{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T11:14:41Z","timestamp":1784632481313,"version":"3.55.0"},"reference-count":72,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004253","name":"Quaid-i-Azam University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004253","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.bbrc.2025.152284","type":"journal-article","created":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T01:49:13Z","timestamp":1751420953000},"page":"152284","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Santonin attenuates Ovalbumin-induced airway inflammation by inhibiting IL-4\/IL-13 signaling"],"prefix":"10.1016","volume":"777","author":[{"given":"Rimsha","family":"Noor","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-9476-8485","authenticated-orcid":false,"given":"Sadaf","family":"Naz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jehan Zeb","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Usama","family":"Mazhar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zaineb","family":"Ilyas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omeyya","family":"Tanveer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ihsan Ul","family":"Haq","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2041-9557","authenticated-orcid":false,"given":"Muhammad Khalid","family":"Tipu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.bbrc.2025.152284_bib1","doi-asserted-by":"crossref","first-page":"327","DOI":"10.3109\/15376516.2015.1053653","article-title":"The effects of chrysophanol on ovalbumin (OVA)-induced chronic lung toxicology by inhibiting Th17 response","volume":"27","author":"Zhang","year":"2017","journal-title":"Toxicol. Mech. Methods"},{"key":"10.1016\/j.bbrc.2025.152284_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2019.117222","article-title":"Potential anti-inflammatory and immunomodulatory effects of carvacrol against ovalbumin-induced asthma in rats","volume":"242","author":"Ezz-Eldin","year":"2020","journal-title":"Life Sci."},{"key":"10.1016\/j.bbrc.2025.152284_bib3","first-page":"1","article-title":"Asthma management: current guidelines and treatment strategies for asthma control","author":"AlHayem","year":"2024","journal-title":"J. Int. Crisis Risk Commun. Res."},{"issue":"21","key":"10.1016\/j.bbrc.2025.152284_bib4","doi-asserted-by":"crossref","first-page":"2006","DOI":"10.1056\/NEJMoa1014350","article-title":"Effect of bronchoconstriction on airway remodeling in asthma","volume":"364","author":"Grainge","year":"2011","journal-title":"N. Engl. J. Med."},{"issue":"2","key":"10.1016\/j.bbrc.2025.152284_bib5","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/j.pharmthera.2005.10.015","article-title":"Oxidative stress in asthma and COPD: antioxidants as a therapeutic strategy","volume":"111","author":"Kirkham","year":"2006","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.bbrc.2025.152284_bib6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s43088-019-0021-0","article-title":"Thymus vulgaris extract modulates dexamethasone induced liver injury and restores the hepatic antioxidant redox system","volume":"8","author":"Abou-Seif","year":"2019","journal-title":"Beni-Suef Univ. J. Basic Appl. Sci."},{"issue":"2","key":"10.1016\/j.bbrc.2025.152284_bib7","doi-asserted-by":"crossref","first-page":"11","DOI":"10.3390\/toxics5020011","article-title":"Vitis vinifera extract ameliorate hepatic and renal dysfunction induced by dexamethasone in albino rats","volume":"5","author":"Hasona","year":"2017","journal-title":"Toxics"},{"issue":"5","key":"10.1016\/j.bbrc.2025.152284_bib8","doi-asserted-by":"crossref","first-page":"3275","DOI":"10.1007\/s00210-023-02814-w","article-title":"Immunostimulant, hepatoprotective, and nephroprotective potential of Bacillus subtilis (NMCC-path-14) in comparison to dexamethasone in alleviating CFA-induced arthritis","volume":"397","author":"Mazhar","year":"2024","journal-title":"N. Schmied. Arch. Pharmacol."},{"key":"10.1016\/j.bbrc.2025.152284_bib9","series-title":"Understanding Allergic Airway Diseases: Contemporary Treatment Paradigm","first-page":"81","article-title":"Nanotechnology in the diagnosis of allergic airway diseases","author":"Gulati","year":"2024"},{"issue":"4","key":"10.1016\/j.bbrc.2025.152284_bib10","doi-asserted-by":"crossref","first-page":"765","DOI":"10.4314\/tjpr.v19i4.13","article-title":"Gastric cancer cell proliferation is inhibited by \u03b1-santonin via targeting of PI3K and AKT activation","volume":"19","author":"Nie","year":"2020","journal-title":"Trop. J. Pharmaceut. Res."},{"key":"10.1016\/j.bbrc.2025.152284_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.indcrop.2024.119169","article-title":"Non-food natural sesquiterpene lactone \u03b1-santonin: chemistry and biology","volume":"220","author":"Yang","year":"2024","journal-title":"Ind. Crop. Prod."},{"key":"10.1016\/j.bbrc.2025.152284_bib12","series-title":"Adverse Effects of Herbal Drugs","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/978-3-642-60367-9_2","article-title":"Artemisia cina","author":"Woerdenbag","year":"1997"},{"key":"10.1016\/j.bbrc.2025.152284_bib13","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.ejmech.2019.04.066","article-title":"Structure-activity relationship and synthetic methodologies of \u03b1-santonin derivatives with diverse bioactivities: a mini-review","volume":"175","author":"Wang","year":"2019","journal-title":"Eur. J. Med. Chem."},{"issue":"1","key":"10.1016\/j.bbrc.2025.152284_bib14","article-title":"Immunomodulatory effects mediated by serotonin","volume":"2015","author":"Arreola","year":"2015","journal-title":"JJ. Immunol. Res."},{"issue":"6","key":"10.1016\/j.bbrc.2025.152284_bib15","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.3390\/cells9061451","article-title":"Targeting the JAK\/STAT signaling pathway using phytocompounds for cancer prevention and therapy","volume":"9","author":"Bose","year":"2020","journal-title":"Cells"},{"issue":"3","key":"10.1016\/j.bbrc.2025.152284_bib16","doi-asserted-by":"crossref","first-page":"756","DOI":"10.5530\/ijper.57.3.92","article-title":"Lycorine attenuates airway inflammation in an OVA induced allergic asthma model","volume":"57","author":"Wang","year":"2023","journal-title":"Ind. J. Pharm. Edu. Res."},{"issue":"1","key":"10.1016\/j.bbrc.2025.152284_bib17","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1002\/biof.1809","article-title":"Crocin attenuates inflammation of lung tissue in ovalbumin\u2010sensitized mice by altering the expression of endoplasmic reticulum stress markers","volume":"48","author":"Aslani","year":"2022","journal-title":"Biofactors"},{"key":"10.1016\/j.bbrc.2025.152284_bib18","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.851374","article-title":"Type IV collagen reduces MUC5AC secretion in the lungs of ovalbumin-sensitized mice","volume":"13","author":"Iwashita","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.bbrc.2025.152284_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2023.131787","article-title":"Effect of NO2 exposure on airway inflammation and oxidative stress in asthmatic mice","volume":"457","author":"Lu","year":"2023","journal-title":"J. Hazard Mater."},{"issue":"2","key":"10.1016\/j.bbrc.2025.152284_bib20","first-page":"88","article-title":"Anti-allergic potential of fisetin in a murine model of OVA-induced allergic rhinitis via inhibition of GATA-3 and Th2 cytokines","volume":"34","author":"Zhao","year":"2018","journal-title":"Biomedica"},{"issue":"6","key":"10.1016\/j.bbrc.2025.152284_bib21","doi-asserted-by":"crossref","first-page":"617","DOI":"10.3390\/cells8060617","article-title":"Protective effects of licochalcone A improve airway hyper-responsiveness and oxidative stress in a mouse model of asthma","volume":"8","author":"Huang","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.bbrc.2025.152284_bib22","first-page":"1","article-title":"Ameliorates acute and chronic inflammations by suppressing inflammatory mediators, a comprehensive exploration using in vitro and in vivo models","volume":"18","author":"Majid","year":"2018","journal-title":"BMC Compl. Alternative Med."},{"key":"10.1016\/j.bbrc.2025.152284_bib23","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2024.1446304","article-title":"Chrysophanol attenuates cognitive impairment, neuroinflammation, and oxidative stress by TLR4\/NF\u03baB-Nrf2\/HO-1 and BDNF\/VEGF signaling in stress-intensified PTZ induced epilepsy in mice","volume":"15","author":"Khan","year":"2024","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.bbrc.2025.152284_bib24","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2021.807434","article-title":"Anxiety and depression assessments in a mouse model of congenital blindness","volume":"15","author":"Bouguiyoud","year":"2022","journal-title":"Front. Neurosci."},{"issue":"9","key":"10.1016\/j.bbrc.2025.152284_bib25","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1007\/s00726-022-03185-x","article-title":"N-Acetyl-L-cysteine in human rheumatoid arthritis and its effects on nitric oxide (NO) and malondialdehyde (MDA): analytical and clinical considerations","volume":"54","author":"Tsikas","year":"2022","journal-title":"Amino Acids"},{"key":"10.1016\/j.bbrc.2025.152284_bib26","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.biopha.2018.12.047","article-title":"Effect of 25-methoxy hispidol A isolated from Poncirus trifoliate against bacteria-induced anxiety and depression by targeting neuroinflammation, oxidative stress and apoptosis in mice","volume":"111","author":"Shal","year":"2019","journal-title":"Biomed. Pharmacother."},{"issue":"6","key":"10.1016\/j.bbrc.2025.152284_bib27","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1038\/s41422-020-0318-5","article-title":"Pathological evidence for residual SARS-CoV-2 in pulmonary tissues of a ready-for-discharge patient","volume":"30","author":"Yao","year":"2020","journal-title":"Cell Res."},{"issue":"8","key":"10.1016\/j.bbrc.2025.152284_bib28","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/S0968-4328(03)00098-2","article-title":"Staining methods applied to glycol methacrylate embedded tissue sections","volume":"34","author":"Cerri","year":"2003","journal-title":"Micron"},{"issue":"3","key":"10.1016\/j.bbrc.2025.152284_bib29","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.21037\/jtd-24-1751","article-title":"Deficiency of toll-like receptor 4 attenuates airway inflammation and remodeling in an ovalbumine-induced mouse asthma model","volume":"17","author":"Hou","year":"2025","journal-title":"J. Thorac. Dis."},{"issue":"4","key":"10.1016\/j.bbrc.2025.152284_bib30","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/j.jcmgh.2023.12.011","article-title":"Th2 cell activation in chronic liver disease is driven by local IL33 and contributes to IL13-dependent fibrogenesis","volume":"17","author":"Rei\u00dfing","year":"2024","journal-title":"Cell. Mol. Gastroenterol. Hepatol."},{"key":"10.1016\/j.bbrc.2025.152284_bib31","article-title":"Expression analysis of transforming growth factor beta (TGF-\u03b2) in oral squamous cell carcinoma","volume":"9","author":"Ganesh","year":"2024","journal-title":"Oral Oncol. Rep."},{"issue":"1","key":"10.1016\/j.bbrc.2025.152284_bib32","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-024-72433-9","article-title":"Phylogenetic position of the pigeon mite, Ornithonyssus sylviarum, with amplification of its immunogenetic biomarkers in Egypt","volume":"14","author":"Salem","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbrc.2025.152284_bib33","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.neuro.2023.03.004","article-title":"Thiamethoxam evoked neural oxido-inflammatory stress in male rats through modulation of Nrf2\/NF-kB\/iNOS signaling and inflammatory cytokines: neuroprotective effect of silymarin","volume":"96","author":"Habotta","year":"2023","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.bbrc.2025.152284_bib34","article-title":"Aucubin regulates allergic airway inflammation in ovalbumin-induced allergic asthma in mice by controlling Th2 cytokines","author":"Li","year":"2025","journal-title":"Pharmacogn. Mag."},{"issue":"5","key":"10.1016\/j.bbrc.2025.152284_bib35","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1016\/j.jaip.2019.02.030","article-title":"IgE-mediated multimorbidities in allergic asthma and the potential for omalizumab therapy","volume":"7","author":"Humbert","year":"2019","journal-title":"J. Allergy Clin. Immunol. Pract."},{"key":"10.1016\/j.bbrc.2025.152284_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2024.124127","article-title":"High humidity and NO2 co-exposure exacerbates allergic asthma by increasing oxidative stress, inflammatory and TRP protein expressions in lung tissue","volume":"353","author":"Lu","year":"2024","journal-title":"Environ. Pollut."},{"issue":"6","key":"10.1016\/j.bbrc.2025.152284_bib37","first-page":"2171","article-title":"Pistacia weinmannifolia root exerts a protective role in ovalbumin-induced lung inflammation in a mouse allergic asthma model","volume":"44","author":"Lee","year":"2019","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.bbrc.2025.152284_bib38","doi-asserted-by":"crossref","DOI":"10.1002\/mrc.5445","article-title":"Deciphering molecular structures: NMR spectroscopy and quantum mechanical insights of halogenated 4 H\u2010Chromenediones","author":"Martins","year":"2024","journal-title":"Magn. Reson. Chem."},{"key":"10.1016\/j.bbrc.2025.152284_bib39","series-title":"Discover Applied Sciences","author":"Khatoon","year":"2024"},{"issue":"12","key":"10.1016\/j.bbrc.2025.152284_bib40","doi-asserted-by":"crossref","first-page":"2728","DOI":"10.3390\/molecules25122728","article-title":"Pharmacological evaluation of Artemisia cina crude CO2 subcritical extract after the removal of santonin by means of high speed countercurrent chromatography","volume":"25","author":"Sakipova","year":"2020","journal-title":"Molecules"},{"key":"10.1016\/j.bbrc.2025.152284_bib41","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12890-019-1001-9","article-title":"Comparison of asthma phenotypes in OVA-induced mice challenged via inhaled and intranasal routes","volume":"19","author":"Kim","year":"2019","journal-title":"BMC Pulm. Med."},{"key":"10.1016\/j.bbrc.2025.152284_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.116887","article-title":"Effects of total alkaloids from Alstonia scholaris (L.) R. Br. on ovalbumin-induced asthma mice","volume":"318","author":"Tong","year":"2024","journal-title":"J. Ethnopharmacol."},{"issue":"2","key":"10.1016\/j.bbrc.2025.152284_bib43","first-page":"647","article-title":"Subcutaneous immunotherapy against tree pollen, grass pollen, artemisia pollen, Alternaria alternata and house dust mites efficiency mediators: a review","volume":"18","author":"Lisiecka","year":"2024","journal-title":"Int. J. Brain Cognit. Sci."},{"issue":"13","key":"10.1016\/j.bbrc.2025.152284_bib44","doi-asserted-by":"crossref","first-page":"7031","DOI":"10.3390\/ijms25137031","article-title":"C-Phycocyanin prevents oxidative stress, inflammation, and lung remodeling in an ovalbumin-induced rat asthma model","volume":"25","author":"Mundo-Franco","year":"2024","journal-title":"Int. J. Mol. Sci."},{"issue":"5","key":"10.1016\/j.bbrc.2025.152284_bib45","doi-asserted-by":"crossref","first-page":"2477","DOI":"10.4049\/jimmunol.162.5.2477","article-title":"Effects of Th2 cytokines on chemokine expression in the lung: IL-13 potently induces eotaxin expression by airway epithelial cells","volume":"162","author":"Li","year":"1999","journal-title":"J. Immunol."},{"issue":"11","key":"10.1016\/j.bbrc.2025.152284_bib46","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1080\/17476348.2018.1520095","article-title":"Recent developments in the use of biologics targeting IL-5, IL-4, or IL-13 in severe refractory asthma","volume":"12","author":"Walsh","year":"2018","journal-title":"Expet Rev. Respir. Med."},{"issue":"2","key":"10.1016\/j.bbrc.2025.152284_bib47","article-title":"3-CARENE suppresses inflammatory cytokine INTERLEUKIN-4, INTERLEUKIN-5 and INTERLEUKIN-13 in amurine model of asthma","volume":"75","author":"Kim","year":"2024","journal-title":"J. Physiol. Pharmacol."},{"key":"10.1016\/j.bbrc.2025.152284_bib48","doi-asserted-by":"crossref","DOI":"10.4028\/b-fVvR5S","article-title":"The role of extracellular vesicles in murine asthma model: insights into IgE-Independent mast cell activation within animal science","author":"Kim","year":"2024","journal-title":"J. Anim. Sci. Technol."},{"issue":"2","key":"10.1016\/j.bbrc.2025.152284_bib49","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1007\/s10787-024-01432-z","article-title":"Anti-inflammatory and anti-arthritic potential of Coagulansin-A: in vitro and in vivo studies","volume":"32","author":"Naz","year":"2024","journal-title":"Inflammopharmacology"},{"key":"10.1016\/j.bbrc.2025.152284_bib50","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.freeradbiomed.2023.12.031","article-title":"Tectorigenin inhibits oxidative stress by activating the Keap1\/Nrf2\/HO-1 signaling pathway in Th2-mediated allergic asthmatic mice","volume":"212","author":"Jiang","year":"2024","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bbrc.2025.152284_bib51","doi-asserted-by":"crossref","DOI":"10.1016\/j.mam.2021.101026","article-title":"Molecular mechanisms of oxidative stress in asthma","volume":"85","author":"Michaeloudes","year":"2022","journal-title":"Mol. Aspect. Med."},{"key":"10.1016\/j.bbrc.2025.152284_bib52","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpba.2021.114477","article-title":"Biomarkers of oxidative stress and antioxidant defense","volume":"209","author":"Demirci-Cekic","year":"2022","journal-title":"J. Pharmaceut. Biomed. Anal."},{"key":"10.1016\/j.bbrc.2025.152284_bib53","doi-asserted-by":"crossref","unstructured":"Sule, R.O., L. Condon, and A.V. Gomes, A common feature of pesticides: oxidative Stress\u2014the role of oxidative stress in pesticide\u2010induced toxicity. Oxid. Med. Cell. Longev., 2022. 2022(1): p. 5563759.","DOI":"10.1155\/2022\/5563759"},{"issue":"3","key":"10.1016\/j.bbrc.2025.152284_bib54","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1007\/s00210-023-02678-0","article-title":"Echinochrome exhibits anti-asthmatic activity through the suppression of airway inflammation, oxidative stress, and histopathological alterations in ovalbumin-induced asthma in BALB\/c mice","volume":"397","author":"Abdelmawgood","year":"2024","journal-title":"N. Schmied. Arch. Pharmacol."},{"key":"10.1016\/j.bbrc.2025.152284_bib55","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2024.116426","article-title":"Green nanotech paradigm for enhancing sesquiterpene lactone therapeutics in cancer","volume":"173","author":"Zahra","year":"2024","journal-title":"Biomed. Pharmacother."},{"issue":"4","key":"10.1016\/j.bbrc.2025.152284_bib56","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1080\/02770903.2020.1870129","article-title":"Evaluation of oxidative stress biomarkers and antioxidant parameters in allergic asthma patients with different level of asthma control","volume":"59","author":"Karadogan","year":"2022","journal-title":"J. Asthma"},{"key":"10.1016\/j.bbrc.2025.152284_bib57","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2021.106435","article-title":"Short-term exposure to ozone, nitrogen dioxide, and sulphur dioxide and emergency department visits and hospital admissions due to asthma: a systematic review and meta-analysis","volume":"150","author":"Zheng","year":"2021","journal-title":"Environ. Int."},{"issue":"9","key":"10.1016\/j.bbrc.2025.152284_bib58","doi-asserted-by":"crossref","first-page":"3001","DOI":"10.3390\/app10093001","article-title":"Applications of sesquiterpene lactones: a review of some potential success cases","volume":"10","author":"Moujir","year":"2020","journal-title":"Appl. Sci."},{"key":"10.1016\/j.bbrc.2025.152284_bib59","first-page":"1","article-title":"\u03b2-glucan nanoparticles alleviate acute asthma by suppressing ferroptosis and DNA damage in mice","author":"Ebeed","year":"2024","journal-title":"Apoptosis"},{"issue":"7","key":"10.1016\/j.bbrc.2025.152284_bib60","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1248\/bpb.b23-00804","article-title":"Alantolactone induced apoptosis and DNA damage of cervical cancer through ATM\/CHK2 signaling pathway","volume":"47","author":"Zhang","year":"2024","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.bbrc.2025.152284_bib61","series-title":"The Investigation of Intrinsic Abnormalities in the Airway Smooth Muscle Cells in Asthma","author":"Sutcliffe","year":"2014"},{"issue":"6","key":"10.1016\/j.bbrc.2025.152284_bib62","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1016\/j.cell.2021.02.016","article-title":"The basic immunology of asthma","volume":"184","author":"Hammad","year":"2021","journal-title":"Cell"},{"issue":"12","key":"10.1016\/j.bbrc.2025.152284_bib63","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2023.e22491","article-title":"Analytical study on couple stress flow of GO-EG and GO-W nanofluid over an extending cylinder along with variable viscosity","volume":"9","author":"Rehman","year":"2023","journal-title":"Heliyon"},{"issue":"3","key":"10.1016\/j.bbrc.2025.152284_bib64","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1111\/j.1365-2567.2010.03392.x","article-title":"The effects of triptolide on airway remodelling and transforming growth factor\u2010\u03b21\/Smad signalling pathway in ovalbumin\u2010sensitized mice","volume":"132","author":"Chen","year":"2011","journal-title":"Immunology"},{"issue":"6","key":"10.1016\/j.bbrc.2025.152284_bib65","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1016\/j.jaci.2008.04.016","article-title":"Potentiation of IL-19 expression in airway epithelia by IL-17A and IL-4\/IL-13: important implications in asthma","volume":"121","author":"Huang","year":"2008","journal-title":"J. Allergy Clin. Immunol."},{"issue":"5","key":"10.1016\/j.bbrc.2025.152284_bib66","doi-asserted-by":"crossref","first-page":"897","DOI":"10.2174\/1570180820666230117141701","article-title":"Huatan tongluo decoction inhibits inflammatory infiltration and airway remodeling by attenuating TGF-\u03b21\/Smad2\/3 and oxidative stress-mediated NF-kB\/HIF-1\u03b1\/MMPs signaling pathway in chronic asthma mice","volume":"21","author":"Lao","year":"2024","journal-title":"Lett. Drug Des. Discov."},{"key":"10.1016\/j.bbrc.2025.152284_bib67","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1007\/s00011-021-01482-x","article-title":"Targeting JAK\/STAT signaling pathways in treatment of inflammatory bowel disease","volume":"70","author":"Wang","year":"2021","journal-title":"Inflamm. Res."},{"issue":"3","key":"10.1016\/j.bbrc.2025.152284_bib68","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.3390\/molecules27031142","article-title":"Anti-inflammatory and immunoregulatory action of sesquiterpene lactones","volume":"27","author":"Pa\u00e7o","year":"2022","journal-title":"Molecules"},{"issue":"2","key":"10.1016\/j.bbrc.2025.152284_bib69","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1046\/j.1365-2249.2001.01602.x","article-title":"Proinflammatory cytokines (IL-17, IL-6, IL-18 and IL-12) and Th cytokines (IFN-\u03b3, IL-4, IL-10 and IL-13) in patients with allergic asthma","volume":"125","author":"Wong","year":"2001","journal-title":"Clin. Exp. Immunol."},{"issue":"1","key":"10.1016\/j.bbrc.2025.152284_bib70","doi-asserted-by":"crossref","first-page":"L27","DOI":"10.1152\/ajplung.00398.2014","article-title":"Nrf2 reduces allergic asthma in mice through enhanced airway epithelial cytoprotective function","volume":"309","author":"Sussan","year":"2015","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"issue":"8","key":"10.1016\/j.bbrc.2025.152284_bib71","doi-asserted-by":"crossref","first-page":"3133","DOI":"10.1172\/JCI43598","article-title":"Identification of an IFN-\u03b3\/mast cell axis in a mouse model of chronic asthma","volume":"121","author":"Yu","year":"2011","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.bbrc.2025.152284_bib72","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.lfs.2018.08.013","article-title":"Polydatin attenuates reactive oxygen species-induced airway remodeling by promoting Nrf2-mediated antioxidant signaling in asthma mouse model","volume":"218","author":"Zeng","year":"2019","journal-title":"Life Sci."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X25009994?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X25009994?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T08:40:06Z","timestamp":1774860006000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X25009994"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":72,"alternative-id":["S0006291X25009994"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2025.152284","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Santonin attenuates Ovalbumin-induced airway inflammation by inhibiting IL-4\/IL-13 signaling","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2025.152284","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"152284"}}