{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T10:16:14Z","timestamp":1772792174648,"version":"3.50.1"},"reference-count":25,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82204391"],"award-info":[{"award-number":["82204391"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.bbrc.2025.152416","type":"journal-article","created":{"date-parts":[[2025,7,29]],"date-time":"2025-07-29T15:36:05Z","timestamp":1753803365000},"page":"152416","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Protective effects of propafenone, propranolol, and amiodarone against isoproterenol-induced lethal arrhythmias in IGF1R deficiency mice"],"prefix":"10.1016","volume":"778","author":[{"given":"Zhipeng","family":"Sun","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanbo","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junshuai","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jialu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongye","family":"Yue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Houjun","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingquan","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lane","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"26","key":"10.1016\/j.bbrc.2025.152416_bib1","doi-asserted-by":"crossref","first-page":"2773","DOI":"10.1182\/blood.2024024258","article-title":"IGF1R signaling in perinatal mesenchymal stem cells determines definitive hematopoiesis in bone marrow","volume":"144","author":"Qi","year":"2024","journal-title":"Blood"},{"issue":"6","key":"10.1016\/j.bbrc.2025.152416_bib2","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1159\/000527123","article-title":"The history of the insulin-like growth factor system","volume":"95","author":"Miller","year":"2022","journal-title":"Horm. Res. Paediatr."},{"issue":"4","key":"10.1016\/j.bbrc.2025.152416_bib3","doi-asserted-by":"crossref","first-page":"H1470","DOI":"10.1152\/ajpheart.00838.2020","article-title":"FoxO1 is required for physiological cardiac hypertrophy induced by exercise but not by constitutively active PI3K","volume":"320","author":"Weeks","year":"2021","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"6","key":"10.1016\/j.bbrc.2025.152416_bib4","doi-asserted-by":"crossref","first-page":"7451","DOI":"10.1096\/fj.201802338RR","article-title":"Tsg101 positively regulates physiologic-like cardiac hypertrophy through FIP3-mediated endosomal recycling of IGF-1R","volume":"33","author":"Essandoh","year":"2019","journal-title":"FASEB J."},{"issue":"25","key":"10.1016\/j.bbrc.2025.152416_bib5","doi-asserted-by":"crossref","first-page":"1853","DOI":"10.1161\/CIRCULATIONAHA.122.059863","article-title":"Fine-tuning cardiac insulin-like growth factor 1 receptor signaling to promote health and longevity","volume":"145","author":"Abdellatif","year":"2022","journal-title":"Circulation"},{"issue":"10","key":"10.1016\/j.bbrc.2025.152416_bib6","doi-asserted-by":"crossref","first-page":"2500","DOI":"10.1080\/15548627.2022.2095835","article-title":"Spermidine overrides INSR (insulin receptor)-IGF1R (insulin-like growth factor 1 receptor)-mediated inhibition of autophagy in the aging heart","volume":"18","author":"Abdellatif","year":"2022","journal-title":"Autophagy"},{"issue":"7","key":"10.1016\/j.bbrc.2025.152416_bib7","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1038\/s41419-021-03965-5","article-title":"IGF-1 protects against angiotensin II-induced cardiac fibrosis by targeting \u03b1SMA","volume":"12","author":"Ock","year":"2021","journal-title":"Cell Death Dis."},{"issue":"18","key":"10.1016\/j.bbrc.2025.152416_bib8","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.123.029631","article-title":"Insulin-like growth factor 1 receptor deficiency alleviates angiotensin II-Induced cardiac fibrosis through the protein kinase B\/Extracellular signal-regulated kinase\/nuclear Factor-\u03baB pathway","volume":"12","author":"Zhu","year":"2023","journal-title":"J. Am. Heart Assoc."},{"issue":"5","key":"10.1016\/j.bbrc.2025.152416_bib9","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1139\/bcb-2022-0199","article-title":"Mechanism of myocardial fibrosis regulation by IGF-1R in atrial fibrillation through the PI3K\/Akt\/FoxO3a pathway","volume":"101","author":"Zhang","year":"2023","journal-title":"Biochem. Cell. Biol."},{"issue":"5","key":"10.1016\/j.bbrc.2025.152416_bib10","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1038\/s12276-023-00988-0","article-title":"Insulin signaling is critical for sinoatrial node maintenance and function","volume":"55","author":"Ock","year":"2023","journal-title":"Exp. Mol. Med."},{"issue":"11","key":"10.1016\/j.bbrc.2025.152416_bib11","doi-asserted-by":"crossref","first-page":"2531","DOI":"10.1210\/me.2008-0265","article-title":"Insulin-like growth factor I receptor signaling is required for exercise-induced cardiac hypertrophy","volume":"22","author":"Kim","year":"2008","journal-title":"Mol. Endocrinol."},{"issue":"18","key":"10.1016\/j.bbrc.2025.152416_bib12","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.123.029631","article-title":"Insulin-like growth factor 1 receptor deficiency alleviates angiotensin II-Induced cardiac fibrosis through the protein kinase B\/Extracellular signal-regulated kinase\/nuclear Factor-\u03baB pathway","volume":"12","author":"Zhu","year":"2023","journal-title":"J. Am. Heart Assoc."},{"issue":"Suppl 3","key":"10.1016\/j.bbrc.2025.152416_bib13","first-page":"159","article-title":"Compensatory mechanisms for cardiac dysfunction in myocardial infarction","volume":"86","author":"Ertl","year":"1991","journal-title":"Basic Res. Cardiol."},{"issue":"5","key":"10.1016\/j.bbrc.2025.152416_bib14","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1097\/HJH.0b013e3282fbf619","article-title":"Is cardiac hypertrophy a required compensatory mechanism in pressure-overloaded heart?","volume":"26","author":"Samuel","year":"2008","journal-title":"J. Hypertens."},{"issue":"1","key":"10.1016\/j.bbrc.2025.152416_bib15","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1007\/s00018-024-05512-9","article-title":"Potential compensatory mechanisms preserving cardiac function in myotubular myopathy","volume":"81","author":"Simon","year":"2024","journal-title":"Cell. Mol. Life Sci."},{"issue":"11","key":"10.1016\/j.bbrc.2025.152416_bib16","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.1016\/j.hrthm.2012.07.023","article-title":"Relevance of calmodulin\/CaMKII activation for arrhythmogenesis in the AV block dog","volume":"9","author":"Bourgonje","year":"2012","journal-title":"Heart Rhythm"},{"key":"10.1016\/j.bbrc.2025.152416_bib17","doi-asserted-by":"crossref","DOI":"10.1007\/s00380-025-02529-3","article-title":"Influence and molecular mechanism of cinnamaldehyde against ventricular arrhythmia via the TAK1-p38MAPK-NLRP3 pathway","author":"Ma","year":"2025","journal-title":"Heart Vessel."},{"issue":"19","key":"10.1016\/j.bbrc.2025.152416_bib18","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1161\/CIRCULATIONAHA.121.057757","article-title":"Exercise causes arrhythmogenic remodeling of intracellular calcium dynamics in Plakophilin-2-Deficient hearts","volume":"145","author":"van Opbergen","year":"2022","journal-title":"Circulation"},{"key":"10.1016\/j.bbrc.2025.152416_bib19","doi-asserted-by":"crossref","DOI":"10.1038\/srep13490","article-title":"Selective Connexin43 inhibition prevents ISO-induced arrhythmias and lethality in muscular dystrophy mice","volume":"5","author":"Gonzalez","year":"2015","journal-title":"Sci. Rep."},{"issue":"5","key":"10.1016\/j.bbrc.2025.152416_bib20","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1161\/CIRCULATIONAHA.121.056018","article-title":"An international multicenter cohort study on \u03b2-Blockers for the treatment of symptomatic children with catecholaminergic polymorphic ventricular tachycardia","volume":"145","author":"Peltenburg","year":"2022","journal-title":"Circulation"},{"issue":"5","key":"10.1016\/j.bbrc.2025.152416_bib21","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1001\/jamacardio.2022.0219","article-title":"Outcomes of patients with catecholaminergic polymorphic ventricular tachycardia treated with \u03b2-Blockers","volume":"7","author":"Mazzanti","year":"2022","journal-title":"JAMA Cardiol."},{"issue":"8","key":"10.1016\/j.bbrc.2025.152416_bib22","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1056\/NEJMoa2409501","article-title":"VANISH2 study team. Catheter ablation or antiarrhythmic drugs for ventricular tachycardia","volume":"392","author":"Sapp","year":"2025","journal-title":"N. Engl. J. Med."},{"issue":"15","key":"10.1016\/j.bbrc.2025.152416_bib23","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1016\/j.jacc.2022.01.050","article-title":"Substrate ablation vs antiarrhythmic drug therapy for symptomatic ventricular tachycardia","volume":"79","author":"Arenal","year":"2022","journal-title":"J. Am. Coll. Cardiol."},{"issue":"11","key":"10.1016\/j.bbrc.2025.152416_bib24","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1007\/s00134-023-07208-3","article-title":"Propafenone versus amiodarone for supraventricular arrhythmias in septic shock: a randomised controlled trial","volume":"49","author":"Balik","year":"2023","journal-title":"Intensive Care Med."},{"issue":"6","key":"10.1016\/j.bbrc.2025.152416_bib25","doi-asserted-by":"crossref","DOI":"10.1093\/europace\/euae121","article-title":"Safety and efficacy of long-term sodium channel blocker therapy for early rhythm control: the EAST-AFNET 4 trial","volume":"26","author":"Rillig","year":"2024","journal-title":"Europace"}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X25011313?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X25011313?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T07:29:41Z","timestamp":1772782181000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X25011313"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":25,"alternative-id":["S0006291X25011313"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2025.152416","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Protective effects of propafenone, propranolol, and amiodarone against isoproterenol-induced lethal arrhythmias in IGF1R deficiency mice","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2025.152416","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"152416"}}