{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T17:16:53Z","timestamp":1788715013014,"version":"build-2803163510"},"reference-count":75,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R35GM145409"],"award-info":[{"award-number":["R35GM145409"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2025,7]]},"DOI":"10.1016\/j.bbrc.2025.151988","type":"journal-article","created":{"date-parts":[[2025,5,9]],"date-time":"2025-05-09T23:06:56Z","timestamp":1746832016000},"page":"151988","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Electrochemical interpretations for the study of molnupiravir binding interactions with bovine serum albumin and DNA and molecular dynamics studies"],"prefix":"10.1016","volume":"769","author":[{"given":"Harish","family":"Jammigumpula","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravi","family":"Arukula","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashish Kumar","family":"Agrahari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-3510-4907","authenticated-orcid":false,"given":"Abdallah Othman","family":"Ghnaim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1187-135X","authenticated-orcid":false,"given":"Kiran","family":"Gangarapu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.bbrc.2025.151988_bib1","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.bj.2020.05.023","article-title":"Comprehensive review of coronavirus disease 2019 (COVID-19)","volume":"43","author":"Chauhan","year":"2020","journal-title":"Biomed. J."},{"key":"10.1016\/j.bbrc.2025.151988_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.microc.2023.109297","article-title":"Preparation and characterization of Fe-Gallic acid MOF for determination of antiviral molnupiravir as inhibitor for RNA Corona virus replication","volume":"194","author":"Younis","year":"2023","journal-title":"Microchem. J."},{"issue":"5","key":"10.1016\/j.bbrc.2025.151988_bib3","doi-asserted-by":"crossref","first-page":"262","DOI":"10.24875\/BMHIM.20000183","article-title":"SARS-CoV-2 and influenza: a comparative overview and treatment implications","volume":"77","author":"Manzanares-Meza","year":"2020","journal-title":"Bolet\u00edn m\u00e9dico del Hospital Infantil de M\u00e9xico"},{"issue":"1","key":"10.1016\/j.bbrc.2025.151988_bib4","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/s43556-022-00078-z","article-title":"Significant perspectives on various viral infections targeted antiviral drugs and vaccines including COVID-19 pandemicity","volume":"3","author":"Arumugam","year":"2022","journal-title":"Molecular Biomedicine"},{"issue":"6","key":"10.1016\/j.bbrc.2025.151988_bib5","doi-asserted-by":"crossref","first-page":"2715","DOI":"10.1007\/s10238-022-00949-3","article-title":"Real-world clinical outcomes of treatment with molnupiravir for patients with mild-to-moderate coronavirus disease 2019 during the omicron variant pandemic","volume":"23","author":"Suzuki","year":"2023","journal-title":"Clin. Exp. Med."},{"issue":"8","key":"10.1016\/j.bbrc.2025.151988_bib6","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1007\/s00044-021-02748-z","article-title":"Albumin roles in developing anticancer compounds","volume":"30","author":"Ribeiro","year":"2021","journal-title":"Med. Chem. Res."},{"issue":"3","key":"10.1016\/j.bbrc.2025.151988_bib7","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/S0939-6411(02)00089-9","article-title":"Effect of bovine serum albumin on drug permeability estimation across Caco-2 monolayers","volume":"54","author":"Saha","year":"2002","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.bbrc.2025.151988_bib8","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.saa.2015.12.003","article-title":"Binding interaction of atorvastatin with bovine serum albumin: spectroscopic methods and molecular docking","volume":"156","author":"Wang","year":"2016","journal-title":"Spectrochim. Acta Mol. Biomol. Spectrosc."},{"issue":"32","key":"10.1016\/j.bbrc.2025.151988_bib9","doi-asserted-by":"crossref","first-page":"3739","DOI":"10.2174\/1381612824666181106101448","article-title":"Computational and experimental binding mechanism of DNA-Drug interactions","volume":"24","author":"Selvaraj","year":"2018","journal-title":"Curr. Pharm. Des."},{"issue":"1","key":"10.1016\/j.bbrc.2025.151988_bib10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0003-9861(02)00202-3","article-title":"Thermodynamics of drug\u2013DNA interactions","volume":"403","author":"Haq","year":"2002","journal-title":"Arch. Biochem. Biophys."},{"issue":"4","key":"10.1016\/j.bbrc.2025.151988_bib11","doi-asserted-by":"crossref","first-page":"441","DOI":"10.2174\/1381612003400849","article-title":"G-quadruplex DNA as a target for drug design","volume":"6","author":"Kerwin","year":"2000","journal-title":"Curr. Pharm. Des."},{"issue":"3","key":"10.1016\/j.bbrc.2025.151988_bib12","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1038\/nrc2342","article-title":"DNA repair pathways as targets for cancer therapy","volume":"8","author":"Helleday","year":"2008","journal-title":"Nat. Rev. Cancer"},{"issue":"3","key":"10.1016\/j.bbrc.2025.151988_bib13","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/S0959-440X(98)80064-X","article-title":"Drug\u2014Dna interactions","volume":"8","author":"Chaires","year":"1998","journal-title":"Curr. Opin. Struct. Biol."},{"key":"10.1016\/j.bbrc.2025.151988_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.nanoen.2020.105592","article-title":"Probing local electrochemistry via mechanical cyclic voltammetry curves","volume":"81","author":"Tsai","year":"2021","journal-title":"Nano Energy"},{"key":"10.1016\/j.bbrc.2025.151988_bib15","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.eurpolymj.2016.05.016","article-title":"Electrochemical techniques for investigating redox active macromolecules","volume":"83","author":"Izquierdo","year":"2016","journal-title":"Eur. Polym. J."},{"issue":"1","key":"10.1016\/j.bbrc.2025.151988_bib16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0003-2670(00)00025-8","article-title":"Glassy carbon as electrode material in electro-analytical chemistry","volume":"119","author":"Van der Linden","year":"1980","journal-title":"Anal. Chim. Acta"},{"issue":"4","key":"10.1016\/j.bbrc.2025.151988_bib17","first-page":"161","article-title":"Real-time and label-free bio-sensing of molecular interactions by surface plasmon resonance: a laboratory medicine perspective","volume":"33","author":"Helmerhorst","year":"2012","journal-title":"Clin. Biochem. Rev."},{"key":"10.1016\/j.bbrc.2025.151988_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.trac.2022.116565","article-title":"Advanced on-site and in vitro signal amplification biosensors for biomolecule analysis","volume":"149","author":"Wang","year":"2022","journal-title":"TrAC, Trends Anal. Chem."},{"issue":"59","key":"10.1016\/j.bbrc.2025.151988_bib19","doi-asserted-by":"crossref","first-page":"47367","DOI":"10.1039\/C5RA08790B","article-title":"Unraveling the coptisine\u2013ctDNA binding mechanism by multispectroscopic, electrochemical and molecular docking methods","volume":"5","author":"Mi","year":"2015","journal-title":"RSC Adv."},{"issue":"7","key":"10.1016\/j.bbrc.2025.151988_bib20","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1023\/A:1020365522701","article-title":"Synthesis, characterization, electrochemistry and kinetics of CTDNA binding of a bis ciprofloxacin borate copper(II) complex","volume":"27","author":"Tak","year":"2002","journal-title":"Transit. Met. Chem."},{"key":"10.1016\/j.bbrc.2025.151988_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioelechem.2019.107330","article-title":"Spectro-electrochemistry of ciprofloxacin and probing its interaction with bovine serum albumin","volume":"130","author":"Ipte","year":"2019","journal-title":"Bioelectrochemistry"},{"key":"10.1016\/j.bbrc.2025.151988_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.saa.2021.119809","article-title":"The different interactions of two anticancer drugs with bovine serum albumin based on multi-spectrum method combined with molecular dynamics simulations","volume":"259","author":"Qi","year":"2021","journal-title":"Spectrochim. Acta Mol. Biomol. Spectrosc."},{"issue":"19","key":"10.1016\/j.bbrc.2025.151988_bib23","doi-asserted-by":"crossref","first-page":"9144","DOI":"10.1080\/07391102.2021.1924270","article-title":"Experimental and computational investigation on the binding of anticancer drug gemcitabine with bovine serum albumin","volume":"40","author":"Ali","year":"2022","journal-title":"J. Biomol. Struct. Dyn."},{"key":"10.1016\/j.bbrc.2025.151988_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpba.2022.114693","article-title":"A stability indicating RP-HPLC method for determination of the COVID-19 drug molnupiravir applied using nanoformulations in permeability studies","volume":"214","author":"Re\u00e7ber","year":"2022","journal-title":"J. Pharmaceut. Biomed. Anal."},{"issue":"1","key":"10.1016\/j.bbrc.2025.151988_bib25","doi-asserted-by":"crossref","DOI":"10.2174\/26669587-v3-230221-2022-30","article-title":"New UV spectrophotometric method for the estimation of molnupiravir used in the treatment of COVID-19","volume":"3","author":"Deshpande","year":"2023","journal-title":"The Open COVID Journal"},{"issue":"1","key":"10.1016\/j.bbrc.2025.151988_bib26","first-page":"42","article-title":"Electrochemical behavior of paclitaxel and its determination at glassy carbon electrode","volume":"9","author":"Gowda","year":"2014","journal-title":"Asian J. Pharm. Sci."},{"issue":"22","key":"10.1016\/j.bbrc.2025.151988_bib27","doi-asserted-by":"crossref","first-page":"2633","DOI":"10.1002\/elan.201000272","article-title":"Electrochemical redox behaviour of temozolomide using a glassy carbon electrode","volume":"22","author":"Ghalkhani","year":"2010","journal-title":"Electroanalysis"},{"issue":"3","key":"10.1016\/j.bbrc.2025.151988_bib28","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1002\/dta.200","article-title":"Voltammetric assay of anti\u2010anginal drug nicorandil in different solvents","volume":"3","author":"Jain","year":"2011","journal-title":"Drug Test. Anal."},{"issue":"38","key":"10.1016\/j.bbrc.2025.151988_bib29","doi-asserted-by":"crossref","first-page":"18850","DOI":"10.1016\/j.ijhydene.2020.05.122","article-title":"A glassy carbon electrode modified with tailored nanostructures of cobalt oxide for oxygen reduction reaction","volume":"45","author":"Shahid","year":"2020","journal-title":"Int. J. Hydrogen Energy"},{"key":"10.1016\/j.bbrc.2025.151988_bib30","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1016\/j.ijbiomac.2017.03.136","article-title":"Characterization of the groove binding between di-(2-ethylhexyl) phthalate and calf thymus DNA","volume":"101","author":"Li","year":"2017","journal-title":"Int. J. Biol. Macromol."},{"issue":"2","key":"10.1016\/j.bbrc.2025.151988_bib31","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1002\/(SICI)1099-1352(199603)9:2<175::AID-JMR260>3.0.CO;2-D","article-title":"Molecular docking towards drug discovery","volume":"9","author":"Gschwend","year":"1996","journal-title":"J. Mol. Recogn.: An Interdisciplinary Journal"},{"issue":"1","key":"10.1016\/j.bbrc.2025.151988_bib32","doi-asserted-by":"crossref","first-page":"91","DOI":"10.2174\/0929867043456223","article-title":"Predicting molecular interactions in silico: II. Protein-protein and protein-drug docking","volume":"11","author":"Schneidman-Duhovny","year":"2004","journal-title":"Curr. Med. Chem."},{"issue":"16","key":"10.1016\/j.bbrc.2025.151988_bib33","doi-asserted-by":"crossref","first-page":"1668","DOI":"10.1002\/jcc.20290","article-title":"The amber biomolecular simulation programs","volume":"26","author":"Case","year":"2005","journal-title":"J. Comput. Chem."},{"issue":"2","key":"10.1016\/j.bbrc.2025.151988_bib34","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1002\/wcms.1121","article-title":"An overview of the amber biomolecular simulation package","volume":"3","author":"Salomon-Ferrer","year":"2013","journal-title":"WIREs Computational Molecular Science"},{"issue":"24","key":"10.1016\/j.bbrc.2025.151988_bib35","doi-asserted-by":"crossref","first-page":"15305","DOI":"10.1080\/07391102.2023.2188430","article-title":"SARS-CoV-2 envelope protein attain kac mediated dynamical interaction network to adopt \u2018histone mimic\u2019 at BRD4 interface","volume":"41","author":"Agrahari","year":"2023","journal-title":"J. Biomol. Struct. Dyn."},{"key":"10.1016\/j.bbrc.2025.151988_bib36","first-page":"1","article-title":"Crystallographic mining driven computer-guided approach to identify the ASK1 inhibitor likely to perturb the catalytic region","author":"Haider","year":"2023","journal-title":"J. Biomol. Struct. Dyn."},{"issue":"9","key":"10.1016\/j.bbrc.2025.151988_bib37","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1002\/jcc.20035","article-title":"Development and testing of a general amber force field","volume":"25","author":"Wang","year":"2004","journal-title":"J. Comput. Chem."},{"issue":"40","key":"10.1016\/j.bbrc.2025.151988_bib38","doi-asserted-by":"crossref","first-page":"10269","DOI":"10.1021\/j100142a004","article-title":"A well-behaved electrostatic potential based method using charge restraints for deriving atomic charges: the RESP model","volume":"97","author":"Bayly","year":"1993","journal-title":"The Journal of Physical Chemistry"},{"issue":"2","key":"10.1016\/j.bbrc.2025.151988_bib39","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1063\/1.445869","article-title":"Comparison of simple potential functions for simulating liquid water","volume":"79","author":"Jorgensen","year":"1983","journal-title":"J. Chem. Phys."},{"issue":"12","key":"10.1016\/j.bbrc.2025.151988_bib40","doi-asserted-by":"crossref","first-page":"10089","DOI":"10.1063\/1.464397","article-title":"Particle mesh ewald: an n\u22c5log(N) method for ewald sums in large systems","volume":"98","author":"Darden","year":"1993","journal-title":"J. Chem. Phys."},{"issue":"3","key":"10.1016\/j.bbrc.2025.151988_bib41","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/0021-9991(77)90098-5","article-title":"Numerical integration of the Cartesian equations of motion of a system with constraints: molecular dynamics of n-alkanes","volume":"23","author":"Ryckaert","year":"1977","journal-title":"J. Comput. Phys."},{"issue":"1","key":"10.1016\/j.bbrc.2025.151988_bib42","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1007\/s11033-023-09072-2","article-title":"Identification and structural characterization of a pathogenic ARSA missense variant in two consanguineous families from Jammu and Kashmir (india) with late infantile metachromatic leukodystrophy","volume":"51","author":"Mir","year":"2023","journal-title":"Mol. Biol. Rep."},{"issue":"2","key":"10.1016\/j.bbrc.2025.151988_bib43","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1007\/s11011-017-0121-2","article-title":"A profound computational study to prioritize the disease-causing mutations in PRPS1 gene","volume":"33","author":"Agrahari","year":"2018","journal-title":"Metab. Brain Dis."},{"key":"10.1016\/j.bbrc.2025.151988_bib44","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.jtbi.2017.10.028","article-title":"Substitution impact of highly conserved arginine residue at position 75 in GJB1 gene in association with X-linked Charcot\u2013marie-Tooth disease: a computational study","volume":"437","author":"Agrahari","year":"2018","journal-title":"J. Theor. Biol."},{"issue":"7","key":"10.1016\/j.bbrc.2025.151988_bib45","doi-asserted-by":"crossref","first-page":"3084","DOI":"10.1021\/ct400341p","article-title":"PTRAJ and CPPTRAJ: software for processing and analysis of molecular dynamics trajectory data","volume":"9","author":"Roe","year":"2013","journal-title":"J. Chem. Theor. Comput."},{"issue":"1","key":"10.1016\/j.bbrc.2025.151988_bib46","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/0263-7855(96)00018-5","article-title":"VMD: visual molecular dynamics","volume":"14","author":"Humphrey","year":"1996","journal-title":"J. Mol. Graph."},{"issue":"5","key":"10.1016\/j.bbrc.2025.151988_bib47","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1517\/17460441.2015.1032936","article-title":"The MM\/PBSA and MM\/GBSA methods to estimate ligand-binding affinities","volume":"10","author":"Genheden","year":"2015","journal-title":"Expert Opin Drug Discov"},{"issue":"60","key":"10.1016\/j.bbrc.2025.151988_bib48","doi-asserted-by":"crossref","first-page":"3021","DOI":"10.21105\/joss.03021","article-title":"Seaborn: statistical data visualization","volume":"6","author":"Waskom","year":"2021","journal-title":"J. Open Source Softw."},{"key":"10.1016\/j.bbrc.2025.151988_bib49","series-title":"Techniques and Mechanisms in Electrochemistry","author":"Christensen","year":"2007"},{"issue":"6","key":"10.1016\/j.bbrc.2025.151988_bib50","doi-asserted-by":"crossref","first-page":"2748","DOI":"10.1016\/j.electacta.2010.12.060","article-title":"Electrochemical behavior of catechol, resorcinol and hydroquinone at graphene\u2013chitosan composite film modified glassy carbon electrode and their simultaneous determination in water samples","volume":"56","author":"Yin","year":"2011","journal-title":"Electrochim. Acta"},{"issue":"18","key":"10.1016\/j.bbrc.2025.151988_bib51","doi-asserted-by":"crossref","first-page":"8392","DOI":"10.1039\/C4CP00342J","article-title":"Electrochemical characteristics of nanostructured platinum Electrodes\u2013A cyclic voltammetry study","volume":"16","author":"Daubinger","year":"2014","journal-title":"Phys. Chem. Chem. Phys."},{"issue":"9","key":"10.1016\/j.bbrc.2025.151988_bib52","doi-asserted-by":"crossref","first-page":"471","DOI":"10.3390\/chemosensors11090471","article-title":"A green voltammetric determination of molnupiravir using a disposable screen-printed reduced graphene oxide electrode: application for pharmaceutical dosage and biological fluid forms","volume":"11","author":"Nabil","year":"2023","journal-title":"Chemosensors"},{"key":"10.1016\/j.bbrc.2025.151988_bib53","article-title":"Voltammetric detection of anticancer drug doxorubicin at pencil graphite electrode: a voltammetric study","volume":"1","author":"Deepa","year":"2020","journal-title":"Sens. Int."},{"issue":"9","key":"10.1016\/j.bbrc.2025.151988_bib54","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1038\/s41594-021-00651-0","article-title":"Mechanism of molnupiravir-induced SARS-CoV-2 mutagenesis","volume":"28","author":"Kabinger","year":"2021","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.bbrc.2025.151988_bib55","doi-asserted-by":"crossref","DOI":"10.1016\/j.molstruc.2023.135697","article-title":"Understanding the molecular interaction of BSA protein with antibiotic sulfa molecule(s) for novel drug development","volume":"1287","author":"Mavani","year":"2023","journal-title":"J. Mol. Struct."},{"issue":"7594","key":"10.1016\/j.bbrc.2025.151988_bib56","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1038\/nature17180","article-title":"Therapeutic efficacy of the small molecule GS-5734 against ebola virus in rhesus monkeys","volume":"531","author":"Warren","year":"2016","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.bbrc.2025.151988_bib57","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.107940","article-title":"Remdesivir inhibits SARS-CoV-2 in human lung cells and chimeric SARS-CoV expressing the SARS-CoV-2 RNA polymerase in mice","volume":"32","author":"Pruijssers","year":"2020","journal-title":"Cell Rep."},{"key":"10.1016\/j.bbrc.2025.151988_bib58","doi-asserted-by":"crossref","DOI":"10.1177\/2040206618761299","article-title":"Nucleoside analogs as a rich source of antiviral agents active against arthropod-borne flaviviruses","volume":"26","author":"Eyer","year":"2018","journal-title":"Antiviral Chem. Chemother."},{"issue":"7\u20138","key":"10.1016\/j.bbrc.2025.151988_bib59","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1080\/17425255.2022.2112175","article-title":"Important roles of transporters in the pharmacokinetics of anti-viral nucleoside\/nucleotide analogs","volume":"18","author":"Yang","year":"2022","journal-title":"Expert Opin. Drug Metab. Toxicol."},{"issue":"2","key":"10.1016\/j.bbrc.2025.151988_bib60","doi-asserted-by":"crossref","first-page":"101","DOI":"10.2165\/00003088-199324020-00002","article-title":"Comparative pharmacokinetics of antiviral nucleoside analogues","volume":"24","author":"Morse","year":"1993","journal-title":"Clin. Pharmacokinet."},{"issue":"3","key":"10.1016\/j.bbrc.2025.151988_bib61","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.jconrel.2008.05.010","article-title":"Albumin as a drug carrier: design of prodrugs, drug conjugates and nanoparticles","volume":"132","author":"Kratz","year":"2008","journal-title":"J Control Release"},{"issue":"6","key":"10.1016\/j.bbrc.2025.151988_bib62","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1016\/S0026-895X(25)10691-3","article-title":"The characterization of two specific drug binding sites on human serum albumin","volume":"11","author":"Sudlow","year":"1975","journal-title":"Mol. Pharmacol."},{"issue":"4","key":"10.1016\/j.bbrc.2025.151988_bib63","doi-asserted-by":"crossref","first-page":"728","DOI":"10.3390\/pharmaceutics14040728","article-title":"Emerging albumin-binding anticancer drugs for tumor-targeted drug delivery: current understandings and clinical translation","volume":"14","author":"Cho","year":"2022","journal-title":"Pharmaceutics"},{"issue":"1","key":"10.1016\/j.bbrc.2025.151988_bib64","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s40262-012-0018-5","article-title":"The clinical relevance of plasma protein binding changes","volume":"52","author":"Roberts","year":"2013","journal-title":"Clin. Pharmacokinet."},{"issue":"1","key":"10.1016\/j.bbrc.2025.151988_bib65","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1186\/s43066-023-00279-3","article-title":"Genotoxic effect of tamiflu and adamine on DNA content in Male albino mice","volume":"13","author":"El-Alfy","year":"2023","journal-title":"Egyptian Liver Journal"},{"issue":"1","key":"10.1016\/j.bbrc.2025.151988_bib66","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.108940","article-title":"Antiviral drug screen identifies DNA-Damage response inhibitor as potent blocker of SARS-CoV-2 replication","volume":"35","author":"Garcia","year":"2021","journal-title":"Cell Rep."},{"issue":"20","key":"10.1016\/j.bbrc.2025.151988_bib67","doi-asserted-by":"crossref","first-page":"11256","DOI":"10.1128\/JVI.01028-07","article-title":"Lethal mutagenesis of poliovirus mediated by a mutagenic pyrimidine analogue","volume":"81","author":"Graci","year":"2007","journal-title":"J. Virol."},{"issue":"7","key":"10.1016\/j.bbrc.2025.151988_bib68","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1016\/j.drudis.2022.02.013","article-title":"Nucleosides and emerging viruses: a new story","volume":"27","author":"Roy","year":"2022","journal-title":"Drug Discov. Today"},{"issue":"11","key":"10.1016\/j.bbrc.2025.151988_bib69","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1186\/s13073-014-0115-1","article-title":"Virus-host interactomics: new insights and opportunities for antiviral drug discovery","volume":"6","author":"de Chassey","year":"2014","journal-title":"Genome Med."},{"issue":"11","key":"10.1016\/j.bbrc.2025.151988_bib70","doi-asserted-by":"crossref","DOI":"10.15252\/msb.202110396","article-title":"SARS-CoV-2-host proteome interactions for antiviral drug discovery","volume":"17","author":"Liu","year":"2021","journal-title":"Mol. Syst. Biol."},{"issue":"2","key":"10.1016\/j.bbrc.2025.151988_bib71","doi-asserted-by":"crossref","DOI":"10.3390\/ijms17020144","article-title":"Insights into protein-ligand interactions: mechanisms, models, and methods","volume":"17","author":"Du","year":"2016","journal-title":"Int. J. Mol. Sci."},{"issue":"9","key":"10.1016\/j.bbrc.2025.151988_bib72","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1021\/acsptsci.2c00115","article-title":"Using human serum albumin binding affinities as a proactive strategy to affect the pharmacodynamics and pharmacokinetics of preclinical drug candidates","volume":"5","author":"Fan","year":"2022","journal-title":"ACS Pharmacol. Transl. Sci."},{"issue":"5","key":"10.1016\/j.bbrc.2025.151988_bib73","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1007\/s40262-021-00984-5","article-title":"Pharmacokinetic, pharmacodynamic, and drug-interaction profile of remdesivir, a SARS-CoV-2 replication inhibitor","volume":"60","author":"Humeniuk","year":"2021","journal-title":"Clin. Pharmacokinet."},{"key":"10.1016\/j.bbrc.2025.151988_bib74","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.864742","article-title":"Application of an accessible interface for pharmacokinetic modeling and in vitro to in vivo extrapolation","volume":"13","author":"Hines","year":"2022","journal-title":"Front. Pharmacol."},{"issue":"4","key":"10.1016\/j.bbrc.2025.151988_bib75","doi-asserted-by":"crossref","DOI":"10.1242\/dmm.049065","article-title":"The benefits, limitations and opportunities of preclinical models for neonatal drug development","volume":"15","author":"Campion","year":"2022","journal-title":"Dis. Model. Mech."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X25007028?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X25007028?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,5,17]],"date-time":"2025-05-17T07:51:42Z","timestamp":1747468302000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X25007028"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":75,"alternative-id":["S0006291X25007028"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2025.151988","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Electrochemical interpretations for the study of molnupiravir binding interactions with bovine serum albumin and DNA and molecular dynamics studies","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2025.151988","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"151988"}}