{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T12:35:45Z","timestamp":1777638945065,"version":"3.51.4"},"reference-count":26,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T00:00:00Z","timestamp":1748908800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100011096","name":"Philippines Council for Health Research and Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011096","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001409","name":"Department of Science and Technology, Ministry of Science and Technology, India","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001409","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1R16GM145484-01"],"award-info":[{"award-number":["1R16GM145484-01"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.bbrc.2025.152146","type":"journal-article","created":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T15:07:04Z","timestamp":1748963224000},"page":"152146","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["TLE1 drives EGFR-TKI resistance in EGFR-mutant lung adenocarcinoma through epithelial to mesenchymal transition"],"prefix":"10.1016","volume":"775","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-6817-4772","authenticated-orcid":false,"given":"Ma Carmela","family":"Dela Cruz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Yao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-4857-3297","authenticated-orcid":false,"given":"Nasir","family":"Roberts","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prince","family":"Iheukwumere","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alana","family":"Carmouche","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6116-1818","authenticated-orcid":false,"given":"Paul Mark","family":"Medina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hector","family":"Biliran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"November","key":"10.1016\/j.bbrc.2025.152146_bib1","first-page":"1","article-title":"Roles of transducin-like enhancer of split (TLE) family proteins in tumorigenesis and immune regulation","volume":"10","author":"Yu","year":"2022","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.bbrc.2025.152146_bib2","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.bbrc.2021.01.052","article-title":"Differential functions of TLE1 and TLE3 depending on a specific phosphorylation site","volume":"545","author":"Kornspan","year":"2021","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"3","key":"10.1016\/j.bbrc.2025.152146_bib3","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1158\/0008-5472.CAN-05-1634","article-title":"Grg1 acts as a lung-specific oncogene in a transgenic mouse model","volume":"66","author":"Allen","year":"2006","journal-title":"Cancer Res."},{"issue":"7","key":"10.1016\/j.bbrc.2025.152146_bib4","doi-asserted-by":"crossref","first-page":"3251","DOI":"10.21037\/tlcr-21-582","article-title":"The prognostic role of the Transducin-like enhancer of split protein family in lung adenocarcinoma","volume":"10","author":"Ma","year":"2021","journal-title":"Transl. Lung Cancer Res."},{"key":"10.1016\/j.bbrc.2025.152146_bib5","series-title":"TLE1 Corepressor Promotes Gefitinib Resistance in Lung Cancer A549 Cells via E - Cadherin Silencing","first-page":"1","author":"Yao","year":"2025"},{"issue":"9","key":"10.1016\/j.bbrc.2025.152146_bib6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0163228","article-title":"The anoikis effector bit1 inhibits emt through attenuation of TLE1-mediated repression of E-cadherin in lung cancer cells","volume":"11","author":"Yao","year":"2016","journal-title":"PLoS One"},{"issue":"3\u20134","key":"10.1016\/j.bbrc.2025.152146_bib7","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.bbrc.2014.11.007","article-title":"TLE1 promotes EMT in A549 lung cancer cells through suppression of E-cadherin","volume":"455","author":"Yao","year":"2014","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"7","key":"10.1016\/j.bbrc.2025.152146_bib8","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0101564","article-title":"The anoikis effector Bit1 displays tumor suppressive function in lung cancer cells","volume":"9","author":"Yao","year":"2014","journal-title":"PLoS One"},{"issue":"42","key":"10.1016\/j.bbrc.2025.152146_bib9","doi-asserted-by":"crossref","first-page":"72235","DOI":"10.18632\/oncotarget.19703","article-title":"TLE1 inhibits anoikis and promotes tumorigenicity in human lung cancer cells through ZEB1-mediated E-cadherin repression","volume":"8","author":"Yao","year":"2017","journal-title":"Oncotarget"},{"issue":"6","key":"10.1016\/j.bbrc.2025.152146_bib10","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1038\/s41580-020-0237-9","article-title":"Guidelines and definitions for research on epithelial\u2013mesenchymal transition","volume":"21","author":"Yang","year":"2020","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"18","key":"10.1016\/j.bbrc.2025.152146_bib11","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2021108647","article-title":"Dynamic EMT: a multi\u2010tool for tumor progression","volume":"40","author":"Brabletz","year":"2021","journal-title":"EMBO J."},{"issue":"1","key":"10.1016\/j.bbrc.2025.152146_bib12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/BSR20211754","article-title":"Epithelial-mesenchymal transition and its transcription factors","volume":"42","author":"Debnath","year":"2022","journal-title":"Biosci. Rep."},{"issue":"16_suppl","key":"10.1016\/j.bbrc.2025.152146_bib13","doi-asserted-by":"crossref","DOI":"10.1200\/JCO.2024.42.16_suppl.8524","article-title":"\u201c IGF - 1R, E-cadherin, N-cadherin, and occludin gene expression and resistance to EGFR tyrosine-kinase inhibitors in patients with lung adenocarcinoma in Serbia. ,\u201d","volume":"42","author":"Jokic","year":"2024","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.bbrc.2025.152146_bib14","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2024.1366260","article-title":"Mechanisms of resistance to targeted therapy and immunotherapy in non-small cell lung cancer: promising strategies to overcoming challenges","volume":"15","author":"Xiang","year":"2024","journal-title":"Front. Immunol."},{"issue":"10","key":"10.1016\/j.bbrc.2025.152146_bib15","doi-asserted-by":"crossref","first-page":"2225","DOI":"10.1002\/cncr.32802","article-title":"Annual report to the nation on the status of cancer, part I: national cancer statistics","volume":"126","author":"Henley","year":"2020","journal-title":"Cancer"},{"issue":"April","key":"10.1016\/j.bbrc.2025.152146_bib16","article-title":"Epithelial\u2013mesenchymal transition (EMT) and its role in acquired epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) chemoresistance in non-small cell lung cancer (NSCLC)","author":"Dela Cruz","year":"2024","journal-title":"Cancer Pathog. Ther."},{"issue":"14","key":"10.1016\/j.bbrc.2025.152146_bib17","doi-asserted-by":"crossref","DOI":"10.3390\/cancers14143337","article-title":"Resistance to TKIs in EGFR-Mutated non-small cell lung cancer: from mechanisms to new therapeutic strategies","volume":"14","author":"Koulouris","year":"2022","journal-title":"Cancers"},{"issue":"1","key":"10.1016\/j.bbrc.2025.152146_bib18","first-page":"7","article-title":"Worldwide prevalence of epidermal growth factor receptor mutations in non-small cell lung cancer: a meta-analysis","volume":"26","author":"Melosky","year":"2022","journal-title":"Am. J. Cancer Res."},{"issue":"3","key":"10.1016\/j.bbrc.2025.152146_bib19","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.jtho.2021.11.003","article-title":"The 2021 WHO classification of lung tumors: impact of advances since 2015","volume":"17","author":"Nicholson","year":"2022","journal-title":"J. Thorac. Oncol."},{"issue":"12","key":"10.1016\/j.bbrc.2025.152146_bib20","doi-asserted-by":"crossref","first-page":"3764","DOI":"10.21037\/tcr-23-956","article-title":"Clinical advances in EGFR-TKI combination therapy for EGFR-mutated NSCLC: a narrative review","volume":"12","author":"Zhang","year":"2023","journal-title":"Transl. Cancer Res."},{"issue":"5","key":"10.1016\/j.bbrc.2025.152146_bib21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3892\/ijo.2021.5270","article-title":"Mechanisms and management of 3rd-generation EGFR-TKI resistance in advanced non-small cell lung cancer","volume":"59","author":"He","year":"2021","journal-title":"Int. J. Oncol."},{"issue":"5","key":"10.1016\/j.bbrc.2025.152146_bib22","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines11051490","article-title":"DCLK1 drives EGFR-TKI-Acquired resistance in lung adenocarcinoma by remodeling the epithelial\u2013mesenchymal transition status","volume":"11","author":"Yan","year":"2023","journal-title":"Biomedicines"},{"issue":"6","key":"10.1016\/j.bbrc.2025.152146_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbamcr.2021.119016","article-title":"Alisertib inhibits migration and invasion of EGFR-TKI resistant cells by partially reversing the epithelial-mesenchymal transition","volume":"1868","author":"Wang","year":"2021","journal-title":"Biochim. Biophys. Acta Mol. Cell Res."},{"issue":"5","key":"10.1016\/j.bbrc.2025.152146_bib24","doi-asserted-by":"crossref","first-page":"1904","DOI":"10.21037\/tlcr-20-522","article-title":"Epithelial-to-mesenchymal transition is a resistance mechanism to sequential MET-TKI treatment of MET-amplified EGFR-TKI resistant non-small cell lung cancer cells","volume":"9","author":"Clement","year":"2020","journal-title":"Transl. Lung Cancer Res."},{"issue":"5","key":"10.1016\/j.bbrc.2025.152146_bib25","doi-asserted-by":"crossref","first-page":"408","DOI":"10.3892\/ol.2022.13528","article-title":"Drug resistance mechanisms and progress in the treatment of EGFR-mutated lung adenocarcinoma","volume":"24","author":"Sun","year":"2022","journal-title":"Oncol. Lett."},{"issue":"3","key":"10.1016\/j.bbrc.2025.152146_bib26","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.pccm.2024.08.002","article-title":"Overcoming EGFR-TKI resistance by targeting the tumor microenvironment","volume":"2","author":"Zhang","year":"2024","journal-title":"Chin. Med. J. Pulm. Crit. Care. Med."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X25008605?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X25008605?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,7,8]],"date-time":"2025-07-08T08:00:36Z","timestamp":1751961636000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X25008605"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":26,"alternative-id":["S0006291X25008605"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2025.152146","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"TLE1 drives EGFR-TKI resistance in EGFR-mutant lung adenocarcinoma through epithelial to mesenchymal transition","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2025.152146","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"152146"}}