{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T21:19:16Z","timestamp":1787779156919,"version":"build-2784847793"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002241","name":"Japan Science and Technology Agency","doi-asserted-by":"publisher","award":["JPMJSP2129"],"award-info":[{"award-number":["JPMJSP2129"]}],"id":[{"id":"10.13039\/501100002241","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["23K10928"],"award-info":[{"award-number":["23K10928"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["23K24207"],"award-info":[{"award-number":["23K24207"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["22K06466"],"award-info":[{"award-number":["22K06466"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2025,7]]},"DOI":"10.1016\/j.bbrc.2025.152025","type":"journal-article","created":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T19:27:27Z","timestamp":1747250847000},"page":"152025","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["High Affinity Staining for Histological Immunoreactivity revealed phosphorylated tau within amyloid-cored plaques in the brain of AD model mice"],"prefix":"10.1016","volume":"771","author":[{"given":"Yuto","family":"Higashi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanta","family":"Ikuno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9659-9251","authenticated-orcid":false,"given":"Takashi","family":"Saito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takaomi C.","family":"Saido","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomohiro","family":"Miyasaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7011-6891","authenticated-orcid":false,"given":"Nobuto","family":"Kakuda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8433-4846","authenticated-orcid":false,"given":"Satoru","family":"Funamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.bbrc.2025.152025_bib1","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1093\/oxfordjournals.jbchem.a135625","article-title":"One of the antigenic determinants of paired helical filaments is related to tau protein","volume":"99","author":"Nukina","year":"1986","journal-title":"J. Biochem."},{"issue":"13","key":"10.1016\/j.bbrc.2025.152025_bib2","doi-asserted-by":"crossref","first-page":"6084","DOI":"10.1016\/S0021-9258(17)38495-8","article-title":"Microtubule-associated protein tau. A component of alzheimer paired helical filaments","volume":"261","author":"Grundke-Iqbal","year":"1986","journal-title":"J. Biol. Chem."},{"issue":"11","key":"10.1016\/j.bbrc.2025.152025_bib3","doi-asserted-by":"crossref","first-page":"4044","DOI":"10.1073\/pnas.83.11.4044","article-title":"Microtubule-associated protein tau (Tau) is a major antigenic component of paired helical filaments in alzheimer disease","volume":"83","author":"Kosik","year":"1986","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"11","key":"10.1016\/j.bbrc.2025.152025_bib4","doi-asserted-by":"crossref","first-page":"4040","DOI":"10.1073\/pnas.83.11.4040","article-title":"Neurofibrillary tangles of alzheimer disease share antigenic determinants with the axonal microtubule-associated protein tau (Tau) [published correction appears in proc natl acad sci U S A 1986 Dec;83(24):9773]","volume":"83","author":"Wood","year":"1986","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"1","key":"10.1016\/j.bbrc.2025.152025_bib5","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1002\/ana.410410106","article-title":"Neuronal loss correlates with but exceeds neurofibrillary tangles in alzheimer's disease","volume":"41","author":"G\u00f3mez-Isla","year":"1997","journal-title":"Ann. Neurol."},{"issue":"6","key":"10.1016\/j.bbrc.2025.152025_bib6","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1212\/WNL.52.6.1158","article-title":"The biochemical pathway of neurofibrillary degeneration in aging and alzheimer's disease","volume":"52","author":"Delacourte","year":"1999","journal-title":"Neurology"},{"issue":"6","key":"10.1016\/j.bbrc.2025.152025_bib7","doi-asserted-by":"crossref","first-page":"2465","DOI":"10.1046\/j.1471-4159.1998.71062465.x","article-title":"New phosphorylation sites identified in hyperphosphorylated tau (paired helical filament-tau) from alzheimer's disease brain using nanoelectrospray mass spectrometry","volume":"71","author":"Hanger","year":"1998","journal-title":"J. Neurochem."},{"issue":"32","key":"10.1016\/j.bbrc.2025.152025_bib8","doi-asserted-by":"crossref","first-page":"23645","DOI":"10.1074\/jbc.M703269200","article-title":"Novel phosphorylation sites in tau from alzheimer brain support a role for casein kinase 1 in disease pathogenesis","volume":"282","author":"Hanger","year":"2007","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.bbrc.2025.152025_bib9","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.neulet.2003.08.011","article-title":"Cerebrospinal fluid markers for prediction of alzheimer's disease","volume":"352","author":"Zetterberg","year":"2003","journal-title":"Neurosci. Lett."},{"issue":"7","key":"10.1016\/j.bbrc.2025.152025_bib10","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1212\/01.WNL.0000156914.16988.56","article-title":"CSF Abeta42 and tau or phosphorylated tau and prediction of progressive mild cognitive impairment","volume":"64","author":"Herukka","year":"2005","journal-title":"Neurology"},{"key":"10.1016\/j.bbrc.2025.152025_bib11","doi-asserted-by":"crossref","unstructured":"Saint-Aubert L, Lemoine L, Chiotis K, Leuzy A, Rodriguez-Vieitez E, Nordberg A. Tau PET imaging: present and future directions Mol. Neurodegener. 12(1) (19. Published 2017 Feb20), 10.1186\/s13024-017-0162-3.","DOI":"10.1186\/s13024-017-0162-3"},{"issue":"6248","key":"10.1016\/j.bbrc.2025.152025_bib12","doi-asserted-by":"crossref","DOI":"10.1126\/science.1255555","article-title":"NEURODEGENERATION. Alzheimer's and Parkinson's diseases: the prion concept in relation to assembled A\u03b2, tau, and \u03b1-synuclein","volume":"349","author":"Goedert","year":"2015","journal-title":"Science"},{"issue":"5054","key":"10.1016\/j.bbrc.2025.152025_bib13","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1126\/science.1566067","article-title":"Alzheimer's disease: the amyloid Cascade hypothesis","volume":"256","author":"Hardy","year":"1992","journal-title":"Science"},{"issue":"4","key":"10.1016\/j.bbrc.2025.152025_bib14","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/S0168-0102(98)00061-3","article-title":"Activation of tau protein kinase I\/glycogen synthase kinase-3beta by amyloid beta peptide (25-35) enhances phosphorylation of tau in hippocampal neurons","volume":"31","author":"Takashima","year":"1998","journal-title":"Neurosci. Res."},{"key":"10.1016\/j.bbrc.2025.152025_bib15","doi-asserted-by":"crossref","unstructured":"Zhang H, Wei W, Zhao M, et al. Interaction between A\u03b2 and tau in the pathogenesis of alzheimer's disease Int. J. Biol. Sci. 17(9) (Published 2021 May 27), pp. 2181-2192, 10.7150\/ijbs.57078.","DOI":"10.7150\/ijbs.57078"},{"issue":"9","key":"10.1016\/j.bbrc.2025.152025_bib16","doi-asserted-by":"crossref","first-page":"2759","DOI":"10.1093\/brain\/awab134","article-title":"Amyloid-\u03b2 toxicity modulates tau phosphorylation through the PAX6 signalling pathway","volume":"144","author":"Zhang","year":"2021","journal-title":"Brain"},{"issue":"1","key":"10.1016\/j.bbrc.2025.152025_bib17","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/S0002-9440(10)63812-6","article-title":"Filamentous tau in oligodendrocytes and astrocytes of transgenic mice expressing the human tau isoform with the P301L mutation","volume":"162","author":"Lin","year":"2003","journal-title":"Am. J. Pathol."},{"issue":"34","key":"10.1016\/j.bbrc.2025.152025_bib18","doi-asserted-by":"crossref","first-page":"6781","DOI":"10.1523\/JNEUROSCI.2845-18.2019","article-title":"Ectopic expression induces abnormal somatodendritic distribution of tau in the mouse","volume":"39","author":"Kubo","year":"2019","journal-title":"Brain J Neurosci"},{"issue":"19","key":"10.1016\/j.bbrc.2025.152025_bib19","doi-asserted-by":"crossref","first-page":"2441","DOI":"10.1091\/mbc.E19-03-0183","article-title":"Regulatory mechanisms for the axonal localization of tau protein in neurons","volume":"30","author":"Iwata","year":"2019","journal-title":"Mol. Biol. Cell"},{"issue":"6","key":"10.1016\/j.bbrc.2025.152025_bib20","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1016\/j.cell.2020.10.029","article-title":"Tau PTM profiles identify patient heterogeneity and stages of alzheimer's disease","volume":"183","author":"Wesseling","year":"2020","journal-title":"Cell"},{"issue":"2","key":"10.1016\/j.bbrc.2025.152025_bib21","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1111\/j.1471-4159.2004.02155.x","article-title":"Primed phosphorylation of tau at Thr231 by glycogen synthase kinase 3beta (GSK3beta) plays a critical role in regulating tau's ability to bind and stabilize microtubules","volume":"88","author":"Cho","year":"2004","journal-title":"J. Neurochem"},{"issue":"1","key":"10.1016\/j.bbrc.2025.152025_bib22","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1074\/jbc.M206236200","article-title":"Glycogen synthase kinase 3beta phosphorylates tau at both primed and unprimed sites. Differential impact on microtubule binding","volume":"278","author":"Cho","year":"2003","journal-title":"J. Biol. Chem."},{"issue":"13","key":"10.1016\/j.bbrc.2025.152025_bib23","first-page":"7679","article-title":"Microtubule-associated protein\/microtubule affinity-regulating kinase (P110mark). A novel protein kinase that regulates tau-microtubule interactions and dynamic instability by phosphorylation at the Alzheimer-specific site serine 262","volume":"270","author":"Drewes","year":"1995","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.bbrc.2025.152025_bib24","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/0896-6273(93)90279-Z","article-title":"Phosphorylation of Ser262 strongly reduces binding of tau to microtubules: distinction between PHF-Like immunoreactivity and microtubule binding","volume":"11","author":"Biernat","year":"1993","journal-title":"Neuron"},{"key":"10.1016\/j.bbrc.2025.152025_bib25","doi-asserted-by":"crossref","unstructured":"\u0160imi\u0107 G, Babi\u0107 Leko M, Wray S, et al. Tau protein hyperphosphorylation and aggregation in alzheimer's disease and other tauopathies, and possible neuroprotective strategies Biomolecules. 6(1):6 (Published 2016 Jan 6), 10.3390\/biom6010006.","DOI":"10.3390\/biom6010006"},{"key":"10.1016\/j.bbrc.2025.152025_bib26","doi-asserted-by":"crossref","unstructured":"Stieler JT, Bullmann T, Kohl F, et al. The physiological link between metabolic rate depression and tau phosphorylation in Mammalian hibernation PLoS One. 6(1):e14530 (Published 2011 Jan 18), 10.1371\/journal.pone.0014530.","DOI":"10.1371\/journal.pone.0014530"},{"issue":"12","key":"10.1016\/j.bbrc.2025.152025_bib27","doi-asserted-by":"crossref","first-page":"2245","DOI":"10.1111\/cns.13970","article-title":"Tau antibody 77G7 targeting microtubule binding domain suppresses proteopathic tau to seed tau aggregation","volume":"28","author":"Li","year":"2022","journal-title":"CNS Neurosci. Ther."},{"issue":"Pt 6","key":"10.1016\/j.bbrc.2025.152025_bib28","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1242\/jcs.114.6.1179","article-title":"Inhibition of neuronal maturation in primary hippocampal neurons from tau deficient mice","volume":"114","author":"Dawson","year":"2001","journal-title":"J. Cell Sci."},{"issue":"5","key":"10.1016\/j.bbrc.2025.152025_bib29","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1038\/nn.3697","article-title":"Single app knock-in mouse models of alzheimer's disease","volume":"17","author":"Saito","year":"2014","journal-title":"Nat. Neurosci."},{"issue":"10","key":"10.1016\/j.bbrc.2025.152025_bib30","doi-asserted-by":"crossref","first-page":"2401","DOI":"10.1523\/JNEUROSCI.5561-03.2004","article-title":"Alterations in glucose metabolism induce hypothermia leading to tau hyperphosphorylation through differential inhibition of kinase and phosphatase activities: implications for alzheimer's disease","volume":"24","author":"Planel","year":"2004","journal-title":"J. Neurosci."},{"issue":"5","key":"10.1016\/j.bbrc.2025.152025_bib31","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1074\/jbc.M117.798918","article-title":"Isoform-independent and -dependent phosphorylation of microtubule-associated protein tau in mouse brain during postnatal development","volume":"293","author":"Tuerde","year":"2018","journal-title":"J. Biol. Chem."},{"issue":"2","key":"10.1016\/j.bbrc.2025.152025_bib32","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1002\/glia.10153","article-title":"Microglia and inflammatory mechanisms in the clearance of amyloid beta peptide","volume":"40","author":"Rogers","year":"2002","journal-title":"Glia"},{"issue":"6","key":"10.1016\/j.bbrc.2025.152025_bib33","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1007\/BF00687883","article-title":"Demonstration of microglial cells in and around senile (neuritic) plaques in the alzheimer brain. An immunohistochemical study using a novel monoclonal antibody","volume":"77","author":"Haga","year":"1989","journal-title":"Acta Neuropathol."},{"issue":"5","key":"10.1016\/j.bbrc.2025.152025_bib34","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/0197-4580(95)00092-S","article-title":"Role of microglia in senile plaque formation","volume":"16","author":"Mackenzie","year":"1995","journal-title":"Neurobiol. Aging"},{"issue":"7","key":"10.1016\/j.bbrc.2025.152025_bib35","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1016\/j.cell.2017.05.018","article-title":"A unique microglia type associated with restricting development of alzheimer's disease","volume":"169","author":"Keren-Shaul","year":"2017","journal-title":"Cell"},{"issue":"5","key":"10.1016\/j.bbrc.2025.152025_bib36","first-page":"1073","article-title":"Disease-associated microglia: a universal immune sensor of","volume":"173","author":"Deczkowska","year":"2018","journal-title":"Neurodegeneration Cell"},{"issue":"5","key":"10.1016\/j.bbrc.2025.152025_bib37","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1002\/cne.24577","article-title":"Distribution of endogenous normal tau in the mouse brain","volume":"527","author":"Kubo","year":"2019","journal-title":"J. Comp. Neurol."},{"issue":"11","key":"10.1016\/j.bbrc.2025.152025_bib38","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1038\/nn.4132","article-title":"Depletion of microglia and inhibition of exosome synthesis halt tau propagation","volume":"18","author":"Asai","year":"2015","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.bbrc.2025.152025_bib39","doi-asserted-by":"crossref","unstructured":"Maphis N, Jiang S, Xu G, et al. Selective suppression of the \u03b1 isoform of p38 MAPK rescues late-stage tau pathology Alzheimers Res. Ther. 8(1):54 (Published 2016 Dec 15), 10.1186\/s13195-016-0221-y.","DOI":"10.1186\/s13195-016-0221-y"},{"issue":"5","key":"10.1016\/j.bbrc.2025.152025_bib40","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1523\/JNEUROSCI.23-05-01605.2003","article-title":"Interleukin-1 mediates pathological effects of microglia on tau phosphorylation and on synaptophysin synthesis in cortical neurons through a p38-MAPK pathway","volume":"23","author":"Li","year":"2003","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbrc.2025.152025_bib41","doi-asserted-by":"crossref","unstructured":"Bol\u00f3s M, Llorens-Mart\u00edn M, Jurado-Arjona J, Hern\u00e1ndez F, R\u00e1bano A, Avila J. Direct evidence of internalization of tau by microglia in vitro and In Vivo J Alzheimers Dis. 50(1) (2016), pp. 77-87, 10.3233\/JAD-150704.","DOI":"10.3233\/JAD-150704"},{"issue":"2","key":"10.1016\/j.bbrc.2025.152025_bib42","doi-asserted-by":"crossref","DOI":"10.1002\/alz.14418","article-title":"Microglia internalize tau monomers and fibrils using distinct receptors but similar mechanisms","volume":"21","author":"Falkon","year":"2025","journal-title":"Alzheimer's Dement."},{"issue":"8","key":"10.1016\/j.bbrc.2025.152025_bib43","doi-asserted-by":"crossref","first-page":"2027","DOI":"10.1016\/j.celrep.2018.10.078","article-title":"Secretion of tau via an unconventional non-vesicular mechanism","volume":"25","author":"Merezhko","year":"2018","journal-title":"Cell Rep."},{"issue":"1","key":"10.1016\/j.bbrc.2025.152025_bib44","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.febslet.2011.11.022","article-title":"Proteostasis of tau. Tau overexpression results in its secretion via membrane vesicles","volume":"586","author":"Sim\u00f3n","year":"2012","journal-title":"FEBS Lett."},{"issue":"3","key":"10.1016\/j.bbrc.2025.152025_bib45","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.nbd.2012.05.021","article-title":"Constitutive secretion of tau protein by an unconventional mechanism","volume":"48","author":"Chai","year":"2012","journal-title":"Neurobiol. Dis."},{"issue":"22","key":"10.1016\/j.bbrc.2025.152025_bib46","doi-asserted-by":"crossref","first-page":"4153","DOI":"10.1016\/j.cell.2022.09.033","article-title":"TREM2 drives microglia response to amyloid-\u03b2 via SYK-Dependent and -independent pathways","volume":"185","author":"Wang","year":"2022","journal-title":"Cell"},{"issue":"11","key":"10.1016\/j.bbrc.2025.152025_bib47","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1038\/s41582-018-0072-1","article-title":"TREM2 - a key player in microglial biology and alzheimer disease","volume":"14","author":"Ulland","year":"2018","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.bbrc.2025.152025_bib48","doi-asserted-by":"crossref","unstructured":"Claes C, Danhash EP, Hasselmann J, et al. Plaque-associated human microglia accumulate lipid droplets in a chimeric model of alzheimer's disease Mol. Neurodegener. 16(1):50 (Published 2021 Jul 23), 10.1186\/s13024-021-00473-0.","DOI":"10.1186\/s13024-021-00473-0"}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X25007399?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X25007399?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T20:37:06Z","timestamp":1787776626000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X25007399"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":48,"alternative-id":["S0006291X25007399"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2025.152025","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"High Affinity Staining for Histological Immunoreactivity revealed phosphorylated tau within amyloid-cored plaques in the brain of AD model mice","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2025.152025","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"152025"}}