{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T11:13:13Z","timestamp":1784200393214,"version":"3.55.0"},"reference-count":65,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002923","name":"National Scientific and Technical Research Council","doi-asserted-by":"publisher","award":["PIP11220200102356"],"award-info":[{"award-number":["PIP11220200102356"]}],"id":[{"id":"10.13039\/501100002923","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021778","name":"National Agency for the Promotion of Research Technological Development and Innovation","doi-asserted-by":"publisher","award":["PICT 2020-00936"],"award-info":[{"award-number":["PICT 2020-00936"]}],"id":[{"id":"10.13039\/501100021778","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000097","name":"National Center for Research Resources","doi-asserted-by":"publisher","award":["PD4251"],"award-info":[{"award-number":["PD4251"]}],"id":[{"id":"10.13039\/100000097","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000097","name":"National Center for Research Resources","doi-asserted-by":"publisher","award":["CB904"],"award-info":[{"award-number":["CB904"]}],"id":[{"id":"10.13039\/100000097","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000097","name":"National Center for Research Resources","doi-asserted-by":"publisher","award":["e1282"],"award-info":[{"award-number":["e1282"]}],"id":[{"id":"10.13039\/100000097","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000097","name":"National Center for Research Resources","doi-asserted-by":"publisher","award":["CB1072"],"award-info":[{"award-number":["CB1072"]}],"id":[{"id":"10.13039\/100000097","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000097","name":"National Center for Research Resources","doi-asserted-by":"publisher","award":["e1072"],"award-info":[{"award-number":["e1072"]}],"id":[{"id":"10.13039\/100000097","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007869","name":"National University of the South General Secretariat of Science and Technology","doi-asserted-by":"publisher","award":["PGI 24\/B366"],"award-info":[{"award-number":["PGI 24\/B366"]}],"id":[{"id":"10.13039\/501100007869","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007869","name":"National University of the South General Secretariat of Science and Technology","doi-asserted-by":"publisher","award":["PGI 24\/B298"],"award-info":[{"award-number":["PGI 24\/B298"]}],"id":[{"id":"10.13039\/501100007869","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005740","name":"Universidad Nacional del Sur","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005740","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.bbrc.2025.152401","type":"journal-article","created":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T23:15:28Z","timestamp":1753312528000},"page":"152401","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Gain-of-function mutations in Caenorhabditis elegans levamisole-sensitive nicotinic receptors evaluated at the single-channel level"],"prefix":"10.1016","volume":"778","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0234-9930","authenticated-orcid":false,"given":"Ignacio","family":"Berg\u00e9","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8411-5467","authenticated-orcid":false,"given":"Guillermina","family":"Hernando","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0388-6129","authenticated-orcid":false,"given":"Cecilia","family":"Bouzat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2025.152401_bib1","first-page":"1","article-title":"Nicotinic ACh receptors","author":"Wonnacott","year":"2014","journal-title":"Tocris Rev. TOCRIS Biosc. Scient."},{"issue":"4","key":"10.1016\/j.bbrc.2025.152401_bib2","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1017\/S0033583513000061","article-title":"Nicotinic acetylcholine receptor and the structural basis of neuromuscular transmission: insights from Torpedo postsynaptic membranes","volume":"46","author":"Unwin","year":"2013","journal-title":"Q. Rev. Biophys."},{"issue":"8","key":"10.1016\/j.bbrc.2025.152401_bib3","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1016\/j.neuron.2022.01.013","article-title":"Conformational transitions and ligand-binding to a muscle-type nicotinic acetylcholine receptor","volume":"110","author":"Zarkadas","year":"2022","journal-title":"Neuron [Internet]"},{"issue":"6","key":"10.1016\/j.bbrc.2025.152401_bib4","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1016\/j.neuron.2020.03.012","article-title":"Structure of the native muscle-type nicotinic receptor and inhibition by snake venom toxins","volume":"106","author":"Rahman","year":"2020","journal-title":"Neuron [Internet]"},{"issue":"3","key":"10.1016\/j.bbrc.2025.152401_bib5","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1152\/physrev.00015.2011","article-title":"End-plate acetylcholine receptor: structure, mechanism, pharmacology, and disease","volume":"92","author":"Sine","year":"2012","journal-title":"Physiol. Rev."},{"issue":"10","key":"10.1016\/j.bbrc.2025.152401_bib6","doi-asserted-by":"crossref","first-page":"1873","DOI":"10.1113\/JP275100","article-title":"The dual-gate model for pentameric ligand-gated ion channels activation and desensitization","volume":"596","author":"Gielen","year":"2018","journal-title":"J. Physiol."},{"issue":"3","key":"10.1016\/j.bbrc.2025.152401_bib7","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/j.neuron.2016.03.032","article-title":"Emerging molecular mechanisms of signal transduction in pentameric ligand-gated ion channels","volume":"90","author":"Nemecz","year":"2016","journal-title":"Neuron"},{"issue":"6347","key":"10.1016\/j.bbrc.2025.152401_bib8","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1038\/353846a0","article-title":"Mutations in the channel domain alter desensitization of a neuronal nicotinic receptor","volume":"353","author":"Revah","year":"1991","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.bbrc.2025.152401_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/S0026-895X(25)10484-7","article-title":"The role of conserved leucines in the M2 domain of the acetylcholine receptor in channel gating","volume":"48","author":"Filatov","year":"1995","journal-title":"Mol. Pharmacol."},{"issue":"6540","key":"10.1016\/j.bbrc.2025.152401_bib10","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1038\/376514a0","article-title":"Channel gating governed symmetrically by conserved leucine residues in the M2 domain of nicotinic receptors","volume":"376","author":"Labarca","year":"1995","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2025.152401_bib11","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.cophys.2017.12.012","article-title":"A tale of ligands big and small: an update on how pentameric ligand-gated ion channels interact with agonists and proteins","volume":"2","author":"Pless","year":"2018","journal-title":"Curr. Opin. Physiol."},{"issue":"9","key":"10.1016\/j.bbrc.2025.152401_bib12","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.3390\/molecules22091550","article-title":"Acetylcholinesterase and nicotinic acetylcholine receptors in schistosomes and other parasitic helminths","volume":"22","author":"You","year":"2017","journal-title":"Molecules"},{"key":"10.1016\/j.bbrc.2025.152401_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2023.106813","article-title":"Advances in small molecule selective ligands for heteromeric nicotinic acetylcholine receptors","volume":"194","author":"Matera","year":"2023","journal-title":"Pharmacol. Res."},{"issue":"6068","key":"10.1016\/j.bbrc.2025.152401_bib14","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1038\/321406a0","article-title":"Molecular distinction between fetal and adult forms of muscle acetylcholine receptor","volume":"321","author":"Mishina","year":"1986","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.bbrc.2025.152401_bib15","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1002\/bies.10377","article-title":"Functional genomics of the nicotinic acetylcholine receptor gene family of the nematode, Caenorhabditis elegans","volume":"26","author":"Jones","year":"2004","journal-title":"Bioessays"},{"issue":"4","key":"10.1016\/j.bbrc.2025.152401_bib16","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1007\/s12551-023-01080-7","article-title":"The diverse family of Cys-loop receptors in Caenorhabditis elegans: insights from electrophysiological studies","volume":"15","author":"Hernando","year":"2023","journal-title":"Biophys. Rev."},{"issue":"9","key":"10.1016\/j.bbrc.2025.152401_bib17","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1038\/12160","article-title":"One GABA and two acetylcholine receptors function at the C. elegans neuromuscular junction","volume":"2","author":"Richmond","year":"1999","journal-title":"Nat. Neurosci."},{"issue":"6","key":"10.1016\/j.bbrc.2025.152401_bib18","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1093\/hmg\/9.6.869","article-title":"A role for Caenorhabditis elegans in understanding the function and interactions of human disease genes","volume":"9","author":"Culetto","year":"2000","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.bbrc.2025.152401_bib19","series-title":"Acetylcholine","first-page":"1","author":"Rand","year":"2007"},{"issue":"15","key":"10.1016\/j.bbrc.2025.152401_bib20","doi-asserted-by":"crossref","first-page":"5843","DOI":"10.1523\/JNEUROSCI.17-15-05843.1997","article-title":"Caenorhabditis elegans levamisole resistance genes lev-1, unc-29, and unc-38 encode functional nicotinic acetylcholine receptor subunits","volume":"17","author":"Fleming","year":"1997","journal-title":"J. Neurosci."},{"issue":"41","key":"10.1016\/j.bbrc.2025.152401_bib21","doi-asserted-by":"crossref","first-page":"42476","DOI":"10.1074\/jbc.M404370200","article-title":"The Caenorhabditis elegans unc-63 gene encodes a levamisole-sensitive nicotinic acetylcholine receptor alpha subunit","volume":"279","author":"Culetto","year":"2004","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.bbrc.2025.152401_bib22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1471-4159.2004.02951.x","article-title":"The Caenorhabditis elegans lev-8 gene encodes a novel type of nicotinic acetylcholine receptor alpha subunit","volume":"93","author":"Towers","year":"2005","journal-title":"J. Neurochem."},{"issue":"47","key":"10.1016\/j.bbrc.2025.152401_bib23","doi-asserted-by":"crossref","first-page":"18590","DOI":"10.1073\/pnas.0806933105","article-title":"Eight genes are required for functional reconstitution of the Caenorhabditis elegans levamisole-sensitive acetylcholine receptor","volume":"105","author":"Boulin","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"17","key":"10.1016\/j.bbrc.2025.152401_bib24","doi-asserted-by":"crossref","first-page":"2636","DOI":"10.1038\/emboj.2009.204","article-title":"An ER-resident membrane protein complex regulates nicotinic acetylcholine receptor subunit composition at the synapse","volume":"28","author":"Almedom","year":"2009","journal-title":"EMBO J."},{"issue":"2","key":"10.1016\/j.bbrc.2025.152401_bib25","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1017\/S003118201400170X","article-title":"The evolution of pentameric ligand-gated ion-channels and the changing family of anthelmintic drug targets","volume":"142","author":"Beech","year":"2015","journal-title":"Parasitology"},{"issue":"9","key":"10.1016\/j.bbrc.2025.152401_bib26","doi-asserted-by":"crossref","first-page":"3247","DOI":"10.1096\/fj.08-110502","article-title":"Levamisole resistance resolved at the single-channel level in Caenorhabditis elegans","volume":"22","author":"Qian","year":"2008","journal-title":"FASEB J."},{"issue":"3","key":"10.1016\/j.bbrc.2025.152401_bib27","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1124\/mol.112.079962","article-title":"Contribution of subunits to Caenorhabditis elegans levamisole-sensitive nicotinic receptor function","volume":"82","author":"Hernando","year":"2012","journal-title":"Mol. Pharmacol."},{"issue":"5","key":"10.1016\/j.bbrc.2025.152401_bib28","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1124\/mol.106.033514","article-title":"Activation of single nicotinic receptor channels from Caenorhabditis elegans muscle","volume":"71","author":"Rayes","year":"2007","journal-title":"Mol. Pharmacol."},{"issue":"5","key":"10.1016\/j.bbrc.2025.152401_bib29","first-page":"461","article-title":"Congenital myasthenic syndromes: pathogenesis, diagnosis, and treatment","volume":"14","author":"Engel","year":"2015","journal-title":"Lancet Neurol."},{"issue":"4","key":"10.1016\/j.bbrc.2025.152401_bib30","doi-asserted-by":"crossref","first-page":"3730","DOI":"10.3390\/ijms24043730","article-title":"Clinical and pathologic features of congenital myasthenic syndromes caused by 35 genes-A comprehensive review","volume":"24","author":"Ohno","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"3","key":"10.1016\/j.bbrc.2025.152401_bib31","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1073\/pnas.92.3.758","article-title":"Congenital myasthenic syndrome caused by prolonged acetylcholine receptor channel openings due to a mutation in the M2 domain of the epsilon subunit","volume":"92","author":"Ohno","year":"1995","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"10","key":"10.1016\/j.bbrc.2025.152401_bib32","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1002\/humu.23043","article-title":"Mutations causing slow-channel myasthenia reveal that a valine ring in the channel pore of muscle AChR is optimized for stabilizing channel gating","volume":"37","author":"Shen","year":"2016","journal-title":"Hum. Mutat."},{"issue":"3","key":"10.1016\/j.bbrc.2025.152401_bib33","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.coph.2004.12.007","article-title":"Current understanding of congenital myasthenic syndromes","volume":"5","author":"Engel","year":"2005","journal-title":"Curr. Opin. Pharmacol."},{"issue":"2","key":"10.1016\/j.bbrc.2025.152401_bib34","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.97826","article-title":"Mutations causing congenital myasthenia reveal principal coupling pathway in the acetylcholine receptor \u03b5-subunit","volume":"3","author":"Shen","year":"2018","journal-title":"JCI Insight"},{"issue":"1","key":"10.1016\/j.bbrc.2025.152401_bib35","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/0896-6273(95)90077-2","article-title":"Molecular dissection of subunit interfaces in the acetylcholine receptor: identification of determinants of alpha-conotoxin M1 selectivity","volume":"15","author":"Sine","year":"1995","journal-title":"Neuron"},{"issue":"20","key":"10.1016\/j.bbrc.2025.152401_bib36","article-title":"Determinants of the repetitive-CMAP occurrence and therapy efficacy in slow-channel myasthenia","volume":"95","author":"Di","year":"2020","journal-title":"Neurology [Internet]"},{"issue":"4","key":"10.1016\/j.bbrc.2025.152401_bib37","doi-asserted-by":"crossref","first-page":"2550","DOI":"10.1074\/jbc.M110.177238","article-title":"A Cys-loop mutation in the Caenorhabditis elegans nicotinic receptor subunit UNC-63 impairs but does not abolish channel function","volume":"286","author":"Jones","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2025.152401_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.vascn.2025.107583","article-title":"Drug combination assays using Caenorhabditis elegans as a model system","volume":"131","author":"Hernando","year":"2025","journal-title":"J. Pharmacol. Toxicol. Methods"},{"issue":"4","key":"10.1016\/j.bbrc.2025.152401_bib39","doi-asserted-by":"crossref","DOI":"10.1093\/genetics\/iyac003","article-title":"WormBase in 2022-data, processes, and tools for analyzing Caenorhabditis elegans","volume":"220","author":"Davis","year":"2022","journal-title":"Genetics"},{"key":"10.1016\/j.bbrc.2025.152401_bib40","doi-asserted-by":"crossref","DOI":"10.1895\/wormbook.1.101.1","article-title":"Maintenance of C. elegans","author":"Stiernagle","year":"2006","journal-title":"WormBook [Internet]"},{"issue":"12","key":"10.1016\/j.bbrc.2025.152401_bib41","doi-asserted-by":"crossref","first-page":"3959","DOI":"10.1002\/j.1460-2075.1991.tb04966.x","article-title":"Efficient gene transfer in C.elegans: extrachromosomal maintenance and integration of transforming sequences","volume":"10","author":"Mello","year":"1991","journal-title":"EMBO J."},{"key":"10.1016\/j.bbrc.2025.152401_bib42","series-title":"Transformation and Microinjection","author":"Evans","year":"2006"},{"issue":"4","key":"10.1016\/j.bbrc.2025.152401_bib43","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/S0896-6273(02)00591-3","article-title":"A primary culture system for functional analysis of C. elegans neurons and muscle cells","volume":"33","author":"Christensen","year":"2002","journal-title":"Neuron"},{"issue":"1","key":"10.1016\/j.bbrc.2025.152401_bib44","doi-asserted-by":"crossref","first-page":"5422","DOI":"10.1038\/s41598-025-89883-4","article-title":"Unraveling anthelmintic targets and mechanisms of action of trans-cinnamaldehyde from cinnamon essential oil","volume":"15","author":"Hernando","year":"2025","journal-title":"Sci. Rep."},{"issue":"4","key":"10.1016\/j.bbrc.2025.152401_bib45","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0095072","article-title":"Caenorhabditis elegans neuromuscular junction: GABA receptors and ivermectin action","volume":"9","author":"Hernando","year":"2014","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.bbrc.2025.152401_bib46","doi-asserted-by":"crossref","first-page":"1920","DOI":"10.1016\/S0006-3495(02)75541-0","article-title":"Subunit-Selective contribution to channel gating of the M4 domain of the nicotinic receptor","volume":"82","author":"Bouzat","year":"2002","journal-title":"Biophys. J."},{"issue":"4","key":"10.1016\/j.bbrc.2025.152401_bib47","doi-asserted-by":"crossref","DOI":"10.1002\/ana.410430411","article-title":"Quinidine sulfate therapy for the slow-channel congenital myasthenic syndrome","volume":"43","author":"Harper","year":"1998","journal-title":"Ann. Neurol."},{"issue":"2","key":"10.1016\/j.bbrc.2025.152401_bib48","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.nurt.2007.01.001","article-title":"The therapy of congenital myasthenic syndromes","volume":"4","author":"Engel","year":"2007","journal-title":"Neurotherapeutics"},{"issue":"1","key":"10.1016\/j.bbrc.2025.152401_bib49","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1111\/j.1749-6632.1998.tb10928.x","article-title":"AChR channel blockade by quinidine sulfate reduces channel open duration in the slow-channel congenital myasthenic syndrome","volume":"841","author":"Fukudome","year":"1998","journal-title":"Ann. N. Y. Acad. Sci."},{"issue":"NOV","key":"10.1016\/j.bbrc.2025.152401_bib50","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.3389\/fphar.2018.01339","article-title":"Effects of quinine, quinidine and chloroquine on human muscle nicotinic acetylcholine receptors","volume":"9","author":"Gisselmann","year":"2018","journal-title":"Front. Pharmacol."},{"issue":"1","key":"10.1016\/j.bbrc.2025.152401_bib51","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.jmb.2014.07.030","article-title":"Hydrophobic gating in ion channels","volume":"427","author":"Aryal","year":"2015","journal-title":"J. Mol. Biol."},{"issue":"13","key":"10.1016\/j.bbrc.2025.152401_bib52","doi-asserted-by":"crossref","first-page":"2457","DOI":"10.1007\/s00018-017-2741-4","article-title":"Molecular function of the novel \u03b17\u03b22 nicotinic receptor","volume":"75","author":"Nielsen","year":"2018","journal-title":"Cell. Mol. Life Sci."},{"issue":"1","key":"10.1016\/j.bbrc.2025.152401_bib53","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1085\/jgp.201411333","article-title":"The atypical cation-conduction and gating properties of ELIC underscore the marked functional versatility of the pentameric ligand-gated ion-channel fold","volume":"146","author":"Gonzalez-Gutierrez","year":"2015","journal-title":"J. Gen. Physiol."},{"issue":"42","key":"10.1016\/j.bbrc.2025.152401_bib54","doi-asserted-by":"crossref","first-page":"13932","DOI":"10.1523\/JNEUROSCI.1515-10.2010","article-title":"A dominant mutation in a neuronal acetylcholine receptor subunit leads to motor neuron degeneration in Caenorhabditis elegans","volume":"30","author":"Barbagallo","year":"2010","journal-title":"J. Neurosci."},{"issue":"12","key":"10.1016\/j.bbrc.2025.152401_bib55","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1002\/bies.201100082","article-title":"Invertebrate models of spinal muscular atrophy: insights into mechanisms and potential therapeutics","volume":"33","author":"Grice","year":"2011","journal-title":"Bioessays"},{"key":"10.1016\/j.bbrc.2025.152401_bib56","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22094891","article-title":"Caenorhabditis elegans as a model system for Duchenne muscular dystrophy","volume":"22","author":"Ellwood","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.bbrc.2025.152401_bib57","doi-asserted-by":"crossref","first-page":"99","DOI":"10.3390\/cells13010099","article-title":"Amyotrophic lateral sclerosis mechanism: insights from the Caenorhabditis elegans models","volume":"13","author":"Chen","year":"2024","journal-title":"Cells"},{"issue":"42","key":"10.1016\/j.bbrc.2025.152401_bib58","doi-asserted-by":"crossref","first-page":"25835","DOI":"10.1074\/jbc.271.42.25835","article-title":"Modulation of muscle nicotinic acetylcholine receptors by the glucocorticoid hydrocortisone","volume":"271","author":"Bouzat","year":"1996","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.bbrc.2025.152401_bib59","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1196\/annals.1254.016","article-title":"Congenital myasthenic syndromes: multiple molecular targets at the neuromuscular junction","volume":"998","author":"Engel","year":"2003","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.bbrc.2025.152401_bib60","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.cophys.2018.04.008","article-title":"The nicotinic acetylcholine receptor as a molecular machine for neuromuscular transmission","volume":"4","author":"Bouzat","year":"2018","journal-title":"Curr. Opin. Physiol."},{"issue":"15","key":"10.1016\/j.bbrc.2025.152401_bib61","doi-asserted-by":"crossref","first-page":"5651","DOI":"10.1523\/JNEUROSCI.17-15-05651.1997","article-title":"Slow-channel myasthenic syndrome caused by enhanced activation, desensitization, and agonist binding affinity attributable to mutation in the M2 domain of the acetylcholine receptor alpha subunit","volume":"17","author":"Milone","year":"1997","journal-title":"J. Neurosci."},{"issue":"9","key":"10.1016\/j.bbrc.2025.152401_bib62","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1093\/hmg\/5.9.1217","article-title":"New mutations in acetylcholine receptor subunit genes reveal heterogeneity in the slow-channel congenital myasthenic syndrome","volume":"5","author":"Engel","year":"1996","journal-title":"Hum. Mol. Genet."},{"issue":"10","key":"10.1016\/j.bbrc.2025.152401_bib63","doi-asserted-by":"crossref","first-page":"2066","DOI":"10.1002\/acn3.50902","article-title":"Slow-channel myasthenia due to novel mutation in M2 domain of AChR delta subunit","volume":"6","author":"Shen","year":"2019","journal-title":"Ann. Clin. Transl. Neurol."},{"key":"10.1016\/j.bbrc.2025.152401_bib64","doi-asserted-by":"crossref","DOI":"10.1016\/j.jocn.2021.12.016","article-title":"Treatment of slow-channel congenital myasthenic syndrome in a Thai family with fluoxetine","volume":"96","author":"Dejthevaporn","year":"2022","journal-title":"J. Clin. Neurosci."},{"key":"10.1016\/j.bbrc.2025.152401_bib65","series-title":"Subunit Positioning and Diversity of the Nematode Levamisole-Sensitive Acetylcholine Receptor [Internet]","first-page":"2024","author":"Noonan","year":"2024"}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X25011167?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X25011167?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T03:52:21Z","timestamp":1772769141000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X25011167"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":65,"alternative-id":["S0006291X25011167"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2025.152401","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Gain-of-function mutations in Caenorhabditis elegans levamisole-sensitive nicotinic receptors evaluated at the single-channel level","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2025.152401","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"152401"}}