{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T05:08:05Z","timestamp":1793336885508,"version":"4.5.0"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,4,10]],"date-time":"2025-04-10T00:00:00Z","timestamp":1744243200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82101777"],"award-info":[{"award-number":["82101777"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1016\/j.bbrc.2025.151788","type":"journal-article","created":{"date-parts":[[2025,4,10]],"date-time":"2025-04-10T16:23:30Z","timestamp":1744302210000},"page":"151788","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["FAK regulates trophoblast functions of invasion and proliferation through Rap1 pathway in early-onset preeclampsia"],"prefix":"10.1016","volume":"763","author":[{"given":"Tingting","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-3860-2517","authenticated-orcid":false,"given":"Hai","family":"Tong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruixin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youqing","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongbo","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-3741-8676","authenticated-orcid":false,"given":"Xue","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2025.151788_bib1","article-title":"Prevention of preeclampsia","volume":"25","author":"Ma","year":"2020","journal-title":"Semin. Fetal Neonatal Med."},{"key":"10.1016\/j.bbrc.2025.151788_bib2","doi-asserted-by":"crossref","first-page":"F1315","DOI":"10.1152\/ajprenal.00071.2020","article-title":"Preeclampsia beyond pregnancy: long-term consequences for mother and child","volume":"318","author":"Turbeville","year":"2020","journal-title":"Am. J. Physiol. Ren. Physiol."},{"key":"10.1016\/j.bbrc.2025.151788_bib3","doi-asserted-by":"crossref","DOI":"10.1111\/obr.13411","article-title":"Long-term effects of preeclampsia on metabolic and biochemical outcomes in offspring: what can be expected from a meta-analysis?","volume":"23","author":"Bi","year":"2022","journal-title":"Obes. Rev."},{"key":"10.1016\/j.bbrc.2025.151788_bib4","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.768669","article-title":"Dysregulated BMP2 in the placenta may contribute to early-onset preeclampsia by regulating human trophoblast expression of extracellular matrix and adhesion molecules","volume":"9","author":"Yi","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.bbrc.2025.151788_bib5","doi-asserted-by":"crossref","first-page":"1690","DOI":"10.1016\/j.jacc.2020.08.014","article-title":"Preeclampsia\u2014pathophysiology and clinical presentations","volume":"76","author":"Ives","year":"2020","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.bbrc.2025.151788_bib6","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1038\/nm1429","article-title":"Soluble endoglin contributes to the pathogenesis of preeclampsia","volume":"12","author":"Venkatesha","year":"2006","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbrc.2025.151788_bib7","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1161\/HYPERTENSIONAHA.115.05883","article-title":"Placental-specific sFLT-1 e15a protein is increased in preeclampsia, antagonizes vascular endothelial growth factor signaling, and has antiangiogenic activity","volume":"66","author":"Palmer","year":"2015","journal-title":"Hypertension"},{"key":"10.1016\/j.bbrc.2025.151788_bib8","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S0065-230X(08)00403-X","article-title":"FAK expression regulation and therapeutic potential","volume":"101","author":"Li","year":"2008","journal-title":"Adv. Cancer Res."},{"key":"10.1016\/j.bbrc.2025.151788_bib9","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1002\/(SICI)1097-0347(199810)20:7<634::AID-HED10>3.0.CO;2-M","article-title":"Focal adhesion kinase expression in oral cancers","volume":"20","author":"Kornberg","year":"1998","journal-title":"Head Neck"},{"key":"10.1016\/j.bbrc.2025.151788_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.mce.2020.110730","article-title":"Hyposialylated angiopoietin-like-4 induces apoptosis of podocytes via \u03b21 Integrin\/FAK signaling in diabetic nephropathy","volume":"505","author":"Guo","year":"2020","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.bbrc.2025.151788_bib11","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1038\/labinvest.3780362","article-title":"Focal adhesion kinase is a key mediator of human trophoblast development","volume":"81","author":"MacPhee","year":"2001","journal-title":"Lab. Invest."},{"key":"10.1016\/j.bbrc.2025.151788_bib12","doi-asserted-by":"crossref","first-page":"3262","DOI":"10.1128\/MCB.01345-09","article-title":"Downregulation of Rap1GAP in human tumor cells alters cell\/matrix and cell\/cell adhesion","volume":"30","author":"Tsygankova","year":"2010","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.bbrc.2025.151788_bib13","doi-asserted-by":"crossref","first-page":"4962","DOI":"10.1158\/0008-5472.CAN-08-4269","article-title":"Activation of Rap1 promotes prostate cancer metastasis","volume":"69","author":"Bailey","year":"2009","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbrc.2025.151788_bib14","doi-asserted-by":"crossref","first-page":"4590","DOI":"10.1158\/0008-5472.CAN-09-3414","article-title":"Preventing the activation or cycling of the Rap1 GTPase alters adhesion and cytoskeletal dynamics and blocks metastatic melanoma cell extravasation into the lungs","volume":"70","author":"Freeman","year":"2010","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbrc.2025.151788_bib15","doi-asserted-by":"crossref","first-page":"6243","DOI":"10.1038\/sj.onc.1206534","article-title":"Rap1A and rap1B ras-family proteins are prominently expressed in the nucleus of squamous carcinomas: nuclear translocation of GTP-Bound active form","volume":"22","author":"Mitra","year":"2003","journal-title":"Oncogene"},{"key":"10.1016\/j.bbrc.2025.151788_bib16","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.semcancer.2018.03.005","article-title":"Ras and Rap1: a tale of two GTPases","volume":"54","author":"Shah","year":"2019","journal-title":"Semin. Cancer Biol."},{"key":"10.1016\/j.bbrc.2025.151788_bib17","doi-asserted-by":"crossref","first-page":"24636","DOI":"10.1074\/jbc.M113.464594","article-title":"Tumor cell migration and invasion are enhanced by depletion of Rap1 GTPase-activating protein (Rap1GAP)","volume":"288","author":"Tsygankova","year":"2013","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2025.151788_bib18","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1177\/0022034520917058","article-title":"RAP1-RAC1 signaling has an important role in adhesion and migration in HNSCC","volume":"99","author":"Liu","year":"2020","journal-title":"J. Dent. Res."},{"key":"10.1016\/j.bbrc.2025.151788_bib19","first-page":"1","article-title":"ACOG practice bulletin no. 202: gestational hypertension and preeclampsia","volume":"133","year":"2019","journal-title":"Obstet. Gynecol."},{"key":"10.1016\/j.bbrc.2025.151788_bib20","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1161\/HYPERTENSIONAHA.117.10250","article-title":"Dysregulated expression of RPS4Y1 (ribosomal protein S4, Y-Linked 1) impairs STAT3 (signal transducer and activator of transcription 3) signaling to suppress trophoblast cell migration and invasion in preeclampsia","volume":"71","author":"Chen","year":"2018","journal-title":"Hypertension"},{"key":"10.1016\/j.bbrc.2025.151788_bib21","doi-asserted-by":"crossref","first-page":"3479","DOI":"10.1007\/s00018-019-03104-6","article-title":"Human placenta and trophoblast development: key molecular mechanisms and model systems","volume":"76","author":"Knofler","year":"2019","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.bbrc.2025.151788_bib22","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.cell.2015.09.001","article-title":"Nuclear FAK controls chemokine transcription, tregs, and evasion of anti-tumor immunity","volume":"163","author":"Serrels","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.bbrc.2025.151788_bib23","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1038\/nrc3792","article-title":"FAK in cancer: mechanistic findings and clinical applications","volume":"14","author":"Sulzmaier","year":"2014","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.bbrc.2025.151788_bib24","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1369\/0022155414561498","article-title":"Understanding the roles of FAK in cancer","volume":"63","author":"Yoon","year":"2015","journal-title":"J. Histochem. Cytochem."},{"key":"10.1016\/j.bbrc.2025.151788_bib25","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0002-9440(10)61677-X","article-title":"Plasma membrane-associated pY397FAK is a marker of cytotrophoblast invasion in vivo and in vitro","volume":"159","author":"Ilic","year":"2001","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.bbrc.2025.151788_bib26","doi-asserted-by":"crossref","first-page":"3995","DOI":"10.1158\/0008-5472.CAN-17-1548","article-title":"Multikinase inhibitor CT-707 targets liver cancer by interrupting the hypoxia-activated IGF-1R\u2013YAP axis","volume":"78","author":"Zhu","year":"2018","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbrc.2025.151788_bib27","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.ccell.2019.01.009","article-title":"A platform of synthetic lethal gene interaction networks reveals that the GNAQ uveal melanoma oncogene controls the hippo pathway through FAK","volume":"35","author":"Feng","year":"2019","journal-title":"Cancer Cell"},{"key":"10.1016\/j.bbrc.2025.151788_bib28","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1007\/s00418-002-0396-0","article-title":"Invasive depth of extravillous trophoblast correlates with cellular phenotype: a comparison of intra- and extrauterine implantation sites","volume":"117","author":"Kemp","year":"2002","journal-title":"Histochem. Cell Biol."},{"key":"10.1016\/j.bbrc.2025.151788_bib29","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1083\/jcb.148.4.779","article-title":"Exogenous expression of N-cadherin in breast cancer cells induces cell migration, invasion, and metastasis","volume":"148","author":"Hazan","year":"2000","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.bbrc.2025.151788_bib30","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S0304-3835(01)00759-5","article-title":"Cadherins and the tumour progression: is it all in a switch?","volume":"176","author":"Cavallaro","year":"2002","journal-title":"Cancer Lett."},{"key":"10.1016\/j.bbrc.2025.151788_bib31","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1038\/ncb3257","article-title":"Definition of a consensus integrin adhesome and its dynamics during adhesion complex assembly and disassembly","volume":"17","author":"Horton","year":"2015","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.bbrc.2025.151788_bib32","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1038\/embor.2011.5","article-title":"Quantitative proteomics of the integrin adhesome show a myosin II-dependent recruitment of LIM domain proteins","volume":"12","author":"Schiller","year":"2011","journal-title":"EMBO Rep."},{"key":"10.1016\/j.bbrc.2025.151788_bib33","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0167-4889(01)00123-9","article-title":"Biochemical signals and biological responses elicited by the focal adhesion kinase","volume":"1540","author":"Schaller","year":"2001","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbrc.2025.151788_bib34","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0023123","article-title":"FAK regulates intestinal epithelial cell survival and proliferation during mucosal wound healing","volume":"6","author":"Owen","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.bbrc.2025.151788_bib35","doi-asserted-by":"crossref","first-page":"2050","DOI":"10.1158\/1535-7163.MCT-13-1063","article-title":"FAK inhibition disrupts a \u03b25 integrin signaling axis controlling anchorage-independent ovarian carcinoma growth","volume":"13","author":"Tancioni","year":"2014","journal-title":"Mol. Cancer Therapeut."},{"key":"10.1016\/j.bbrc.2025.151788_bib36","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1002\/ijc.20607","article-title":"Differential expression ofProtease activated receptor 1 (Par1) and pY397FAK in benign and malignant human ovarian tissue samples","volume":"113","author":"Grisaru-Granovsky","year":"2005","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.bbrc.2025.151788_bib37","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1016\/j.placenta.2013.06.311","article-title":"Human placental multipotent mesenchymal stromal cells modulate trophoblast migration via Rap1 activation","volume":"34","author":"Chen","year":"2013","journal-title":"Placenta"},{"key":"10.1016\/j.bbrc.2025.151788_bib38","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.2147\/IJGM.S348175","article-title":"Gene expression network analysis identifies potential targets for prevention of preeclampsia","volume":"15","author":"Xia","year":"2022","journal-title":"Int. J. Gen. Med."},{"key":"10.1016\/j.bbrc.2025.151788_bib39","doi-asserted-by":"crossref","first-page":"5022","DOI":"10.1074\/jbc.M409701200","article-title":"Local activation of Rap1 contributes to directional vascular endothelial cell migration accompanied by extension of microtubules on which RAPL, a Rap1-associating molecule, localizes","volume":"280","author":"Fujita","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2025.151788_bib40","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1128\/MCB.26.2.643-653.2006","article-title":"Rap1A-Deficient T and B cells show impaired integrin-mediated cell adhesion","volume":"26","author":"Duchniewicz","year":"2006","journal-title":"Mol. Cell Biol."},{"issue":"1","key":"10.1016\/j.bbrc.2025.151788_bib41","doi-asserted-by":"crossref","DOI":"10.1002\/rmb2.12537","article-title":"Small GTP-Binding protein Rap1 mediates EGF and HB-EGF signaling and modulates EGF receptor expression in HTR-8\/SVneo extravillous trophoblast cells","volume":"22","author":"Yoshie","year":"2023","journal-title":"Reprod. Med. Biol."},{"key":"10.1016\/j.bbrc.2025.151788_bib42","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1165\/rcmb.2014-0376OC","article-title":"Role of krev interaction Trapped-1 in prostacyclin-induced protection against lung vascular permeability induced by excessive mechanical forces and thrombin receptor activating peptide 6","volume":"53","author":"Meliton","year":"2015","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.bbrc.2025.151788_bib43","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1074\/jbc.M509188200","article-title":"Crystal structure of the FERM domain of focal adhesion kinase","volume":"281","author":"Ceccarelli","year":"2006","journal-title":"J. Biol. Chem."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X25005029?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X25005029?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,4,21]],"date-time":"2025-04-21T16:14:34Z","timestamp":1745252074000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X25005029"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":43,"alternative-id":["S0006291X25005029"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2025.151788","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"FAK regulates trophoblast functions of invasion and proliferation through Rap1 pathway in early-onset preeclampsia","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2025.151788","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"151788"}}