{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T09:37:51Z","timestamp":1778837871870,"version":"3.51.4"},"reference-count":22,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004826","name":"Beijing Natural Science Foundation","doi-asserted-by":"publisher","award":["7242042"],"award-info":[{"award-number":["7242042"]}],"id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["802430023"],"award-info":[{"award-number":["802430023"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81970524"],"award-info":[{"award-number":["81970524"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82130018"],"award-info":[{"award-number":["82130018"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82430023"],"award-info":[{"award-number":["82430023"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1016\/j.bbrc.2025.151522","type":"journal-article","created":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T11:09:41Z","timestamp":1740136181000},"page":"151522","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["ITGA8 deficiency in hepatic stellate cells attenuates CCl4-Induced liver fibrosis via suppression of COL11A1"],"prefix":"10.1016","volume":"756","author":[{"given":"Xuzhen","family":"Yan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenyue","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yiwen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aiting","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"You","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2025.151522_bib1","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1146\/annurev-pathol-011110-130246","article-title":"Pathogenesis of liver fibrosis","volume":"6","author":"Hernandez-Gea","year":"2011","journal-title":"Annu. Rev. Pathol."},{"issue":"7","key":"10.1016\/j.bbrc.2025.151522_bib2","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1046\/j.1440-1746.1999.01928.x","article-title":"Liver fibrogenesis and the role of hepatic stellate cells: new insights and prospects for therapy","volume":"14","author":"Li","year":"1999","journal-title":"J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.bbrc.2025.151522_bib3","doi-asserted-by":"crossref","first-page":"d808","DOI":"10.2741\/reeves","article-title":"Activation of hepatic stellate cells--a key issue in liver fibrosis","volume":"7","author":"Reeves","year":"2002","journal-title":"Front. Biosci."},{"issue":"12","key":"10.1016\/j.bbrc.2025.151522_bib4","doi-asserted-by":"crossref","first-page":"22613","DOI":"10.1002\/jcp.28827","article-title":"Dynamics of elastin in liver fibrosis: accumulates late during progression and degrades slowly in regression","volume":"234","author":"Chen","year":"2019","journal-title":"J. Cell. Physiol."},{"issue":"Suppl 3","key":"10.1016\/j.bbrc.2025.151522_bib5","first-page":"S84","article-title":"Hepatic stellate cells and the reversal of fibrosis","volume":"21","author":"Kisseleva","year":"2006","journal-title":"J. Gastroenterol. Hepatol."},{"issue":"3","key":"10.1016\/j.bbrc.2025.151522_bib6","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1111\/liv.15157","article-title":"Integrins as a drug target in liver fibrosis","volume":"42","author":"Rahman","year":"2022","journal-title":"Liver Int."},{"issue":"3","key":"10.1016\/j.bbrc.2025.151522_bib7","doi-asserted-by":"crossref","first-page":"G425","DOI":"10.1152\/ajpgi.00050.2011","article-title":"Role of integrins in fibrosing liver diseases","volume":"301","author":"Patsenker","year":"2011","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"issue":"3","key":"10.1016\/j.bbrc.2025.151522_bib8","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.jhep.2007.11.021","article-title":"Integrin alphavbeta6 is a marker of the progression of biliary and portal liver fibrosis and a novel target for antifibrotic therapies","volume":"48","author":"Popov","year":"2008","journal-title":"J. Hepatol."},{"issue":"2","key":"10.1016\/j.bbrc.2025.151522_bib9","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.ajpath.2020.10.011","article-title":"Integrin \u03b21 establishes liver microstructure and modulates transforming growth factor \u03b2 during liver development and regeneration","volume":"191","author":"Masuzaki","year":"2021","journal-title":"Am. J. Pathol."},{"issue":"10","key":"10.1016\/j.bbrc.2025.151522_bib10","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202100374R","article-title":"Selective depletion of hepatic stellate cells-specific LOXL1 alleviates liver fibrosis","volume":"35","author":"Yang","year":"2021","journal-title":"Faseb j"},{"issue":"6","key":"10.1016\/j.bbrc.2025.151522_bib11","doi-asserted-by":"crossref","first-page":"G608","DOI":"10.1152\/ajpgi.00004.2023","article-title":"Selective inhibition of hepatic stellate cell and fibroblast-derived LOXL1 attenuates BDL- and Mdr2(-\/-)-induced cholestatic liver fibrosis","volume":"325","author":"Yan","year":"2023","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"issue":"11","key":"10.1016\/j.bbrc.2025.151522_bib12","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0048362","article-title":"Tubulointerstitial de novo expression of the \u03b18 integrin chain in a rodent model of renal fibrosis--a potential target for anti-fibrotic therapy?","volume":"7","author":"Hartner","year":"2012","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.bbrc.2025.151522_bib13","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.yjmcc.2003.11.007","article-title":"Alpha8beta1 integrin is upregulated in myofibroblasts of fibrotic and scarring myocardium","volume":"36","author":"Bouzeghrane","year":"2004","journal-title":"J. Mol. Cell. Cardiol."},{"issue":"6","key":"10.1016\/j.bbrc.2025.151522_bib14","doi-asserted-by":"crossref","first-page":"1927","DOI":"10.1016\/S0002-9440(10)65066-3","article-title":"Expression of the integrin alpha8beta1 during pulmonary and hepatic fibrosis","volume":"156","author":"Levine","year":"2000","journal-title":"Am. J. Pathol."},{"issue":"5","key":"10.1016\/j.bbrc.2025.151522_bib15","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0197937","article-title":"Role of integrin alpha8 in murine model of lung fibrosis","volume":"13","author":"Hung","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.bbrc.2025.151522_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2024.107363","article-title":"Homodimerization of CB(2) cannabinoid receptor triggered by a bivalent ligand enhances cellular signaling","volume":"208","author":"Navarro","year":"2024","journal-title":"Pharmacol. Res."},{"issue":"1","key":"10.1016\/j.bbrc.2025.151522_bib17","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-12691-y","article-title":"Modeling the kinetics of integrin receptor binding to hepatic extracellular matrix proteins","volume":"7","author":"Hudson","year":"2017","journal-title":"Sci. Rep."},{"issue":"7","key":"10.1016\/j.bbrc.2025.151522_bib18","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1177\/0885328218823457","article-title":"Identification of specific integrin cross-talk for dermal fibroblast cell adhesion using a mixed peptide-chitosan matrix","volume":"33","author":"Hozumi","year":"2019","journal-title":"J. Biomater. Appl."},{"key":"10.1016\/j.bbrc.2025.151522_bib19","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms14348","article-title":"\u03b1V-class integrins exert dual roles on \u03b15\u03b21 integrins to strengthen adhesion to fibronectin","volume":"8","author":"Bharadwaj","year":"2017","journal-title":"Nat. Commun."},{"issue":"2","key":"10.1016\/j.bbrc.2025.151522_bib20","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1007\/s00109-020-02026-2","article-title":"Cooperative signaling between integrins and growth factor receptors in fibrosis","volume":"99","author":"Maldonado","year":"2021","journal-title":"J. Mol. Med. (Berl.)"},{"issue":"11_Supplement","key":"10.1016\/j.bbrc.2025.151522_bib21","doi-asserted-by":"crossref","DOI":"10.1158\/1557-3265.OVCASYMP16-TMEM-017","article-title":"Abstract TMEM-017: collagen type xi alpha 1 (COL11A1) IS a novel stromal mediator of chemoresIStance","volume":"23","author":"Rada","year":"2017","journal-title":"Clin. Cancer Res."},{"issue":"2","key":"10.1016\/j.bbrc.2025.151522_bib22","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.canlet.2016.09.001","article-title":"A COL11A1-correlated pan-cancer gene signature of activated fibroblasts for the prioritization of therapeutic targets","volume":"382","author":"Jia","year":"2016","journal-title":"Cancer Lett."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X25002360?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X25002360?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T18:04:36Z","timestamp":1777399476000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X25002360"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":22,"alternative-id":["S0006291X25002360"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2025.151522","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"ITGA8 deficiency in hepatic stellate cells attenuates CCl4-Induced liver fibrosis via suppression of COL11A1","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2025.151522","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"151522"}}