{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:33:41Z","timestamp":1787063621669,"version":"build-2736575974"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004681","name":"Higher Education Commission, Pakistan","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004681","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1016\/j.bbrc.2025.151615","type":"journal-article","created":{"date-parts":[[2025,3,10]],"date-time":"2025-03-10T03:22:17Z","timestamp":1741576937000},"page":"151615","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Plausible role of carveol in gastrointestinal disorders: Mechanistic insights via H+\/K+-ATPase and voltage-gated calcium channel inhibition"],"prefix":"10.1016","volume":"758","author":[{"given":"Huma","family":"Aslam","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arif-ullah","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2639-0997","authenticated-orcid":false,"given":"Neelum Gul","family":"Qazi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1126-6317","authenticated-orcid":false,"given":"Sameen Fatima","family":"Ansari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amber Mahmood","family":"Minhas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arooj Mohsin","family":"Alvi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fawad","family":"Ali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2025.151615_bib1","first-page":"99","article-title":"Worldwide prevalence and burden of functional gastrointestinal disorders, results of Rome","volume":"160","author":"Sperber","year":"2021","journal-title":"Foundation Global Study"},{"key":"10.1016\/j.bbrc.2025.151615_bib2","author":"Aslam","year":"2022","journal-title":"Pharmacological basis of bergapten in gastrointestinal diseases focusing on H+\/K+ ATPase and voltage-gated calcium channel inhibition: A toxicol. evaluation on vital organs"},{"key":"10.1016\/j.bbrc.2025.151615_bib3","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1007\/s11938-020-00277-z","article-title":"Burden of Gastroduodenal Diseases from the Global Perspective","volume":"18","author":"Milivojevic","year":"2020","journal-title":"Current Treatment Options in Gastroenterology"},{"key":"10.1016\/j.bbrc.2025.151615_bib4","first-page":"43","article-title":"Mechanism of abnormal intestinal motility in inflammatory bowel disease: how smooth muscle contraction is reduced?","volume":"43","author":"Ohama","year":"2007"},{"key":"10.1016\/j.bbrc.2025.151615_bib5","first-page":"391","volume":"vol. 1","author":"Jehangir","year":"2019"},{"key":"10.1016\/j.bbrc.2025.151615_bib6","first-page":"6783","article-title":"Global burden of diarrheal diseases among children in developing countries: incidence, etiology, and insights from new molecular diagnostic techniques","volume":"35","author":"Kotloff","year":"2017"},{"key":"10.1016\/j.bbrc.2025.151615_bib7","first-page":"e98","article-title":"Room for improvement in the treatment of Helicobacter pylori infection: lessons from the European Registry on H","volume":"56","author":"Nyssen","year":"2022","journal-title":"pylori management (Hp-EuReg)"},{"key":"10.1016\/j.bbrc.2025.151615_bib8","doi-asserted-by":"crossref","first-page":"2357","DOI":"10.1038\/ajg.2010.253","article-title":"Psychological dysfunction is associated with symptom severity but not disease etiology or degree of gastric retention in patients with gastroparesis","volume":"105","author":"Hasler","year":"2010","journal-title":"Official journal of the American College of Gastroenterology"},{"key":"10.1016\/j.bbrc.2025.151615_bib9","first-page":"5065","volume":"27","author":"Razzaq","year":"2022","journal-title":"Novel isoxazole derivative attenuates ethanol-induced gastric mucosal injury through inhibition of H+\/K+-ATPase pump, oxidative stress and inflammatory pathways"},{"key":"10.1016\/j.bbrc.2025.151615_bib10","first-page":"468","volume":"24","author":"Bahmani","year":"2014","journal-title":"Identif. Med. Plants Treat.Urmia Gastrointest.Disord"},{"key":"10.1016\/j.bbrc.2025.151615_bib11","first-page":"627375","article-title":"New perspectives on how to discover drugs from herbal medicines: CAM\u2019s outstanding contribution to modern therapeutics","volume":"1","author":"Pan","year":"2013","journal-title":"Alternative Medicine"},{"key":"10.1016\/j.bbrc.2025.151615_bib12","first-page":"250","volume":"5","author":"Patlevi\u010d","year":"2016","journal-title":"Reactive oxygen species and anti-oxidant defense in human gastrointestinal diseases"},{"key":"10.1016\/j.bbrc.2025.151615_bib13","first-page":"863","volume":"137","author":"Ringer","year":"2005","journal-title":"Monoterpene metabolism. Cloning, expression, and characterization of (\u2212)-isopiperitenol\/(\u2212)-carveol dehydrogenase of peppermint and spearmint"},{"key":"10.1016\/j.bbrc.2025.151615_bib14","article-title":"Carveol attenuates seizure severity and neuroinflammation in pentylenetetrazole-kindled epileptic rats by regulating the Nrf2 signaling pathway","volume":"1","author":"Alvi","year":"2021","journal-title":"Oxidative medicine and cellular longevity"},{"issue":"1","key":"10.1016\/j.bbrc.2025.151615_bib15","doi-asserted-by":"crossref","first-page":"8082560","DOI":"10.1155\/2020\/8082560","article-title":"(\u2010)\u2010cis\u2010Carveol, a Natural Compound, Improves \u03b2\u2010Amyloid\u2010Peptide 1\u201042\u2010Induced Memory Impairment and Oxidative Stress in the Rat Hippocampus","volume":"2020","author":"Hritcu","year":"2020","journal-title":"BioMed Research International"},{"key":"10.1016\/j.bbrc.2025.151615_bib16","author":"Rahman","year":"2021","journal-title":"Carveol a naturally-derived potent and emerging Nrf2 activator protects against acetaminophen-induced hepatotoxicity"},{"key":"10.1016\/j.bbrc.2025.151615_bib17","first-page":"2681","volume":"25","author":"Evaristo Rodrigues da Silva","year":"2020","journal-title":"Relaxant effect of monoterpene (\u2212)-Carveol on isolated human umbilical cord arteries and the involvement of ion channels"},{"key":"10.1016\/j.bbrc.2025.151615_bib18","first-page":"529","volume":"vol. 8","author":"Sachan","year":"2016"},{"key":"10.1016\/j.bbrc.2025.151615_bib19","first-page":"5919","article-title":"Pharmacological basis of rumex hastatus D. Don in gastrointestinal diseases with focusing effects on H+\/K+-ATPase, calcium channels inhibition and PDE mediated signaling: toxicological evaluation on","volume":"27","author":"Qazi","year":"2022","journal-title":"Vital Organs"},{"key":"10.1016\/j.bbrc.2025.151615_bib20","first-page":"5659","volume":"14","author":"Faheem","year":"2021","journal-title":"Investigation of 1, 3, 4 oxadiazole derivative in PTZ-induced neurodegeneration: a simulation and molecular approach"},{"key":"10.1016\/j.bbrc.2025.151615_bib21","first-page":"1","volume":"1","author":"Qazi","year":"2024"},{"key":"10.1016\/j.bbrc.2025.151615_bib22","first-page":"1","volume":"vol. 17","author":"Sisay","year":"2017"},{"key":"10.1016\/j.bbrc.2025.151615_bib23","volume":"1","author":"Ansari","year":"2019","journal-title":"In vivo, proteomic, and in silico investigation of sapodilla for therapeutic potential in gastrointestinal disorders"},{"key":"10.1016\/j.bbrc.2025.151615_bib24","article-title":"Effect of rumex dentatus on gastrointestinal protection and toxicology in rodents via investigating H+\/K+-ATPase, calcium channels","volume":"13","author":"Qazi","year":"2022","journal-title":"PDE mediated signaling"},{"key":"10.1016\/j.bbrc.2025.151615_bib25","first-page":"136","volume":"26","author":"Rehman","year":"2012","journal-title":"Studies on antidiarrheal and antispasmodic activities of Lepidium sativum crude extract in rats"},{"key":"10.1016\/j.bbrc.2025.151615_bib26","first-page":"762","article-title":"Chemical identification, antibacterial effect and synergistic potential of mentha arvensis with 5-fluorouracil against HCT-116 colon cancer cell line","volume":"38","author":"Ullah","year":"2019","journal-title":"Lat. Am. J. Pharm"},{"key":"10.1016\/j.bbrc.2025.151615_bib27","first-page":"1","volume":"11","author":"Noor","year":"2017","journal-title":"Synthesis, characterization, anti-ulcer action and molecular docking evaluation of novel benzimidazole-pyrazole hybrids"},{"key":"10.1016\/j.bbrc.2025.151615_bib28","volume":"13","author":"Noman","year":"2022","journal-title":"Pharmacological investigation of brucine anti-ulcer potential"},{"key":"10.1016\/j.bbrc.2025.151615_bib29","doi-asserted-by":"crossref","first-page":"46358","DOI":"10.1021\/acsomega.2c04977","article-title":"Anti-diabetic activity of brucine in streptozotocin-induced rats: in silico, in vitro and in vivo studies","volume":"7","author":"Khan","year":"2022","journal-title":"ACS omega"},{"key":"10.1016\/j.bbrc.2025.151615_bib31","author":"Periwal","year":"2022","journal-title":"Bioactivity assessment of natural compounds using machine learning models trained on target similarity between drugs"},{"key":"10.1016\/j.bbrc.2025.151615_bib32","first-page":"23","volume":"13","author":"Liu","year":"2018","journal-title":"Molecular dynamics simulations and novel drug discovery"},{"key":"10.1016\/j.bbrc.2025.151615_bib33","first-page":"9179","volume":"109","author":"Tunaru","year":"2012","journal-title":"Castor oil induces laxation and uterus contraction via ricinoleic acid activating prostaglandin EP3 receptors"},{"key":"10.1016\/j.bbrc.2025.151615_bib34","first-page":"262","volume":"vol. 11","author":"Sadraei","year":"2022"},{"key":"10.1016\/j.bbrc.2025.151615_bib35","first-page":"1","volume":"15","author":"Mehmood","year":"2015","journal-title":"a. medicine, Antidiarrhoeal, antisecretory and antispasmodic activities of Matricaria chamomilla are mediated predominantly through K+-channels activation"},{"key":"10.1016\/j.bbrc.2025.151615_bib36","first-page":"613","volume":"18","author":"Tshibangu-Kabamba","year":"2021","journal-title":"Hepatology, Helicobacter pylori infection and antibiotic resistance\u2014from biology to clinical implications"},{"key":"10.1016\/j.bbrc.2025.151615_bib37","series-title":"Green Sustainable Process for Chemical and Environmental Engineering and Science","first-page":"235","article-title":"Inhibitory activity of biosurfactants against H+-K+ ATPases and defense against gastric ulcers","author":"Sarkar","year":"2022"},{"key":"10.1016\/j.bbrc.2025.151615_bib38","series-title":"Phytotherapeutic Modalities for the Management of Helicobacter pylori Associated Peptic Ulcer","author":"Zahid","year":"2020"},{"key":"10.1016\/j.bbrc.2025.151615_bib39","first-page":"1751","volume":"23","author":"Sharifi-Rad","year":"2018","journal-title":"Anti-ulcer agents: From plant extracts to phytochemicals in healing promotion"}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X25003298?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X25003298?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,4,6]],"date-time":"2025-04-06T04:46:33Z","timestamp":1743914793000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X25003298"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":38,"alternative-id":["S0006291X25003298"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2025.151615","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Plausible role of carveol in gastrointestinal disorders: Mechanistic insights via H+\/K+-ATPase and voltage-gated calcium channel inhibition","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2025.151615","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"151615"}}