{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T16:44:17Z","timestamp":1786985057838,"version":"build-2736575974"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["RS-2023-00251806"],"award-info":[{"award-number":["RS-2023-00251806"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["RS-2023-00222390"],"award-info":[{"award-number":["RS-2023-00222390"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.1016\/j.bbrc.2025.151444","type":"journal-article","created":{"date-parts":[[2025,2,4]],"date-time":"2025-02-04T02:39:34Z","timestamp":1738636774000},"page":"151444","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Dab1 expression level controls Reelin-induced PI3K-Akt activation in early GABAergic neurons"],"prefix":"10.1016","volume":"751","author":[{"given":"Kavitha","family":"Sajukumar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prabhakar","family":"Yadav","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-6626-6349","authenticated-orcid":false,"given":"Gum Hwa","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2025.151444_bib1","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1038\/374719a0","article-title":"A protein related to extracellular matrix proteins deleted in the mouse mutant reeler","volume":"374","author":"D'Arcangelo","year":"1995","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2025.151444_bib2","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S0896-6273(03)00819-5","article-title":"Reelin promotes hippocampal dendrite development through the VLDLR\/ApoER2-Dab1 pathway","volume":"41","author":"Niu","year":"2004","journal-title":"Neuron"},{"key":"10.1016\/j.bbrc.2025.151444_bib3","doi-asserted-by":"crossref","first-page":"10339","DOI":"10.1523\/JNEUROSCI.1917-08.2008","article-title":"The Reelin signaling pathway promotes dendritic spine development in hippocampal neurons","volume":"28","author":"Niu","year":"2008","journal-title":"J. Neurosci. : the official journal of the Society for Neuroscience"},{"key":"10.1016\/j.bbrc.2025.151444_bib4","doi-asserted-by":"crossref","first-page":"3719","DOI":"10.1242\/dev.125.18.3719","article-title":"Disabled-1 acts downstream of Reelin in a signaling pathway that controls laminar organization in the mammalian brain","volume":"125","author":"Rice","year":"1998","journal-title":"Development"},{"key":"10.1016\/j.bbrc.2025.151444_bib5","doi-asserted-by":"crossref","first-page":"15652","DOI":"10.1523\/JNEUROSCI.2010-13.2013","article-title":"Dab1 is required for synaptic plasticity and associative learning","volume":"33","author":"Trotter","year":"2013","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbrc.2025.151444_bib6","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1101\/gad.13.6.643","article-title":"Reelin-induced tyrosine [corrected] phosphorylation of disabled 1 during neuronal positioning","volume":"13","author":"Howell","year":"1999","journal-title":"Genes Dev."},{"key":"10.1016\/j.bbrc.2025.151444_bib7","doi-asserted-by":"crossref","first-page":"16008","DOI":"10.1074\/jbc.M101422200","article-title":"Identification of reelin-induced sites of tyrosyl phosphorylation on disabled 1","volume":"276","author":"Keshvara","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2025.151444_bib8","doi-asserted-by":"crossref","first-page":"122","DOI":"10.3389\/fncel.2016.00122","article-title":"New insights into reelin-mediated signaling pathways","volume":"10","author":"Lee","year":"2016","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.bbrc.2025.151444_bib9","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1038\/39607","article-title":"Neuronal position in the developing brain is regulated by mouse disabled-1","volume":"389","author":"Howell","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2025.151444_bib10","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1038\/79246","article-title":"Autosomal recessive lissencephaly with cerebellar hypoplasia is associated with human RELN mutations","volume":"26","author":"Hong","year":"2000","journal-title":"Nat. Genet."},{"key":"10.1016\/j.bbrc.2025.151444_bib11","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1038\/sj.mp.4000129","article-title":"Reelin mutations in mouse and man: from reeler mouse to schizophrenia, mood disorders, autism and lissencephaly","volume":"6","author":"Fatemi","year":"2001","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.bbrc.2025.151444_bib12","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1002\/humu.23584","article-title":"Rare RELN variants affect Reelin-DAB1 signal transduction in autism spectrum disorder","volume":"39","author":"Sanchez-Sanchez","year":"2018","journal-title":"Hum. Mutat."},{"key":"10.1016\/j.bbrc.2025.151444_bib13","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1038\/s41439-020-00125-7","article-title":"Rare single-nucleotide DAB1 variants and their contribution to Schizophrenia and autism spectrum disorder susceptibility","volume":"7","author":"Nawa","year":"2020","journal-title":"Hum Genome Var"},{"key":"10.1016\/j.bbrc.2025.151444_bib14","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1074\/mcp.M113.035600","article-title":"Analysis of the human tissue-specific expression by genome-wide integration of transcriptomics and antibody-based proteomics","volume":"13","author":"Fagerberg","year":"2014","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1016\/j.bbrc.2025.151444_bib15","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1038\/nature13992","article-title":"A comparative encyclopedia of DNA elements in the mouse genome","volume":"515","author":"Yue","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2025.151444_bib16","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22041745","article-title":"Disabled 1 is part of a signaling pathway activated by epidermal growth factor receptor","volume":"22","author":"Dlugosz","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbrc.2025.151444_bib17","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.neulet.2013.07.032","article-title":"VEGF activates NR2B phosphorylation through Dab1 pathway","volume":"552","author":"Howell","year":"2013","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.bbrc.2025.151444_bib18","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.conb.2016.10.003","article-title":"Cortical interneuron specification: the juncture of genes, time and geometry","volume":"42","author":"Bandler","year":"2017","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.bbrc.2025.151444_bib19","doi-asserted-by":"crossref","first-page":"2318","DOI":"10.1111\/febs.15872","article-title":"Interneuron development and dysfunction","volume":"289","author":"Yang","year":"2022","journal-title":"FEBS J."},{"key":"10.1016\/j.bbrc.2025.151444_bib20","doi-asserted-by":"crossref","first-page":"7779","DOI":"10.1523\/JNEUROSCI.18-19-07779.1998","article-title":"Regional and cellular patterns of reelin mRNA expression in the forebrain of the developing and adult mouse","volume":"18","author":"Alcantara","year":"1998","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbrc.2025.151444_bib21","doi-asserted-by":"crossref","first-page":"6924","DOI":"10.1523\/JNEUROSCI.0245-06.2006","article-title":"Layer acquisition by cortical GABAergic interneurons is independent of Reelin signaling","volume":"26","author":"Pla","year":"2006","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbrc.2025.151444_bib22","doi-asserted-by":"crossref","DOI":"10.1242\/dev.199718","article-title":"Reelin restricts dendritic growth of interneurons in the neocortex","volume":"148","author":"Hamad","year":"2021","journal-title":"Development"},{"key":"10.1016\/j.bbrc.2025.151444_bib23","article-title":"Reelin affects signaling pathways of a group of inhibitory neurons and the development of inhibitory synapses in primary neurons","volume":"22","author":"Lee","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbrc.2025.151444_bib24","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1093\/emboj\/16.1.121","article-title":"Mouse disabled (mDab1): a Src binding protein implicated in neuronal development","volume":"16","author":"Howell","year":"1997","journal-title":"EMBO J."},{"key":"10.1016\/j.bbrc.2025.151444_bib25","doi-asserted-by":"crossref","first-page":"423","DOI":"10.3389\/fncel.2017.00423","article-title":"A method to culture GABAergic interneurons derived from the medial ganglionic eminence","volume":"11","author":"Franchi","year":"2017","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.bbrc.2025.151444_bib26","doi-asserted-by":"crossref","first-page":"5662","DOI":"10.1523\/JNEUROSCI.23-13-05662.2003","article-title":"Brain-derived neurotrophic factor mediates activity-dependent dendritic growth in nonpyramidal neocortical interneurons in developing organotypic cultures","volume":"23","author":"Jin","year":"2003","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbrc.2025.151444_bib27","doi-asserted-by":"crossref","first-page":"e45","DOI":"10.1093\/nar\/29.9.e45","article-title":"A new mathematical model for relative quantification in real-time RT-PCR","volume":"29","author":"Pfaffl","year":"2001","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bbrc.2025.151444_bib28","series-title":"FastQC","author":"Simon","year":"2010"},{"key":"10.1016\/j.bbrc.2025.151444_bib29","series-title":"BBMap","author":"Bushnell","year":"2014"},{"key":"10.1016\/j.bbrc.2025.151444_bib30","series-title":"FASTX Toolkit","author":"Lab","year":"2014"},{"key":"10.1016\/j.bbrc.2025.151444_bib31","series-title":"R: A Language and Environment for Statistical Computing","author":"Team","year":"2020"},{"key":"10.1016\/j.bbrc.2025.151444_bib32","doi-asserted-by":"crossref","first-page":"R22","DOI":"10.1186\/gb-2011-12-3-r22","article-title":"Improving RNA-Seq expression estimates by correcting for fragment bias","volume":"12","author":"Roberts","year":"2011","journal-title":"Genome Biol."},{"key":"10.1016\/j.bbrc.2025.151444_bib33","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1126\/science.aar6821","article-title":"Early emergence of cortical interneuron diversity in the mouse embryo","volume":"360","author":"Mi","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.bbrc.2025.151444_bib34","doi-asserted-by":"crossref","first-page":"7786","DOI":"10.1523\/JNEUROSCI.1807-07.2007","article-title":"Physiologically distinct temporal cohorts of cortical interneurons arise from telencephalic Olig2-expressing precursors","volume":"27","author":"Miyoshi","year":"2007","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbrc.2025.151444_bib35","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1093\/cercor\/bhw369","article-title":"ApoER2 controls not only neuronal migration in the intermediate zone but also termination of migration in the developing cerebral cortex","volume":"28","author":"Hirota","year":"2018","journal-title":"Cereb Cortex"},{"key":"10.1016\/j.bbrc.2025.151444_bib36","doi-asserted-by":"crossref","first-page":"7113","DOI":"10.1128\/MCB.00928-07","article-title":"Reelin signals through phosphatidylinositol 3-kinase and Akt to control cortical development and through mTor to regulate dendritic growth","volume":"27","author":"Jossin","year":"2007","journal-title":"Molecular and cellular biology"},{"key":"10.1016\/j.bbrc.2025.151444_bib37","doi-asserted-by":"crossref","first-page":"20307","DOI":"10.1074\/jbc.M114.576249","article-title":"Reelin induces Erk1\/2 signaling in cortical neurons through a non-canonical pathway","volume":"289","author":"Lee","year":"2014","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2025.151444_bib38","doi-asserted-by":"crossref","first-page":"49958","DOI":"10.1074\/jbc.M209205200","article-title":"Reelin-mediated signaling locally regulates protein kinase B\/Akt and glycogen synthase kinase 3beta","volume":"277","author":"Beffert","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2025.151444_bib39","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1016\/j.neuron.2015.03.033","article-title":"LRP8-Reelin-Regulated neuronal enhancer signature underlying learning and memory formation","volume":"86","author":"Telese","year":"2015","journal-title":"Neuron"},{"key":"10.1016\/j.bbrc.2025.151444_bib40","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22179297","article-title":"Development, diversity, and death of MGE-derived cortical interneurons","volume":"22","author":"Williams","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbrc.2025.151444_bib41","doi-asserted-by":"crossref","first-page":"9293","DOI":"10.1128\/MCB.23.24.9293-9302.2003","article-title":"Regulation of protein tyrosine kinase signaling by substrate degradation during brain development","volume":"23","author":"Arnaud","year":"2003","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.bbrc.2025.151444_bib42","doi-asserted-by":"crossref","first-page":"2717","DOI":"10.1101\/gad.1604207","article-title":"Cullin 5 regulates Dab1 protein levels and neuron positioning during cortical development","volume":"21","author":"Feng","year":"2007","journal-title":"Genes Dev."},{"key":"10.1016\/j.bbrc.2025.151444_bib43","doi-asserted-by":"crossref","first-page":"4527","DOI":"10.1523\/JNEUROSCI.17-12-04527.1997","article-title":"Brain-derived neurotrophic factor mediates the activity-dependent regulation of inhibition in neocortical cultures","volume":"17","author":"Rutherford","year":"1997","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbrc.2025.151444_bib44","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1002\/jdn.10242","article-title":"GABAergic neurons maturation is regulated by a delicate network","volume":"83","author":"Gao","year":"2023","journal-title":"Int. J. Dev. Neurosci."},{"key":"10.1016\/j.bbrc.2025.151444_bib45","doi-asserted-by":"crossref","DOI":"10.1523\/ENEURO.0433-22.2023","article-title":"Heterozygous Dab1 null mutation disrupts neocortical and hippocampal development","volume":"10","author":"Honda","year":"2023","journal-title":"eNeuro"},{"key":"10.1016\/j.bbrc.2025.151444_bib46","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1038\/nn.4216","article-title":"Adult mouse cortical cell taxonomy revealed by single cell transcriptomics","volume":"19","author":"Tasic","year":"2016","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.bbrc.2025.151444_bib47","doi-asserted-by":"crossref","first-page":"3221","DOI":"10.1073\/pnas.95.6.3221","article-title":"Reelin is preferentially expressed in neurons synthesizing gamma-aminobutyric acid in cortex and hippocampus of adult rats","volume":"95","author":"Pesold","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbrc.2025.151444_bib48","first-page":"10","article-title":"Fate of cajal-retzius neurons in the postnatal mouse neocortex","volume":"4","author":"Chowdhury","year":"2010","journal-title":"Front. Neuroanat."},{"key":"10.1016\/j.bbrc.2025.151444_bib49","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/0306-4522(90)90027-2","article-title":"Cajal-Retzius cell ontogenesis and death in mouse brain visualized with horseradish peroxidase and electron microscopy","volume":"36","author":"Derer","year":"1990","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbrc.2025.151444_bib50","first-page":"1644","article-title":"NKCC1-Mediated GABAergic signaling promotes postnatal cell death in neocortical cajal-retzius cells","volume":"27","author":"Blanquie","year":"2017","journal-title":"Cereb Cortex"},{"key":"10.1016\/j.bbrc.2025.151444_bib51","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1523\/JNEUROSCI.4515-09.2010","article-title":"Genetic fate mapping reveals that the caudal ganglionic eminence produces a large and diverse population of superficial cortical interneurons","volume":"30","author":"Miyoshi","year":"2010","journal-title":"J. Neurosci."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X25001585?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X25001585?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,4,28]],"date-time":"2025-04-28T16:00:22Z","timestamp":1745856022000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X25001585"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":51,"alternative-id":["S0006291X25001585"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2025.151444","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dab1 expression level controls Reelin-induced PI3K-Akt activation in early GABAergic neurons","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2025.151444","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"151444"}}