{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T00:55:24Z","timestamp":1780102524688,"version":"3.54.0"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004731","name":"Zhejiang Province Natural Science Foundation","doi-asserted-by":"publisher","award":["LY22C090003"],"award-info":[{"award-number":["LY22C090003"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.bbrc.2025.152157","type":"journal-article","created":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T15:49:21Z","timestamp":1749052161000},"page":"152157","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Potential Therapy for Alzheimer's Disease: Modulating Tunneling Nanotube Dynamics Restores Mitochondrial Transport and Ameliorates A\u03b2-induced Toxicity"],"prefix":"10.1016","volume":"775","author":[{"given":"Jing","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianya","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2025.152157_bib1","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1146\/annurev-med-042915-103753","article-title":"Update on Alzheimer's Disease therapy and prevention strategies","volume":"68","author":"Graham","year":"2017","journal-title":"Annu. Rev. Med."},{"key":"10.1016\/j.bbrc.2025.152157_bib2","doi-asserted-by":"crossref","first-page":"4693","DOI":"10.1021\/bi00069a001","article-title":"The carboxy terminus of the beta amyloid protein is critical for the seeding of amyloid formation: implications for the pathogenesis of Alzheimer's disease","volume":"32","author":"Jarrett","year":"1993","journal-title":"Biochemistry"},{"key":"10.1016\/j.bbrc.2025.152157_bib3","doi-asserted-by":"crossref","first-page":"5579","DOI":"10.1038\/s41467-020-19177-y","article-title":"Systematic elucidation of neuron-astrocyte interaction in models of amyotrophic lateral sclerosis using multi-modal integrated bioinformatics workflow","volume":"11","author":"Mishra","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbrc.2025.152157_bib4","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/nrn2168","article-title":"Intracellular amyloid-beta in Alzheimer's disease","volume":"8","author":"LaFerla","year":"2007","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.bbrc.2025.152157_bib5","doi-asserted-by":"crossref","first-page":"489","DOI":"10.5858\/2001-125-0489-IAAPDO","article-title":"Intraneuronal abeta-amyloid precedes development of amyloid plaques in Down syndrome","volume":"125","author":"Gyure","year":"2001","journal-title":"Arch. Pathol. Lab Med."},{"key":"10.1016\/j.bbrc.2025.152157_bib6","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1001\/jamaneurol.2019.1424","article-title":"Association of amyloid and Tau ith cognition in preclinical alzheimer disease: a longitudinal Study","volume":"76","author":"Hanseeuw","year":"2019","journal-title":"JAMA Neurol."},{"key":"10.1016\/j.bbrc.2025.152157_bib7","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1046\/j.1460-9568.2003.02444.x","article-title":"Age-dependent cognitive decline in the APP23 model precedes amyloid deposition","volume":"17","author":"Van Dam","year":"2003","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.bbrc.2025.152157_bib8","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/nrn2168","article-title":"Intracellular amyloid-\u03b2 in Alzheimer's disease","volume":"8","author":"LaFerla","year":"2007","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.bbrc.2025.152157_bib9","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-020-15120-3","article-title":"Amyloid-\u03b242\/40 ratio drives tau pathology in 3D human neural cell culture models of Alzheimer's disease","volume":"11","author":"Kwak","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbrc.2025.152157_bib10","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.abk1051","article-title":"Widespread cell stress and mitochondrial dysfunction occur in patients with early Alzheimer's disease","volume":"14","author":"Venkataraman","year":"2022","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.bbrc.2025.152157_bib11","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1046\/j.1471-4159.1994.63062179.x","article-title":"Cortical cytochrome oxidase activity is reduced in Alzheimer's disease","volume":"63","author":"Mutisya Em","year":"1994","journal-title":"J. Neurochem."},{"key":"10.1016\/j.bbrc.2025.152157_bib12","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1038\/nature25143","article-title":"Enhancing mitochondrial proteostasis reduces amyloid-\u03b2 proteotoxicity","volume":"552","author":"Sorrentino","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2025.152157_bib13","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.1038\/s41593-019-0539-4","article-title":"A single-cell atlas of entorhinal cortex from individuals with Alzheimer's disease reveals cell-type-specific gene expression regulation","volume":"22","author":"Grubman","year":"2019","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.bbrc.2025.152157_bib14","article-title":"Amyloid-\u03b2 impairs mitochondrial dynamics and autophagy in Alzheimer's disease experimental models","volume":"12","author":"de la Cueva","year":"2022","journal-title":"Sci Rep-Uk"},{"key":"10.1016\/j.bbrc.2025.152157_bib15","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.nbd.2019.03.008","article-title":"Regional hypometabolism in the 3xTg mouse model of Alzheimer's disease","volume":"127","author":"Adlimoghaddam","year":"2019","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.bbrc.2025.152157_bib16","article-title":"Peering into tunneling nanotubes-the path forward","volume":"40","author":"Cervantes","year":"2021","journal-title":"Embo J"},{"key":"10.1016\/j.bbrc.2025.152157_bib17","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1038\/s41467-018-08178-7","article-title":"Correlative cryo-electron microscopy reveals the structure of TNTs in neuronal cells","volume":"10","author":"Sartori-Rupp","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbrc.2025.152157_bib18","article-title":"Developing neurons form transient nanotubes facilitating electrical coupling and calcium signaling with distant astrocytes","volume":"7","author":"Wang","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.bbrc.2025.152157_bib19","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1002\/wnan.80","article-title":"Intercellular nanotubes: insights from imaging studies and beyond","volume":"2","author":"Hurtig","year":"2010","journal-title":"Wiley Interdiscip. Rev. Nanomed. Nanobiotechnol."},{"key":"10.1016\/j.bbrc.2025.152157_bib20","first-page":"3678","article-title":"Transfer of polyglutamine aggregates in neuronal cells occurs in tunneling nanotubes","volume":"126","author":"Costanzo","year":"2013","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.bbrc.2025.152157_bib21","article-title":"Astrocyte-to-neuron intercellular prion transfer is mediated by cell-cell contact","volume":"6","author":"Victoria","year":"2016","journal-title":"Sci Rep-Uk"},{"key":"10.1016\/j.bbrc.2025.152157_bib22","doi-asserted-by":"crossref","first-page":"11835","DOI":"10.1523\/JNEUROSCI.0983-17.2017","article-title":"Human astrocytes transfer aggregated Alpha-synuclein via tunneling nanotubes","volume":"37","author":"Rostami","year":"2017","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbrc.2025.152157_bib23","doi-asserted-by":"crossref","DOI":"10.1038\/s41419-023-05835-8","article-title":"Tunnelling nanotubes between neuronal and microglial cells allow bi-directional transfer of \u03b1-Synuclein and mitochondria","volume":"14","author":"Chakraborty","year":"2023","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.bbrc.2025.152157_bib24","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1186\/s40478-016-0386-4","article-title":"Tunneling nanotube (TNT)-mediated neuron-to neuron transfer of pathological Tau protein assemblies","volume":"4","author":"Tardivel","year":"2016","journal-title":"Acta Neuropathol Commun"},{"key":"10.1016\/j.bbrc.2025.152157_bib25","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1038\/cdd.2010.147","article-title":"Tunneling-nanotube development in astrocytes depends on p53 activation","volume":"18","author":"Wang","year":"2011","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.bbrc.2025.152157_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadis.2021.166246","article-title":"Amyloid-beta induced membrane damage instigates tunneling nanotube-like conduits by p21-activated kinase dependent actin remodulation","volume":"1867","author":"Dilna","year":"2021","journal-title":"Biochim. Biophys. Acta Mol. Basis Dis."},{"key":"10.1016\/j.bbrc.2025.152157_bib27","article-title":"Tunneling nanotubes, TNT, communicate glioblastoma with surrounding non-tumor astrocytes to adapt them to hypoxic and metabolic tumor conditions","volume":"11","author":"Valdebenito","year":"2021","journal-title":"Sci Rep-Uk"},{"key":"10.1016\/j.bbrc.2025.152157_bib28","doi-asserted-by":"crossref","first-page":"6614","DOI":"10.1016\/j.cell.2024.08.029","article-title":"Intercellular nanotube-mediated mitochondrial transfer enhances T cell metabolic fitness and antitumor efficacy","volume":"187","author":"Baldwin","year":"2024","journal-title":"Cell"},{"key":"10.1016\/j.bbrc.2025.152157_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainresbull.2024.110921","article-title":"Tunneling nanotubes: the transport highway for astrocyte-neuron communication in the central nervous system","volume":"209","author":"Zhou","year":"2024","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.bbrc.2025.152157_bib30","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1016\/j.bbabio.2014.02.007","article-title":"Mitochondrial import and degradation of amyloid-\u03b2 peptide","volume":"1837","author":"Pinho","year":"2014","journal-title":"Bba-Bioenergetics"},{"key":"10.1016\/j.bbrc.2025.152157_bib31","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.redox.2017.10.014","article-title":"Oxidative stress and the amyloid beta peptide in Alzheimer's disease","volume":"14","author":"Cheignon","year":"2018","journal-title":"Redox Biol."},{"key":"10.1016\/j.bbrc.2025.152157_bib32","doi-asserted-by":"crossref","DOI":"10.1038\/celldisc.2017.44","article-title":"A role for ErbB signaling in the induction of reactive astrogliosis","volume":"3","author":"Chen","year":"2017","journal-title":"Cell Discov"},{"key":"10.1016\/j.bbrc.2025.152157_bib33","doi-asserted-by":"crossref","DOI":"10.1186\/s12989-024-00562-0","article-title":"ROS\/mtROS promotes TNTs formation via the PI3K\/AKT\/mTOR pathway to protect against mitochondrial damages in glial cells induced by engineered nanomaterials","volume":"21","author":"Lin","year":"2024","journal-title":"Part. Fibre Toxicol."},{"key":"10.1016\/j.bbrc.2025.152157_bib34","article-title":"Developing neurons form transient nanotubes facilitating electrical coupling and calcium signaling with distant astrocytes","volume":"7","author":"Wang","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.bbrc.2025.152157_bib35","doi-asserted-by":"crossref","DOI":"10.3390\/cancers12102798","article-title":"Cx43 and associated cell signaling pathways regulate tunneling nanotubes in breast cancer cells","volume":"12","author":"Tishchenko","year":"2020","journal-title":"Cancers"},{"key":"10.1016\/j.bbrc.2025.152157_bib36","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abj3995","article-title":"Formation of cellular close-ended tunneling nanotubes through mechanical deformation","volume":"8","author":"Chang","year":"2022","journal-title":"Sci. Adv."},{"key":"10.1016\/j.bbrc.2025.152157_bib37","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1007\/s00418-019-01806-3","article-title":"Triple labelling of actin filaments, intermediate filaments and microtubules for broad application in cell biology: uncovering the cytoskeletal composition in tunneling nanotubes","volume":"152","author":"Resnik","year":"2019","journal-title":"Histochem. Cell Biol."},{"key":"10.1016\/j.bbrc.2025.152157_bib38","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1038\/cdd.2014.211","article-title":"Transfer of mitochondria via tunneling nanotubes rescues apoptotic PC12 cells","volume":"22","author":"Wang","year":"2015","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.bbrc.2025.152157_bib39","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2023.1221671","article-title":"GFAP serves as a structural element of tunneling nanotubes between glioblastoma cells and could play a role in the intercellular transfer of mitochondria","volume":"11","author":"Simone","year":"2023","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.bbrc.2025.152157_bib40","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1167\/iovs.18-26055","article-title":"Myosin-X silencing in the trabecular meshwork suggests a role for tunneling nanotubes in outflow regulation","volume":"60","author":"Sun","year":"2019","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.bbrc.2025.152157_bib41","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1038\/ncb1990","article-title":"M-Sec promotes membrane nanotube formation by interacting with Ral and the exocyst complex","volume":"11","author":"Hase","year":"2009","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.bbrc.2025.152157_bib42","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1038\/s43018-023-00556-5","article-title":"GAP43-dependent mitochondria transfer from astrocytes enhances glioblastoma tumorigenicity","volume":"4","author":"Watson","year":"2023","journal-title":"Nat. Cancer"},{"key":"10.1016\/j.bbrc.2025.152157_bib43","doi-asserted-by":"crossref","first-page":"8547","DOI":"10.1038\/s41598-017-08950-7","article-title":"The Role of Rho-GTPases and actin polymerization during Macrophage Tunneling Nanotube Biogenesis","volume":"7","author":"Hanna","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbrc.2025.152157_bib44","article-title":"Astrocyte-to-neuron transportation of enhanced green fluorescent protein in cerebral cortex requires F-actin dependent tunneling nanotubes","volume":"11","author":"Chen","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbrc.2025.152157_bib45","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1073\/pnas.1816656115","article-title":"MITO-Tag Mice enable rapid isolation and multimodal profiling of mitochondria from specific cell types in vivo","volume":"116","author":"Bayraktar","year":"2019","journal-title":"P Natl Acad Sci USA"},{"key":"10.1016\/j.bbrc.2025.152157_bib46","doi-asserted-by":"crossref","DOI":"10.1016\/j.ceb.2024.102325","article-title":"Cytoskeletal crosstalk: a focus on intermediate filaments","volume":"87","author":"Pradeau-Ph\u00e9lut","year":"2024","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.bbrc.2025.152157_bib47","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1038\/s41580-018-0067-1","article-title":"Actin-microtubule crosstalk in cell biology","volume":"20","author":"Dogterom","year":"2019","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.bbrc.2025.152157_bib48","doi-asserted-by":"crossref","DOI":"10.3390\/cells13070607","article-title":"Cooperation of various cytoskeletal components orchestrates intercellular spread of mitochondria between B-Lymphoma cells through tunnelling nanotubes","volume":"13","author":"Halasz","year":"2024","journal-title":"Cells"},{"key":"10.1016\/j.bbrc.2025.152157_bib49","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1016\/j.neuron.2010.09.039","article-title":"Molecular motors in neurons: transport mechanisms and roles in brain function, development, and disease","volume":"68","author":"Hirokawa","year":"2010","journal-title":"Neuron (Camb., Mass.)"},{"key":"10.1016\/j.bbrc.2025.152157_bib50","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.00749-17","article-title":"Pseudorabies virus US3-Induced tunneling nanotubes contain stabilized microtubules, interact with neighboring cells via cadherins, and allow intercellular molecular communication","volume":"91","author":"Jansens","year":"2017","journal-title":"J. Virol."},{"key":"10.1016\/j.bbrc.2025.152157_bib51","doi-asserted-by":"crossref","first-page":"81","DOI":"10.4161\/chan.2.2.6003","article-title":"Connexin and pannexin hemichannels of neurons and astrocytes","volume":"2","author":"Thompson","year":"2008","journal-title":"Channels"}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X2500871X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X2500871X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,7,8]],"date-time":"2025-07-08T08:00:30Z","timestamp":1751961630000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X2500871X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":51,"alternative-id":["S0006291X2500871X"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2025.152157","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Potential Therapy for Alzheimer's Disease: Modulating Tunneling Nanotube Dynamics Restores Mitochondrial Transport and Ameliorates A\u03b2-induced Toxicity","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2025.152157","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"152157"}}