{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T12:54:39Z","timestamp":1777726479649,"version":"3.51.4"},"reference-count":95,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100018806","name":"Department of Science and Technology of Hubei Province","doi-asserted-by":"publisher","award":["2022CFB270"],"award-info":[{"award-number":["2022CFB270"]}],"id":[{"id":"10.13039\/501100018806","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.bbrc.2025.152325","type":"journal-article","created":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T07:54:38Z","timestamp":1752566078000},"page":"152325","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Progress in the application of stem cell therapy for moyamoya disease"],"prefix":"10.1016","volume":"778","author":[{"given":"Kaixuan","family":"Yan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiangping","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pengfei","family":"Yan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaobin","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2025.152325_bib1","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/S1474-4422(22)00165-X","article-title":"Moyamoya disease: diagnosis and interventions","volume":"21","author":"Ihara","year":"2022","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.bbrc.2025.152325_bib2","doi-asserted-by":"crossref","first-page":"307","DOI":"10.2176\/jns-nmc.2022-0072","article-title":"Diagnostic criteria for moyamoya disease - 2021 revised version","volume":"62","author":"Kuroda","year":"2022","journal-title":"Neurol. Med.-Chir."},{"key":"10.1016\/j.bbrc.2025.152325_bib3","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1001\/archneur.1969.00480090076012","article-title":"Cerebrovascular \"moyamoya\" disease. Disease showing abnormal net-like vessels in base of brain","volume":"20","author":"Suzuki","year":"1969","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.bbrc.2025.152325_bib4","series-title":"Moyamoya Disease: Current Knowledge and Future Perspectives","author":"Kuroda","year":"2021"},{"key":"10.1016\/j.bbrc.2025.152325_bib5","article-title":"Epidemiology of moyamoya disease in China: a nationwide hospital-based study","volume":"18","author":"Zhang","year":"2022","journal-title":"Lancet Reg Health West Pac"},{"key":"10.1016\/j.bbrc.2025.152325_bib6","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1161\/STROKEAHA.122.041932","article-title":"Five-year stroke risk and its predictors in asymptomatic moyamoya disease: asymptomatic moyamoya registry (AMORE)","volume":"54","author":"Kuroda","year":"2023","journal-title":"Stroke"},{"key":"10.1016\/j.bbrc.2025.152325_bib7","first-page":"229","article-title":"Moyamoya disease: a review of clinical research","volume":"70","author":"Hishikawa","year":"2016","journal-title":"Acta Med. Okayama"},{"key":"10.1016\/j.bbrc.2025.152325_bib8","doi-asserted-by":"crossref","first-page":"165","DOI":"10.2176\/jns-nmc.2021-0382","article-title":"Japanese guidelines for the management of moyamoya disease: guidelines from the research committee on moyamoya disease and Japan stroke society","volume":"62","author":"Fujimura","year":"2021","journal-title":"Neurol. Med.-Chir."},{"key":"10.1016\/j.bbrc.2025.152325_bib9","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s41016-023-00318-3","article-title":"Chinese expert consensus on the treatment of MMD","volume":"9","author":"Bao","year":"2023","journal-title":"Chin Neurosurg J"},{"key":"10.1016\/j.bbrc.2025.152325_bib10","doi-asserted-by":"crossref","DOI":"10.3389\/fsurg.2022.966430","article-title":"Surgical techniques and indications for treatment of adult moyamoya disease","volume":"9","author":"Nguyen","year":"2022","journal-title":"Front. Surg."},{"key":"10.1016\/j.bbrc.2025.152325_bib11","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.1007\/s10143-021-01689-w","article-title":"Surgical revascularization vs. conservative treatment for adult hemorrhagic moyamoya disease: analysis of rebleeding in 322 consecutive patients","volume":"45","author":"Yu","year":"2022","journal-title":"Neurosurg. Rev."},{"key":"10.1016\/j.bbrc.2025.152325_bib12","doi-asserted-by":"crossref","first-page":"e190","DOI":"10.1016\/j.wneu.2018.01.212","article-title":"Postoperative cerebral infarction risk factors and postoperative management of pediatric patients with moyamoya disease","volume":"113","author":"Muraoka","year":"2018","journal-title":"World Neurosurg."},{"key":"10.1016\/j.bbrc.2025.152325_bib13","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1007\/s10143-020-01393-1","article-title":"Limits and pitfalls of indirect revascularization in moyamoya disease and syndrome","volume":"44","author":"Fiaschi","year":"2021","journal-title":"Neurosurg. Rev."},{"key":"10.1016\/j.bbrc.2025.152325_bib14","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1016\/j.sjbs.2019.12.016","article-title":"Therapeutic effect of autologous bone marrow stem cell mobilization combined with anti-infective therapy on moyamoya disease","volume":"27","author":"Zhao","year":"2020","journal-title":"Saudi J. Biol. Sci."},{"key":"10.1016\/j.bbrc.2025.152325_bib15","doi-asserted-by":"crossref","first-page":"733","DOI":"10.2174\/1574888X17666220607121027","article-title":"Application of induced pluripotent stem cells in moyamoya disease: progress and promises","volume":"18","author":"Xue","year":"2023","journal-title":"Curr. Stem Cell Res. Ther."},{"key":"10.1016\/j.bbrc.2025.152325_bib16","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1161\/01.RES.0000137877.89448.78","article-title":"Endothelial progenitor cells: characterization and role in vascular biology","volume":"95","author":"Urbich","year":"2004","journal-title":"Circ. Res."},{"key":"10.1016\/j.bbrc.2025.152325_bib17","article-title":"Identification of RNF213 as a susceptibility gene for moyamoya disease and its possible role in vascular development","volume":"6","author":"Liu","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.bbrc.2025.152325_bib18","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.bbrc.2013.07.004","article-title":"Downregulation of securin by the variant RNF213 R4810K (Rs112735431, G>A) reduces angiogenic activity of induced pluripotent stem cell-derived vascular endothelial cells from moyamoya patients","volume":"438","author":"Hitomi","year":"2013","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbrc.2025.152325_bib19","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0163561","article-title":"Cellular functions and gene and protein expression profiles in endothelial cells derived from moyamoya disease-specific iPS cells","volume":"11","author":"Hamauchi","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.bbrc.2025.152325_bib20","doi-asserted-by":"crossref","first-page":"767","DOI":"10.2176\/nmc.51.767","article-title":"Bone marrow-derived endothelial progenitor cells participate in the initiation of moyamoya disease","volume":"51","author":"Sugiyama","year":"2011","journal-title":"Neurol. Med.-Chir."},{"key":"10.1016\/j.bbrc.2025.152325_bib21","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.stem.2024.01.003","article-title":"Metabolic regulation of the hallmarks of stem cell biology","volume":"31","author":"Jackson","year":"2024","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.bbrc.2025.152325_bib22","first-page":"375","article-title":"The stem cell system","volume":"37","author":"Schofield","year":"1983","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.bbrc.2025.152325_bib23","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1177\/0963689718773363","article-title":"Stem cell therapy: a promising therapeutic method for intracerebral hemorrhage","volume":"27","author":"Gao","year":"2018","journal-title":"Cell Transplant."},{"key":"10.1016\/j.bbrc.2025.152325_bib24","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21197380","article-title":"Clinical trials of stem cell therapy for cerebral ischemic stroke","volume":"21","author":"Kawabori","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbrc.2025.152325_bib25","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1126\/science.275.5302.964","article-title":"Isolation of putative progenitor endothelial cells for angiogenesis","volume":"275","author":"Asahara","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.bbrc.2025.152325_bib26","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.bcmd.2013.11.004","article-title":"Endothelial progenitors","volume":"52","author":"Pelosi","year":"2014","journal-title":"Blood Cells Mol. Dis."},{"key":"10.1016\/j.bbrc.2025.152325_bib27","doi-asserted-by":"crossref","first-page":"C664","DOI":"10.1152\/ajpcell.00200.2018","article-title":"Revascularization and endothelial progenitor cells in stroke","volume":"315","author":"Esquiva","year":"2018","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.bbrc.2025.152325_bib28","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1161\/STROKEAHA.108.529420","article-title":"Increased levels of circulating endothelial progenitor cells in patients with moyamoya disease","volume":"40","author":"Rafat","year":"2009","journal-title":"Stroke"},{"key":"10.1016\/j.bbrc.2025.152325_bib29","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24021233","article-title":"Increase of circulating endothelial progenitor cells and released angiogenic factors in children with moyamoya arteriopathy","volume":"24","author":"Gorla","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbrc.2025.152325_bib30","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1186\/s13287-022-03196-1","article-title":"Combination of indirect revascularization and endothelial progenitor cell transplantation improved cerebral perfusion and ameliorated tauopathy in a rat model of bilateral ICA ligation","volume":"13","author":"Wang","year":"2022","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.bbrc.2025.152325_bib31","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1186\/s13287-023-03465-7","article-title":"Local transplantation of mesenchymal stem cells improves encephalo-myo-synangiosis-mediated collateral neovascularization in chronic brain ischemia","volume":"14","author":"Zhang","year":"2023","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.bbrc.2025.152325_bib32","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1186\/s13287-022-03050-4","article-title":"The potential use of mesenchymal stem cells and their exosomes in parkinson's disease treatment","volume":"13","author":"Heris","year":"2022","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.bbrc.2025.152325_bib33","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.3892\/etm.2021.10456","article-title":"RNF213 gene silencing upregulates transforming growth factor \u03b21 expression in bone marrow-derived mesenchymal stem cells and is involved in the onset of moyamoya disease","volume":"22","author":"Wang","year":"2021","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.bbrc.2025.152325_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2020.119942","article-title":"Mesenchymal stem cell-derived magnetic extracellular nanovesicles for targeting and treatment of ischemic stroke","volume":"243","author":"Kim","year":"2020","journal-title":"Biomaterials"},{"key":"10.1016\/j.bbrc.2025.152325_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.114817","article-title":"Mesenchymal stem cell-derived exosomes in cardiovascular and cerebrovascular diseases: from mechanisms to therapy","volume":"163","author":"Pan","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.bbrc.2025.152325_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2021.113700","article-title":"Bone marrow mesenchymal stem cell-derived exosomes attenuate cerebral ischemia-reperfusion injury-induced neuroinflammation and pyroptosis by modulating microglia M1\/M2 phenotypes","volume":"341","author":"Liu","year":"2021","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.bbrc.2025.152325_bib37","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/1471-2202-11-52","article-title":"Intravenous administration of mesenchymal stem cells exerts therapeutic effects on parkinsonian model of rats: focusing on neuroprotective effects of stromal cell-derived factor-1alpha","volume":"11","author":"Wang","year":"2010","journal-title":"BMC Neurosci."},{"key":"10.1016\/j.bbrc.2025.152325_bib38","doi-asserted-by":"crossref","first-page":"269","DOI":"10.31083\/j.fbl2810269","article-title":"Microglia and stem cells for ischemic stroke treatment-mechanisms, current status, and therapeutic challenges","volume":"28","author":"Markowska","year":"2023","journal-title":"Front. Biosci. (Landmark Ed.)"},{"key":"10.1016\/j.bbrc.2025.152325_bib39","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/j.jstrokecerebrovasdis.2015.10.013","article-title":"Neuroprotective effects of brain-derived neurotrophic factor and noggin-modified bone mesenchymal stem cells in focal cerebral ischemia in rats","volume":"25","author":"Lu","year":"2016","journal-title":"J. Stroke Cerebrovasc. Dis."},{"key":"10.1016\/j.bbrc.2025.152325_bib40","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1007\/s12975-022-00984-y","article-title":"Neural stem cells therapy for ischemic stroke: progress and challenges","volume":"13","author":"Zhao","year":"2022","journal-title":"Transl Stroke Res"},{"key":"10.1016\/j.bbrc.2025.152325_bib41","doi-asserted-by":"crossref","first-page":"1997","DOI":"10.1042\/BST20200923","article-title":"How neural stem cells contribute to neocortex development","volume":"49","author":"Xing","year":"2021","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.bbrc.2025.152325_bib42","doi-asserted-by":"crossref","DOI":"10.3390\/cells10092377","article-title":"Human neural stem cells for cell-based medicinal products","volume":"10","author":"Fernandez-Mu\u00f1oz","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.bbrc.2025.152325_bib43","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.ajem.2021.01.021","article-title":"Hyperbaric oxygen therapy mobilized circulating stem cells and improved delayed encephalopathy after acute carbon monoxide poisoning with up-regulation of brain-derived neurotrophic factor","volume":"42","author":"Zhang","year":"2021","journal-title":"Am. J. Emerg. Med."},{"key":"10.1016\/j.bbrc.2025.152325_bib44","doi-asserted-by":"crossref","first-page":"679","DOI":"10.5607\/en.2019.28.6.679","article-title":"Glial cell line-derived neurotrophic factor-overexpressing human neural stem\/progenitor cells enhance therapeutic efficiency in rat with traumatic spinal cord injury","volume":"28","author":"Hwang","year":"2019","journal-title":"Exp Neurobiol"},{"key":"10.1016\/j.bbrc.2025.152325_bib45","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1002\/sctm.20-0290","article-title":"Nerve growth factor (NGF) and NGF receptors in mesenchymal stem\/stromal cells: impact on potential therapies","volume":"10","author":"Zha","year":"2021","journal-title":"Stem Cells Transl. Med."},{"key":"10.1016\/j.bbrc.2025.152325_bib46","doi-asserted-by":"crossref","first-page":"97","DOI":"10.55782\/ane-2023-010","article-title":"Fasudil alleviates cerebral ischemia-reperfusion injury by inhibiting inflammation and improving neurotrophic factor expression in rats","volume":"83","author":"Guo","year":"2023","journal-title":"Acta Neurobiol. Exp."},{"key":"10.1016\/j.bbrc.2025.152325_bib47","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24043866","article-title":"Neurotrophic factors as regenerative therapy for neurodegenerative diseases: current status, challenges and future perspectives","volume":"24","author":"El Ouaamari","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbrc.2025.152325_bib48","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/s00441-014-1914-9","article-title":"Control of neural stem cell self-renewal and differentiation in drosophila","volume":"359","author":"Kang","year":"2015","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.bbrc.2025.152325_bib49","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainres.2020.146726","article-title":"Wnt-activated olfactory ensheathing cells stimulate neural stem cell proliferation and neuronal differentiation","volume":"1735","author":"Yue","year":"2020","journal-title":"Brain Res."},{"key":"10.1016\/j.bbrc.2025.152325_bib50","doi-asserted-by":"crossref","first-page":"1836","DOI":"10.1038\/nprot.2012.116","article-title":"Directed differentiation of human pluripotent stem cells to cerebral cortex neurons and neural networks","volume":"7","author":"Shi","year":"2012","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.bbrc.2025.152325_bib51","doi-asserted-by":"crossref","first-page":"12456","DOI":"10.1021\/acs.jafc.1c04011","article-title":"Gallic acid induces neural stem cell differentiation into neurons and proliferation through the MAPK\/ERK pathway","volume":"69","author":"Jiang","year":"2021","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.bbrc.2025.152325_bib52","doi-asserted-by":"crossref","first-page":"2142","DOI":"10.1177\/15353702221114099","article-title":"Human stem cell-derived neurons and neural circuitry therapeutics: next frontier in spinal cord injury repair","volume":"247","author":"Paredes-Espinosa","year":"2022","journal-title":"Exp Biol Med (Maywood)"},{"key":"10.1016\/j.bbrc.2025.152325_bib53","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2315100121","article-title":"Gephyrin promotes autonomous assembly and synaptic localization of GABAergic postsynaptic components without presynaptic GABA release","volume":"121","author":"Carricaburu","year":"2024","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbrc.2025.152325_bib54","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.stem.2020.08.014","article-title":"Human stem cell-derived neurons repair circuits and restore neural function","volume":"28","author":"Xiong","year":"2021","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.bbrc.2025.152325_bib55","doi-asserted-by":"crossref","DOI":"10.3390\/cells10123296","article-title":"Neural stem cells: promoting axonal regeneration and spinal cord connectivity","volume":"10","author":"de Freria","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.bbrc.2025.152325_bib56","doi-asserted-by":"crossref","first-page":"510","DOI":"10.7150\/thno.89008","article-title":"Exosomes derived from CD271(+)CD56(+) bone marrow mesenchymal stem cell subpopoulation identified by single-cell RNA sequencing promote axon regeneration after spinal cord injury","volume":"14","author":"Sun","year":"2024","journal-title":"Theranostics"},{"key":"10.1016\/j.bbrc.2025.152325_bib57","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1002\/cbin.11500","article-title":"Potential role of NGF, BDNF, and their receptors in oligodendrocytes differentiation from neural stem cell: an in vitro study","volume":"45","author":"Langhnoja","year":"2021","journal-title":"Cell Biol. Int."},{"key":"10.1016\/j.bbrc.2025.152325_bib58","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1007\/s12015-021-10218-7","article-title":"Mouse neural stem cell differentiation and human adipose mesenchymal stem cell transdifferentiation into Neuron- and oligodendrocyte-like cells with myelination potential","volume":"18","author":"Santos","year":"2022","journal-title":"Stem Cell Rev Rep"},{"key":"10.1016\/j.bbrc.2025.152325_bib59","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1007\/s00415-019-09421-x","article-title":"Promoting remyelination in multiple sclerosis","volume":"268","author":"Cunniffe","year":"2021","journal-title":"J. Neurol."},{"key":"10.1016\/j.bbrc.2025.152325_bib60","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1002\/sctm.21-0021","article-title":"Advances in mesenchymal stem cell therapy for immune and inflammatory diseases: use of cell-free products and human pluripotent stem cell-derived mesenchymal stem cells","volume":"10","author":"Wang","year":"2021","journal-title":"Stem Cells Transl. Med."},{"key":"10.1016\/j.bbrc.2025.152325_bib61","doi-asserted-by":"crossref","DOI":"10.1111\/xen.12774","article-title":"Recellularized bovine pericardium with autologous mesenchymal stem cells reduces immune activation","volume":"29","author":"Bozso","year":"2022","journal-title":"Xenotransplantation"},{"key":"10.1016\/j.bbrc.2025.152325_bib62","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1038\/s41423-023-01020-1","article-title":"Culture-expanded mesenchymal stromal cell therapy: does it work in knee osteoarthritis? A pathway to clinical success","volume":"20","author":"Copp","year":"2023","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.bbrc.2025.152325_bib63","doi-asserted-by":"crossref","first-page":"2007","DOI":"10.2147\/JIR.S308078","article-title":"Orexin-A attenuates inflammatory responses in lipopolysaccharide-induced neural stem cells by regulating NF-KB and phosphorylation of MAPK\/P38\/Erk pathways","volume":"14","author":"Ye","year":"2021","journal-title":"J. Inflamm. Res."},{"key":"10.1016\/j.bbrc.2025.152325_bib64","doi-asserted-by":"crossref","DOI":"10.3390\/ijms17091380","article-title":"Anti-inflammatory mechanism of neural stem cell transplantation in spinal cord injury","volume":"17","author":"Cheng","year":"2016","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbrc.2025.152325_bib65","doi-asserted-by":"crossref","first-page":"2629","DOI":"10.1161\/STROKEAHA.122.041611","article-title":"M2 microglia extracellular vesicle miR-124 regulates neural stem cell differentiation in ischemic stroke via AAK1\/NOTCH","volume":"54","author":"Song","year":"2023","journal-title":"Stroke"},{"key":"10.1016\/j.bbrc.2025.152325_bib66","doi-asserted-by":"crossref","first-page":"2153","DOI":"10.1016\/j.stem.2021.08.015","article-title":"Human microglia states are conserved across experimental models and regulate neural stem cell responses in chimeric organoids","volume":"28","author":"Popova","year":"2021","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.bbrc.2025.152325_bib67","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1186\/s12974-019-1597-y","article-title":"Astrocytic endothelin-1 overexpression promotes neural progenitor cells proliferation and differentiation into astrocytes via the Jak2\/Stat3 pathway after stroke","volume":"16","author":"Cheng","year":"2019","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.bbrc.2025.152325_bib68","article-title":"Oxidative-signaling in neural stem cell-mediated plasticity: implications for neurodegenerative diseases","volume":"10","author":"Santos","year":"2021","journal-title":"Antioxidants (Basel)"},{"key":"10.1016\/j.bbrc.2025.152325_bib69","article-title":"Tetrahydrofolate alleviates the inhibitory effect of oxidative stress on neural stem cell proliferation through PTEN\/Akt\/mTOR pathway","volume":"2022","author":"Zhang","year":"2022","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.bbrc.2025.152325_bib70","article-title":"ROS-scavenging hydrogels synergize with neural stem cells to enhance spinal cord injury repair via regulating microenvironment and facilitating nerve regeneration","volume":"12","author":"Liu","year":"2023","journal-title":"Adv. Healthcare Mater."},{"key":"10.1016\/j.bbrc.2025.152325_bib71","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/j.molmed.2022.08.009","article-title":"Moyamoya disease emerging as an immune-related angiopathy","volume":"28","author":"Asselman","year":"2022","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.bbrc.2025.152325_bib72","first-page":"125","article-title":"Adipose tissue-derived stem cells: immunomodulatory effects and therapeutic potential","volume":"35","author":"Al-Ghadban","year":"2020","journal-title":"Physiology (Bethesda)"},{"key":"10.1016\/j.bbrc.2025.152325_bib73","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/j.tips.2020.06.009","article-title":"Mesenchymal stem cell immunomodulation: mechanisms and therapeutic potential","volume":"41","author":"Song","year":"2020","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.bbrc.2025.152325_bib74","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1186\/s13287-021-02168-1","article-title":"Enhanced cell survival and therapeutic benefits of IL-10-expressing multipotent mesenchymal stromal cells for muscular dystrophy","volume":"12","author":"Nitahara-Kasahara","year":"2021","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.bbrc.2025.152325_bib75","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/9355692","article-title":"Adipose-derived stem cell-incubated HA-Rich sponge matrix implant modulates oxidative stress to enhance VEGF and TGF-\u03b2 secretions for extracellular matrix reconstruction in vivo","volume":"2022","author":"Cheng","year":"2022","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.bbrc.2025.152325_bib76","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/s13287-020-02070-2","article-title":"Mesenchymal stem cell-secreted prostaglandin E(2) ameliorates acute liver failure via attenuation of cell death and regulation of macrophage polarization","volume":"12","author":"Wang","year":"2021","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.bbrc.2025.152325_bib77","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1080\/08820139.2022.2055478","article-title":"Mesenchymal stem cells-derived exosomes ameliorate lupus by inducing M2 macrophage polarization and regulatory T cell expansion in MRL\/Lpr mice","volume":"51","author":"Sun","year":"2022","journal-title":"Immunol. Investig."},{"key":"10.1016\/j.bbrc.2025.152325_bib78","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1186\/s13287-022-03174-7","article-title":"Mesenchymal stem cell-derived exosome-educated macrophages alleviate systemic lupus erythematosus by promoting efferocytosis and recruitment of IL-17(+) regulatory T cell","volume":"13","author":"Zhang","year":"2022","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.bbrc.2025.152325_bib79","doi-asserted-by":"crossref","first-page":"167","DOI":"10.3340\/jkns.2015.58.3.167","article-title":"Role of a burr hole and calvarial bone marrow-derived stem cells in the ischemic rat brain: a possible mechanism for the efficacy of multiple burr hole surgery in moyamoya disease","volume":"58","author":"Nam","year":"2015","journal-title":"J. Korean Neurosurg. Soc."},{"key":"10.1016\/j.bbrc.2025.152325_bib80","doi-asserted-by":"crossref","DOI":"10.1016\/j.jstrokecerebrovasdis.2020.105305","article-title":"Vascular smooth muscle cell derived from IPS cell of moyamoya disease - comparative characterization with endothelial cell transcriptome","volume":"29","author":"Tokairin","year":"2020","journal-title":"J. Stroke Cerebrovasc. Dis."},{"key":"10.1016\/j.bbrc.2025.152325_bib81","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1186\/s12920-018-0385-3","article-title":"Circulating miRNome profiling in moyamoya disease-discordant monozygotic twins and endothelial microRNA expression analysis using iPS cell line","volume":"11","author":"Uchino","year":"2018","journal-title":"BMC Med. Genom."},{"key":"10.1016\/j.bbrc.2025.152325_bib82","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1038\/jcbfm.2008.67","article-title":"Circulating endothelial progenitor cells as a pathogenetic marker of moyamoya disease","volume":"28","author":"Jung","year":"2008","journal-title":"J. Cerebr. Blood Flow Metabol."},{"key":"10.1016\/j.bbrc.2025.152325_bib83","doi-asserted-by":"crossref","first-page":"N11","DOI":"10.1227\/01.neu.0000351423.30085.9d","article-title":"Endothelial progenitor cells in moyamoya disease","volume":"64","author":"Sherma","year":"2009","journal-title":"Neurosurgery"},{"key":"10.1016\/j.bbrc.2025.152325_bib84","article-title":"Influence of autologous bone marrow stem cell therapy on the levels of inflammatory factors and Conexin43 of patients with moyamoya disease","volume":"2022","author":"Zhao","year":"2022","journal-title":"Comput. Intell. Neurosci."},{"key":"10.1016\/j.bbrc.2025.152325_bib85","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1002\/jnr.22228","article-title":"Decreased level and defective function of circulating endothelial progenitor cells in children with moyamoya disease","volume":"88","author":"Kim","year":"2010","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.bbrc.2025.152325_bib86","doi-asserted-by":"crossref","DOI":"10.3389\/fsurg.2022.929871","article-title":"Experimental animal models for moyamoya disease: a species-oriented scoping review","volume":"9","author":"Cao","year":"2022","journal-title":"Front. Surg."},{"key":"10.1016\/j.bbrc.2025.152325_bib87","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1038\/s41583-019-0257-7","article-title":"The future of stem cell therapies for parkinson disease","volume":"21","author":"Parmar","year":"2020","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.bbrc.2025.152325_bib88","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.pneurobio.2018.04.005","article-title":"Pluripotent stem cell-based therapy for parkinson's disease: current status and future prospects","volume":"168","author":"Sonntag","year":"2018","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.bbrc.2025.152325_bib89","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.mam.2015.06.007","article-title":"Being human: the role of pluripotent stem cells in regenerative medicine and humanizing alzheimer's disease models","volume":"43\u201344","author":"Sproul","year":"2015","journal-title":"Mol. Aspect. Med."},{"key":"10.1016\/j.bbrc.2025.152325_bib90","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2022.101655","article-title":"The future of stem cell therapies of alzheimer's disease","volume":"80","author":"Wang","year":"2022","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.bbrc.2025.152325_bib91","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1186\/s13287-017-0567-5","article-title":"Alzheimer's disease, dementia, and stem cell therapy","volume":"8","author":"Duncan","year":"2017","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.bbrc.2025.152325_bib92","doi-asserted-by":"crossref","first-page":"E4","DOI":"10.3171\/2009.1.FOCUS08302","article-title":"Pathophysiology and genetic factors in moyamoya disease","volume":"26","author":"Achrol","year":"2009","journal-title":"Neurosurg. Focus"},{"key":"10.1016\/j.bbrc.2025.152325_bib93","doi-asserted-by":"crossref","first-page":"7519","DOI":"10.4238\/2015.July.3.27","article-title":"Treatment of moyamoya disease by multipoint skull drilling for indirect revascularization combined with mobilization of autologous bone marrow stem cells","volume":"14","author":"Wu","year":"2015","journal-title":"Genet. Mol. Res."},{"key":"10.1016\/j.bbrc.2025.152325_bib94","doi-asserted-by":"crossref","first-page":"473","DOI":"10.3389\/fnins.2020.00473","article-title":"Application of stem cells in stroke: a multifactorial approach","volume":"14","author":"Singh","year":"2020","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.bbrc.2025.152325_bib95","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1080\/14712598.2023.2175605","article-title":"Applications of mesenchymal stem cells in ocular surface diseases: sources and routes of delivery","volume":"23","author":"Soleimani","year":"2023","journal-title":"Expet Opin. Biol. Ther."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X2501040X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X2501040X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T10:46:42Z","timestamp":1777459602000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X2501040X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":95,"alternative-id":["S0006291X2501040X"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2025.152325","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Progress in the application of stem cell therapy for moyamoya disease","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2025.152325","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"152325"}}