{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T22:43:11Z","timestamp":1793227391985,"version":"4.5.0"},"reference-count":62,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.bbrc.2025.152364","type":"journal-article","created":{"date-parts":[[2025,7,16]],"date-time":"2025-07-16T15:01:46Z","timestamp":1752678106000},"page":"152364","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Comparative analysis of anticancer properties of So and selenium nanoparticles in a thioacetamide-induced HCC model"],"prefix":"10.1016","volume":"778","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-9013-9855","authenticated-orcid":false,"given":"Elena G.","family":"Varlamova","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dmitry E.","family":"Burmistrov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergey V.","family":"Gudkov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1664-4906","authenticated-orcid":false,"given":"Vladimir V.","family":"Rogachev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Egor A.","family":"Turovsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.bbrc.2025.152364_bib1","doi-asserted-by":"crossref","first-page":"E359","DOI":"10.1002\/ijc.29210","article-title":"Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012","volume":"136","author":"Ferlay","year":"2015","journal-title":"Int. J. Cancer"},{"issue":"1","key":"10.1016\/j.bbrc.2025.152364_bib2","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1002\/hep.28453","article-title":"Lipiodol transarterial chemoembolization for hepatocellular carcinoma: a systematic review of efficacy and safety data","volume":"64","author":"Lencioni","year":"2016","journal-title":"Hepatology"},{"issue":"3","key":"10.1016\/j.bbrc.2025.152364_bib3","first-page":"318","article-title":"Recent advances of So nanoformulations for cancer therapy: smart nanosystem and combination therapy","volume":"16","author":"Chen","year":"2021","journal-title":"Asian J. Pharm. Sci."},{"issue":"19","key":"10.1016\/j.bbrc.2025.152364_bib4","doi-asserted-by":"crossref","first-page":"7099","DOI":"10.1158\/0008-5472.CAN-04-1443","article-title":"BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF\/MEK\/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis","volume":"64","author":"Wilhelm","year":"2004","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbrc.2025.152364_bib5","first-page":"2329","article-title":"In vivo biodistribution, biocompatibility, and efficacy of So-loaded lipid-based nanosuspensions evaluated experimentally in cancer","volume":"11","author":"Yang","year":"2016","journal-title":"Int. J. Nanomed."},{"key":"10.1016\/j.bbrc.2025.152364_bib6","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.actbio.2018.05.049","article-title":"A dual-targeting reconstituted high density lipoprotein leveraging the synergy of So and antimiRNA21 for enhanced hepatocellular carcinoma therapy","volume":"75","author":"Li","year":"2018","journal-title":"Acta Biomater."},{"issue":"9","key":"10.1016\/j.bbrc.2025.152364_bib7","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1016\/j.dld.2011.04.022","article-title":"Fatal gastric bleeding during So treatment for hepatocellular carcinoma recurrence after liver transplantation","volume":"43","author":"Mancuso","year":"2011","journal-title":"Dig. Liver Dis."},{"issue":"1","key":"10.1016\/j.bbrc.2025.152364_bib8","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1134\/S160767292001007X","article-title":"Activation of signal pathways of apoptosis under conditions of prolonged ER-Stress caused by exposure of mouse testicular teratoma cells to selenium-containing compounds","volume":"490","author":"Goltyaev","year":"2020","journal-title":"Dokl. Biochem. Biophys."},{"issue":"1","key":"10.1016\/j.bbrc.2025.152364_bib9","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1134\/S1607672918030018","article-title":"Influence of sodium selenite on the mRNA expression of the Mammalian selenocysteine-containing protein genes in testicle and prostate cancer cells","volume":"480","author":"Kuznetsova","year":"2018","journal-title":"Dokl. Biochem. Biophys."},{"issue":"3","key":"10.1016\/j.bbrc.2025.152364_bib10","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1134\/S0026893318030147","article-title":"[Effect of Sodium Selenite on Gene Expression of SELF, SELW, and TGR Selenoproteins in Adenocarcinoma Cells of the Human Prostate]","volume":"52","author":"Varlamova","year":"2018","journal-title":"Mol. Biol. (Mosk)"},{"issue":"1","key":"10.1016\/j.bbrc.2025.152364_bib11","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1134\/S1607672916030121","article-title":"Expression of human selenoprotein genes selh, selk, selm, sels, selv, and gpx-6 in various tumor cell lines","volume":"468","author":"Varlamova","year":"2016","journal-title":"Dokl. Biochem. Biophys."},{"key":"10.1016\/j.bbrc.2025.152364_bib12","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2021.781608","article-title":"RGD peptide-conjugated selenium nanocomposite inhibits human glioma growth by triggering mitochondrial dysfunction and ROS-dependent MAPKs activation","volume":"9","author":"Liu","year":"2021","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.bbrc.2025.152364_bib13","doi-asserted-by":"crossref","first-page":"2508","DOI":"10.1039\/C8BM00670A","article-title":"Autophagy is an important action mode for functionalized selenium nanoparticles to exhibit anti-colorectal cancer activity","volume":"6","author":"Huang","year":"2018","journal-title":"Biomater. Sci."},{"key":"10.1016\/j.bbrc.2025.152364_bib14","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1016\/j.nano.2015.01.009","article-title":"Rational design of cancer-targeted selenium nanoparticles to antagonize multidrug resistance in cancer cells","volume":"11","author":"Liu","year":"2015","journal-title":"Nanomed. Nanotechnol. Biol. Med."},{"issue":"15","key":"10.1016\/j.bbrc.2025.152364_bib15","doi-asserted-by":"crossref","first-page":"7798","DOI":"10.3390\/ijms22157798","article-title":"Mechanisms of the cytotoxic effect of selenium nanoparticles in different human cancer cell lines","volume":"22","author":"Varlamova","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"3","key":"10.1016\/j.bbrc.2025.152364_bib16","doi-asserted-by":"crossref","first-page":"2411","DOI":"10.3390\/ijms24032411","article-title":"Ca2+-Dependent effects of the Selenium-So nanocomplex on glioblastoma cells and astrocytes of the cerebral cortex: anticancer agent and cytoprotector","volume":"24","author":"Varlamova","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbrc.2025.152364_bib17","doi-asserted-by":"crossref","DOI":"10.1002\/jbt.22989","article-title":"Selenium nanoparticles and quercetin suppress thioacetamide-induced hepatocellular carcinoma in rats: attenuation of inflammation involvement","volume":"36","author":"Mohamed","year":"2022","journal-title":"J. Biochem. Mol. Toxicol."},{"key":"10.1016\/j.bbrc.2025.152364_bib18","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1016\/j.ijbiomac.2019.07.031","article-title":"Selenium nanoparticles fabricated in laminarin polysaccharides solutions exert their cytotoxicities in HepG2 cells by inhibiting autophagy and promoting apoptosis","volume":"137","author":"Cui","year":"2019","journal-title":"Int. J. Biol. Macromol."},{"issue":"13","key":"10.1016\/j.bbrc.2025.152364_bib19","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.3390\/cells13131102","article-title":"Molecular mechanisms of the therapeutic effect of selenium nanoparticles in hepatocellular carcinoma","volume":"13","author":"Varlamova","year":"2024","journal-title":"Cells"},{"issue":"13","key":"10.1016\/j.bbrc.2025.152364_bib20","doi-asserted-by":"crossref","DOI":"10.3390\/ijms241310547","article-title":"The role of selenium nanoparticles in the treatment of liver pathologies of various natures","volume":"24","author":"Goltyaev","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbrc.2025.152364_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.etap.2021.103668","article-title":"Saxagliptin defers thioacetamide-induced hepatocarcinogenesis in rats: a novel suppressive impact on Wnt\/Hedgehog\/Notch1 signaling","volume":"86","author":"Abd Elhameed","year":"2021","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.bbrc.2025.152364_bib22","doi-asserted-by":"crossref","DOI":"10.3389\/fchem.2024.1449570","article-title":"Fabrication and growth mechanism of t-selenium nanorods during laser ablation and fragmentation in organic liquids","volume":"12","author":"Baimler","year":"2024","journal-title":"Front. Chem."},{"key":"10.1016\/j.bbrc.2025.152364_bib23","doi-asserted-by":"crossref","DOI":"10.3389\/fchem.2024.1463612","article-title":"Mini-review on laser-induced nanoparticle heating and melting","volume":"12","author":"Baimler","year":"2024","journal-title":"Front. Chem."},{"issue":"9","key":"10.1016\/j.bbrc.2025.152364_bib24","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1515\/CCLM.2007.262","article-title":"New perspectives and strategy research biomarkers for hepatocellular carcinoma","volume":"45","author":"Saffroy","year":"2007","journal-title":"Clin. Chem. Lab. Med."},{"issue":"12","key":"10.1016\/j.bbrc.2025.152364_bib25","doi-asserted-by":"crossref","first-page":"3596","DOI":"10.1002\/jmv.25704","article-title":"OPN is a promising serological biomarker for hepatocellular carcinoma diagnosis","volume":"92","author":"Zhu","year":"2020","journal-title":"J. Med. Virol."},{"key":"10.1016\/j.bbrc.2025.152364_bib26","doi-asserted-by":"crossref","first-page":"35","DOI":"10.2147\/JHC.S48517","article-title":"Critical analysis of the potential of targeting GPC3 in hepatocellular carcinoma","volume":"1","author":"Nakatsura","year":"2014","journal-title":"J. Hepatocell. Carcinoma"},{"key":"10.1016\/j.bbrc.2025.152364_bib27","doi-asserted-by":"crossref","first-page":"63","DOI":"10.2147\/JHC.S116513","article-title":"GPC-3 in hepatocellular carcinoma: current perspectives","volume":"3","author":"Wu","year":"2016","journal-title":"J. Hepatocell. Carcinoma"},{"key":"10.1016\/j.bbrc.2025.152364_bib28","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1146\/annurev-immunol-032414-112123","article-title":"Interleukin-22: immunobiology and pathology","volume":"33","author":"Dudakov","year":"2015","journal-title":"Annu. Rev. Immunol."},{"issue":"23","key":"10.1016\/j.bbrc.2025.152364_bib29","doi-asserted-by":"crossref","first-page":"2723","DOI":"10.3390\/cells12232723","article-title":"Antifibrotic effect of selenium-containing nanoparticles on a model of TAA-Induced liver fibrosis","volume":"12","author":"Varlamova","year":"2023","journal-title":"Cells"},{"key":"10.1016\/j.bbrc.2025.152364_bib30","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1002\/hep.1840140211","article-title":"Immunohistochemical detection of transforming growth factor-\u03b21 in fibrotic liver diseases","volume":"14","author":"Nagy","year":"1991","journal-title":"Hepatology"},{"key":"10.1016\/j.bbrc.2025.152364_bib31","first-page":"760","article-title":"Transforming growth factor-beta 1 (TGF-\u03b21) and TGF-\u03b21 receptors in normal, cirrhotic, and neoplastic human livers","volume":"21","author":"Bedossa","year":"1995","journal-title":"Hepatology"},{"issue":"6","key":"10.1016\/j.bbrc.2025.152364_bib32","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1038\/nri3834","article-title":"Regulation of tumour necrosis factor signalling: live or let die","volume":"15","author":"Brenner","year":"2015","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.bbrc.2025.152364_bib33","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/j.biopha.2018.12.004","article-title":"Insight into the role of TRAIL in liver diseases","volume":"110","author":"Jiang","year":"2019","journal-title":"Biomed. Pharmacother."},{"issue":"12","key":"10.1016\/j.bbrc.2025.152364_bib34","doi-asserted-by":"crossref","first-page":"6641","DOI":"10.3390\/ijms23126641","article-title":"Comparative analysis of the cytotoxic effect of a complex of selenium nanoparticles doped with So, \"Naked\" selenium nanoparticles, and So on human hepatocyte carcinoma HepG2 cells","volume":"23","author":"Varlamova","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.bbrc.2025.152364_bib35","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1038\/s41392-024-02075-w","article-title":"Hepatocellular carcinoma: signaling pathways and therapeutic advances","volume":"10","author":"Zheng","year":"2025","journal-title":"Signal Transduct. Targeted Ther."},{"issue":"10","key":"10.1016\/j.bbrc.2025.152364_bib36","doi-asserted-by":"crossref","first-page":"3070","DOI":"10.3390\/ijms19103070","article-title":"Proteoglycans are attractive biomarkers and therapeutic targets in hepatocellular carcinoma","volume":"19","author":"Tanaka","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbrc.2025.152364_bib37","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.27692","article-title":"RIPK1-RIPK3-MLKL-dependent necrosis promotes the aging of mouse male reproductive system","volume":"6","author":"Li","year":"2017","journal-title":"eLife"},{"issue":"12","key":"10.1016\/j.bbrc.2025.152364_bib38","doi-asserted-by":"crossref","first-page":"2961","DOI":"10.1002\/ijc.27604","article-title":"EGFR activation is a potential determinant of primary resistance of hepatocellular carcinoma cells to So","volume":"131","author":"Ezzoukhry","year":"2012","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.bbrc.2025.152364_bib39","doi-asserted-by":"crossref","first-page":"7569","DOI":"10.2147\/OTT.S173360","article-title":"ADAMTS8 targets ERK to suppress cell proliferation, invasion, and metastasis of hepatocellular carcinoma","volume":"11","author":"Zhao","year":"2018","journal-title":"OncoTargets Ther."},{"key":"10.1016\/j.bbrc.2025.152364_bib40","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.21037\/atm-22-5827","article-title":"Prognostic analysis of RAS-related lncRNAs in liver hepatocellular carcinoma","volume":"10","author":"Li","year":"2022","journal-title":"Ann. Transl. Med."},{"key":"10.1016\/j.bbrc.2025.152364_bib41","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1111\/eci.12441","article-title":"The ras\/mapk pathway and hepatocarcinoma: pathogenesis and therapeutic implications","volume":"45","author":"Delire","year":"2015","journal-title":"Eur. J. Clin. Invest."},{"key":"10.1016\/j.bbrc.2025.152364_bib42","first-page":"1997","article-title":"Erk\/mapk signalling pathway and tumorigenesis","volume":"19","author":"Guo","year":"2020","journal-title":"Exp. Ther. Med."},{"issue":"21","key":"10.1016\/j.bbrc.2025.152364_bib43","doi-asserted-by":"crossref","first-page":"12901","DOI":"10.1074\/jbc.273.21.12901","article-title":"Induction of cyclooxygenase-2 by the activated MEKK1 --> SEK1\/MKK4 --> mitogen-activated protein kinase pathway","volume":"273","author":"Guan","year":"1998","journal-title":"J. Biol. Chem."},{"issue":"6","key":"10.1016\/j.bbrc.2025.152364_bib44","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1101\/gad.1989311","article-title":"The role of JNK in the development of hepatocellular carcinoma","volume":"25","author":"Das","year":"2011","journal-title":"Genes Dev."},{"key":"10.1016\/j.bbrc.2025.152364_bib45","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1053\/j.gastro.2006.01.006","article-title":"Ubiquitous activation of Ras and Jak\/Stat pathways in human HCC","volume":"130","author":"Calvisi","year":"2006","journal-title":"Gastroenterology"},{"key":"10.1016\/j.bbrc.2025.152364_bib46","doi-asserted-by":"crossref","first-page":"3423","DOI":"10.4161\/cc.9.17.12946","article-title":"IL-6, a risk factor for hepatocellular carcinoma: FLLL32 inhibits IL-6-Induced STAT3 phosphorylation in human hepatocellular cancer cells","volume":"9","author":"Liu","year":"2010","journal-title":"Cell Cycle"},{"key":"10.1016\/j.bbrc.2025.152364_bib47","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.semcancer.2020.09.011","article-title":"Targeting hypoxia\u2010inducible factor\u20101, for cancer treatment: recent advances in developing small\u2010molecule inhibitors from natural compounds","volume":"80","author":"Ma","year":"2020","journal-title":"Semin. Cancer Biol."},{"key":"10.1016\/j.bbrc.2025.152364_bib48","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.ccr.2009.02.015","article-title":"Persistently activated Stat3 maintains constitutive NF-kappaB activity in tumors","volume":"15","author":"Lee","year":"2009","journal-title":"Cancer Cell"},{"key":"10.1016\/j.bbrc.2025.152364_bib49","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1038\/cr.2010.183","article-title":"NF-\u03baB and STAT3 - key players in liver inflammation and cancer","volume":"21","author":"He","year":"2011","journal-title":"Cell Res."},{"key":"10.1016\/j.bbrc.2025.152364_bib50","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.ccr.2009.01.009","article-title":"Inflammation and cancer: IL-6 and STAT3 complete the link","volume":"15","author":"Bromberg","year":"2009","journal-title":"Cancer Cell"},{"issue":"9","key":"10.1016\/j.bbrc.2025.152364_bib51","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1158\/2326-6066.CIR-14-0112","article-title":"NF-\u03baB, an active player in human cancers","volume":"2","author":"Xia","year":"2014","journal-title":"Cancer Immunol. Res."},{"key":"10.1016\/j.bbrc.2025.152364_bib52","doi-asserted-by":"crossref","DOI":"10.1016\/j.metabol.2023.155771","article-title":"Cooperative STAT3-NFkB signaling modulates mitochondrial dysfunction and metabolic profiling in hepatocellular carcinoma","volume":"152","author":"Ishteyaque","year":"2024","journal-title":"Metabolism"},{"issue":"6","key":"10.1016\/j.bbrc.2025.152364_bib53","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.1016\/S0002-9440(10)63747-9","article-title":"Physiological and pathological responses to hypoxia","volume":"164","author":"Michiels","year":"2004","journal-title":"Am. J. Pathol."},{"issue":"1","key":"10.1016\/j.bbrc.2025.152364_bib54","doi-asserted-by":"crossref","first-page":"58","DOI":"10.3109\/13880209.2012.710241","article-title":"Acute and subacute toxicity of novel biogenic selenium nanoparticles in mice","volume":"51","author":"Shakibaie","year":"2013","journal-title":"Pharm. Biol."},{"issue":"1","key":"10.1016\/j.bbrc.2025.152364_bib55","doi-asserted-by":"crossref","first-page":"24","DOI":"10.57256\/2949-0715-2022-1-24-32","article-title":"Selenium in nanoform:toxicity and safety","volume":"1","author":"Shurygina","year":"2022","journal-title":"Baikal Med. J."},{"issue":"1","key":"10.1016\/j.bbrc.2025.152364_bib56","doi-asserted-by":"crossref","DOI":"10.2217\/hep-2020-0001","article-title":"JAK\/STAT signaling in hepatocellular carcinoma","volume":"7","author":"Hin Tang","year":"2020","journal-title":"Hepat Oncol."},{"issue":"1","key":"10.1016\/j.bbrc.2025.152364_bib57","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.jhep.2012.02.019","article-title":"Epidermal growth factor receptor and HER-3 restrict cell response to So in hepatocellular carcinoma cells","volume":"57","author":"Blivet-Van Eggelpo\u00ebl","year":"2012","journal-title":"J. Hepatol."},{"issue":"5","key":"10.1016\/j.bbrc.2025.152364_bib58","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1016\/j.cellsig.2014.01.026","article-title":"Upregulation of HIF-2\u03b1 induced by So contributes to the resistance by activating the TGF-\u03b1\/EGFR pathway in hepatocellular carcinoma cells","volume":"26","author":"Zhao","year":"2014","journal-title":"Cell. Signal."},{"issue":"1","key":"10.1016\/j.bbrc.2025.152364_bib59","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.canlet.2012.10.021","article-title":"Long-term exposure to So of liver cancer cells induces resistance with epithelial-to-mesenchymal transition, increased invasion and risk of rebound growth","volume":"329","author":"van Malenstein","year":"2013","journal-title":"Cancer Lett."},{"issue":"5","key":"10.1016\/j.bbrc.2025.152364_bib60","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1016\/j.ccr.2014.04.019","article-title":"Focal gains of VEGFA: candidate predictors of So response in hepatocellular carcinoma","volume":"25","author":"Llovet","year":"2014","journal-title":"Cancer Cell"},{"issue":"12","key":"10.1016\/j.bbrc.2025.152364_bib61","doi-asserted-by":"crossref","first-page":"1997","DOI":"10.1038\/bjc.2012.145","article-title":"Activation of JNK and high expression level of CD133 predict a poor response to So in hepatocellular carcinoma","volume":"106","author":"Hagiwara","year":"2012","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.bbrc.2025.152364_bib62","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/1741-7015-7-41","article-title":"Phosphorylated ERK is a potential predictor of sensitivity to So when treating hepatocellular carcinoma: evidence from an in vitro study","volume":"7","author":"Zhang","year":"2009","journal-title":"BMC Med."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X25010794?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X25010794?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T01:20:21Z","timestamp":1755739221000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X25010794"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":62,"alternative-id":["S0006291X25010794"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2025.152364","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Comparative analysis of anticancer properties of So and selenium nanoparticles in a thioacetamide-induced HCC model","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2025.152364","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"152364"}}