{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T16:22:32Z","timestamp":1791390152197,"version":"4.3.3"},"reference-count":76,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100023530","name":"Forschungszentrum Dynamische Systeme, Otto-von-Guericke-Universit\u00e4t Magdeburg","doi-asserted-by":"publisher","award":["PPM-00383-14"],"award-info":[{"award-number":["PPM-00383-14"]}],"id":[{"id":"10.13039\/501100023530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100023530","name":"Forschungszentrum Dynamische Systeme, Otto-von-Guericke-Universit\u00e4t Magdeburg","doi-asserted-by":"publisher","award":["BPV-00277-16"],"award-info":[{"award-number":["BPV-00277-16"]}],"id":[{"id":"10.13039\/501100023530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021847","name":"Centro Svizzero di Calcolo Scientifico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100021847","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004901","name":"Minas Gerais State Foundation of Support to the Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.bbrc.2025.152322","type":"journal-article","created":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T07:58:07Z","timestamp":1752566287000},"page":"152322","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Ovarian cancer cell heterogeneity and paclitaxel response in vitro 2D and 3D cancer cell models and xenograft growth in the chicken chorioallantoic membrane (CAM)"],"prefix":"10.1016","volume":"777","author":[{"given":"Aline Brito","family":"de Lima","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8748-6052","authenticated-orcid":false,"given":"Bryan \u00d4rtero Perez","family":"Gon\u00e7alves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milene Pereira","family":"Moreira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00e1rbara Avelar Ferreira","family":"Barros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8068-5211","authenticated-orcid":false,"given":"Agnaldo Lopes","family":"da Silva Filho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00edlvia Lig\u00f3rio","family":"Fialho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6181-9410","authenticated-orcid":false,"given":"Let\u00edcia","family":"da Concei\u00e7\u00e3o Braga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciana Maria","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2025.152322_bib1","doi-asserted-by":"crossref","first-page":"2089","DOI":"10.2741\/3364","article-title":"Ovarian cancer: pathology, biology, and disease models","volume":"14","author":"Rosen","year":"2009","journal-title":"Front. Biosci. (Landmark Ed.)"},{"key":"10.1016\/j.bbrc.2025.152322_bib2","doi-asserted-by":"crossref","DOI":"10.3390\/ijms17122113","article-title":"Molecular characterization of epithelial ovarian cancer: implications for diagnosis and treatment","volume":"17","author":"Rojas","year":"2016","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbrc.2025.152322_bib3","first-page":"394","article-title":"Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"68","author":"Bray","year":"2018","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.bbrc.2025.152322_bib4","doi-asserted-by":"crossref","first-page":"R59","DOI":"10.1530\/REP-14-0234","article-title":"Epithelial ovarian cancer stem cells: underlying complexity of a simple paradigm","volume":"149","author":"Garson","year":"2015","journal-title":"Reproduction"},{"key":"10.1016\/j.bbrc.2025.152322_bib5","doi-asserted-by":"crossref","first-page":"3187","DOI":"10.2217\/fon.15.251","article-title":"Current state of biomarkers in ovarian cancer prognosis","volume":"11","author":"Au","year":"2015","journal-title":"Future Oncol."},{"key":"10.1016\/j.bbrc.2025.152322_bib6","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1097\/GCO.0000000000000340","article-title":"Pathogenesis and heterogeneity of ovarian cancer","volume":"29","author":"Kroeger","year":"2017","journal-title":"Curr. Opin. Obstet. Gynecol."},{"key":"10.1016\/j.bbrc.2025.152322_bib7","doi-asserted-by":"crossref","first-page":"50","DOI":"10.5732\/cjc.014.10273","article-title":"Pathobiology of ovarian carcinomas","volume":"34","author":"Devouassoux-Shisheboran","year":"2015","journal-title":"Chin. J. Cancer"},{"key":"10.1016\/j.bbrc.2025.152322_bib8","doi-asserted-by":"crossref","first-page":"2631","DOI":"10.1002\/cncr.11345","article-title":"Pathology and classification of ovarian tumors","volume":"97","author":"Chen","year":"2003","journal-title":"Cancer"},{"key":"10.1016\/j.bbrc.2025.152322_bib9","first-page":"465","article-title":"Natural history of ovarian cancer","volume":"8","author":"Vargas","year":"2014","journal-title":"ecancermedicalscience"},{"key":"10.1016\/j.bbrc.2025.152322_bib10","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1097\/PAS.0b013e3181cf3d79","article-title":"The origin and pathogenesis of epithelial ovarian cancer: a proposed unifying theory","volume":"34","author":"Kurman","year":"2010","journal-title":"Am. J. Surg. Pathol."},{"key":"10.1016\/j.bbrc.2025.152322_bib11","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/S1470-2045(14)70049-X","article-title":"Gynecologic Cancer InterGroup, Carboplatin plus paclitaxel once a week versus every 3 weeks in patients with advanced ovarian cancer (MITO-7): a randomised, multicentre, open-label, phase 3 trial","volume":"15","author":"Pignata","year":"2014","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.bbrc.2025.152322_bib12","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1016\/S1470-2045(13)70363-2","article-title":"Long-term results of dose-dense paclitaxel and carboplatin versus conventional paclitaxel and carboplatin for treatment of advanced epithelial ovarian, fallopian tube, or primary peritoneal cancer (JGOG 3016): a randomised, controlled, open-label trial","volume":"14","author":"Katsumata","year":"2013","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.bbrc.2025.152322_bib13","doi-asserted-by":"crossref","first-page":"413076","DOI":"10.1155\/2015\/413076","article-title":"Paclitaxel and its evolving role in the management of ovarian cancer","volume":"2015","author":"Kampan","year":"2015","journal-title":"BioMed Res. Int."},{"key":"10.1016\/j.bbrc.2025.152322_bib14","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1093\/jnci\/djg036","article-title":"Gynakologische Onkologie Ovarian Cancer Study, A randomized clinical trial of cisplatin\/paclitaxel versus carboplatin\/paclitaxel as first-line treatment of ovarian cancer","volume":"95","author":"du Bois","year":"2003","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/j.bbrc.2025.152322_bib15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1056\/NEJM199601043340101","article-title":"Cyclophosphamide and cisplatin compared with paclitaxel and cisplatin in patients with stage III and stage IV ovarian cancer","volume":"334","author":"McGuire","year":"1996","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bbrc.2025.152322_bib16","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.canlet.2016.01.009","article-title":"Overcoming cisplatin resistance of ovarian cancer cells by targeting HIF-1-regulated cancer metabolism","volume":"373","author":"Ai","year":"2016","journal-title":"Cancer Lett."},{"key":"10.1016\/j.bbrc.2025.152322_bib17","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1080\/14737140.2017.1398088","article-title":"Optimizing treatment in recurrent epithelial ovarian cancer","volume":"17","author":"Corrado","year":"2017","journal-title":"Expert Rev. Anticancer Ther."},{"key":"10.1016\/j.bbrc.2025.152322_bib18","doi-asserted-by":"crossref","DOI":"10.3390\/cancers10080241","article-title":"Can stemness and chemoresistance Be therapeutically targeted via signaling pathways in ovarian cancer?","volume":"10","author":"Roy","year":"2018","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.bbrc.2025.152322_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.yexmp.2020.104520","article-title":"Central nervous system (CNS) tumor cell heterogeneity contributes to differential platinum-based response in an in vitro 2D and 3D cell culture approach","volume":"116","author":"Goncalves","year":"2020","journal-title":"Exp. Mol. Pathol."},{"key":"10.1016\/j.bbrc.2025.152322_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.acthis.2021.151768","article-title":"Phenotypic changes on central nervous system (CNS) tumor cell lines cultured in vitro 2D and 3D models and treated with cisplatin","volume":"123","author":"Perez Goncalves","year":"2021","journal-title":"Acta Histochem."},{"key":"10.1016\/j.bbrc.2025.152322_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.acthis.2022.151849","article-title":"Markers to sensibility and relapse on IMR-32 neuroblastoma cell line cultured in monolayer (2D) and neurosphere (3D) models cisplatin-treated","volume":"124","author":"Goncalves","year":"2022","journal-title":"Acta Histochem."},{"key":"10.1016\/j.bbrc.2025.152322_bib22","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.ygyno.2014.12.005","article-title":"Cancer stem-like cells of ovarian clear cell carcinoma are enriched in the ALDH-high population associated with an accelerated scavenging system in reactive oxygen species","volume":"137","author":"Mizuno","year":"2015","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/j.bbrc.2025.152322_bib23","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.canlet.2012.10.023","article-title":"Ovarian cancer stem cells: working towards the root of stemness","volume":"338","author":"Foster","year":"2013","journal-title":"Cancer Lett."},{"key":"10.1016\/j.bbrc.2025.152322_bib24","doi-asserted-by":"crossref","first-page":"2134","DOI":"10.1002\/jcp.27581","article-title":"Overview of CD24 as a new molecular marker in ovarian cancer","volume":"234","author":"Tarhriz","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.bbrc.2025.152322_bib25","doi-asserted-by":"crossref","first-page":"708036","DOI":"10.1155\/2012\/708036","article-title":"Significance of CD44 and CD24 as cancer stem cell markers: an enduring ambiguity","volume":"2012","author":"Jaggupilli","year":"2012","journal-title":"Clin. Dev. Immunol."},{"key":"10.1016\/j.bbrc.2025.152322_bib26","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1080\/14712598.2017.1271874","article-title":"Targeting cancer stem cells with natural killer cell immunotherapy","volume":"17","author":"Luna","year":"2017","journal-title":"Expet Opin. Biol. Ther."},{"key":"10.1016\/j.bbrc.2025.152322_bib27","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.btre.2017.11.004","article-title":"Cancer cell lines involving cancer stem cell populations respond to oxidative stress","volume":"17","author":"Yilmazer","year":"2018","journal-title":"Biotechnol Rep (Amst)"},{"key":"10.1016\/j.bbrc.2025.152322_bib28","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1111\/brv.12293","article-title":"Three-dimensional cell culture model utilization in cancer stem cell research","volume":"92","author":"Bielecka","year":"2017","journal-title":"Biol. Rev. Camb. Phil. Soc."},{"key":"10.1016\/j.bbrc.2025.152322_bib29","doi-asserted-by":"crossref","first-page":"872957","DOI":"10.1155\/2013\/872957","article-title":"Enhancement of cisplatin-mediated apoptosis in ovarian cancer cells through potentiating G2\/M arrest and p21 upregulation by combinatorial epigallocatechin gallate and sulforaphane","volume":"2013","author":"Chen","year":"2013","journal-title":"J. Oncol."},{"key":"10.1016\/j.bbrc.2025.152322_bib30","doi-asserted-by":"crossref","first-page":"295","DOI":"10.3389\/fgene.2013.00295","article-title":"The role of microRNAs in the regulation of cancer stem cells","volume":"4","author":"Takahashi","year":"2014","journal-title":"Front. Genet."},{"key":"10.1016\/j.bbrc.2025.152322_bib31","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/s12307-017-0203-z","article-title":"Three-dimensional cellular arrangement in epithelial ovarian cancer cell lines TOV-21g and SKOV-3 is associated with apoptosis-related miRNA expression modulation","volume":"11","author":"de Lima","year":"2018","journal-title":"Cancer Microenviron."},{"key":"10.1016\/j.bbrc.2025.152322_bib32","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25020837","article-title":"Experimental tumor induction and evaluation of its treatment in the chicken embryo chorioallantoic membrane model: a systematic review","volume":"25","author":"Mesas","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbrc.2025.152322_bib33","doi-asserted-by":"crossref","DOI":"10.3390\/cancers13051093","article-title":"The chicken chorioallantoic membrane tumor assay as a relevant in vivo model to study the impact of hypoxia on tumor progression and metastasis","volume":"13","author":"Harper","year":"2021","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.bbrc.2025.152322_bib34","doi-asserted-by":"crossref","first-page":"D805","DOI":"10.1093\/nar\/gku1075","article-title":"COSMIC: exploring the world's knowledge of somatic mutations in human cancer","volume":"43","author":"Forbes","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bbrc.2025.152322_bib35","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S0165-0270(99)00193-4","article-title":"Comparison of the LDH and MTT assays for quantifying cell death: validity for neuronal apoptosis?","volume":"96","author":"Lobner","year":"2000","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.bbrc.2025.152322_bib36","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0022-1759(83)90303-4","article-title":"Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays","volume":"65","author":"Mosmann","year":"1983","journal-title":"J. Immunol. Methods"},{"key":"10.1016\/j.bbrc.2025.152322_bib37","doi-asserted-by":"crossref","DOI":"10.1038\/srep14701","article-title":"An automated fitting procedure and software for dose-response curves with multiphasic features","volume":"5","author":"Di Veroli","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbrc.2025.152322_bib38","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/cbdd.12923","article-title":"New 3-alkylpyridine marine alkaloid analogues as promising antitumor agents against the CD44(+\/high)\/CD24(-\/low) subset of triple-negative breast cancer cell line","volume":"90","author":"de Lima","year":"2017","journal-title":"Chem. Biol. Drug Des."},{"key":"10.1016\/j.bbrc.2025.152322_bib39","doi-asserted-by":"crossref","first-page":"2315","DOI":"10.1038\/nprot.2006.339","article-title":"Clonogenic assay of cells in vitro","volume":"1","author":"Franken","year":"2006","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.bbrc.2025.152322_bib40","doi-asserted-by":"crossref","first-page":"e51","DOI":"10.1093\/nar\/gkr1259","article-title":"Correction of RT-qPCR data for genomic DNA-derived signals with ValidPrime","volume":"40","author":"Laurell","year":"2012","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bbrc.2025.152322_bib41","doi-asserted-by":"crossref","first-page":"W167","DOI":"10.1093\/nar\/gku443","article-title":"NetworkAnalyst--integrative approaches for protein-protein interaction network analysis and visual exploration","volume":"42","author":"Xia","year":"2014","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bbrc.2025.152322_bib42","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1038\/nprot.2015.052","article-title":"NetworkAnalyst for statistical, visual and network-based meta-analysis of gene expression data","volume":"10","author":"Xia","year":"2015","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.bbrc.2025.152322_bib43","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.bbrc.2025.152322_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.acthis.2021.151821","article-title":"Identification of best housekeeping genes for the normalization of RT-qPCR in human cell lines","volume":"124","author":"da Conceicao Braga","year":"2022","journal-title":"Acta Histochem."},{"key":"10.1016\/j.bbrc.2025.152322_bib45","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1186\/s13048-019-0588-z","article-title":"Ovarian cancer stem cells and targeted therapy","volume":"12","author":"Keyvani","year":"2019","journal-title":"J. Ovarian Res."},{"key":"10.1016\/j.bbrc.2025.152322_bib46","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1038\/s41392-020-00430-1","article-title":"Targeting cancer stem cells for reversing therapy resistance: mechanism, signaling, and prospective agents","volume":"6","author":"Zhou","year":"2021","journal-title":"Signal Transduct. Targeted Ther."},{"key":"10.1016\/j.bbrc.2025.152322_bib47","doi-asserted-by":"crossref","first-page":"852839","DOI":"10.1155\/2013\/852839","article-title":"New hypothesis on pathogenesis of ovarian cancer lead to future tailored approaches","volume":"2013","author":"Rescigno","year":"2013","journal-title":"BioMed Res. Int."},{"key":"10.1016\/j.bbrc.2025.152322_bib48","first-page":"379","article-title":"Borderline tumours of the ovary, current controversies regarding their diagnosis and treatment","volume":"7","author":"Patrono","year":"2013","journal-title":"ecancermedicalscience"},{"key":"10.1016\/j.bbrc.2025.152322_bib49","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.critrevonc.2013.08.017","article-title":"Sensitivity and resistance to treatment in the primary management of epithelial ovarian cancer","volume":"89","author":"Colombo","year":"2014","journal-title":"Crit. Rev. Oncol. Hematol."},{"key":"10.1016\/j.bbrc.2025.152322_bib50","doi-asserted-by":"crossref","first-page":"2358","DOI":"10.1073\/pnas.1120733109","article-title":"Human ovarian cancer stem\/progenitor cells are stimulated by doxorubicin but inhibited by Mullerian inhibiting substance","volume":"109","author":"Meirelles","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbrc.2025.152322_bib51","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1186\/s12885-016-2956-z","article-title":"Chemotherapy curable malignancies and cancer stem cells: a biological review and hypothesis","volume":"16","author":"Savage","year":"2016","journal-title":"BMC Cancer"},{"key":"10.1016\/j.bbrc.2025.152322_bib52","doi-asserted-by":"crossref","first-page":"4411","DOI":"10.1073\/pnas.1421365112","article-title":"Enhanced expression of DNA polymerase eta contributes to cisplatin resistance of ovarian cancer stem cells","volume":"112","author":"Srivastava","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbrc.2025.152322_bib53","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.biocel.2018.12.010","article-title":"Ovarian cancer stem cells: what progress have we made?","volume":"107","author":"Al-Alem","year":"2019","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.bbrc.2025.152322_bib54","doi-asserted-by":"crossref","first-page":"301","DOI":"10.7150\/jca.8610","article-title":"Investigating molecular profiles of ovarian cancer: an update on cancer stem cells","volume":"5","author":"Tomao","year":"2014","journal-title":"J. Cancer"},{"key":"10.1016\/j.bbrc.2025.152322_bib55","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.1111\/jog.12758","article-title":"Epithelial ovarian cancer with CD117 phenotype is highly aggressive and resistant to chemotherapy","volume":"41","author":"Conic","year":"2015","journal-title":"J. Obstet. Gynaecol. Res."},{"key":"10.1016\/j.bbrc.2025.152322_bib56","doi-asserted-by":"crossref","first-page":"2672","DOI":"10.1038\/onc.2010.35","article-title":"CD24+ cells from hierarchically organized ovarian cancer are enriched in cancer stem cells","volume":"29","author":"Gao","year":"2010","journal-title":"Oncogene"},{"key":"10.1016\/j.bbrc.2025.152322_bib57","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S0092-8674(02)00625-6","article-title":"Apoptosis: a link between cancer genetics and chemotherapy","volume":"108","author":"Johnstone","year":"2002","journal-title":"Cell"},{"key":"10.1016\/j.bbrc.2025.152322_bib58","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19061690","article-title":"Pharmacological targeting of cell cycle, apoptotic and cell adhesion signaling pathways implicated in chemoresistance of cancer cells","volume":"19","author":"Alimbetov","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbrc.2025.152322_bib59","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1111\/j.1749-6632.2012.06734.x","article-title":"Molecular determinants of ovarian cancer chemoresistance: new insights into an old conundrum","volume":"1271","author":"Ali","year":"2012","journal-title":"Ann. N. Y. Acad. Sci."},{"issue":"Suppl 10","key":"10.1016\/j.bbrc.2025.152322_bib60","doi-asserted-by":"crossref","first-page":"x315","DOI":"10.1093\/annonc\/mdl280","article-title":"Chemoresistance in solid tumours","volume":"17","author":"Wilson","year":"2006","journal-title":"Ann. Oncol."},{"key":"10.1016\/j.bbrc.2025.152322_bib61","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/onc.2010.460","article-title":"Towards novel paradigms for cancer therapy","volume":"30","author":"Pavet","year":"2011","journal-title":"Oncogene"},{"key":"10.1016\/j.bbrc.2025.152322_bib62","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1016\/j.bbrc.2009.10.090","article-title":"Association of caspase-8 mutation with chemoresistance to cisplatin in HOC313 head and neck squamous cell carcinoma cells","volume":"390","author":"Liu","year":"2009","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbrc.2025.152322_bib63","first-page":"31","article-title":"Understanding the role of the death receptor 5\/FADD\/caspase-8 death signaling in cancer metastasis","volume":"3","author":"Sun","year":"2011","journal-title":"Mol. Cell. Pharmacol."},{"key":"10.1016\/j.bbrc.2025.152322_bib64","doi-asserted-by":"crossref","DOI":"10.1016\/j.prp.2024.155592","article-title":"TNFRSF10D expression as a potential biomarker for cisplatin-induced damage and ovarian tumor relapse prediction","volume":"263","author":"Goncales","year":"2024","journal-title":"Pathol. Res. Pract."},{"key":"10.1016\/j.bbrc.2025.152322_bib65","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1158\/2159-8290.CD-15-0011","article-title":"The BCL2 family: key mediators of the apoptotic response to targeted anticancer therapeutics","volume":"5","author":"Hata","year":"2015","journal-title":"Cancer Discov."},{"key":"10.1016\/j.bbrc.2025.152322_bib66","first-page":"5416923","article-title":"Cancer stem cells (CSCs) in drug resistance and their therapeutic implications in cancer treatment","volume":"2018","author":"Phi","year":"2018","journal-title":"Stem Cell. Int."},{"key":"10.1016\/j.bbrc.2025.152322_bib67","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1016\/j.biopha.2016.09.087","article-title":"Differential role of microRNAs in prognosis, diagnosis, and therapy of ovarian cancer","volume":"84","author":"Mahdian-Shakib","year":"2016","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.bbrc.2025.152322_bib68","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1111\/j.1365-2184.2012.00845.x","article-title":"Programmed cell death pathways in cancer: a review of apoptosis, autophagy and programmed necrosis","volume":"45","author":"Ouyang","year":"2012","journal-title":"Cell Prolif."},{"key":"10.1016\/j.bbrc.2025.152322_bib69","doi-asserted-by":"crossref","first-page":"60074","DOI":"10.18632\/oncotarget.11054","article-title":"Upregulation of miR-181c inhibits chemoresistance by targeting ST8SIA4 in chronic myelocytic leukemia","volume":"7","author":"Zhao","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.bbrc.2025.152322_bib70","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1016\/j.ijbiomac.2018.12.075","article-title":"The microRNA miR-181c enhances chemosensitivity and reduces chemoresistance in breast cancer cells via down-regulating osteopontin","volume":"125","author":"Han","year":"2019","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.bbrc.2025.152322_bib71","doi-asserted-by":"crossref","first-page":"44466","DOI":"10.18632\/oncotarget.6298","article-title":"Upregulation of miR-181c contributes to chemoresistance in pancreatic cancer by inactivating the Hippo signaling pathway","volume":"6","author":"Chen","year":"2015","journal-title":"Oncotarget"},{"key":"10.1016\/j.bbrc.2025.152322_bib72","first-page":"1037","article-title":"miR-26a inhibits the proliferation of ovarian cancer cells via regulating CDC6 expression","volume":"8","author":"Sun","year":"2016","journal-title":"Am. J. Transl. Res."},{"key":"10.1016\/j.bbrc.2025.152322_bib73","article-title":"MiR-26a promotes ovarian cancer proliferation and tumorigenesis","volume":"9","author":"Shen","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.bbrc.2025.152322_bib74","doi-asserted-by":"crossref","first-page":"249393","DOI":"10.1155\/2014\/249393","article-title":"The role of microRNAs in ovarian cancer","volume":"2014","author":"Kinose","year":"2014","journal-title":"BioMed Res. Int."},{"key":"10.1016\/j.bbrc.2025.152322_bib75","doi-asserted-by":"crossref","first-page":"2177","DOI":"10.3892\/or.2016.4985","article-title":"miR-17 inhibits ovarian cancer cell peritoneal metastasis by targeting ITGA5 and ITGB1","volume":"36","author":"Gong","year":"2016","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.bbrc.2025.152322_bib76","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2016.461","article-title":"MiR-26 enhances chemosensitivity and promotes apoptosis of hepatocellular carcinoma cells through inhibiting autophagy","volume":"8","author":"Jin","year":"2017","journal-title":"Cell Death Dis."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X2501037X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X2501037X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T11:12:12Z","timestamp":1777461132000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X2501037X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":76,"alternative-id":["S0006291X2501037X"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2025.152322","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ovarian cancer cell heterogeneity and paclitaxel response in vitro 2D and 3D cancer cell models and xenograft growth in the chicken chorioallantoic membrane (CAM)","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2025.152322","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"152322"}}