{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T03:44:07Z","timestamp":1783655047506,"version":"3.55.0"},"reference-count":56,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["2023JJ60052"],"award-info":[{"award-number":["2023JJ60052"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1016\/j.bbrc.2025.151657","type":"journal-article","created":{"date-parts":[[2025,3,18]],"date-time":"2025-03-18T13:14:18Z","timestamp":1742303658000},"page":"151657","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["High glucose-induced alternative splicing of MEF2D in macrophages promotes vascular chronic inflammation in type 2 diabetes mellitus by mediating M1 macrophage polarization"],"prefix":"10.1016","volume":"758","author":[{"given":"Yuqi","family":"He","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haitao","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2025.151657_bib1","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/2902351","article-title":"An overview of murine high fat diet as a model for type 2 diabetes mellitus","volume":"2016","author":"Heydemann","year":"2016","journal-title":"J. Diabetes Res."},{"key":"10.1016\/j.bbrc.2025.151657_bib2","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1177\/1479164112455817","article-title":"CD40-CD40L: linking pancreatic, adipose tissue and vascular inflammation in type 2 diabetes and its complications","volume":"10","author":"Seijkens","year":"2013","journal-title":"Diabetes Vasc. Dis. Res."},{"key":"10.1016\/j.bbrc.2025.151657_bib3","first-page":"758","article-title":"Effect of numbers of metabolic syndrome components on mortality in patients with antineutrophil cytoplasmic antibody-associated vasculitis with metabolic syndrome","volume":"40","author":"Park","year":"2022","journal-title":"Clin. Exp. Rheumatol."},{"key":"10.1016\/j.bbrc.2025.151657_bib4","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1174249","article-title":"Arterial wall fibrosis in Takayasu arteritis and its potential for therapeutic modulation","volume":"14","author":"Misra","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bbrc.2025.151657_bib5","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.867260","article-title":"The role of M1\/M2 macrophage polarization in rheumatoid arthritis synovitis","volume":"13","author":"Cutolo","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bbrc.2025.151657_bib6","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abn1702","article-title":"Beyond autophagy: LC3-associated phagocytosis and endocytosis","volume":"8","author":"Pena-Martinez","year":"2022","journal-title":"Sci. Adv."},{"key":"10.1016\/j.bbrc.2025.151657_bib7","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2022.1091147","article-title":"Insulin resistance, autophagy and apoptosis in patients with polycystic ovary syndrome: association with PI3K signaling pathway","volume":"13","author":"Tong","year":"2022","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.bbrc.2025.151657_bib8","doi-asserted-by":"crossref","first-page":"2025","DOI":"10.1038\/s12276-023-01081-2","article-title":"The CREG1-FBXO27-LAMP2 axis alleviates diabetic cardiomyopathy by promoting autophagy in cardiomyocytes","volume":"55","author":"Liu","year":"2023","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.bbrc.2025.151657_bib9","doi-asserted-by":"crossref","first-page":"2837","DOI":"10.1080\/15548627.2023.2235196","article-title":"LAMP2A, LAMP2B and LAMP2C: similar structures, divergent roles","volume":"19","author":"Qiao","year":"2023","journal-title":"Autophagy"},{"key":"10.1016\/j.bbrc.2025.151657_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.110410","article-title":"Sialic acids promote macrophage M1 polarization and atherosclerosis by upregulating ROS and autophagy blockage","volume":"120","author":"Hu","year":"2023","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.bbrc.2025.151657_bib11","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.1161\/ATVBAHA.120.314291","article-title":"Cav-1 (Caveolin-1) deficiency increases autophagy in the endothelium and attenuates vascular inflammation and atherosclerosis","volume":"40","author":"Zhang","year":"2020","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.bbrc.2025.151657_bib12","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.adf2248","article-title":"The transcription factor Mef2d regulates B:T synapse-dependent GC-T(FH) differentiation and IL-21-mediated humoral immunity","volume":"8","author":"Kim","year":"2023","journal-title":"Sci. Immunol."},{"key":"10.1016\/j.bbrc.2025.151657_bib13","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20201859","article-title":"Loss of Mef2D function enhances TLR induced IL-10 production in macrophages","volume":"40","author":"Pattison","year":"2020","journal-title":"Biosci. Rep."},{"key":"10.1016\/j.bbrc.2025.151657_bib14","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1080\/15548627.2021.1968228","article-title":"MEF2D-NR4A1-FAM134B2-mediated reticulophagy contributes to amino acid homeostasis","volume":"18","author":"Shiozaki","year":"2022","journal-title":"Autophagy"},{"key":"10.1016\/j.bbrc.2025.151657_bib15","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.gendis.2023.03.029","article-title":"High glucose promotes macrophage M1 polarization through miR-32\/Mef2d\/cAMP signaling pathway","volume":"11","author":"Chen","year":"2024","journal-title":"Genes Dis."},{"key":"10.1016\/j.bbrc.2025.151657_bib16","doi-asserted-by":"crossref","DOI":"10.3390\/nu12092568","article-title":"Dietary complex and slow digestive carbohydrates prevent fat deposits during catch-up growth in rats","volume":"12","author":"Salto","year":"2020","journal-title":"Nutrients"},{"key":"10.1016\/j.bbrc.2025.151657_bib17","doi-asserted-by":"crossref","first-page":"8145","DOI":"10.1021\/acs.jafc.2c01888","article-title":"circMEF2D negatively regulated by HNRNPA1 inhibits proliferation and differentiation of myoblasts via miR-486-PI3K\/AKT Axis","volume":"70","author":"Zhang","year":"2022","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.bbrc.2025.151657_bib18","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1097\/CM9.0000000000002214","article-title":"Dysfunctional gene splicing in glucose metabolism may contribute to Alzheimer's disease","volume":"136","author":"Deng","year":"2023","journal-title":"Chin Med J (Engl)"},{"key":"10.1016\/j.bbrc.2025.151657_bib19","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1007\/s00125-019-4925-y","article-title":"Oestrogen receptor beta mediates the actions of bisphenol-A on ion channel expression in mouse pancreatic beta cells","volume":"62","author":"Martinez-Pinna","year":"2019","journal-title":"Diabetologia"},{"key":"10.1016\/j.bbrc.2025.151657_bib20","article-title":"Molecular mechanisms of epileptic encephalopathy caused by KCNMA1 loss-of-function mutations","volume":"12","author":"Yao","year":"2021","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.bbrc.2025.151657_bib21","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1080\/15548627.2022.2148808","article-title":"MCOLN3\/TRPML3 bridges the regulation of autophagosome biogenesis by PtdIns3P and the calcium channel","volume":"19","author":"Lei","year":"2023","journal-title":"Autophagy"},{"key":"10.1016\/j.bbrc.2025.151657_bib22","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.2174\/1871530320999200904123618","article-title":"Macrovascular protecting effects of berberine through anti-inflammation and intervention of BKCa in type 2 diabetes mellitus rats","volume":"21","author":"Wu","year":"2021","journal-title":"Endocr., Metab. Immune Disord.: Drug Targets"},{"key":"10.1016\/j.bbrc.2025.151657_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainres.2020.146878","article-title":"MEF2D upregulation protects neurons from oxygen-glucose deprivation\/re-oxygenation-induced injury by enhancing Nrf2 activation","volume":"1741","author":"Wang","year":"2020","journal-title":"Brain Res."},{"key":"10.1016\/j.bbrc.2025.151657_bib24","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.yjmcc.2020.03.001","article-title":"Regulation of KCNMA1 transcription by Nrf2 in coronary arterial smooth muscle cells","volume":"140","author":"Sun","year":"2020","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.bbrc.2025.151657_bib25","article-title":"Comparative proteomic analysis of polarized human THP-1 and mouse RAW264.7 macrophages","volume":"12","author":"Li","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bbrc.2025.151657_bib26","article-title":"TET1 knockdown inhibits porphyromonas gingivalis LPS\/IFN-gamma-Induced M1 macrophage polarization through the NF-kappaB pathway in THP-1 cells","volume":"20","author":"Huang","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbrc.2025.151657_bib27","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.1113\/JP282454","article-title":"Development and characterisation of a rat model that exhibits both metabolic dysfunction and neurodegeneration seen in type 2 diabetes","volume":"600","author":"Southam","year":"2022","journal-title":"J. Physiol."},{"key":"10.1016\/j.bbrc.2025.151657_bib28","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1161\/CIRCRESAHA.121.320047","article-title":"Autophagy is differentially regulated in leukocyte and nonleukocyte foam cells during atherosclerosis","volume":"130","author":"Robichaud","year":"2022","journal-title":"Circ. Res."},{"key":"10.1016\/j.bbrc.2025.151657_bib29","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1900\/RDS.2022.18.157","article-title":"Sarcopenia and chronic complications of type 2 diabetes mellitus","volume":"18","author":"Purnamasari","year":"2022","journal-title":"Rev. Diabet. Stud."},{"key":"10.1016\/j.bbrc.2025.151657_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.abb.2022.109116","article-title":"ATP6V1H deficiency impairs glucose tolerance by augmenting endoplasmic reticulum stress in high fat diet fed mice","volume":"716","author":"Yang","year":"2022","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.bbrc.2025.151657_bib31","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.lfs.2016.02.043","article-title":"Relationship of endothelin-1 and NLRP3 inflammasome activation in HT22 hippocampal cells in diabetes","volume":"159","author":"Ward","year":"2016","journal-title":"Life Sci."},{"key":"10.1016\/j.bbrc.2025.151657_bib32","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1111\/jre.12912","article-title":"Hyperglycemia modulates M1\/M2 macrophage polarization via reactive oxygen species overproduction in ligature-induced periodontitis","volume":"56","author":"Zhang","year":"2021","journal-title":"J. Periodontal. Res."},{"key":"10.1016\/j.bbrc.2025.151657_bib33","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/s11010-018-3411-z","article-title":"High-glucose-induced changes in macrophage secretome: regulation of immune response","volume":"452","author":"Kaewarpai","year":"2019","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.bbrc.2025.151657_bib34","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines12071575","article-title":"High glucose increases lactate and induces the transforming growth factor beta-smad 1\/5 atherogenic pathway in primary human macrophages","volume":"12","author":"Awad","year":"2024","journal-title":"Biomedicines"},{"key":"10.1016\/j.bbrc.2025.151657_bib35","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1038\/s41467-023-37017-7","article-title":"Alternatively spliced exon regulates context-dependent MEF2D higher-order assembly during myogenesis","volume":"14","author":"Gonczi","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbrc.2025.151657_bib36","doi-asserted-by":"crossref","first-page":"10318","DOI":"10.1074\/jbc.M707623200","article-title":"Myocyte enhancer factor 2A is transcriptionally autoregulated","volume":"283","author":"Ramachandran","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2025.151657_bib37","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1186\/s13046-022-02291-8","article-title":"Autophagy-based unconventional secretion of HMGB1 in glioblastoma promotes chemosensitivity to temozolomide through macrophage M1-like polarization","volume":"41","author":"Li","year":"2022","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.bbrc.2025.151657_bib38","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1080\/15548627.2015.1009787","article-title":"Impaired macrophage autophagy increases the immune response in obese mice by promoting proinflammatory macrophage polarization","volume":"11","author":"Liu","year":"2015","journal-title":"Autophagy"},{"key":"10.1016\/j.bbrc.2025.151657_bib39","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1038\/s41420-021-00797-2","article-title":"Autophagy deficiency promotes M1 macrophage polarization to exacerbate acute liver injury via ATG5 repression during aging","volume":"7","author":"Liu","year":"2021","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.bbrc.2025.151657_bib40","first-page":"3619","article-title":"Macrophages exhibit a large repertoire of activation states via multiple mechanisms of macrophage-activating factors","volume":"36","author":"Sumiya","year":"2016","journal-title":"Anticancer Res."},{"key":"10.1016\/j.bbrc.2025.151657_bib41","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.immuni.2014.06.008","article-title":"Macrophage activation and polarization: nomenclature and experimental guidelines","volume":"41","author":"Murray","year":"2014","journal-title":"Immunity"},{"key":"10.1016\/j.bbrc.2025.151657_bib42","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/9239354","article-title":"Panax notoginseng saponins regulate macrophage polarization under hyperglycemic condition via NF-kappaB signaling pathway","volume":"2018","author":"Zhao","year":"2018","journal-title":"BioMed Res. Int."},{"key":"10.1016\/j.bbrc.2025.151657_bib43","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1186\/s12933-023-01818-3","article-title":"Down-regulation of WWP2 aggravates Type 2 diabetes mellitus-induced vascular endothelial injury through modulating ubiquitination and degradation of DDX3X","volume":"22","author":"You","year":"2023","journal-title":"Cardiovasc. Diabetol."},{"key":"10.1016\/j.bbrc.2025.151657_bib44","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.jhep.2019.03.014","article-title":"Macrophage p38alpha promotes nutritional steatohepatitis through M1 polarization","volume":"71","author":"Zhang","year":"2019","journal-title":"J. Hepatol."},{"key":"10.1016\/j.bbrc.2025.151657_bib45","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1186\/s13054-021-03775-3","article-title":"Exosomal miR-30d-5p of neutrophils induces M1 macrophage polarization and primes macrophage pyroptosis in sepsis-related acute lung injury","volume":"25","author":"Jiao","year":"2021","journal-title":"Crit. Care"},{"key":"10.1016\/j.bbrc.2025.151657_bib46","doi-asserted-by":"crossref","first-page":"2634","DOI":"10.1002\/jbm.a.36457","article-title":"The promotion of tissue engineering blood vessel patency by CGS21680 through regulating pro-inflammatory activities of endothelial progenitor cell","volume":"106","author":"Chen","year":"2018","journal-title":"J. Biomed. Mater. Res."},{"key":"10.1016\/j.bbrc.2025.151657_bib47","doi-asserted-by":"crossref","first-page":"73","DOI":"10.31083\/j.rcm2302073","article-title":"Biomarkers of endothelial activation and dysfunction in cardiovascular diseases","volume":"23","author":"Zhang","year":"2022","journal-title":"Rev. Cardiovasc. Med."},{"key":"10.1016\/j.bbrc.2025.151657_bib48","doi-asserted-by":"crossref","first-page":"4389","DOI":"10.1177\/0300060519859141","article-title":"Carotid artery color Doppler ultrasonography and plasma levels of lipoprotein-associated phospholipase A2 and cystatin C in arteriosclerotic cerebral infarction","volume":"47","author":"Huang","year":"2019","journal-title":"J. Int. Med. Res."},{"key":"10.1016\/j.bbrc.2025.151657_bib49","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1007\/s11239-022-02709-2","article-title":"Biomarkers associated with coronary high-risk plaques","volume":"54","author":"Nakajima","year":"2022","journal-title":"J. Thromb. Thrombolysis"},{"key":"10.1016\/j.bbrc.2025.151657_bib50","doi-asserted-by":"crossref","first-page":"10836","DOI":"10.1073\/pnas.1302028110","article-title":"MitoBK(Ca) is encoded by the Kcnma1 gene, and a splicing sequence defines its mitochondrial location","volume":"110","author":"Singh","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbrc.2025.151657_bib51","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2020.101679","article-title":"Complex interplay between autophagy and oxidative stress in the development of pulmonary disease","volume":"36","author":"Ornatowski","year":"2020","journal-title":"Redox Biol."},{"key":"10.1016\/j.bbrc.2025.151657_bib52","doi-asserted-by":"crossref","DOI":"10.3390\/cells10082125","article-title":"Calcium signaling regulates autophagy and apoptosis","volume":"10","author":"Sukumaran","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.bbrc.2025.151657_bib53","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1080\/15548627.2019.1644076","article-title":"ALS-FTLD-linked mutations of SQSTM1\/p62 disrupt selective autophagy and NFE2L2\/NRF2 anti-oxidative stress pathway","volume":"16","author":"Deng","year":"2020","journal-title":"Autophagy"},{"key":"10.1016\/j.bbrc.2025.151657_bib54","doi-asserted-by":"crossref","first-page":"2851","DOI":"10.2147\/JIR.S307624","article-title":"Regulation of IFN-is by MEF2D promotes inflammatory homeostasis in microglia","volume":"14","author":"Lu","year":"2021","journal-title":"J. Inflamm. Res."},{"key":"10.1016\/j.bbrc.2025.151657_bib55","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1038\/s41431-018-0297-x","article-title":"A rare regulatory variant in the MEF2D gene affects gene regulation and splicing and is associated with a SLE sub-phenotype in Swedish cohorts","volume":"27","author":"Farias","year":"2019","journal-title":"Eur. J. Hum. Genet."},{"key":"10.1016\/j.bbrc.2025.151657_bib56","doi-asserted-by":"crossref","first-page":"4354","DOI":"10.1128\/IAI.01783-05","article-title":"Cell activation by ligands of the toll-like receptor and interleukin-1 receptor family depends on the function of the large-conductance potassium channel MaxiK in human macrophages","volume":"74","author":"Scheel","year":"2006","journal-title":"Infect. Immun."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X25003717?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X25003717?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T02:08:34Z","timestamp":1778638114000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X25003717"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":56,"alternative-id":["S0006291X25003717"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2025.151657","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"High glucose-induced alternative splicing of MEF2D in macrophages promotes vascular chronic inflammation in type 2 diabetes mellitus by mediating M1 macrophage polarization","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2025.151657","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"151657"}}