{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T04:19:35Z","timestamp":1777436375979,"version":"3.51.4"},"reference-count":87,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,7,24]],"date-time":"2025-07-24T00:00:00Z","timestamp":1753315200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010711","name":"Cancer Foundation Finland","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020019","name":"Biocenter, University of Oulu","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100020019","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006306","name":"Sigrid Jus\u00e9lius Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006306","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018949","name":"Oulu University Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100018949","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006196","name":"University of Oulu","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006196","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002341","name":"Research Council of Finland","doi-asserted-by":"publisher","award":["361305"],"award-info":[{"award-number":["361305"]}],"id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002341","name":"Research Council of Finland","doi-asserted-by":"publisher","award":["314183"],"award-info":[{"award-number":["314183"]}],"id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.bbrc.2025.152402","type":"journal-article","created":{"date-parts":[[2025,7,24]],"date-time":"2025-07-24T15:03:38Z","timestamp":1753369418000},"page":"152402","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["PALB2 mutations increase oncogenic properties of breast epithelial cells by enhancing JAM3 and PARVB expression"],"prefix":"10.1016","volume":"778","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5997-9266","authenticated-orcid":false,"given":"Hanna","family":"Tuppurainen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0581-2529","authenticated-orcid":false,"given":"Marjut","family":"N\u00e4tynki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4880-0504","authenticated-orcid":false,"given":"Niina","family":"Laurila","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2449-0521","authenticated-orcid":false,"given":"Katri","family":"Pylk\u00e4s","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0932-9104","authenticated-orcid":false,"given":"Robert","family":"Winqvist","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4019-0091","authenticated-orcid":false,"given":"Hellevi","family":"Peltoketo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2025.152402_bib1","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1038\/s41523-017-0024-8","article-title":"The contribution of pathogenic variants in breast cancer susceptibility genes to familial breast cancer risk","volume":"3","author":"Slavin","year":"2017","journal-title":"NPJ Breast Cancer"},{"key":"10.1016\/j.bbrc.2025.152402_bib2","doi-asserted-by":"crossref","first-page":"6788","DOI":"10.1073\/pnas.0701724104","article-title":"Analysis of PALB2\/FANCN-associated breast cancer families","volume":"104","author":"Tischkowitz","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbrc.2025.152402_bib3","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1038\/nature05609","article-title":"A recurrent mutation in PALB2 in Finnish cancer families","volume":"446","author":"Erkko","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2025.152402_bib4","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1200\/JCO.19.01907","article-title":"Cancer risks associated with germline PALB2 pathogenic variants: an international study of 524 families","volume":"38","author":"Yang","year":"2020","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.bbrc.2025.152402_bib5","article-title":"Pathology of tumors associated with pathogenic germline variants in 9 breast cancer susceptibility genes","volume":"8","author":"Mavaddat","year":"2022","journal-title":"JAMA Oncol."},{"key":"10.1016\/j.bbrc.2025.152402_bib6","doi-asserted-by":"crossref","first-page":"7353","DOI":"10.1158\/0008-5472.CAN-10-1012","article-title":"PALB2\/FANCN: recombining cancer and Fanconi anemia","volume":"70","author":"Tischkowitz","year":"2010","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbrc.2025.152402_bib7","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1038\/ng1942","article-title":"Fanconi anemia is associated with a defect in the BRCA2 partner PALB2","volume":"39","author":"Xia","year":"2007","journal-title":"Nat. Genet."},{"key":"10.1016\/j.bbrc.2025.152402_bib8","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/j.molcel.2006.05.022","article-title":"Control of BRCA2 cellular and clinical functions by a nuclear partner, PALB2","volume":"22","author":"Xia","year":"2006","journal-title":"Mol. Cell"},{"key":"10.1016\/j.bbrc.2025.152402_bib9","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1038\/nrc3181","article-title":"BRCA1 and BRCA2: different roles in a common pathway of genome protection","volume":"12","author":"Roy","year":"2012","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.bbrc.2025.152402_bib10","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1038\/s41388-018-0535-2","article-title":"PALB2 connects BRCA1 and BRCA2 in the G2\/M checkpoint response","volume":"38","author":"Simhadri","year":"2019","journal-title":"Oncogene"},{"key":"10.1016\/j.bbrc.2025.152402_bib11","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/j.cub.2009.02.018","article-title":"PALB2 links BRCA1 and BRCA2 in the DNA-Damage response","volume":"19","author":"Zhang","year":"2009","journal-title":"Curr. Biol."},{"key":"10.1016\/j.bbrc.2025.152402_bib12","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1083\/jcb.201404111","article-title":"Phosphorylated RPA recruits PALB2 to stalled DNA replication forks to facilitate fork recovery","volume":"206","author":"Murphy","year":"2014","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.bbrc.2025.152402_bib13","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/j.celrep.2014.01.009","article-title":"Breast cancer proteins PALB2 and BRCA2 stimulate polymerase eta in recombination-associated DNA synthesis at blocked replication forks","volume":"6","author":"Buisson","year":"2014","journal-title":"Cell Rep."},{"key":"10.1016\/j.bbrc.2025.152402_bib14","doi-asserted-by":"crossref","first-page":"2578","DOI":"10.1038\/ncomms3578","article-title":"Heterozygous mutations in PALB2 cause DNA replication and damage response defects","volume":"4","author":"Nikkil\u00e4","year":"2013","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbrc.2025.152402_bib15","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.1128\/MCB.06271-11","article-title":"PALB2 interacts with KEAP1 to promote NRF2 nuclear accumulation and function","volume":"32","author":"Ma","year":"2012","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.bbrc.2025.152402_bib16","doi-asserted-by":"crossref","first-page":"7671","DOI":"10.1073\/pnas.1620208114","article-title":"MRG15-mediated tethering of PALB2 to unperturbed chromatin protects active genes from genotoxic stress","volume":"114","author":"Bleuyard","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbrc.2025.152402_bib17","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1242\/jcs.060178","article-title":"MRG15 binds directly to PALB2 and stimulates homology-directed repair of chromosomal breaks","volume":"123","author":"Hayakawa","year":"2010","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.bbrc.2025.152402_bib18","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1038\/embor.2011.243","article-title":"ChAM, a novel motif that mediates PALB2 intrinsic chromatin binding and facilitates DNA repair","volume":"13","author":"Bleuyard","year":"2012","journal-title":"EMBO Rep."},{"key":"10.1016\/j.bbrc.2025.152402_bib19","doi-asserted-by":"crossref","first-page":"21127","DOI":"10.1074\/jbc.C109.023937","article-title":"MRG15 is a novel PALB2-interacting factor involved in homologous recombination","volume":"284","author":"Sy","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2025.152402_bib20","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1007\/s00018-024-05183-6","article-title":"PALB2-mutated human mammary cells display a broad spectrum of morphological and functional abnormalities induced by increased TGF\u03b2 signaling","volume":"81","author":"Tuppurainen","year":"2024","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.bbrc.2025.152402_bib21","first-page":"6075","article-title":"Isolation and characterization of a spontaneously immortalized human breast epithelial cell line, MCF-10","volume":"50","author":"Soule","year":"1990","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbrc.2025.152402_bib22","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.semcdb.2017.07.032","article-title":"Regulation of cell polarity by cell adhesion receptors","volume":"81","author":"Ebnet","year":"2018","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.bbrc.2025.152402_bib23","doi-asserted-by":"crossref","first-page":"2408","DOI":"10.1002\/jcp.25390","article-title":"The integrin-mediated ILK-Parvin-\u03b1Pix signaling axis controls differentiation in mammary epithelial cells","volume":"231","author":"Rooney","year":"2016","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.bbrc.2025.152402_bib24","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/S1046-2023(03)00032-X","article-title":"Morphogenesis and oncogenesis of MCF-10A mammary epithelial acini grown in three-dimensional basement membrane cultures","volume":"30","author":"Debnath","year":"2003","journal-title":"Methods"},{"key":"10.1016\/j.bbrc.2025.152402_bib25","doi-asserted-by":"crossref","first-page":"E803","DOI":"10.1073\/pnas.1103423108","article-title":"Intersection of FOXO- and RUNX1-mediated gene expression programs in single breast epithelial cells during morphogenesis and tumor progression","volume":"108","author":"Wang","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbrc.2025.152402_bib26","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1093\/bioinformatics\/btr260","article-title":"Molecular signatures database (MSigDB) 3.0","volume":"27","author":"Liberzon","year":"2011","journal-title":"Bioinformatics"},{"key":"10.1016\/j.bbrc.2025.152402_bib27","series-title":"Stem Cell Transcriptional Networks: Methods and Protocols","first-page":"153","article-title":"A description of the molecular signatures database (MSigDB) web site","author":"Liberzon","year":"2014"},{"key":"10.1016\/j.bbrc.2025.152402_bib28","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1038\/ng1180","article-title":"PGC-1\u03b1-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes","volume":"34","author":"Mootha","year":"2003","journal-title":"Nat. Genet."},{"key":"10.1016\/j.bbrc.2025.152402_bib29","doi-asserted-by":"crossref","first-page":"15545","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles","volume":"102","author":"Subramanian","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbrc.2025.152402_bib30","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.mex.2014.05.002","article-title":"Macropinosome quantitation assay","volume":"1","author":"Wang","year":"2014","journal-title":"MethodsX"},{"key":"10.1016\/j.bbrc.2025.152402_bib31","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1038\/nprot.2014.004","article-title":"Determining the macropinocytic index of cells through a quantitative image-based assay","volume":"9","author":"Commisso","year":"2014","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.bbrc.2025.152402_bib32","doi-asserted-by":"crossref","DOI":"10.1083\/jcb.153.6.1251","article-title":"A novel integrin-linked kinase-binding protein, affixin, is involved in the early stage of cell-substrate interaction","volume":"153","author":"Yamaji","year":"2001","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.bbrc.2025.152402_bib33","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1152\/physrev.00004.2017","article-title":"Junctional adhesion molecules (JAMs): cell adhesion receptors with pleiotropic functions in cell physiology and development","volume":"97","author":"Ebnet","year":"2017","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.bbrc.2025.152402_bib34","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.ccr.2013.08.012","article-title":"An integrin-linked machinery of cytoskeletal regulation that enables experimental tumor initiation and metastatic colonization","volume":"24","author":"Shibue","year":"2013","journal-title":"Cancer Cell"},{"key":"10.1016\/j.bbrc.2025.152402_bib35","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1016\/j.cell.2011.06.010","article-title":"Life at the leading edge","volume":"145","author":"Ridley","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.bbrc.2025.152402_bib36","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1038\/nrm2447","article-title":"Shaping cups into phagosomes and macropinosomes","volume":"9","author":"Swanson","year":"2008","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.bbrc.2025.152402_bib37","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1111\/j.1600-0854.2009.00878.x","article-title":"Defining macropinocytosis","volume":"10","author":"Kerr","year":"2009","journal-title":"Traffic"},{"key":"10.1016\/j.bbrc.2025.152402_bib38","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1042\/bj20031253","article-title":"Size-dependent internalization of particles via the pathways of clathrin- and caveolae-mediated endocytosis","volume":"377","author":"Rejman","year":"2004","journal-title":"Biochem. J."},{"key":"10.1016\/j.bbrc.2025.152402_bib39","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2017.00261","article-title":"Macropinocytosis: a metabolic adaptation to nutrient stress in cancer","volume":"8","author":"Recouvreux","year":"2017","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.bbrc.2025.152402_bib40","doi-asserted-by":"crossref","first-page":"2086","DOI":"10.1158\/0008-5472.CAN-20-2218","article-title":"Therapeutic targeting of DGKA-mediated macropinocytosis leads to phospholipid reprogramming in Tuberous sclerosis complex","volume":"81","author":"Kovalenko","year":"2021","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbrc.2025.152402_bib41","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1002\/glia.20941","article-title":"Cooperative expression of junctional adhesion molecule\u2010C and \u2010B supports growth and invasion of glioma","volume":"58","author":"Tenan","year":"2010","journal-title":"Glia"},{"key":"10.1016\/j.bbrc.2025.152402_bib42","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1152\/physrev.00045.2020","article-title":"Rho GTPase signaling in cancer progression and dissemination","volume":"102","author":"Crosas-Molist","year":"2022","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.bbrc.2025.152402_bib43","doi-asserted-by":"crossref","first-page":"3214","DOI":"10.1158\/1078-0432.CCR-08-3128","article-title":"The breast cancer susceptibility mutation PALB2 1592delT is associated with an aggressive tumor phenotype","volume":"15","author":"Heikkinen","year":"2009","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.bbrc.2025.152402_bib44","doi-asserted-by":"crossref","first-page":"3383","DOI":"10.1245\/s10434-020-09158-2","article-title":"Clinicopathological features and outcomes in individuals with breast cancer and ATM, CHEK2, or PALB2 mutations","volume":"28","author":"Bergstrom","year":"2021","journal-title":"Ann. Surg Oncol."},{"key":"10.1016\/j.bbrc.2025.152402_bib45","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1128\/MCB.01617-06","article-title":"Parvin-\u03b2 inhibits breast cancer tumorigenicity and promotes CDK9-Mediated peroxisome proliferator-activated receptor gamma 1 phosphorylation","volume":"28","author":"Johnstone","year":"2008","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.bbrc.2025.152402_bib46","doi-asserted-by":"crossref","first-page":"2457","DOI":"10.2147\/CMAR.S189937","article-title":"JAM3 functions as a novel tumor suppressor and is inactivated by DNA methylation in colorectal cancer","volume":"11","author":"Zhou","year":"2019","journal-title":"Cancer Manag. Res."},{"key":"10.1016\/j.bbrc.2025.152402_bib47","doi-asserted-by":"crossref","first-page":"1830","DOI":"10.1074\/jbc.M605666200","article-title":"JAM-C regulates tight junctions and integrin-mediated cell adhesion and migration","volume":"282","author":"Mandicourt","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2025.152402_bib48","article-title":"Prognostic significance of JAM 3 in gastric cancer: an observational study from TCGA and GEO","volume":"102","author":"Zhao","year":"2023","journal-title":"Medicine"},{"key":"10.1016\/j.bbrc.2025.152402_bib49","doi-asserted-by":"crossref","first-page":"4096","DOI":"10.1158\/0008-5472.CAN-10-2794","article-title":"A novel function of junctional adhesion molecule-C in mediating melanoma cell metastasis","volume":"71","author":"Langer","year":"2011","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbrc.2025.152402_bib50","doi-asserted-by":"crossref","first-page":"4244","DOI":"10.1096\/fj.13-230441","article-title":"Endothelial cell junctional adhesion molecule C plays a key role in the development of tumors in a murine model of ovarian cancer","volume":"27","author":"Leinster","year":"2013","journal-title":"FASEB J."},{"key":"10.1016\/j.bbrc.2025.152402_bib51","doi-asserted-by":"crossref","first-page":"5675","DOI":"10.1007\/s13277-014-1751-1","article-title":"JAM-C promotes lymphangiogenesis and nodal metastasis in non-small cell lung cancer","volume":"35","author":"Hao","year":"2014","journal-title":"Tumor Biol."},{"key":"10.1016\/j.bbrc.2025.152402_bib52","doi-asserted-by":"crossref","first-page":"8276","DOI":"10.1074\/jbc.M608836200","article-title":"Junctional adhesion Molecule-C promotes metastatic potential of HT1080 human fibrosarcoma","volume":"282","author":"Fuse","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2025.152402_bib53","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1016\/j.bbamcr.2018.01.008","article-title":"Junctional adhesion molecule C (JAM-C) dimerization aids cancer cell migration and metastasis","volume":"1865","author":"Garrido-Urbani","year":"2018","journal-title":"Biochim. Biophys. Acta Mol. Cell Res."},{"key":"10.1016\/j.bbrc.2025.152402_bib54","doi-asserted-by":"crossref","first-page":"6627","DOI":"10.1158\/0008-5472.CAN-17-1223","article-title":"JAM-C identifies src family kinase-activated leukemia-initiating cells and predicts poor prognosis in acute myeloid leukemia","volume":"77","author":"De Grandis","year":"2017","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbrc.2025.152402_bib55","doi-asserted-by":"crossref","first-page":"6339","DOI":"10.1158\/0008-5472.CAN-18-0642","article-title":"JAM-C expression as a biomarker to predict outcome of patients with acute myeloid leukemia\u2014letter","volume":"78","author":"von Bonin","year":"2018","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbrc.2025.152402_bib56","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1038\/ng1947","article-title":"Biallelic mutations in PALB2 cause Fanconi anemia subtype FA-N and predispose to childhood cancer","volume":"39","author":"Reid","year":"2007","journal-title":"Nat. Genet."},{"key":"10.1016\/j.bbrc.2025.152402_bib57","doi-asserted-by":"crossref","DOI":"10.1002\/mgg3.1746","article-title":"A rare PALB2 germline variant causing G2\/M cell cycle arrest is associated with isolated myelosarcoma in infancy","volume":"9","author":"Beer","year":"2021","journal-title":"Mol. Genet. Genomic Med."},{"key":"10.1016\/j.bbrc.2025.152402_bib58","doi-asserted-by":"crossref","DOI":"10.1038\/s41408-020-00396-x","article-title":"Loss of PALB2 predicts poor prognosis in acute myeloid leukemia and suggests novel therapeutic strategies targeting the DNA repair pathway","volume":"11","author":"Padella","year":"2021","journal-title":"Blood Cancer J."},{"key":"10.1016\/j.bbrc.2025.152402_bib59","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1172\/JCI93198","article-title":"JAM3 maintains leukemia-initiating cell self-renewal through LRP5\/AKT\/\u03b2-catenin\/CCND1 signaling","volume":"128","author":"Zhang","year":"2018","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbrc.2025.152402_bib60","doi-asserted-by":"crossref","first-page":"4878","DOI":"10.1158\/0008-5472.CAN-20-1829","article-title":"Junctional adhesion molecules in cancer: a paradigm for the diverse functions of cell-cell interactions in tumor progression","volume":"80","author":"Lauko","year":"2020","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbrc.2025.152402_bib61","doi-asserted-by":"crossref","first-page":"4046","DOI":"10.1016\/j.febslet.2012.10.005","article-title":"The junctional adhesion molecule\u2010B regulates JAM\u2010C\u2010dependent melanoma cell metastasis","volume":"586","author":"Arcangeli","year":"2012","journal-title":"FEBS Lett."},{"key":"10.1016\/j.bbrc.2025.152402_bib62","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.bbamcr.2004.01.006","article-title":"The PINCH\u2013ILK\u2013parvin complexes: assembly, functions and regulation","volume":"1692","author":"Wu","year":"2004","journal-title":"Biochim. Biophys. Acta Mol. Cell Res."},{"key":"10.1016\/j.bbrc.2025.152402_bib63","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1038\/nrm1789","article-title":"ILK, PINCH and parvin: the tIPP of integrin signalling","volume":"7","author":"Legate","year":"2006","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.bbrc.2025.152402_bib64","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1093\/hmg\/ddg019","article-title":"Interaction of alphaPIX (ARHGEF6) with beta-parvin (PARVB) suggests an involvement of alphaPIX in integrin-mediated signaling","volume":"12","author":"Rosenberger","year":"2003","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.bbrc.2025.152402_bib65","doi-asserted-by":"crossref","first-page":"387","DOI":"10.3109\/07357907.2015.1047508","article-title":"Focal adhesion proteins \u03b1- and \u03b2-Parvin are overexpressed in human colorectal cancer and correlate with tumor progression","volume":"33","author":"Bravou","year":"2015","journal-title":"Cancer Invest."},{"key":"10.1016\/j.bbrc.2025.152402_bib66","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1007\/s10735-020-09888-3","article-title":"Integrin-linked kinase (ILK) regulates KRAS, IPP complex and ras suppressor-1 (RSU1) promoting lung adenocarcinoma progression and poor survival","volume":"51","author":"Nikou","year":"2020","journal-title":"J. Mol. Histol."},{"key":"10.1016\/j.bbrc.2025.152402_bib67","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1038\/bjc.2014.590","article-title":"PARVB overexpression increases cell migration capability and defines high risk for endophytic growth and metastasis in tongue squamous cell carcinoma","volume":"112","author":"Eslami","year":"2015","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.bbrc.2025.152402_bib68","doi-asserted-by":"crossref","DOI":"10.1016\/j.tranon.2023.101861","article-title":"PARVB promotes malignant melanoma progression and is enhanced by hypoxic conditions","volume":"42","author":"Wang","year":"2024","journal-title":"Transl. Oncol."},{"key":"10.1016\/j.bbrc.2025.152402_bib69","doi-asserted-by":"crossref","first-page":"9115","DOI":"10.1038\/s41598-024-59464-y","article-title":"NET-related gene signature for predicting AML prognosis","volume":"14","author":"Wang","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbrc.2025.152402_bib70","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1186\/s12967-023-04494-9","article-title":"A novel NET-related gene signature for predicting DLBCL prognosis","volume":"21","author":"Shi","year":"2023","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.bbrc.2025.152402_bib71","article-title":"Construction of novel methylation-driven gene model and investigation of PARVB function in glioblastoma","volume":"11","author":"Yu","year":"2021","journal-title":"Front. Oncol."},{"key":"10.1016\/j.bbrc.2025.152402_bib72","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.trecan.2019.04.002","article-title":"Macropinocytosis in cancer: a complex signaling network","volume":"5","author":"Zhang","year":"2019","journal-title":"Trends Cancer"},{"key":"10.1016\/j.bbrc.2025.152402_bib73","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1016\/j.febslet.2008.01.064","article-title":"Affixin activates Rac1 via \u03b2PIX in C2C12 myoblast","volume":"582","author":"Matsuda","year":"2008","journal-title":"FEBS Lett."},{"key":"10.1016\/j.bbrc.2025.152402_bib74","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1111\/j.1356-9597.2004.00717.x","article-title":"The first CH domain of affixin activates Cdc42 and Rac1 through \u03b1PIX, a Cdc42\/Rac1\u2010specific guanine nucleotide exchanging factor","volume":"9","author":"Mishima","year":"2004","journal-title":"Genes Cells"},{"key":"10.1016\/j.bbrc.2025.152402_bib75","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2014.00374","article-title":"Small GTPases and phosphoinositides in the regulatory mechanisms of macropinosome formation and maturation","volume":"5","author":"Egami","year":"2014","journal-title":"Front. Physiol."},{"key":"10.1016\/j.bbrc.2025.152402_bib76","series-title":"Macropinocytosis: Functions and Mechanisms","first-page":"85","article-title":"Macropinocytosis and cell migration: don't drink and drive","author":"Delgado","year":"2022"},{"key":"10.1016\/j.bbrc.2025.152402_bib77","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1038\/s41388-021-02159-9","article-title":"A low amino acid environment promotes cell macropinocytosis through the YY1-FGD6 axis in Ras-mutant pancreatic ductal adenocarcinoma","volume":"41","author":"Zhang","year":"2022","journal-title":"Oncogene"},{"key":"10.1016\/j.bbrc.2025.152402_bib78","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1038\/s41467-020-14928-3","article-title":"Macropinocytosis confers resistance to therapies targeting cancer anabolism","volume":"11","author":"Jayashankar","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbrc.2025.152402_bib79","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.21873\/anticanres.16931","article-title":"Therapeutic options targeting the ataxia-telangiectasia mutated (ATM)-mediated DNA damage response, macropinocytosis, and adaptive immunity in ovarian cancer","volume":"44","author":"Tseng","year":"2024","journal-title":"Anticancer Res."},{"key":"10.1016\/j.bbrc.2025.152402_bib80","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1002\/2211-5463.12356","article-title":"High expression of PALB2 predicts poor prognosis in patients with advanced breast cancer","volume":"8","author":"Li","year":"2017","journal-title":"FEBS Open Bio"},{"key":"10.1016\/j.bbrc.2025.152402_bib81","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1002\/embj.201385567","article-title":"Genome-wide analysis reveals a role for BRCA1 and PALB2 in transcriptional co-activation","volume":"33","author":"Gardini","year":"2014","journal-title":"EMBO J."},{"key":"10.1016\/j.bbrc.2025.152402_bib82","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.tibs.2018.10.008","article-title":"The tumor suppressor PALB2: inside out","volume":"44","author":"Ducy","year":"2019","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.bbrc.2025.152402_bib83","doi-asserted-by":"crossref","DOI":"10.1016\/j.bpc.2016.12.001","article-title":"Advances in structural studies of recombination mediator proteins","volume":"225","author":"Korolev","year":"2017","journal-title":"Biophys. Chem."},{"key":"10.1016\/j.bbrc.2025.152402_bib84","article-title":"Four novel BRCA variants found in Chinese hereditary breast cancer patients by next-generation sequencing","volume":"516","author":"fei Liu","year":"2021","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.bbrc.2025.152402_bib85","doi-asserted-by":"crossref","DOI":"10.1111\/cas.13552","article-title":"Long non-coding RNA RP11-552M11.4 promotes cells proliferation, migration and invasion by targeting BRCA2 in ovarian cancer","volume":"109","author":"Huang","year":"2018","journal-title":"Cancer Sci."},{"key":"10.1016\/j.bbrc.2025.152402_bib86","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.3390\/cancers11091228","article-title":"Keratin-14 (KRT14) positive leader cells mediate mesothelial clearance and invasion by ovarian cancer cells","volume":"11","author":"Bilandzic","year":"2019","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.bbrc.2025.152402_bib87","doi-asserted-by":"crossref","first-page":"E854","DOI":"10.1073\/pnas.1508541113","article-title":"Polyclonal breast cancer metastases arise from collective dissemination of keratin 14-expressing tumor cell clusters","volume":"113","author":"Cheung","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U. S. A."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X25011179?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X25011179?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:58:48Z","timestamp":1777377528000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X25011179"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":87,"alternative-id":["S0006291X25011179"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2025.152402","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"PALB2 mutations increase oncogenic properties of breast epithelial cells by enhancing JAM3 and PARVB expression","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2025.152402","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"152402"}}