},{"key":"10.1016\/j.bbrc.2025.151365_bib41","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1016\/j.bbalip.2018.07.003","article-title":"The prostaglandin EP4 receptor is a master regulator of the expression of PGE(2) receptors following inflammatory activation in human monocytic cells, Biochimica et biophysica acta","volume":"1863","author":"Kashmiry","year":"2018","journal-title":"Molecular and cell biology of lipids"},{"key":"10.1016\/j.bbrc.2025.151365_bib42","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/1463216","article-title":"Activated platelets induce an anti-inflammatory response of monocytes\/macrophages through cross-regulation of PGE(2) and cytokines","volume":"2017","author":"Linke","year":"2017","journal-title":"Mediat. Inflamm."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X25000798?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X25000798?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T08:52:09Z","timestamp":1740387129000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X25000798"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":42,"alternative-id":["S0006291X25000798"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2025.151365","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"SW033291 promotes liver regeneration after acetaminophen-induced liver injury in mice","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2025.151365","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"151365"}}