{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T03:54:07Z","timestamp":1793937247595,"version":"4.8.0"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,2,7]],"date-time":"2025-02-07T00:00:00Z","timestamp":1738886400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100016692","name":"Key Research and Development Program of Ningxia","doi-asserted-by":"publisher","award":["2023BEG02011"],"award-info":[{"award-number":["2023BEG02011"]}],"id":[{"id":"10.13039\/100016692","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82060057"],"award-info":[{"award-number":["82060057"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82260086"],"award-info":[{"award-number":["82260086"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004772","name":"Ningxia Hui Autonomous Region Natural Science Foundation","doi-asserted-by":"publisher","award":["2023AAC03555"],"award-info":[{"award-number":["2023AAC03555"]}],"id":[{"id":"10.13039\/501100004772","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.1016\/j.bbrc.2025.151417","type":"journal-article","created":{"date-parts":[[2025,2,5]],"date-time":"2025-02-05T11:13:50Z","timestamp":1738754030000},"page":"151417","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Lactobacillus rhamnosus GG ameliorates atherosclerosis via suppression of oxidative stress and inflammation by reshaping the gut microbiota"],"prefix":"10.1016","volume":"751","author":[{"given":"Yajuan","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhixia","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ru","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junbai","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liting","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiwei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiyan","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Libo","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenke","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxia","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaobin","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5776-8681","authenticated-orcid":false,"given":"Hao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10","key":"10.1016\/j.bbrc.2025.151417_bib1","doi-asserted-by":"crossref","first-page":"16812","DOI":"10.1002\/jcp.28350","article-title":"A review on coronary artery disease, its risk factors, and therapeutics","volume":"234","author":"Malakar","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.bbrc.2025.151417_bib2","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/8563845","article-title":"Targeting early atherosclerosis: a focus on oxidative stress and inflammation","volume":"2019","author":"Marchio","year":"2019","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"23","key":"10.1016\/j.bbrc.2025.151417_bib3","doi-asserted-by":"crossref","DOI":"10.3390\/cells11233843","article-title":"The role of oxidative stress in atherosclerosis","volume":"11","author":"Batty","year":"2022","journal-title":"Cells"},{"issue":"11","key":"10.1016\/j.bbrc.2025.151417_bib4","doi-asserted-by":"crossref","first-page":"e450","DOI":"10.1016\/S2542-5196(19)30212-8","article-title":"Associations between habitual flavonoid intake and hospital admissions for atherosclerotic cardiovascular disease: a prospective cohort study","volume":"3","author":"Dalgaard","year":"2019","journal-title":"Lancet Planet. Health"},{"issue":"4","key":"10.1016\/j.bbrc.2025.151417_bib5","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1003095","article-title":"Febuxostat does not delay progression of carotid atherosclerosis in patients with asymptomatic hyperuricemia: a randomized, controlled trial","volume":"17","author":"Tanaka","year":"2020","journal-title":"PLoS Med."},{"issue":"26","key":"10.1016\/j.bbrc.2025.151417_bib6","doi-asserted-by":"crossref","first-page":"2497","DOI":"10.1056\/NEJMoa1912388","article-title":"Efficacy and safety of low-dose colchicine after myocardial infarction","volume":"381","author":"Tardif","year":"2019","journal-title":"N. Engl. J. Med."},{"issue":"1","key":"10.1016\/j.bbrc.2025.151417_bib7","doi-asserted-by":"crossref","DOI":"10.3390\/nu13010144","article-title":"Role of gut microbiota and their metabolites on atherosclerosis, hypertension and human blood platelet function: a review","volume":"13","author":"Duttaroy","year":"2021","journal-title":"Nutrients"},{"issue":"5","key":"10.1016\/j.bbrc.2025.151417_bib8","doi-asserted-by":"crossref","DOI":"10.3390\/nu9050521","article-title":"Antioxidant properties of probiotic bacteria","volume":"9","author":"Wang","year":"2017","journal-title":"Nutrients"},{"issue":"5","key":"10.1016\/j.bbrc.2025.151417_bib9","doi-asserted-by":"crossref","first-page":"e45","DOI":"10.1016\/j.hlc.2021.09.006","article-title":"The effects of probiotics on inflammation, endothelial dysfunction, and atherosclerosis progression: a mechanistic overview","volume":"31","author":"Mahdavi-Roshan","year":"2022","journal-title":"Heart Lung Circ."},{"issue":"5","key":"10.1016\/j.bbrc.2025.151417_bib10","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1016\/j.dsx.2020.05.034","article-title":"Lactobacillus rhamnosus GG and HbA1c in middle age and older adults without type 2 diabetes mellitus: a preliminary randomized study","volume":"14","author":"Sanborn","year":"2020","journal-title":"Diabetes Metab Syndr"},{"issue":"1","key":"10.1016\/j.bbrc.2025.151417_bib11","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/s41522-024-00486-9","article-title":"Lactobacillus rhamnosus GG ameliorates hyperuricemia in a novel model","volume":"10","author":"Fu","year":"2024","journal-title":"NPJ Biofilms Microbiomes"},{"issue":"5","key":"10.1016\/j.bbrc.2025.151417_bib12","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1016\/j.cmet.2020.03.006","article-title":"Gut-resident lactobacilli activate hepatic Nrf2 and protect against oxidative liver injury","volume":"31","author":"Saeedi","year":"2020","journal-title":"Cell Metab."},{"issue":"4\u20136","key":"10.1016\/j.bbrc.2025.151417_bib13","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.mam.2011.10.006","article-title":"Oxidative stress in health and disease: the therapeutic potential of Nrf2 activation","volume":"32","author":"Hybertson","year":"2011","journal-title":"Mol Aspects Med"},{"issue":"13","key":"10.1016\/j.bbrc.2025.151417_bib14","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21134777","article-title":"NRF2, a transcription factor for stress response and beyond","volume":"21","author":"He","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbrc.2025.151417_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.110296","article-title":"Aspirin ameliorates atherosclerotic immuno-inflammation through regulating the Treg\/Th17 axis and CD39-CD73 adenosine signaling via remodeling the gut microbiota in ApoE(-\/-) mice","volume":"120","author":"Bai","year":"2023","journal-title":"Int. Immunopharmacol."},{"issue":"4","key":"10.1016\/j.bbrc.2025.151417_bib16","doi-asserted-by":"crossref","DOI":"10.3390\/microorganisms12040794","article-title":"Molecular mechanisms of Lacticaseibacillus rhamnosus, LGG(\u00ae) probiotic function","volume":"12","author":"Leser","year":"2024","journal-title":"Microorganisms"},{"issue":"1","key":"10.1016\/j.bbrc.2025.151417_bib17","doi-asserted-by":"crossref","first-page":"62","DOI":"10.3945\/an.112.003103","article-title":"Emerging role of Nrf2 in adipocytes and adipose biology","volume":"4","author":"Schneider","year":"2013","journal-title":"Adv. Nutr."},{"key":"10.1016\/j.bbrc.2025.151417_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.111382","article-title":"Activation of sigma-1 receptor ameliorates sepsis-induced myocardial injury by mediating the Nrf2\/HO1 signaling pathway to attenuate mitochondrial oxidative stress","volume":"127","author":"Li","year":"2024","journal-title":"Int. Immunopharmacol."},{"issue":"10","key":"10.1016\/j.bbrc.2025.151417_bib19","doi-asserted-by":"crossref","first-page":"4905","DOI":"10.1039\/D3FO00967J","article-title":"Cardamonin targets KEAP1\/NRF2 signaling for protection against atherosclerosis","volume":"14","author":"Fan","year":"2023","journal-title":"Food Funct."},{"issue":"6","key":"10.1016\/j.bbrc.2025.151417_bib20","doi-asserted-by":"crossref","DOI":"10.3390\/molecules27061990","article-title":"Dihydrohomoplantagin and homoplantaginin, major flavonoid glycosides from salvia plebeia R. Br. Inhibit oxLDL-induced endothelial cell injury and restrict atherosclerosis via activating Nrf2 anti-oxidation signal pathway","volume":"27","author":"Meng","year":"2022","journal-title":"Molecules"},{"issue":"2","key":"10.1016\/j.bbrc.2025.151417_bib21","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1007\/s00059-019-4790-y","article-title":"Immunity and inflammation in atherosclerosis","volume":"44","author":"Wolf","year":"2019","journal-title":"Herz"},{"issue":"4","key":"10.1016\/j.bbrc.2025.151417_bib22","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/s41577-021-00584-1","article-title":"How the immune system shapes atherosclerosis: roles of innate and adaptive immunity","volume":"22","author":"Roy","year":"2022","journal-title":"Nat. Rev. Immunol."},{"issue":"1","key":"10.1016\/j.bbrc.2025.151417_bib23","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1161\/ATVBAHA.119.312802","article-title":"Macrophages in atherosclerosis regression","volume":"40","author":"Barrett","year":"2020","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"3","key":"10.1016\/j.bbrc.2025.151417_bib24","doi-asserted-by":"crossref","DOI":"10.1172\/JCI173034","article-title":"Itaconate suppresses atherosclerosis by activating a Nrf2-dependent antiinflammatory response in macrophages in mice","volume":"134","author":"Song","year":"2023","journal-title":"J. Clin. Investig."},{"issue":"7","key":"10.1016\/j.bbrc.2025.151417_bib25","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1038\/nri2785","article-title":"FOXP3+ regulatory T cells in the human immune system","volume":"10","author":"Sakaguchi","year":"2010","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.bbrc.2025.151417_bib26","doi-asserted-by":"crossref","first-page":"2795","DOI":"10.3389\/fimmu.2019.02795","article-title":"Getting to the heart of the matter: the role of regulatory T-cells (Tregs) in cardiovascular disease (CVD) and atherosclerosis","volume":"10","author":"Albany","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bbrc.2025.151417_bib27","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2024.1375340","article-title":"Dimethyl fumarate alleviates allergic asthma by strengthening the Nrf2 signaling pathway in regulatory T cells","volume":"15","author":"Cen","year":"2024","journal-title":"Front. Immunol."},{"issue":"3","key":"10.1016\/j.bbrc.2025.151417_bib28","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1161\/CIRCRESAHA.119.316461","article-title":"Regulatory T cells license macrophage pro-resolving functions during atherosclerosis regression","volume":"127","author":"Sharma","year":"2020","journal-title":"Circ. Res."},{"issue":"1","key":"10.1016\/j.bbrc.2025.151417_bib29","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1158\/0008-5472.CAN-06-3037","article-title":"The terminology issue for myeloid-derived suppressor cells","volume":"67","author":"Gabrilovich","year":"2007","journal-title":"Cancer Res."},{"issue":"5","key":"10.1016\/j.bbrc.2025.151417_bib30","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1016\/j.immuni.2021.04.004","article-title":"MDSC: markers, development, states, and unaddressed complexity","volume":"54","author":"Hegde","year":"2021","journal-title":"Immunity"},{"issue":"1","key":"10.1016\/j.bbrc.2025.151417_bib31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12967-021-03207-4","article-title":"Bilirubin ameliorates murine atherosclerosis through inhibiting cholesterol synthesis and reshaping the immune system","volume":"20","author":"Wen","year":"2022","journal-title":"J. Transl. Med."},{"issue":"1","key":"10.1016\/j.bbrc.2025.151417_bib32","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2023.2190304","article-title":"Lactobacillus rhamnosus GG ameliorates osteoporosis in ovariectomized rats by regulating the Th17\/Treg balance and gut microbiota structure","volume":"15","author":"Guo","year":"2023","journal-title":"Gut Microbes"},{"issue":"6","key":"10.1016\/j.bbrc.2025.151417_bib33","doi-asserted-by":"crossref","first-page":"G969","DOI":"10.1152\/ajpgi.00072.2021","article-title":"Limosilactobacillus reuteri and Lacticaseibacillus rhamnosus GG differentially affect gut microbes and metabolites in mice with Treg deficiency","volume":"320","author":"Liu","year":"2021","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.bbrc.2025.151417_bib34","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2020.607735","article-title":"Probiotic Lactobacillus rhamnosus GG promotes mouse gut microbiota diversity and T cell differentiation","volume":"11","author":"Shi","year":"2020","journal-title":"Front. Microbiol."},{"issue":"4","key":"10.1016\/j.bbrc.2025.151417_bib35","doi-asserted-by":"crossref","first-page":"2953","DOI":"10.1039\/D0FO00178C","article-title":"Alleviating effects of noni fruit polysaccharide on hepatic oxidative stress and inflammation in rats under a high-fat diet and its possible mechanisms","volume":"11","author":"Yang","year":"2020","journal-title":"Food Funct."},{"issue":"47","key":"10.1016\/j.bbrc.2025.151417_bib36","doi-asserted-by":"crossref","first-page":"14864","DOI":"10.1021\/acs.jafc.2c06417","article-title":"Fucoidan ameliorated dextran sulfate sodium-induced ulcerative colitis by modulating gut microbiota and bile acid metabolism","volume":"70","author":"Liu","year":"2022","journal-title":"J. Agric. Food Chem."},{"issue":"1","key":"10.1016\/j.bbrc.2025.151417_bib37","doi-asserted-by":"crossref","first-page":"3612","DOI":"10.1038\/s41598-022-07317-x","article-title":"Endurance exercise ameliorates Western diet-induced atherosclerosis through modulation of microbiota and its metabolites","volume":"12","author":"Huang","year":"2022","journal-title":"Sci. Rep."},{"issue":"Pt A","key":"10.1016\/j.bbrc.2025.151417_bib38","article-title":"Zanthoxylum bungeanum amides ameliorates nonalcoholic fatty liver via regulating gut microbiota and activating AMPK\/Nrf2 signaling","volume":"318","author":"Peng","year":"2024","journal-title":"J. Ethnopharmacol."},{"issue":"1","key":"10.1016\/j.bbrc.2025.151417_bib39","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s40104-023-00958-6","article-title":"Dietary supplementation of benzoic acid and essential oils combination enhances intestinal resilience against LPS stimulation in weaned piglets","volume":"15","author":"Cui","year":"2024","journal-title":"J. Anim. Sci. Biotechnol."},{"key":"10.1016\/j.bbrc.2025.151417_bib40","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2020.558525","article-title":"Inulin exerts beneficial effects on non-alcoholic fatty liver disease via modulating gut microbiome and suppressing the lipopolysaccharide-toll-like receptor 4-m\u03c8-nuclear factor-\u03baB-nod-like receptor protein 3 pathway via gut-liver Axis in mice","volume":"11","author":"Bao","year":"2020","journal-title":"Front. Pharmacol."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X25001317?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X25001317?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T14:52:16Z","timestamp":1762095136000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X25001317"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":40,"alternative-id":["S0006291X25001317"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2025.151417","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Lactobacillus rhamnosus GG ameliorates atherosclerosis via suppression of oxidative stress and inflammation by reshaping the gut microbiota","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2025.151417","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"151417"}}