{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T21:19:04Z","timestamp":1787779144331,"version":"build-2784847793"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82273563,81972962"],"award-info":[{"award-number":["82273563,81972962"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82273563"],"award-info":[{"award-number":["82273563"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81972962"],"award-info":[{"award-number":["81972962"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82304025"],"award-info":[{"award-number":["82304025"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004517","name":"Tianjin University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004517","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006606","name":"Tianjin Municipal Natural Science Foundation","doi-asserted-by":"publisher","award":["22JCQNJC00960"],"award-info":[{"award-number":["22JCQNJC00960"]}],"id":[{"id":"10.13039\/501100006606","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2025,7]]},"DOI":"10.1016\/j.bbrc.2025.152028","type":"journal-article","created":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T11:40:24Z","timestamp":1747395624000},"page":"152028","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Deficiency of inducible nitric oxide synthase (iNOS) enhances MC903-induced atopic dermatitis-like inflammation in mice"],"prefix":"10.1016","volume":"771","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0512-5641","authenticated-orcid":false,"given":"Jing","family":"Luo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenxi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-7341-7816","authenticated-orcid":false,"given":"Yufei","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruitan","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junkai","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoyue","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengke","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianyu","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingxi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pan","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Long","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2933-2207","authenticated-orcid":false,"given":"Lizhi","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2025.152028_bib1","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1007\/s10753-021-01615-8","article-title":"Regulatory role of nitric oxide in cutaneous inflammation","volume":"45","author":"Man","year":"2022","journal-title":"Inflammation"},{"key":"10.1016\/j.bbrc.2025.152028_bib2","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.freeradbiomed.2019.10.411","article-title":"iNOS as a metabolic enzyme under stress conditions","volume":"146","author":"Anavi","year":"2020","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bbrc.2025.152028_bib3","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/j.bcp.2009.04.021","article-title":"Reduced skin inflammatory response in mice lacking inducible nitric oxide synthase","volume":"78","author":"Medeiros","year":"2009","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.bbrc.2025.152028_bib4","doi-asserted-by":"crossref","first-page":"2682","DOI":"10.1002\/ijc.24984","article-title":"Expression and prognostic significance of iNOS in uveal melanoma","volume":"126","author":"Johansson","year":"2010","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.bbrc.2025.152028_bib5","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.niox.2006.01.006","article-title":"Nitric oxide produced by iNOS is associated with collagen synthesis in keloid scar formation","volume":"14","author":"Hsu","year":"2006","journal-title":"Nitric Oxide"},{"key":"10.1016\/j.bbrc.2025.152028_bib6","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1034\/j.1398-9995.2001.00131.x","article-title":"Increased serum nitrate levels in infants with atopic dermatitis","volume":"56","author":"Taniuchi","year":"2001","journal-title":"Allergy"},{"key":"10.1016\/j.bbrc.2025.152028_bib7","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1111\/j.1346-8138.2008.00579.x","article-title":"Co-localization of inducible nitric oxide synthase and phosphorylated akt in the lesional skins of patients with melasma","volume":"36","author":"Jo","year":"2009","journal-title":"J. Dermatol."},{"key":"10.1016\/j.bbrc.2025.152028_bib8","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1111\/j.1365-2133.1996.tb06963.x","article-title":"Increased expression of inducible nitric oxide synthase in psoriatic skin and cytokine-stimulated cultured keratinocytes","volume":"134","author":"Sirsj\u00f6","year":"1996","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.bbrc.2025.152028_bib9","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1111\/exd.14470","article-title":"Role of nitric oxide in regulating epidermal permeability barrier function","volume":"31","author":"Man","year":"2022","journal-title":"Exp. Dermatol."},{"key":"10.1016\/j.bbrc.2025.152028_bib10","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1111\/exd.14176","article-title":"Inducible nitric oxide synthase is required for epidermal permeability barrier homeostasis in mice","volume":"29","author":"Dang","year":"2020","journal-title":"Exp. Dermatol."},{"key":"10.1016\/j.bbrc.2025.152028_bib11","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2021.687381","article-title":"Nitric oxide system and bronchial epithelium: more than a barrier","volume":"12","author":"Bayarri","year":"2021","journal-title":"Front. Physiol."},{"key":"10.1016\/j.bbrc.2025.152028_bib12","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1038\/mi.2014.6","article-title":"An airway epithelial iNOS-DUOX2-thyroid peroxidase metabolome drives Th1\/Th2 nitrative stress in human severe asthma","volume":"7","author":"Voraphani","year":"2014","journal-title":"Mucosal Immunol."},{"key":"10.1016\/j.bbrc.2025.152028_bib13","doi-asserted-by":"crossref","first-page":"389","DOI":"10.3109\/07853899509002592","article-title":"Nitric oxide and airway disease","volume":"27","author":"Barnes","year":"1995","journal-title":"Ann. Med."},{"key":"10.1016\/j.bbrc.2025.152028_bib14","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1007\/s40265-016-0643-7","article-title":"Calcipotriol\/betamethasone dipropionate foam: a review in plaque psoriasis","volume":"76","author":"Kim","year":"2016","journal-title":"Drugs"},{"key":"10.1016\/j.bbrc.2025.152028_bib15","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1038\/s41419-021-04159-9","article-title":"A novel function of NLRP3 independent of inflammasome as a key transcription factor of IL-33 in epithelial cells of atopic dermatitis","volume":"12","author":"Zheng","year":"2021","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.bbrc.2025.152028_bib16","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/jid.2008.106","article-title":"Animal models of atopic dermatitis","volume":"129","author":"Jin","year":"2009","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.bbrc.2025.152028_bib17","doi-asserted-by":"crossref","first-page":"11736","DOI":"10.1073\/pnas.0604575103","article-title":"Topical vitamin D3 and low-calcemic analogs induce thymic stromal lymphopoietin in mouse keratinocytes and trigger an atopic dermatitis","volume":"103","author":"Li","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbrc.2025.152028_bib18","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.bbrc.2017.01.054","article-title":"Phospholipase C\u03b5 deficiency delays the early stage of cutaneous wound healing and attenuates scar formation in mice","volume":"484","author":"Zhu","year":"2017","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbrc.2025.152028_bib19","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1111\/1523-1747.ep12277593","article-title":"Dispase, a neutral protease from Bacillus polymyxa, is a powerful fibronectinase and type IV collagenase","volume":"93","author":"Stenn","year":"1989","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.bbrc.2025.152028_bib20","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.immuni.2015.07.007","article-title":"Barrier epithelial cells and the control of type 2 immunity","volume":"43","author":"Hammad","year":"2015","journal-title":"Immunity"},{"key":"10.1016\/j.bbrc.2025.152028_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.jenvman.2023.118702","article-title":"Sodium nitroprusside alleviates nanoplastics-induced developmental toxicity by suppressing apoptosis, ferroptosis and inflammation","volume":"345","author":"Chen","year":"2023","journal-title":"J. Environ. Manag."},{"key":"10.1016\/j.bbrc.2025.152028_bib22","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1007\/s001340050759","article-title":"The nitric oxide donor sodium nitroprusside protects against hepatic microcirculatory dysfunction in early endotoxaemia","volume":"24","author":"Gundersen","year":"1998","journal-title":"Intensive Care Med."},{"key":"10.1016\/j.bbrc.2025.152028_bib23","doi-asserted-by":"crossref","first-page":"101S","DOI":"10.1111\/1523-1747.ep12876053","article-title":"Cytokine modulation of keratinocyte cytokines","volume":"94","author":"Ansel","year":"1990","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.bbrc.2025.152028_bib24","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.cell.2013.08.057","article-title":"The epithelial cell-derived atopic dermatitis cytokine TSLP activates neurons to induce itch","volume":"155","author":"Wilson","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.bbrc.2025.152028_bib25","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1111\/exd.12383","article-title":"TLR2 and TLR4 expression in atopic dermatitis, contact dermatitis and psoriasis","volume":"23","author":"Panzer","year":"2014","journal-title":"Exp. Dermatol."},{"key":"10.1016\/j.bbrc.2025.152028_bib26","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1111\/j.1600-0625.2011.01277.x","article-title":"Intrinsic alterations of pro-inflammatory mediators in unstimulated and TLR-2 stimulated keratinocytes from atopic dermatitis patients","volume":"20","author":"Niebuhr","year":"2011","journal-title":"Exp. Dermatol."},{"key":"10.1016\/j.bbrc.2025.152028_bib27","doi-asserted-by":"crossref","first-page":"2531","DOI":"10.1016\/j.jid.2020.04.013","article-title":"A nitric oxide-releasing topical medication as a potential treatment option for atopic dermatitis through antimicrobial and anti-inflammatory activity","volume":"140","author":"Guttman-Yassky","year":"2020","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.bbrc.2025.152028_bib28","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1111\/j.1365-4362.1995.tb01602.x","article-title":"Clinical application of nitric oxide synthase inhibitor for atopic dermatitis","volume":"34","author":"Morita","year":"1995","journal-title":"Int. J. Dermatol."},{"key":"10.1016\/j.bbrc.2025.152028_bib29","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1111\/j.1600-0625.2011.01360.x","article-title":"Inducible nitric oxide synthase (iNOS) and \u03b1-melanocyte-stimulating hormones of iNOS origin play important roles in the allergic reactions of atopic dermatitis in mice","volume":"20","author":"Orita","year":"2011","journal-title":"Exp. Dermatol."},{"key":"10.1016\/j.bbrc.2025.152028_bib30","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.jare.2022.03.003","article-title":"iNOS contributes to heart failure with preserved ejection fraction through mitochondrial dysfunction and Akt S-nitrosylation","volume":"43","author":"Guo","year":"2023","journal-title":"J. Adv. Res."},{"key":"10.1016\/j.bbrc.2025.152028_bib31","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.niox.2016.10.001","article-title":"Nitrosothiol formation and S-nitrosation signaling through nitric oxide synthases","volume":"63","author":"Wynia-Smith","year":"2017","journal-title":"Nitric Oxide"},{"key":"10.1016\/j.bbrc.2025.152028_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2023.104753","article-title":"Indoleamine dioxygenase and tryptophan dioxygenase activities are regulated through control of cell heme allocation by nitric oxide","volume":"299","author":"Biswas","year":"2023","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2025.152028_bib33","doi-asserted-by":"crossref","first-page":"1432","DOI":"10.1111\/all.12699","article-title":"Exaggerated IDO1 expression and activity in langerhans cells from patients with atopic dermatitis upon viral stimulation: a potential predictive biomarker for high risk of eczema herpeticum","volume":"70","author":"Staudacher","year":"2015","journal-title":"Allergy"},{"key":"10.1016\/j.bbrc.2025.152028_bib34","doi-asserted-by":"crossref","first-page":"1806","DOI":"10.1016\/j.freeradbiomed.2012.02.029","article-title":"Nitric oxide reduces NADPH oxidase 5 (Nox5) activity by reversible S-nitrosylation","volume":"52","author":"Qian","year":"2012","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bbrc.2025.152028_bib35","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1046\/j.1523-1747.1998.00268.x","article-title":"Biphasic effect of exogenous nitric oxide on proliferation and differentiation in skin derived keratinocytes but not fibroblasts","volume":"111","author":"Krischel","year":"1998","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.bbrc.2025.152028_bib36","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.alit.2021.07.003","article-title":"Subtypes of atopic dermatitis: from phenotype to endotype","volume":"71","author":"Tokura","year":"2022","journal-title":"Allergol. Int."},{"key":"10.1016\/j.bbrc.2025.152028_bib37","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21041314","article-title":"The role of Th17-Related cytokines in atopic dermatitis","volume":"21","author":"Sugaya","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbrc.2025.152028_bib38","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1016\/j.jaci.2015.08.015","article-title":"The Asian atopic dermatitis phenotype combines features of atopic dermatitis and psoriasis with increased TH17 polarization","volume":"136","author":"Noda","year":"2015","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.bbrc.2025.152028_bib39","doi-asserted-by":"crossref","first-page":"4575","DOI":"10.1038\/ncomms5575","article-title":"Nitric oxide enhances Th9 cell differentiation and airway inflammation","volume":"5","author":"Niedbala","year":"2014","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbrc.2025.152028_bib40","doi-asserted-by":"crossref","first-page":"9220","DOI":"10.1073\/pnas.1100667108","article-title":"Regulation of type 17 helper T-cell function by nitric oxide during inflammation","volume":"108","author":"Niedbala","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbrc.2025.152028_bib41","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1084\/jem.20122494","article-title":"T cell\u2013derived inducible nitric oxide synthase switches off Th17 cell differentiation","volume":"210","author":"Jianjun","year":"2013","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.bbrc.2025.152028_bib42","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202002709R","article-title":"Enhanced phenotype of calcipotriol-induced atopic dermatitis in filaggrin-deficient mice","volume":"35","author":"Xiao","year":"2021","journal-title":"FASEB J."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X25007429?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X25007429?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T20:35:00Z","timestamp":1787776500000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X25007429"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":42,"alternative-id":["S0006291X25007429"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2025.152028","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Deficiency of inducible nitric oxide synthase (iNOS) enhances MC903-induced atopic dermatitis-like inflammation in mice","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2025.152028","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"152028"}}