{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T17:35:03Z","timestamp":1772127303985,"version":"3.50.1"},"reference-count":94,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"publisher","award":["3\/1\/2(05)\/OBS\/2022-NCD-II"],"award-info":[{"award-number":["3\/1\/2(05)\/OBS\/2022-NCD-II"]}],"id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1016\/j.bbrc.2025.151567","type":"journal-article","created":{"date-parts":[[2025,3,5]],"date-time":"2025-03-05T00:05:25Z","timestamp":1741133125000},"page":"151567","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Stimulation of auricular vagus nerve ameliorates chronic stress induced metabolic syndrome via activation of Sirtuin-6"],"prefix":"10.1016","volume":"756","author":[{"given":"Arjun Singh","family":"Kaushik","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vipul","family":"Agarwal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neeraj","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mujeeba","family":"Rehman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rishabh","family":"Chaudhary","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siddhi","family":"Srivastava","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sukriti","family":"Srivastava","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vikas","family":"Mishra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2025.151567_bib1","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1177\/1753944717711379","article-title":"Metabolic syndrome: pathophysiology, management, and modulation by natural compounds","volume":"11","author":"Rochlani","year":"2017","journal-title":"Ther. Adv. Cardiovasc. Dis."},{"key":"10.1016\/j.bbrc.2025.151567_bib2","doi-asserted-by":"crossref","first-page":"134","DOI":"10.3390\/diabetology4020015","article-title":"Progress in understanding metabolic syndrome and knowledge of its complex pathophysiology","volume":"4","author":"Jha","year":"2023","journal-title":"Diabetology"},{"key":"10.1016\/j.bbrc.2025.151567_bib3","article-title":"Metabolic syndrome: risk factors, diagnosis, pathogenesis, and management with natural approaches","volume":"3","year":"2023","journal-title":"Food Chem. Adv."},{"key":"10.1016\/j.bbrc.2025.151567_bib4","doi-asserted-by":"crossref","first-page":"2254","DOI":"10.3390\/nu13072254","article-title":"Metabolic syndrome: is it time to add the central nervous system?","volume":"13","author":"Rojas","year":"2021","journal-title":"Nutrients"},{"key":"10.1016\/j.bbrc.2025.151567_bib5","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1242\/dmm.001180","article-title":"A comprehensive definition for metabolic syndrome","volume":"2","author":"Huang","year":"2009","journal-title":"Dis. Model Mech."},{"key":"10.1016\/j.bbrc.2025.151567_bib6","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/s13098-017-0225-1","article-title":"Cardiovascular risk assessment in patients with diabetes","volume":"9","author":"Bertoluci","year":"2017","journal-title":"Diabetol. Metab. Syndr."},{"key":"10.1016\/j.bbrc.2025.151567_bib7","doi-asserted-by":"crossref","first-page":"2735","DOI":"10.1161\/CIRCULATIONAHA.105.169404","article-title":"Diagnosis and management of the metabolic syndrome","volume":"112","author":"Grundy","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.bbrc.2025.151567_bib8","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1038\/s41574-022-00746-8","article-title":"The multiple roles of life stress in metabolic disorders","volume":"19","author":"Kivim\u00e4ki","year":"2023","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.bbrc.2025.151567_bib9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.psyneuen.2004.05.007","article-title":"Role of stress in the pathogenesis of the metabolic syndrome","volume":"30","author":"Rosmond","year":"2005","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.bbrc.2025.151567_bib10","doi-asserted-by":"crossref","first-page":"R55","DOI":"10.1530\/EC-14-0031","article-title":"The appraisal of chronic stress and the development of the metabolic syndrome: a systematic review of prospective cohort studies","volume":"3","author":"Bergmann","year":"2014","journal-title":"Endocrine Connect."},{"key":"10.1016\/j.bbrc.2025.151567_bib11","first-page":"16","article-title":"Chronic unpredictable mild stress progressively disturbs glucose metabolism and appetite hormones in rats","volume":"14","author":"L\u00f3pez L\u00f3pez","year":"2018","journal-title":"Acta Endocrinol."},{"key":"10.1016\/j.bbrc.2025.151567_bib12","doi-asserted-by":"crossref","first-page":"623","DOI":"10.3390\/ijms22020623","article-title":"Molecular mechanisms of glucocorticoid-induced insulin resistance","volume":"22","author":"Beaupere","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbrc.2025.151567_bib13","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.ecl.2013.10.005","article-title":"Mechanisms of glucocorticoid-induced insulin resistance","volume":"43","author":"Geer","year":"2014","journal-title":"Endocrinol Metab. Clin. N. Am."},{"key":"10.1016\/j.bbrc.2025.151567_bib14","doi-asserted-by":"crossref","first-page":"2692","DOI":"10.1210\/jc.2009-0370","article-title":"The pathogenetic role of cortisol in the metabolic syndrome: a hypothesis","volume":"94","author":"Anagnostis","year":"2009","journal-title":"J. Clin. Endocrinol. Metabol."},{"key":"10.1016\/j.bbrc.2025.151567_bib15","doi-asserted-by":"crossref","first-page":"8178","DOI":"10.3390\/ijms23158178","article-title":"New insights into the role of insulin and hypothalamic-pituitary-adrenal (HPA) axis in the metabolic syndrome","volume":"23","author":"Janssen","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbrc.2025.151567_bib16","doi-asserted-by":"crossref","first-page":"3344","DOI":"10.3390\/ijms22073344","article-title":"The \u2018jekyll and hyde\u2019 of gluconeogenesis: early life adversity, later life stress, and metabolic disturbances","volume":"22","author":"Seal","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbrc.2025.151567_bib17","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1016\/j.jpsychires.2011.01.016","article-title":"Altered Sirtuin deacetylase gene expression in patients with a mood disorder","volume":"45","author":"Abe","year":"2011","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.bbrc.2025.151567_bib18","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.14336\/AD.2022.0413","article-title":"SIRT6 in aging, metabolism, inflammation and cardiovascular diseases","volume":"13","author":"Guo","year":"2022","journal-title":"Aging Dis"},{"key":"10.1016\/j.bbrc.2025.151567_bib19","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1111\/j.1474-9726.2009.00544.x","article-title":"SIRT6 protects against pathological damage caused by diet-induced obesity","volume":"9","author":"Kanfi","year":"2010","journal-title":"Aging Cell"},{"key":"10.1016\/j.bbrc.2025.151567_bib20","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1016\/j.bbrc.2018.10.017","article-title":"Phencynonate mediates antidepressant response by activating Sirtuin 6-SOD2\/Prdx6 pathway","volume":"505","author":"Li","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbrc.2025.151567_bib21","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/7374086","article-title":"Chrysophanol alleviates metabolic syndrome by activating the SIRT6\/AMPK signaling pathway in Brown adipocytes","volume":"2020","author":"Liu","year":"2020","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.bbrc.2025.151567_bib22","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2020.598326","article-title":"Sirt6 deacetylase: a potential key regulator in the prevention of obesity, diabetes and neurodegenerative disease","volume":"11","author":"Raj","year":"2020","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.bbrc.2025.151567_bib23","doi-asserted-by":"crossref","first-page":"135","DOI":"10.3389\/fphys.2018.00135","article-title":"The role of Sirt6 in obesity and diabetes","volume":"9","author":"Kuang","year":"2018","journal-title":"Front. Physiol."},{"key":"10.1016\/j.bbrc.2025.151567_bib24","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.tem.2016.10.002","article-title":"SIRT6: novel mechanisms and links to aging and disease","volume":"28","author":"Tasselli","year":"2017","journal-title":"Trends Endocrinol. Metabol."},{"key":"10.1016\/j.bbrc.2025.151567_bib25","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.1161\/CIRCRESAHA.118.314032","article-title":"Endothelial SIRT6 is vital to prevent hypertension and associated cardiorenal injury through targeting Nkx3.2-GATA5 signaling","volume":"124","author":"Guo","year":"2019","journal-title":"Circ. Res."},{"key":"10.1016\/j.bbrc.2025.151567_bib26","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/j.stemcr.2020.06.012","article-title":"Sustained activation of AMPK enhances differentiation of human iPSC-derived cardiomyocytes via sirtuin activation","volume":"15","author":"Sarikhani","year":"2020","journal-title":"Stem Cell Rep."},{"key":"10.1016\/j.bbrc.2025.151567_bib27","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1038\/nrendo.2012.189","article-title":"The vagus nerve and the inflammatory reflex\u2014linking immunity and metabolism","volume":"8","author":"Pavlov","year":"2012","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.bbrc.2025.151567_bib28","doi-asserted-by":"crossref","DOI":"10.1186\/s42234-022-00100-3","article-title":"Vagus nerve stimulation and inflammation: expanding the scope beyond cytokines","volume":"8","author":"Falvey","year":"2022","journal-title":"Bioelectro. Med."},{"key":"10.1016\/j.bbrc.2025.151567_bib29","doi-asserted-by":"crossref","first-page":"8284","DOI":"10.1073\/pnas.1605635113","article-title":"Vagus nerve stimulation inhibits cytokine production and attenuates disease severity in rheumatoid arthritis","volume":"113","author":"Koopman","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.bbrc.2025.151567_bib30","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1042\/CS20210507","article-title":"Clinical perspectives on vagus nerve stimulation: present and future","volume":"136","author":"Goggins","year":"2022","journal-title":"Clin. Sci. (Lond.)"},{"key":"10.1016\/j.bbrc.2025.151567_bib31","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.nurt.2007.10.071","article-title":"Vagus nerve stimulation for epilepsy and depression","volume":"5","author":"Milby","year":"2008","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.bbrc.2025.151567_bib32","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.123.030539","article-title":"Vagus nerve stimulation and inflammation in cardiovascular disease: a state\u2010of\u2010the\u2010art review","volume":"12","author":"Bazoukis","year":"2023","journal-title":"J. Am. Heart Assoc."},{"key":"10.1016\/j.bbrc.2025.151567_bib33","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a034173","article-title":"Vagus nerve stimulation and the cardiovascular system","volume":"10","author":"Capilupi","year":"2020","journal-title":"Cold Spring Harbor Perspect. Med."},{"key":"10.1016\/j.bbrc.2025.151567_bib34","article-title":"Transcutaneous vagus nerve stimulation ameliorates cardiac abnormalities in chronically stressed rats","volume":"397","author":"V","year":"2024","journal-title":"Naunyn-Schmiedebergs Arch Pharmacol"},{"key":"10.1016\/j.bbrc.2025.151567_bib35","article-title":"Safety of transcutaneous auricular vagus nerve stimulation (taVNS): a systematic review and meta-analysis","volume":"12","author":"Kim","year":"2022","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbrc.2025.151567_bib36","doi-asserted-by":"crossref","first-page":"353","DOI":"10.3389\/fphar.2019.00353","article-title":"Transcutaneous vagus nerve stimulation regulates the cholinergic anti-inflammatory pathway to counteract 1, 2-dimethylhydrazine induced colon carcinogenesis in albino wistar rats","volume":"10","author":"Rawat","year":"2019","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.bbrc.2025.151567_bib37","article-title":"Transcutaneous auricular vagus nerve stimulation triggers melatonin secretion and is antidepressive in zucker diabetic fatty rats","volume":"9","author":"Li","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.bbrc.2025.151567_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2021.e08522","article-title":"Interleukin-6 expression and its modulation by diacerein in a rat model of chronic stress induced cardiac dysfunction","volume":"7","author":"Agarwal","year":"2021","journal-title":"Heliyon"},{"key":"10.1016\/j.bbrc.2025.151567_bib39","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fpsyt.2015.00006","article-title":"An efficient chronic unpredictable stress protocol to induce stress-related responses in C57BL\/6 mice","volume":"6","author":"Monteiro","year":"2015","journal-title":"Front. Psychiatr."},{"key":"10.1016\/j.bbrc.2025.151567_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.111046","article-title":"Chronic stress predisposes to the aggravation of inflammation in autoimmune diseases with focus on rheumatoid arthritis and psoriasis","volume":"125","author":"Chaudhary","year":"2023","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.bbrc.2025.151567_bib41","article-title":"Lactobacillus plantarum S9 alleviates lipid profile, insulin resistance, and inflammation in high-fat diet-induced metabolic syndrome rats","volume":"12","author":"Zhao","year":"2022","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbrc.2025.151567_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.physbeh.2023.114207","article-title":"Butein ameliorates chronic stress induced atherosclerosis via targeting anti-inflammatory, anti-fibrotic and BDNF pathways","volume":"267","author":"Rehman","year":"2023","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.bbrc.2025.151567_bib43","doi-asserted-by":"crossref","first-page":"2190","DOI":"10.3390\/antiox11112190","article-title":"Therapeutic effects of Heterotrigona itama (stingless bee) bee bread in improving hepatic lipid metabolism through the activation of the keap1\/Nrf2 signaling pathway in an obese rat model","volume":"11","author":"Zakaria","year":"2022","journal-title":"Antioxidants"},{"key":"10.1016\/j.bbrc.2025.151567_bib44","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1007\/BF00280883","article-title":"Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man","volume":"28","author":"Matthews","year":"1985","journal-title":"Diabetologia"},{"key":"10.1016\/j.bbrc.2025.151567_bib45","article-title":"The relationship between chronic stress, hair cortisol and hypertension","volume":"2","author":"Bautista","year":"2019","journal-title":"Int. J. Cardiol. Hypertension"},{"key":"10.1016\/j.bbrc.2025.151567_bib46","first-page":"672","article-title":"Vagal nerve stimulation for pulmonary hypertension","volume":"3","author":"Ntokou","year":"2018","journal-title":"JACC (J. Am. Coll. Cardiol.): Basic Trans. Sci."},{"key":"10.1016\/j.bbrc.2025.151567_bib47","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0277090","article-title":"Circadian stage-dependent and stimulation duration effects of transcutaneous auricular vagus nerve stimulation on heart rate variability","volume":"17","author":"Geng","year":"2022","journal-title":"PLoS One"},{"key":"10.1016\/j.bbrc.2025.151567_bib48","doi-asserted-by":"crossref","first-page":"44","DOI":"10.3390\/biom8030044","article-title":"A review of the recent advances made with SIRT6 and its implications on aging related processes, major human diseases, and possible therapeutic targets","volume":"8","author":"Khan","year":"2018","journal-title":"Biomolecules"},{"key":"10.1016\/j.bbrc.2025.151567_bib49","doi-asserted-by":"crossref","first-page":"701","DOI":"10.7150\/ijbs.29323","article-title":"Sirt6 suppresses high glucose-induced mitochondrial dysfunction and apoptosis in podocytes through AMPK activation","volume":"15","author":"Fan","year":"2019","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.bbrc.2025.151567_bib50","first-page":"474","volume":"vol. 102","author":"Bian","year":"2022"},{"key":"10.1016\/j.bbrc.2025.151567_bib51","first-page":"1057","article-title":"The impact of stress on body function: a review","volume":"16","author":"Yaribeygi","year":"2017","journal-title":"EXCLI J"},{"key":"10.1016\/j.bbrc.2025.151567_bib52","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/s12912-023-01673-3","article-title":"The impact of night shift stress and sleep disturbance on nurses quality of life: case in Palestine Red Crescent and Al-Ahli Hospital","volume":"23","author":"Al-hrinat","year":"2024","journal-title":"BMC Nurs."},{"key":"10.1016\/j.bbrc.2025.151567_bib53","doi-asserted-by":"crossref","first-page":"203","DOI":"10.2147\/RMHP.S115326","article-title":"The impact of shift work on the psychological and physical health of nurses in a general hospital: a comparison between rotating night shifts and day shifts","volume":"9","author":"Ferri","year":"2016","journal-title":"Risk Manag. Healthc. Policy"},{"key":"10.1016\/j.bbrc.2025.151567_bib54","first-page":"260","article-title":"Estimating the prevalence of stress among Indian students during the COVID-19 pandemic: a cross-sectional study from India","volume":"16","author":"Chhetri","year":"2021","journal-title":"J. Taibah Univ. Med. Sci."},{"key":"10.1016\/j.bbrc.2025.151567_bib55","article-title":"A review on linking stress, depression, and insulin resistance via low-grade chronic inflammation","volume":"36","author":"Mehdi","year":"2023","journal-title":"Biochem. Biophys. Rep."},{"key":"10.1016\/j.bbrc.2025.151567_bib56","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.joim.2020.09.002","article-title":"Yoga as a complementary therapy for metabolic syndrome: a narrative review","volume":"19","author":"Khoshnaw","year":"2021","journal-title":"J. Integrat. Med."},{"key":"10.1016\/j.bbrc.2025.151567_bib57","article-title":"The impact of yoga on stress, metabolic parameters, and cognition of Indian adolescents: a cluster randomized controlled trial","volume":"12","author":"Ranjani","year":"2023","journal-title":"Integrat. Med. Res."},{"key":"10.1016\/j.bbrc.2025.151567_bib58","doi-asserted-by":"crossref","first-page":"2935","DOI":"10.3390\/nu14142935","article-title":"Biomarker of stress, metabolic syndrome and human health","volume":"14","author":"Bouillon-Minois","year":"2022","journal-title":"Nutrients"},{"key":"10.1016\/j.bbrc.2025.151567_bib59","doi-asserted-by":"crossref","first-page":"334","DOI":"10.3390\/endocrines2030031","article-title":"The stress Axis in obesity and diabetes mellitus: an update","volume":"2","author":"Gianotti","year":"2021","journal-title":"Endocrine"},{"key":"10.1016\/j.bbrc.2025.151567_bib60","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1186\/s12986-020-00513-4","article-title":"Chronic stress, epigenetics, and adipose tissue metabolism in the obese state","volume":"17","author":"Xiao","year":"2020","journal-title":"Nutr. Metab."},{"key":"10.1016\/j.bbrc.2025.151567_bib61","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1055\/s-2007-981462","article-title":"Stress mechanisms and metabolic complications","volume":"39","author":"Kyrou","year":"2007","journal-title":"Horm. Metab. Res."},{"key":"10.1016\/j.bbrc.2025.151567_bib62","doi-asserted-by":"crossref","DOI":"10.2174\/1573403X16999201231203854","article-title":"Analysis of heart rate variability and implication of different factors on heart rate variability","volume":"17","author":"Tiwari","year":"2021","journal-title":"Curr. Cardiol. Rev."},{"key":"10.1016\/j.bbrc.2025.151567_bib63","first-page":"3","article-title":"Heart rate variability as important approach for assessment autonomic modulation","volume":"22","author":"Ferreira","year":"2016","journal-title":"Motriz: Rev. Educ. Fis."},{"key":"10.1016\/j.bbrc.2025.151567_bib64","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-68131-x","article-title":"Autonomic function in amnestic and non-amnestic mild cognitive impairment: spectral heart rate variability analysis provides evidence for a brain\u2013heart axis","volume":"10","author":"Nicolini","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbrc.2025.151567_bib65","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1007\/s12012-007-0004-6","article-title":"Heart rate variability in rodents: uses and caveats in toxicological studies","volume":"7","author":"Rowan","year":"2007","journal-title":"Cardiovasc. Toxicol."},{"key":"10.1016\/j.bbrc.2025.151567_bib66","doi-asserted-by":"crossref","DOI":"10.3389\/fpubh.2017.00258","article-title":"An overview of heart rate variability metrics and norms","volume":"5","author":"Shaffer","year":"2017","journal-title":"Front. Public Health"},{"key":"10.1016\/j.bbrc.2025.151567_bib67","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1111\/j.1540-8159.2010.02841.x","article-title":"A quantitative systematic review of normal values for short-term heart rate variability in healthy adults","volume":"33","author":"Nunan","year":"2010","journal-title":"Pacing Clin. Electrophysiol."},{"key":"10.1016\/j.bbrc.2025.151567_bib68","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1139\/cjpp-2016-0557","article-title":"Improved cardiovascular autonomic modulation in transgenic rats expressing an Ang-(1-7)-producing fusion protein","volume":"95","author":"Dartora","year":"2017","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"10.1016\/j.bbrc.2025.151567_bib69","doi-asserted-by":"crossref","first-page":"655","DOI":"10.3390\/jcm8050655","article-title":"Resting heart rate variability predicts vulnerability to pharmacologically-induced ventricular arrhythmias in male rats","volume":"8","author":"Carnevali","year":"2019","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.bbrc.2025.151567_bib70","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0277090","article-title":"Circadian stage-dependent and stimulation duration effects of transcutaneous auricular vagus nerve stimulation on heart rate variability","volume":"17","author":"Geng","year":"2022","journal-title":"PLoS One"},{"key":"10.1016\/j.bbrc.2025.151567_bib71","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1007\/s00210-023-02611-5","article-title":"Transcutaneous vagus nerve stimulation ameliorates cardiac abnormalities in chronically stressed rats","volume":"397","author":"Agarwal","year":"2024","journal-title":"Naunyn-Schmiedebergs Arch Pharmacol"},{"key":"10.1016\/j.bbrc.2025.151567_bib72","doi-asserted-by":"crossref","DOI":"10.1016\/j.pnpbp.2022.110702","article-title":"Astrocytic SIRT6 is a potential anti-depression and anti-anxiety target","volume":"123","author":"Hu","year":"2023","journal-title":"Prog. Neuro Psychopharmacol. Biol. Psychiatr."},{"key":"10.1016\/j.bbrc.2025.151567_bib73","doi-asserted-by":"crossref","first-page":"3208","DOI":"10.1038\/s41467-021-23545-7","article-title":"Restoration of energy homeostasis by SIRT6 extends healthy lifespan","volume":"12","author":"Roichman","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbrc.2025.151567_bib74","doi-asserted-by":"crossref","first-page":"3538","DOI":"10.1038\/s41598-018-21887-9","article-title":"Directed evolution of SIRT6 for improved deacylation and glucose homeostasis maintenance","volume":"8","author":"Gertman","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbrc.2025.151567_bib75","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.18632\/oncotarget.12157","article-title":"Sirtuins in glucose and lipid metabolism","volume":"8","author":"Ye","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.bbrc.2025.151567_bib76","doi-asserted-by":"crossref","first-page":"164","DOI":"10.4093\/dmj.2022.0270","article-title":"Multiple roles of sirtuin 6 in adipose tissue inflammation","volume":"47","author":"Bae","year":"2023","journal-title":"Diabetes Metab. J"},{"key":"10.1016\/j.bbrc.2025.151567_bib77","doi-asserted-by":"crossref","first-page":"29735","DOI":"10.1021\/acsomega.3c04122","article-title":"Harnessing the therapeutic potential of ginsenoside rd for activating SIRT6 in treating a mouse model of nonalcoholic fatty liver disease","volume":"8","author":"Cui","year":"2023","journal-title":"ACS Omega"},{"key":"10.1016\/j.bbrc.2025.151567_bib78","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2019.00187","article-title":"Sirtuins and type 2 diabetes: role in inflammation, oxidative stress, and mitochondrial function","volume":"10","author":"Kitada","year":"2019","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.bbrc.2025.151567_bib79","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.cytogfr.2017.11.001","article-title":"Nuclear sirtuins and inflammatory signaling pathways","volume":"38","author":"Mendes","year":"2017","journal-title":"Cytokine Growth Factor Rev."},{"key":"10.1016\/j.bbrc.2025.151567_bib80","doi-asserted-by":"crossref","first-page":"E493","DOI":"10.1152\/ajpendo.00122.2017","article-title":"SIRT6 regulates metabolic homeostasis in skeletal muscle through activation of AMPK","volume":"313","author":"Cui","year":"2017","journal-title":"Am. J. Physiol. Endocrinol. Metabol."},{"key":"10.1016\/j.bbrc.2025.151567_bib81","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.112563","article-title":"AMPK signaling in diabetes mellitus, insulin resistance and diabetic complications: a pre-clinical and clinical investigation","volume":"146","author":"Entezari","year":"2022","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.bbrc.2025.151567_bib82","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1002\/med.21753","article-title":"Emerging roles of SIRT6 in human diseases and its modulators","volume":"41","author":"Liu","year":"2021","journal-title":"Med. Res. Rev."},{"key":"10.1016\/j.bbrc.2025.151567_bib83","series-title":"Modulation of Sirtuins by Vagus Nerve Stimulation","author":"Levine","year":"2017"},{"key":"10.1016\/j.bbrc.2025.151567_bib84","doi-asserted-by":"crossref","DOI":"10.1038\/emm.2016.16","article-title":"AMPK activators: mechanisms of action and physiological activities","volume":"48","author":"Kim","year":"2016","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.bbrc.2025.151567_bib85","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1038\/ncb2329","article-title":"The AMP-activated protein kinase (AMPK) signaling pathway coordinates cell growth, autophagy, & metabolism","volume":"13","author":"Mihaylova","year":"2011","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.bbrc.2025.151567_bib86","first-page":"47","article-title":"Chapter Three - emerging role of protein kinases in diabetes mellitus: from mechanism to therapy","volume":"vol. 124","author":"Gupta","year":"2021"},{"key":"10.1016\/j.bbrc.2025.151567_bib87","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.expneurol.2017.08.013","article-title":"AMPK activation: role in the signaling pathways of neuroinflammation and neurodegeneration","volume":"298","author":"Peixoto","year":"2017","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.bbrc.2025.151567_bib88","doi-asserted-by":"crossref","first-page":"2394","DOI":"10.18632\/aging.101559","article-title":"Phosphodiesterase 4 inhibitor activates AMPK-SIRT6 pathway to prevent aging-related adipose deposition induced by metabolic disorder","volume":"10","author":"Wang","year":"2018","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.bbrc.2025.151567_bib89","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1111\/jcmm.12938","article-title":"Vagal nerve stimulation improves mitochondrial dynamics via an M3 receptor\/CaMKK\u03b2\/AMPK pathway in isoproterenol-induced myocardial ischaemia","volume":"21","author":"Xue","year":"2017","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.bbrc.2025.151567_bib90","unstructured":"US9833621B2 - Modulation of sirtuins by vagus nerve stimulation - Google Patents n.d https:\/\/patents.google.com\/patent\/US9833621B2\/en (accessed April 16, 2024)."},{"key":"10.1016\/j.bbrc.2025.151567_bib91","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s00441-024-03927-1","article-title":"The possible protective effect of luteolin on cardiovascular and hepatic changes in metabolic syndrome rat model","volume":"399","author":"Fikry","year":"2025","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.bbrc.2025.151567_bib92","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/s40199-023-00458-y","article-title":"Resveratrol and Dulaglutide ameliorate adiposity and liver dysfunction in rats with diet-induced metabolic syndrome: role of SIRT-1\/adipokines\/PPAR\u03b3 and IGF-1","volume":"31","author":"Shamardl","year":"2023","journal-title":"DARU J. Pharm. Sci."},{"key":"10.1016\/j.bbrc.2025.151567_bib93","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-019-55654-1","article-title":"Structural basis for the activation and inhibition of Sirtuin 6 by quercetin and its derivatives","volume":"9","author":"You","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbrc.2025.151567_bib94","doi-asserted-by":"crossref","first-page":"3793","DOI":"10.1074\/jbc.M114.604421","article-title":"Metformin activates AMP-activated protein kinase by promoting formation of the \u03b1\u03b2\u03b3 heterotrimeric complex","volume":"290","author":"Meng","year":"2015","journal-title":"J. Biol. Chem."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X25002815?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X25002815?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,3,18]],"date-time":"2025-03-18T05:33:48Z","timestamp":1742276028000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X25002815"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":94,"alternative-id":["S0006291X25002815"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2025.151567","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Stimulation of auricular vagus nerve ameliorates chronic stress induced metabolic syndrome via activation of Sirtuin-6","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2025.151567","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"151567"}}