{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T21:52:05Z","timestamp":1772920325858,"version":"3.50.1"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1016\/j.bbrc.2025.151647","type":"journal-article","created":{"date-parts":[[2025,3,17]],"date-time":"2025-03-17T17:16:43Z","timestamp":1742231803000},"page":"151647","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["miR-216a-3p alleviates primary Sj\u00f6gren's syndrome by regulating the STAT1\/JAK signaling pathway"],"prefix":"10.1016","volume":"758","author":[{"given":"Yixuan","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liuxiong","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingjing","family":"Cao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoran","family":"Ning","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fang","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9901-6074","authenticated-orcid":false,"given":"Guangyao","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2025.151647_bib1","first-page":"980","article-title":"Sj\u00f6gren's syndrome","volume":"20","author":"Andr\u00e9","year":"2022","journal-title":"J Dtsch Dermatol Ges"},{"key":"10.1016\/j.bbrc.2025.151647_bib2","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1002\/art.39518","article-title":"Rheumatoid factor and disease activity are independent predictors of lymphoma in primary Sj\u00f6gren's syndrome","volume":"68","author":"Nocturne","year":"2016","journal-title":"Arthritis Rheumatol."},{"key":"10.1016\/j.bbrc.2025.151647_bib3","first-page":"354","article-title":"The diagnosis and treatment of Sj\u00f6gren's syndrome","volume":"114","author":"Stefanski","year":"2017","journal-title":"Dtsch Arztebl Int"},{"key":"10.1016\/j.bbrc.2025.151647_bib4","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/s41584-021-00605-2","article-title":"Epithelial-immune cell interplay in primary Sj\u00f6gren syndrome salivary gland pathogenesis","volume":"17","author":"Verstappen","year":"2021","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.bbrc.2025.151647_bib5","doi-asserted-by":"crossref","first-page":"49","DOI":"10.46497\/ArchRheumatol.2022.8607","article-title":"Evaluation of histopathological results of minor salivary gland biopsies in patients with the diagnosis of Sj\u00f6gren's syndrome","volume":"37","author":"Erk\u0131l\u0131n\u00e7","year":"2022","journal-title":"Arch Rheumatol"},{"key":"10.1016\/j.bbrc.2025.151647_bib6","doi-asserted-by":"crossref","DOI":"10.3390\/ijms241311179","article-title":"Outline of salivary gland pathogenesis of Sj\u00f6gren's syndrome and current therapeutic approaches","volume":"24","author":"Yura","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbrc.2025.151647_bib7","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.3389\/fimmu.2020.01393","article-title":"Fc gamma receptors and their role in antigen uptake, presentation, and T cell activation","volume":"11","author":"Junker","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bbrc.2025.151647_bib8","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1136\/annrheumdis-2019-216588","article-title":"Salivary gland epithelial cells from patients with Sj\u00f6gren's syndrome induce B-lymphocyte survival and activation","volume":"79","author":"Rivi\u00e8re","year":"2020","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.bbrc.2025.151647_bib9","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1038\/s41392-021-00791-1","article-title":"The JAK\/STAT signaling pathway: from bench to clinic","volume":"6","author":"Hu","year":"2021","journal-title":"Signal Transduct. Targeted Ther."},{"key":"10.1016\/j.bbrc.2025.151647_bib10","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1038\/s41392-023-01468-7","article-title":"Evolving cognition of the JAK-STAT signaling pathway: autoimmune disorders and cancer","volume":"8","author":"Xue","year":"2023","journal-title":"Signal Transduct. Targeted Ther."},{"key":"10.1016\/j.bbrc.2025.151647_bib11","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.1068260","article-title":"JAK-STAT signaling pathway in the pathogenesis of atopic dermatitis: an updated review","volume":"13","author":"Huang","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bbrc.2025.151647_bib12","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.clim.2016.03.010","article-title":"Cytokine-induced STAT1 activation is increased in patients with primary Sj\u00f6gren's syndrome","volume":"165","author":"Pertovaara","year":"2016","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.bbrc.2025.151647_bib13","first-page":"2297","article-title":"Role of JAK-STAT signaling pathway in pathogenesis and treatment of primary Sj\u00f6gren's syndrome","volume":"136","author":"Li","year":"2023","journal-title":"Chin Med J (Engl)"},{"key":"10.1016\/j.bbrc.2025.151647_bib14","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/7510174","article-title":"MicroRNA in Sj\u00f6gren's syndrome: their potential roles in pathogenesis and diagnosis","volume":"2018","author":"Reale","year":"2018","journal-title":"J Immunol Res"},{"key":"10.1016\/j.bbrc.2025.151647_bib15","doi-asserted-by":"crossref","first-page":"4889","DOI":"10.1167\/iovs.19-27062","article-title":"Comparison of MicroRNA expression in tears of normal subjects and sj\u00f6gren syndrome patients","volume":"60","author":"Kim","year":"2019","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.bbrc.2025.151647_bib16","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1186\/s13046-020-01687-8","article-title":"LncRNA PSMB8-AS1 contributes to pancreatic cancer progression via modulating miR-382-3p\/STAT1\/PD-L1 axis","volume":"39","author":"Zhang","year":"2020","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.bbrc.2025.151647_bib17","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1136\/ard-2023-224842","article-title":"Inhibition of JAK-STAT pathway corrects salivary gland inflammation and interferon driven immune activation in Sj\u00f6gren's disease","volume":"83","author":"Gupta","year":"2024","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.bbrc.2025.151647_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2020.106878","article-title":"Relationships between increased circulating YKL-40, IL-6 and TNF-\u03b1 levels and phenotypes and disease activity of primary Sj\u00f6gren's syndrome","volume":"88","author":"Chen","year":"2020","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.bbrc.2025.151647_bib19","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.freeradbiomed.2023.05.027","article-title":"Interferon-\u03b3 induces salivary gland epithelial cell ferroptosis in Sjogren's syndrome via JAK\/STAT1-mediated inhibition of system Xc","volume":"205","author":"Cao","year":"2023","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bbrc.2025.151647_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaut.2023.103037","article-title":"hsa-miR-424-5p and hsa-miR-513c-3p dysregulation mediated by IFN-\u03b3 is associated with salivary gland dysfunction in Sj\u00f6gren's syndrome patients","volume":"138","author":"Carvajal","year":"2023","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.bbrc.2025.151647_bib21","doi-asserted-by":"crossref","first-page":"7484","DOI":"10.1038\/s41598-020-64422-5","article-title":"miR-744-5p contributes to ocular inflammation in patients with primary Sjogrens Syndrome","volume":"10","author":"Pilson","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbrc.2025.151647_bib22","doi-asserted-by":"crossref","first-page":"6157","DOI":"10.2147\/JIR.S336099","article-title":"Mesenchymal stem cell-originated exosomal circular RNA circFBXW7 attenuates cell proliferation, migration and inflammation of fibroblast-like synoviocytes by targeting miR-216a-3p\/HDAC4 in rheumatoid arthritis","volume":"14","author":"Chang","year":"2021","journal-title":"J. Inflamm. Res."},{"key":"10.1016\/j.bbrc.2025.151647_bib23","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1007\/s10753-021-01538-4","article-title":"Circular RNA circ_0008360 inhibits the proliferation, migration, and inflammation and promotes apoptosis of fibroblast-like synoviocytes by regulating miR-135b-5p\/HDAC4 Axis in rheumatoid arthritis","volume":"45","author":"Hao","year":"2022","journal-title":"Inflammation"},{"key":"10.1016\/j.bbrc.2025.151647_bib24","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1271102","article-title":"SOCS-JAK-STAT inhibitors and SOCS mimetics as treatment options for autoimmune uveitis, psoriasis, lupus, and autoimmune encephalitis","volume":"14","author":"Pandey","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bbrc.2025.151647_bib25","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.coi.2019.09.004","article-title":"B cell targeted therapies in autoimmune disease","volume":"61","author":"Barnas","year":"2019","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.bbrc.2025.151647_bib26","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.681105","article-title":"B cell metabolism and autophagy in autoimmunity","volume":"12","author":"Raza","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bbrc.2025.151647_bib27","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.179433","article-title":"Selective CAR T cell-mediated B cell depletion suppresses IFN signature in SLE","volume":"9","author":"Wilhelm","year":"2024","journal-title":"JCI Insight"},{"key":"10.1016\/j.bbrc.2025.151647_bib28","article-title":"B cells in rheumatoid arthritis:pathogenic mechanisms and treatment prospects","volume":"12","author":"Wu","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bbrc.2025.151647_bib29","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1038\/s41584-021-00740-w","article-title":"New hope for B cell-targeting therapy in pSS","volume":"18","author":"Clarke","year":"2022","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.bbrc.2025.151647_bib30","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1002\/art.42683","article-title":"Multimodal single-cell sequencing of B cells in primary Sj\u00f6gren's syndrome","volume":"76","author":"Arvidsson","year":"2024","journal-title":"Arthritis Rheumatol."},{"key":"10.1016\/j.bbrc.2025.151647_bib31","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23095101","article-title":"Decreased BAFF receptor expression and unaltered B cell receptor signaling in circulating B cells from primary Sj\u00f6gren's syndrome patients at diagnosis","volume":"23","author":"Neys","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbrc.2025.151647_bib32","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25063259","article-title":"B-cell activation biomarkers in salivary glands are related to lymphomagenesis in primary Sj\u00f6gren's disease: a pilot monocentric exploratory study","volume":"25","author":"Bruno","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbrc.2025.151647_bib33","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1136\/annrheumdis-2017-211417","article-title":"Deregulation of microRNA expression in purified T and B lymphocytes from patients with primary Sj\u00f6gren's syndrome","volume":"77","author":"Wang-Renault","year":"2018","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.bbrc.2025.151647_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.coi.2023.102286","article-title":"Cytokine-mediated STAT-dependent pathways underpinning human B-cell differentiation and function","volume":"81","author":"Tangye","year":"2023","journal-title":"Curr. Opin. Immunol."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X25003614?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X25003614?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,4,6]],"date-time":"2025-04-06T08:48:13Z","timestamp":1743929293000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X25003614"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":34,"alternative-id":["S0006291X25003614"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2025.151647","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"miR-216a-3p alleviates primary Sj\u00f6gren's syndrome by regulating the STAT1\/JAK signaling pathway","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2025.151647","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"151647"}}