{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T01:24:37Z","timestamp":1776734677073,"version":"3.51.2"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002402","name":"Sun Yat-Sen University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002402","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81972661"],"award-info":[{"award-number":["81972661"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82273149"],"award-info":[{"award-number":["82273149"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82200438"],"award-info":[{"award-number":["82200438"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010877","name":"Science, Technology and Innovation Commission of Shenzhen Municipality","doi-asserted-by":"publisher","award":["JCYJ20230807110419041"],"award-info":[{"award-number":["JCYJ20230807110419041"]}],"id":[{"id":"10.13039\/501100010877","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021177","name":"Shenzhen Bay Laboratory","doi-asserted-by":"publisher","award":["ZDSYS20230626091402006"],"award-info":[{"award-number":["ZDSYS20230626091402006"]}],"id":[{"id":"10.13039\/501100021177","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1016\/j.bbrc.2025.151847","type":"journal-article","created":{"date-parts":[[2025,4,17]],"date-time":"2025-04-17T12:55:21Z","timestamp":1744894521000},"page":"151847","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["p14ARF interacts with \u03b3-H2AX and is involved in the DNA damage response"],"prefix":"10.1016","volume":"765","author":[{"given":"Minyi","family":"Huang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Zou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8385-3989","authenticated-orcid":false,"given":"Biwei","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanxi","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhongzhou","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huimin","family":"Kong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinxu","family":"Long","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xijun","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mo","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-8146-3704","authenticated-orcid":false,"given":"Xingwu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiangyu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaocheng","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2025.151847_bib1","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1038\/85798","article-title":"DNA double-strand breaks: signaling, repair and the cancer connection","volume":"27","author":"Khanna","year":"2001","journal-title":"Nat. Genet."},{"key":"10.1016\/j.bbrc.2025.151847_bib2","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/s42764-019-00003-9","article-title":"ATM, DNA-PKcs and ATR: shaping development through the regulation of the DNA damage responses","volume":"1","author":"Menolfi","year":"2020","journal-title":"Genome Instabil. Dis."},{"key":"10.1016\/j.bbrc.2025.151847_bib3","doi-asserted-by":"crossref","first-page":"2390","DOI":"10.1158\/0008-5472.CAN-03-3207","article-title":"ATM and DNA-PK function redundantly to phosphorylate H2AX after exposure to ionizing radiation","volume":"64","author":"Stiff","year":"2004","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbrc.2025.151847_bib4","doi-asserted-by":"crossref","first-page":"47759","DOI":"10.1074\/jbc.C100569200","article-title":"Histone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stress","volume":"276","author":"Ward","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2025.151847_bib5","doi-asserted-by":"crossref","first-page":"42462","DOI":"10.1074\/jbc.C100466200","article-title":"ATM phosphorylates histone H2AX in response to DNA double-strand breaks","volume":"276","author":"Burma","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2025.151847_bib6","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1038\/nrc2523","article-title":"GammaH2AX and cancer","volume":"8","author":"Bonner","year":"2008","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.bbrc.2025.151847_bib7","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/S0092-8674(00)81175-7","article-title":"The hMre11\/hRad50 protein complex and Nijmegen breakage syndrome: linkage of double-strand break repair to the cellular DNA damage response","volume":"93","author":"Carney","year":"1998","journal-title":"Cell"},{"key":"10.1016\/j.bbrc.2025.151847_bib8","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1038\/nature01446","article-title":"MDC1 is a mediator of the Mammalian DNA damage checkpoint","volume":"421","author":"Stewart","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2025.151847_bib9","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1016\/j.cell.2005.09.038","article-title":"MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks","volume":"123","author":"Stucki","year":"2005","journal-title":"Cell"},{"key":"10.1016\/j.bbrc.2025.151847_bib10","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1083\/jcb.151.7.1381","article-title":"p53 binding protein 1 (53BP1) is an early participant in the cellular response to DNA double-strand breaks","volume":"151","author":"Schultz","year":"2000","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.bbrc.2025.151847_bib11","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/S0092-8674(00)80503-6","article-title":"Dynamic changes of BRCA1 subnuclear location and phosphorylation state are initiated by DNA damage","volume":"90","author":"Scully","year":"1997","journal-title":"Cell"},{"key":"10.1016\/j.bbrc.2025.151847_bib12","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1038\/35096061","article-title":"The INK4a\/ARF network in tumour suppression","volume":"2","author":"Sherr","year":"2001","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.bbrc.2025.151847_bib13","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/S0092-8674(00)81401-4","article-title":"ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways","volume":"92","author":"Zhang","year":"1998","journal-title":"Cell"},{"key":"10.1016\/j.bbrc.2025.151847_bib14","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/S0092-8674(00)81400-2","article-title":"The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53","volume":"92","author":"Pomerantz","year":"1998","journal-title":"Cell"},{"key":"10.1016\/j.bbrc.2025.151847_bib15","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1038\/8991","article-title":"Nucleolar Arf sequesters Mdm2 and activates p53","volume":"1","author":"Weber","year":"1999","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.bbrc.2025.151847_bib16","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1038\/nrc1954","article-title":"Divorcing ARF and p53: an unsettled case","volume":"6","author":"Sherr","year":"2006","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.bbrc.2025.151847_bib17","doi-asserted-by":"crossref","first-page":"2424","DOI":"10.1101\/gad.12.15.2424","article-title":"Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization","volume":"12","author":"Zindy","year":"1998","journal-title":"Genes Dev."},{"key":"10.1016\/j.bbrc.2025.151847_bib18","doi-asserted-by":"crossref","first-page":"2434","DOI":"10.1101\/gad.12.15.2434","article-title":"E1A signaling to p53 involves the p19(ARF) tumor suppressor","volume":"12","author":"de Stanchina","year":"1998","journal-title":"Genes Dev."},{"key":"10.1016\/j.bbrc.2025.151847_bib19","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1038\/25867","article-title":"p14ARF links the tumour suppressors RB and p53","volume":"395","author":"Bates","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2025.151847_bib20","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1038\/25870","article-title":"p19ARF links the tumour suppressor p53 to Ras","volume":"395","author":"Palmero","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2025.151847_bib21","doi-asserted-by":"crossref","first-page":"13194","DOI":"10.1073\/pnas.95.22.13194","article-title":"p19(Arf) induces p53-dependent apoptosis during abelson virus-mediated pre-B cell transformation","volume":"95","author":"Radfar","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbrc.2025.151847_bib22","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.ccr.2010.06.013","article-title":"Ink4a\/Arf and oncogene-induced senescence prevent tumor progression during alternative colorectal tumorigenesis","volume":"18","author":"Bennecke","year":"2010","journal-title":"Cancer Cell"},{"key":"10.1016\/j.bbrc.2025.151847_bib23","doi-asserted-by":"crossref","first-page":"4339","DOI":"10.1128\/MCB.02240-05","article-title":"p14ARF activates a Tip60-dependent and p53-independent ATM\/ATR\/CHK pathway in response to genotoxic stress","volume":"26","author":"Eymin","year":"2006","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.bbrc.2025.151847_bib24","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1038\/cdd.2009.89","article-title":"Suppression of p53 activity by Siva1","volume":"16","author":"Du","year":"2009","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.bbrc.2025.151847_bib25","article-title":"Protein kinase A regulates ferroptosis by controlling GPX4 m(6)A modification through phosphorylation of ALKBH5","author":"Zhao","year":"2025","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.bbrc.2025.151847_bib26","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1038\/ncomms2533","article-title":"Siva1 inhibits p53 function by acting as an ARF E3 ubiquitin ligase","volume":"4","author":"Wang","year":"2013","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbrc.2025.151847_bib27","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1038\/s41586-024-07487-w","article-title":"Accurate structure prediction of biomolecular interactions with AlphaFold 3","volume":"630","author":"Abramson","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2025.151847_bib28","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1038\/ncb2795","article-title":"Functional interplay between the DNA-damage-response kinase ATM and ARF tumour suppressor protein in human cancer","volume":"15","author":"Velimezi","year":"2013","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.bbrc.2025.151847_bib29","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1126\/science.286.5442.1162","article-title":"Requirement of ATM-dependent phosphorylation of brca1 in the DNA damage response to double-strand breaks","volume":"286","author":"Cortez","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.bbrc.2025.151847_bib30","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1002157","article-title":"Expression of arf tumor suppressor in spermatogonia facilitates meiotic progression in male germ cells","volume":"7","author":"Churchman","year":"2011","journal-title":"PLoS Genet."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X25005613?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X25005613?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T04:54:32Z","timestamp":1769057672000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X25005613"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":30,"alternative-id":["S0006291X25005613"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2025.151847","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"p14ARF interacts with \u03b3-H2AX and is involved in the DNA damage response","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2025.151847","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"151847"}}