{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:21:05Z","timestamp":1790122865964,"version":"4.0.1"},"reference-count":64,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T00:00:00Z","timestamp":1756425600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100017962","name":"Jiangsu Commission of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017962","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82071719"],"award-info":[{"award-number":["82071719"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.bbrc.2025.152448","type":"journal-article","created":{"date-parts":[[2025,8,9]],"date-time":"2025-08-09T14:46:38Z","timestamp":1754750798000},"page":"152448","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Metformin-mediated amelioration of the ovarian microenvironment in autoimmune premature ovarian insufficiency"],"prefix":"10.1016","volume":"779","author":[{"given":"Qian","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenyang","family":"Ge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cong","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lianju","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2866-6096","authenticated-orcid":false,"given":"Yugui","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8975-6044","authenticated-orcid":false,"given":"Wei","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2025.152448_bib1","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1038\/s41572-024-00547-5","article-title":"Premature ovarian insufficiency","volume":"10","author":"Touraine","year":"2024","journal-title":"Nat. Rev. Dis. Primers"},{"key":"10.1016\/j.bbrc.2025.152448_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.coemr.2023.100435","article-title":"Premature ovarian insufficiency","volume":"28","author":"Kapoor","year":"2023","journal-title":"Current Opinion in Endocrine Metabol. Res."},{"key":"10.1016\/j.bbrc.2025.152448_bib3","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/s41420-024-01811-z","article-title":"LncRNA HOTAIR regulates autophagy and proliferation mechanisms in premature ovarian insufficiency through the miR-148b-3p\/ATG14 axis","volume":"10","author":"Luo","year":"2024","journal-title":"Cell Death Discov."},{"key":"10.1016\/j.bbrc.2025.152448_bib4","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.1038\/s41591-023-02405-5","article-title":"Penetrance of pathogenic genetic variants associated with premature ovarian insufficiency","volume":"29","author":"Shekari","year":"2023","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbrc.2025.152448_bib5","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22052594","article-title":"Autoimmune diseases in patients with premature ovarian insufficiency\u2014our current state of knowledge","volume":"22","author":"Szeliga","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbrc.2025.152448_bib6","article-title":"A review of autoimmunity and immune profiles in patients with primary ovarian insufficiency","volume":"101","author":"Chen","year":"2022","journal-title":"Medicine (Baltim.)"},{"key":"10.1016\/j.bbrc.2025.152448_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.rbmo.2024.103815","article-title":"miR-21-5p-loaded bone mesenchymal stem cell-derived exosomes repair ovarian function in autoimmune premature ovarian insufficiency by targeting MSX1","volume":"48","author":"Yang","year":"2024","journal-title":"Reprod. Biomed. Online"},{"key":"10.1016\/j.bbrc.2025.152448_bib8","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/3582648","article-title":"miR-21 and Pellino-1 expression profiling in autoimmune premature ovarian insufficiency","volume":"2020","author":"Li","year":"2020","journal-title":"J. Immunol Res."},{"key":"10.1016\/j.bbrc.2025.152448_bib9","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1038\/s41591-022-02194-3","article-title":"Landscape of pathogenic mutations in premature ovarian insufficiency","volume":"29","author":"Ke","year":"2023","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbrc.2025.152448_bib10","doi-asserted-by":"crossref","first-page":"3428","DOI":"10.1007\/s43032-023-01300-1","article-title":"Potential therapeutic options for premature ovarian insufficiency: experimental and clinical evidence","volume":"30","author":"Ding","year":"2023","journal-title":"Reprod. Sci."},{"key":"10.1016\/j.bbrc.2025.152448_bib11","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1097\/CM9.0000000000000850","article-title":"Where are the theca cells from: the mechanism of theca cells derivation and differentiation","volume":"133","author":"Liu","year":"2020","journal-title":"Chin Med J (Engl)"},{"key":"10.1016\/j.bbrc.2025.152448_bib12","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1016\/j.biocel.2005.01.016","article-title":"Ovarian theca cell","volume":"37","author":"Magoffin","year":"2005","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.bbrc.2025.152448_bib13","doi-asserted-by":"crossref","DOI":"10.1186\/s12967-021-03103-x","article-title":"Effect of the spatial\u2013temporal specific theca cell Cyp17 overexpression on the reproductive phenotype of the novel TC17 mouse","volume":"19","author":"Secchi","year":"2021","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.bbrc.2025.152448_bib14","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2023.1172481","article-title":"Premature ovarian insufficiency: a review on the role of oxidative stress and the application of antioxidants","volume":"14","author":"Shi","year":"2023","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.bbrc.2025.152448_bib15","doi-asserted-by":"crossref","first-page":"R25","DOI":"10.1530\/REP-19-0501","article-title":"The ovarian stroma as a new frontier","volume":"160","author":"Kinnear","year":"2020","journal-title":"Reproduction"},{"key":"10.1016\/j.bbrc.2025.152448_bib16","doi-asserted-by":"crossref","DOI":"10.1186\/s13048-023-01300-4","article-title":"The stromal microenvironment and ovarian aging: mechanisms and therapeutic opportunities","volume":"16","author":"Shen","year":"2023","journal-title":"J. Ovarian Res."},{"key":"10.1016\/j.bbrc.2025.152448_bib17","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1038\/s41574-019-0242-2","article-title":"Understanding the glucoregulatory mechanisms of metformin in type 2 diabetes mellitus","volume":"15","author":"Foretz","year":"2019","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.bbrc.2025.152448_bib18","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1111\/nyas.14141","article-title":"Metformin promotes mitophagy in mononuclear cells: a potential in vitro model for unraveling metformin's mechanism of action","volume":"1463","author":"Bhansali","year":"2019","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.bbrc.2025.152448_bib19","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.cmet.2020.04.015","article-title":"Metformin enhances autophagy and normalizes mitochondrial function to alleviate aging-associated inflammation","volume":"32","author":"Bharath","year":"2020","journal-title":"Cell Metab."},{"key":"10.1016\/j.bbrc.2025.152448_bib20","first-page":"1","article-title":"Metformin: update on mechanisms of action and repurposing potential","author":"Foretz","year":"2023","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.bbrc.2025.152448_bib21","doi-asserted-by":"crossref","first-page":"4921","DOI":"10.1158\/1078-0432.CCR-20-0113","article-title":"Low-dose metformin reprograms the tumor immune microenvironment in human esophageal cancer: results of a phase II clinical trial","volume":"26","author":"Wang","year":"2020","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.bbrc.2025.152448_bib22","doi-asserted-by":"crossref","first-page":"e743","DOI":"10.1210\/clinem\/dgad145","article-title":"Immunomodulatory effects of metformin treatment in pregnant women with PCOS","volume":"108","author":"Ryssdal","year":"2023","journal-title":"J. Clin. Endocrinol. Metabol."},{"key":"10.1016\/j.bbrc.2025.152448_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.rbmo.2024.103814","article-title":"Exosomes derived from mesenchymal stem cells attenuate NLRP3-related pyroptosis in autoimmune premature ovarian insufficiency via the NF-kappaB pathway","volume":"48","author":"Xie","year":"2024","journal-title":"Reprod. Biomed. Online"},{"key":"10.1016\/j.bbrc.2025.152448_bib24","article-title":"Ovarian oxidative stress induced follicle depletion after zona pellucida 3 vaccination is associated with subfertility in BALB\/c mice","volume":"9","author":"Zhang","year":"2022","journal-title":"Front. Vet. Sci."},{"key":"10.1016\/j.bbrc.2025.152448_bib25","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2122217119","article-title":"Let-7 underlies metformin-induced inhibition of hepatic glucose production","volume":"119","author":"Xie","year":"2022","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.bbrc.2025.152448_bib26","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1080\/1061186X.2020.1868478","article-title":"Metformin protects cardiomyocytes against oxygen-glucose deprivation injury by promoting autophagic flux through AMPK pathway","volume":"29","author":"Wu","year":"2021","journal-title":"J. Drug Target."},{"key":"10.1016\/j.bbrc.2025.152448_bib27","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2023.1070264","article-title":"Metformin improves polycystic ovary syndrome in mice by inhibiting ovarian ferroptosis","volume":"14","author":"Peng","year":"2023","journal-title":"Front Endocrinol (Lausanne)"},{"key":"10.1016\/j.bbrc.2025.152448_bib28","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/s13287-024-03646-y","article-title":"Model construction and drug therapy of primary ovarian insufficiency by ultrasound-guided injection","volume":"15","author":"Dai","year":"2024","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.bbrc.2025.152448_bib29","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.jep.2016.08.046","article-title":"Immuno-enhancement effects of yifei tongluo granules on cyclophosphamide-induced immunosuppression in Balb\/c mice","volume":"194","author":"Wang","year":"2016","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.bbrc.2025.152448_bib30","doi-asserted-by":"crossref","DOI":"10.1186\/s41232-023-00309-y","article-title":"TNF-\u03b1 and IFN-\u03b3 prestimulation enhances the therapeutic efficacy of human amniotic epithelial stem cells in chemotherapy-induced ovarian dysfunction","volume":"43","author":"Huang","year":"2023","journal-title":"Inflamm. Regen."},{"key":"10.1016\/j.bbrc.2025.152448_bib31","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1038\/laban.1105","article-title":"A comparison of sexing methods in fetal mice","volume":"45","author":"Deeney","year":"2016","journal-title":"Lab Anim (NY)"},{"key":"10.1016\/j.bbrc.2025.152448_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellsig.2024.111334","article-title":"Chronic stress causes ovarian fibrosis to impair female fertility in mice","volume":"122","author":"Ma","year":"2024","journal-title":"Cell. Signal."},{"key":"10.1016\/j.bbrc.2025.152448_bib33","doi-asserted-by":"crossref","DOI":"10.7717\/peerj.14342","article-title":"Comparative transcriptome sequencing analysis of female and Male decapterus macrosoma","volume":"10","author":"Cai","year":"2022","journal-title":"PeerJ"},{"key":"10.1016\/j.bbrc.2025.152448_bib34","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1097\/FJC.0000000000001028","article-title":"Metformin attenuates hypoxia-induced endothelial cell injury by activating the AMP-activated protein kinase pathway","volume":"77","author":"Hu","year":"2021","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"10.1016\/j.bbrc.2025.152448_bib35","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1093\/abbs\/gmz065","article-title":"Immunomodulatory effect of human amniotic epithelial cells on restoration of ovarian function in mice with autoimmune ovarian disease","volume":"51","author":"Zhang","year":"2019","journal-title":"Acta Biochim. Biophys. Sin."},{"key":"10.1016\/j.bbrc.2025.152448_bib36","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.jep.2016.11.014","article-title":"Protective effects and mechanisms investigation of kuntai capsule on the ovarian function of a novel model with accelerated aging ovaries","volume":"195","author":"Zhang","year":"2017","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.bbrc.2025.152448_bib37","doi-asserted-by":"crossref","first-page":"3742","DOI":"10.1038\/s41467-023-39241-7","article-title":"Systems-level analyses of protein-protein interaction network dysfunctions via epichaperomics identify cancer-specific mechanisms of stress adaptation","volume":"14","author":"Rodina","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbrc.2025.152448_bib38","doi-asserted-by":"crossref","DOI":"10.3390\/genes13020302","article-title":"A review on CYP11A1, CYP17A1, and CYP19A1 polymorphism studies: candidate susceptibility genes for polycystic ovary syndrome (PCOS) and infertility","volume":"13","author":"Heidarzadehpilehrood","year":"2022","journal-title":"Genes"},{"key":"10.1016\/j.bbrc.2025.152448_bib39","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2023.1268248","article-title":"Expression of genes and enzymes involved in ovarian steroidogenesis in relation to human follicular development","volume":"14","author":"Zheng","year":"2023","journal-title":"Front Endocrinol (Lausanne)"},{"key":"10.1016\/j.bbrc.2025.152448_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.jsbmb.2023.106385","article-title":"Seasonal changes of vitamin D(3) and ovarian steroidogenesis in the wild ground squirrels (Citellus dauricus brandt)","volume":"234","author":"Lu","year":"2023","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.bbrc.2025.152448_bib41","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1186\/s13256-024-04654-5","article-title":"A differential expression of an identical mutation in CYP17A1 gene in two infertility patients: a case report","volume":"18","author":"Rabinovich","year":"2024","journal-title":"J. Med. Case Rep."},{"key":"10.1016\/j.bbrc.2025.152448_bib42","doi-asserted-by":"crossref","first-page":"579","DOI":"10.3233\/THC-181510","article-title":"Identification and potential value of candidate microRNAs in granulosa cells of polycystic ovary syndrome","volume":"27","author":"Wang","year":"2019","journal-title":"Technol. Health Care"},{"key":"10.1016\/j.bbrc.2025.152448_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2023.216497","article-title":"Targeting TAM-secreted S100A9 effectively enhances the tumor-suppressive effect of metformin in treating lung adenocarcinoma","volume":"581","author":"Sui","year":"2024","journal-title":"Cancer Lett."},{"key":"10.1016\/j.bbrc.2025.152448_bib44","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1186\/s40364-025-00763-5","article-title":"S100A9 as a potential novel target for experimental autoimmune cystitis and interstitial cystitis\/bladder pain syndrome","volume":"13","author":"Zhao","year":"2025","journal-title":"Biomark. Res."},{"key":"10.1016\/j.bbrc.2025.152448_bib45","doi-asserted-by":"crossref","first-page":"447","DOI":"10.3389\/fimmu.2018.00447","article-title":"Secretion of the phosphorylated form of S100A9 from neutrophils is essential for the proinflammatory functions of extracellular S100A8\/A9","volume":"9","author":"Schenten","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bbrc.2025.152448_bib46","doi-asserted-by":"crossref","DOI":"10.1016\/j.ygcen.2019.113231","article-title":"Endothelins (EDN1, EDN2, EDN3) and their receptors (EDNRA, EDNRB, EDNRB2) in chickens: functional analysis and tissue distribution","volume":"283","author":"Liu","year":"2019","journal-title":"Gen. Comp. Endocrinol."},{"key":"10.1016\/j.bbrc.2025.152448_bib47","article-title":"Single-cell RNA sequencing of peripheral blood reveals immune cell dysfunction in premature ovarian insufficiency","volume":"14","author":"Zhang","year":"2023","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.bbrc.2025.152448_bib48","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1186\/s10020-024-00971-z","article-title":"Dihydroberberine alleviates Th17\/Treg imbalance in premature ovarian insufficiency mice via inhibiting Rheb\/mTOR signaling","volume":"30","author":"Deng","year":"2024","journal-title":"Mol Med."},{"key":"10.1016\/j.bbrc.2025.152448_bib49","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.bpobgyn.2019.07.008","article-title":"Premature ovarian insufficiency and autoimmune diseases","volume":"60","author":"Domniz","year":"2019","journal-title":"Best Pract. Res. Clin. Obstet. Gynaecol."},{"key":"10.1016\/j.bbrc.2025.152448_bib50","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22031371","article-title":"Ovarian aging: molecular mechanisms and medical management","volume":"22","author":"Tesarik","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbrc.2025.152448_bib51","doi-asserted-by":"crossref","DOI":"10.1111\/aji.13622","article-title":"Advances in the cellular immunological pathogenesis and related treatment of primary ovarian insufficiency","volume":"88","author":"Gao","year":"2022","journal-title":"Am. J. Reprod. Immunol."},{"key":"10.1016\/j.bbrc.2025.152448_bib52","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1177\/1933719117732156","article-title":"Restoring ovarian function with human placenta-derived mesenchymal stem cells in autoimmune-induced premature ovarian failure mice mediated by treg cells and associated cytokines","volume":"25","author":"Yin","year":"2018","journal-title":"Reprod. Sci."},{"key":"10.1016\/j.bbrc.2025.152448_bib53","doi-asserted-by":"crossref","DOI":"10.1002\/ctm2.1071","article-title":"Macrophage-derived extracellular vesicles regulate follicular activation and improve ovarian function in old mice by modulating local environment","volume":"12","author":"Xiao","year":"2022","journal-title":"Clin. Transl. Med."},{"key":"10.1016\/j.bbrc.2025.152448_bib54","doi-asserted-by":"crossref","DOI":"10.1016\/j.labinv.2022.100005","article-title":"Regulatory T cells overexpressing Peli1 show better efficacy in repairing ovarian endocrine function in autoimmune premature ovarian insufficiency","volume":"103","author":"Wang","year":"2023","journal-title":"Lab. Invest."},{"key":"10.1016\/j.bbrc.2025.152448_bib55","doi-asserted-by":"crossref","DOI":"10.1016\/j.jri.2024.104253","article-title":"Immunophenotypic profiles and inflammatory markers in premature ovarian insufficiency","volume":"164","author":"Kunicki","year":"2024","journal-title":"J. Reprod. Immunol."},{"key":"10.1016\/j.bbrc.2025.152448_bib56","doi-asserted-by":"crossref","first-page":"2207","DOI":"10.1007\/s10815-019-01572-0","article-title":"Premature ovarian insufficiency (POI) and autoimmunity-an update appraisal","volume":"36","author":"Kirshenbaum","year":"2019","journal-title":"J. Assist. Reprod. Genet."},{"key":"10.1016\/j.bbrc.2025.152448_bib57","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.115470","article-title":"The role of macrophages in polycystic ovarian syndrome and its typical pathological features: a narrative review","volume":"167","author":"Feng","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.bbrc.2025.152448_bib58","doi-asserted-by":"crossref","DOI":"10.1155\/2023\/8821610","article-title":"Regulatory mechanism of M1\/M2 macrophage polarization in the development of autoimmune diseases","volume":"2023","author":"Peng","year":"2023","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.bbrc.2025.152448_bib59","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.116242","article-title":"Jinfeng pills ameliorate premature ovarian insufficiency induced by cyclophosphamide in rats and correlate to modulating IL-17A\/IL-6 axis and MEK\/ERK signals","volume":"307","author":"Hu","year":"2023","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.bbrc.2025.152448_bib60","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2024.116193","article-title":"Indole-3-carbinol ameliorates ovarian damage in female old mice through Nrf2\/HO-1 pathway activation","volume":"223","author":"Hu","year":"2024","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.bbrc.2025.152448_bib61","doi-asserted-by":"crossref","DOI":"10.1016\/j.beem.2021.101594","article-title":"Genetics of ovarian insufficiency and defects of folliculogenesis","volume":"36","author":"Fran\u00e7a","year":"2022","journal-title":"Best Pract. Res. Clin. Endocrinol. Metabol."},{"key":"10.1016\/j.bbrc.2025.152448_bib62","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23010198","article-title":"The effects of separate and combined treatment of Male rats with type 2 diabetes with metformin and orthosteric and allosteric agonists of luteinizing hormone receptor on steroidogenesis and spermatogenesis","volume":"23","author":"Bakhtyukov","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbrc.2025.152448_bib63","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1055\/s-0029-1212105","article-title":"An update on the mechanism of action of the steroidogenic acute regulatory (StAR) protein","volume":"107","author":"Stocco","year":"1999","journal-title":"Exp. Clin. Endocrinol. Diabetes"},{"key":"10.1016\/j.bbrc.2025.152448_bib64","doi-asserted-by":"crossref","DOI":"10.3390\/cells14030213","article-title":"Metformin induces apoptosis and ferroptosis of ovarian cancer cells under energy stress conditions","volume":"14","author":"Wu","year":"2025","journal-title":"Cells"}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X25011635?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X25011635?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T04:26:09Z","timestamp":1779769569000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X25011635"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":64,"alternative-id":["S0006291X25011635"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2025.152448","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Metformin-mediated amelioration of the ovarian microenvironment in autoimmune premature ovarian insufficiency","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2025.152448","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"152448"}}