{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,24]],"date-time":"2025-03-24T04:12:36Z","timestamp":1742789556015,"version":"3.40.2"},"reference-count":20,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2021YFD1800403","2021YFC2600204"],"award-info":[{"award-number":["2021YFD1800403","2021YFC2600204"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1016\/j.bbrc.2025.151624","type":"journal-article","created":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T07:47:27Z","timestamp":1741765647000},"page":"151624","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["High-throughput screening unveils AMG 837 and ROR\u03b3t 13 as the potent Brucella inhibitor by targeting BacA"],"prefix":"10.1016","volume":"757","author":[{"given":"Kai-Xuan","family":"Guo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong-Xia","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian-Dong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng-Dong","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao-Yue","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guo-Hua","family":"Cai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huan-Chun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zheng-Fei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2025.151624_bib1","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/S1473-3099(07)70286-4","article-title":"Human brucellosis","volume":"7","author":"Franco","year":"2007","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.bbrc.2025.151624_bib2","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1097\/QCO.0000000000000920","article-title":"Neurobrucellosis","volume":"36","author":"Soares","year":"2023","journal-title":"Curr. Opin. Infect. Dis."},{"key":"10.1016\/j.bbrc.2025.151624_bib3","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1186\/s12941-024-00724-0","article-title":"Analysis of the Brucella melitensis epidemic in Xinjiang: genotyping, polymorphism, antibiotic resistance and tracing","volume":"23","author":"Yang","year":"2024","journal-title":"Ann. Clin. Microbiol. Antimicrob."},{"key":"10.1016\/j.bbrc.2025.151624_bib4","first-page":"CD007179","article-title":"Antibiotics for treating human brucellosis","volume":"10","author":"Yousefi-Nooraie","year":"2012","journal-title":"COCHRANE DB SYST REV"},{"key":"10.1016\/j.bbrc.2025.151624_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2022.e10108","article-title":"A new use for old drugs: identifying compounds with an anti-obesity effect using a high through-put semi-automated Caenorhabditis elegans screening platform","volume":"8","author":"Haerkens","year":"2022","journal-title":"Heliyon"},{"key":"10.1016\/j.bbrc.2025.151624_bib6","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.chembiol.2020.12.001","article-title":"Recent advances in identifying protein targets in drug discovery","volume":"28","author":"Ha","year":"2021","journal-title":"Cell Chem. Biol."},{"key":"10.1016\/j.bbrc.2025.151624_bib7","doi-asserted-by":"crossref","DOI":"10.1128\/MMBR.00021-19","article-title":"Uncovering the hidden credentials of Brucella virulence","volume":"85","author":"Roop","year":"2021","journal-title":"Microbiol. Mol. Biol. R"},{"key":"10.1016\/j.bbrc.2025.151624_bib8","doi-asserted-by":"crossref","first-page":"3210","DOI":"10.1128\/IAI.68.6.3210-3218.2000","article-title":"Brucella abortus and its closest phylogenetic relative, Ochrobactrum spp., differ in outer membrane permeability and cationic peptide resistance","volume":"68","author":"Velasco","year":"2000","journal-title":"Infect. Immun."},{"key":"10.1016\/j.bbrc.2025.151624_bib9","doi-asserted-by":"crossref","first-page":"5012","DOI":"10.1073\/pnas.0307137101","article-title":"Similarity to peroxisomal-membrane protein family reveals that Sinorhizobium and Brucella BacA affect lipid-A fatty acids","volume":"101","author":"Ferguson","year":"2004","journal-title":"P Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bbrc.2025.151624_bib10","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1111\/j.1462-5822.2005.00629.x","article-title":"Differential inductions of TNF-alpha and IGTP, IIGP by structurally diverse classic and non-classic lipopolysaccharides","volume":"8","author":"Lapaque","year":"2006","journal-title":"Cell. Microbiol."},{"key":"10.1016\/j.bbrc.2025.151624_bib11","doi-asserted-by":"crossref","first-page":"2492","DOI":"10.1126\/science.287.5462.2492","article-title":"Similar requirements of a plant symbiont and a mammalian pathogen for prolonged intracellular survival","volume":"287","author":"LeVier","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.bbrc.2025.151624_bib12","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1038\/s41586-021-03792-w","article-title":"After the pandemic: perspectives on the future trajectory of COVID-19","volume":"596","author":"Telenti","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2025.151624_bib13","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1038\/nprot.2016.051","article-title":"Computational protein-ligand docking and virtual drug screening with the AutoDock suite","volume":"11","author":"Forli","year":"2016","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.bbrc.2025.151624_bib14","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0027270","article-title":"Amg 837: a novel GPR40\/FFA1 agonist that enhances insulin secretion and lowers glucose levels in rodents","volume":"6","author":"Lin","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.bbrc.2025.151624_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2020.112536","article-title":"Discovery of carboxyl-containing biaryl ureas as potent RORgammat inverse agonists","volume":"202","author":"Sun","year":"2020","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bbrc.2025.151624_bib16","doi-asserted-by":"crossref","DOI":"10.1080\/07853890.2023.2295398","article-title":"Brucellosis: epidemiology, pathogenesis, diagnosis and treatment-a comprehensive review","volume":"55","author":"Qureshi","year":"2023","journal-title":"Ann. Med."},{"key":"10.1016\/j.bbrc.2025.151624_bib17","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.molimm.2016.01.001","article-title":"Immunogenicity and protective efficacy of Brucella abortus recombinant protein cocktail (rOmp19+rP39) against B. abortus 544 and B. melitensis 16M infection in murine model","volume":"71","author":"Tadepalli","year":"2016","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.bbrc.2025.151624_bib18","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22073673","article-title":"The mechanism of facultative intracellular parasitism of Brucella","volume":"22","author":"Jiao","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbrc.2025.151624_bib19","doi-asserted-by":"crossref","first-page":"528","DOI":"10.7326\/0003-4819-89-4-528","article-title":"Gentamicin in 1978","volume":"89","author":"Appel","year":"1978","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.bbrc.2025.151624_bib20","doi-asserted-by":"crossref","first-page":"4733","DOI":"10.2147\/DDDT.S341242","article-title":"Clinical effect of doxycycline combined with compound sulfamethoxazole and rifampicin in the treatment of brucellosis spondylitis","volume":"15","author":"Yang","year":"2021","journal-title":"Drug Des. Dev. Ther."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X25003389?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X25003389?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,3,23]],"date-time":"2025-03-23T16:26:40Z","timestamp":1742747200000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X25003389"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":20,"alternative-id":["S0006291X25003389"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2025.151624","relation":{},"ISSN":["0006-291X"],"issn-type":[{"type":"print","value":"0006-291X"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"High-throughput screening unveils AMG 837 and ROR\u03b3t 13 as the potent Brucella inhibitor by targeting BacA","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2025.151624","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"151624"}}