{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T22:09:50Z","timestamp":1790633390783,"version":"4.1.0"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100014358","name":"Second Affiliated Hospital of Soochow University","doi-asserted-by":"publisher","award":["SDFEYBS2408"],"award-info":[{"award-number":["SDFEYBS2408"]}],"id":[{"id":"10.13039\/501100014358","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014358","name":"Second Affiliated Hospital of Soochow University","doi-asserted-by":"publisher","award":["SYW2025098"],"award-info":[{"award-number":["SYW2025098"]}],"id":[{"id":"10.13039\/501100014358","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014358","name":"Second Affiliated Hospital of Soochow University","doi-asserted-by":"publisher","award":["SZFCXK202124"],"award-info":[{"award-number":["SZFCXK202124"]}],"id":[{"id":"10.13039\/501100014358","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014358","name":"Second Affiliated Hospital of Soochow University","doi-asserted-by":"publisher","award":["20232BAB216073"],"award-info":[{"award-number":["20232BAB216073"]}],"id":[{"id":"10.13039\/501100014358","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014358","name":"Second Affiliated Hospital of Soochow University","doi-asserted-by":"publisher","award":["2024-K01"],"award-info":[{"award-number":["2024-K01"]}],"id":[{"id":"10.13039\/501100014358","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004479","name":"Natural Science Foundation of Jiangxi Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004479","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008081","name":"Southeast University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008081","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.bbrc.2025.152539","type":"journal-article","created":{"date-parts":[[2025,8,25]],"date-time":"2025-08-25T05:57:57Z","timestamp":1756101477000},"page":"152539","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Network pharmacology analysis and biological validation of molecular targets regulated by glaucocalyxin a in periodontitis"],"prefix":"10.1016","volume":"781","author":[{"given":"Yuqi","family":"Xin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zichen","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JiaYing","family":"Guan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junjie","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenhan","family":"Hua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingkun","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianlin","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"7","key":"10.1016\/j.bbrc.2025.152539_bib1","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1038\/s41577-020-00488-6","article-title":"Local and systemic mechanisms linking periodontal disease and inflammatory comorbidities","volume":"21","author":"Hajishengallis","year":"2021","journal-title":"Nat. Rev. Immunol."},{"issue":"1","key":"10.1016\/j.bbrc.2025.152539_bib2","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1111\/j.1600-0757.2012.00452.x","article-title":"Periodontal health and global public health","volume":"60","author":"Petersen","year":"2000","journal-title":"Periodontol"},{"key":"10.1016\/j.bbrc.2025.152539_bib3","article-title":"Time to take periodontitis seriously","volume":"10","author":"Chapple","year":"2014","journal-title":"Br. Med. J."},{"issue":"1","key":"10.1016\/j.bbrc.2025.152539_bib4","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1080\/00325481.2018.1396876","article-title":"Chronic periodontitis, inflammatory cytokines, and interrelationship with other chronic diseases","volume":"130","author":"Cardoso","year":"2018","journal-title":"Postgrad. Med. J."},{"key":"10.1016\/j.bbrc.2025.152539_bib5","first-page":"S71","article-title":"Primary prevention of periodontitis: managing gingivitis","volume":"16","author":"Chapple","year":"2015","journal-title":"J. Clin. Periodontol."},{"issue":"1","key":"10.1016\/j.bbrc.2025.152539_bib6","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1186\/s12951-022-01314-y","article-title":"Exosomes derived from reparative M2-like macrophages prevent bone loss in murine periodontitis models via IL-10 mRNA","volume":"5","author":"Chen","year":"2022","journal-title":"J. Nanobiotechnol."},{"issue":"1","key":"10.1016\/j.bbrc.2025.152539_bib7","article-title":"Supportive periodontal therapy (SPT) for maintaining the dentition in adults treated for periodontitis","volume":"1","author":"Manresa","year":"2018","journal-title":"Cochrane Database Syst. Rev."},{"issue":"12","key":"10.1016\/j.bbrc.2025.152539_bib8","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1016\/S2213-8587(18)30038-X","article-title":"Systemic effects of periodontitis treatment in patients with type 2 diabetes: a 12 month, single-centre, investigator-masked, randomised trial","volume":"6","author":"D'Aiuto","year":"2018","journal-title":"Lancet Diabetes Endocrinol."},{"issue":"1","key":"10.1016\/j.bbrc.2025.152539_bib9","doi-asserted-by":"crossref","first-page":"6556","DOI":"10.1038\/s41598-025-91358-5","article-title":"Glaucocalyxin A alleviates ulcerative colitis by inhibiting PI3K\/AKT\/mTOR signaling","volume":"24","author":"Zhou","year":"2025","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.bbrc.2025.152539_bib10","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1186\/s12935-021-02375-z","article-title":"Glaucocalyxin A suppresses multiple myeloma progression in vitro and in vivo through inhibiting the activation of STAT3 signaling pathway","volume":"19","author":"Li","year":"2021","journal-title":"Cancer Cell Int."},{"issue":"4","key":"10.1016\/j.bbrc.2025.152539_bib11","doi-asserted-by":"crossref","first-page":"418","DOI":"10.7150\/ijbs.23602","article-title":"Glaucocalyxin A induces G2\/M cell cycle arrest and apoptosis through the PI3K\/Akt pathway in human bladder cancer cells","volume":"10","author":"Lin","year":"2018","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.bbrc.2025.152539_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2020.106271","article-title":"Glaucocalyxin A alleviates LPS-Mediated septic shock and inflammation via inhibiting NLRP3 inflammasome activation","volume":"81","author":"Hou","year":"2020","journal-title":"Int. Immunopharmacol."},{"issue":"8","key":"10.1016\/j.bbrc.2025.152539_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2023.e19151","article-title":"Comprehensive survey of target prediction web servers for traditional Chinese medicine","volume":"15","author":"Ren","year":"2023","journal-title":"Heliyon"},{"issue":"3","key":"10.1016\/j.bbrc.2025.152539_bib14","first-page":"479","article-title":"Integration strategy of network pharmacology in traditional Chinese medicine: a narrative review","volume":"42","author":"Jiashuo","year":"2022","journal-title":"J. Tradit. Chin. Med."},{"issue":"19","key":"10.1016\/j.bbrc.2025.152539_bib15","doi-asserted-by":"crossref","first-page":"2103","DOI":"10.2147\/DDDT.S494066","article-title":"Deciphering the pharmacological potential of kouqiangjie formula for the treatment of diabetic periodontitis based on network pharmacology, machine learning, molecular dynamics, and animal experiments","volume":"20","author":"Wu","year":"2025","journal-title":"Drug Des. Dev. Ther."},{"issue":"1","key":"10.1016\/j.bbrc.2025.152539_bib16","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1186\/s12903-025-05913-7","article-title":"Baicalin attenuates LPS-Induced periodontal inflammation response by inhibiting autophagy","volume":"10","author":"Cheng","year":"2025","journal-title":"BMC Oral Health"},{"issue":"16","key":"10.1016\/j.bbrc.2025.152539_bib17","doi-asserted-by":"crossref","first-page":"2785","DOI":"10.1002\/jcc.21256","article-title":"AutoDock4 and AutoDockTools4: automated docking with selective receptor flexibility","volume":"30","author":"Morris","year":"2009","journal-title":"J. Comput. Chem."},{"issue":"1","key":"10.1016\/j.bbrc.2025.152539_bib18","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1093\/nar\/28.1.235","article-title":"The protein data bank","volume":"1","author":"Berman","year":"2000","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bbrc.2025.152539_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2024.139753","article-title":"Cold plasma for enhancing covalent conjugation of ovalbumin-gallic acid and its functional properties","volume":"454","author":"Liu","year":"2024","journal-title":"Food Chem."},{"issue":"40","key":"10.1016\/j.bbrc.2025.152539_bib20","article-title":"Conformational space profiling enhances generic molecular representation for AI-Powered ligand-based drug discovery","volume":"11","author":"Wang","year":"2024","journal-title":"Adv. Sci. (Weinh.)"},{"issue":"15","key":"10.1016\/j.bbrc.2025.152539_bib21","doi-asserted-by":"crossref","DOI":"10.1002\/cam4.70074","article-title":"Structure-based pharmacophore modeling for precision inhibition of mutant ESR2 in breast cancer: a systematic computational approach","volume":"13","author":"Islam","year":"2024","journal-title":"Cancer Med."},{"issue":"2","key":"10.1016\/j.bbrc.2025.152539_bib22","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1111\/jre.12823","article-title":"Mechanisms involved in regulation of periodontal ligament cell production of pro-inflammatory cytokines: implications in periodontitis","volume":"56","author":"Nilsson","year":"2021","journal-title":"J. Periodontal. Res."},{"issue":"1","key":"10.1016\/j.bbrc.2025.152539_bib23","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aau3333","article-title":"Porphyromonas gingivalis in alzheimer's disease brains: evidence for disease causation and treatment with small-molecule inhibitors","volume":"23","author":"Dominy","year":"2019","journal-title":"Sci. Adv."},{"key":"10.1016\/j.bbrc.2025.152539_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2022.115589","article-title":"Integrated strategy of network pharmacology, molecular docking, HPLC-DAD and mice model for exploring active ingredients and pharmacological mechanisms of Penthorum chinense pursh against alcoholic liver injury","volume":"298","author":"Jiang","year":"2022","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.bbrc.2025.152539_bib25","article-title":"Glaucocalyxin A suppresses osteoclastogenesis induced by RANKL and osteoporosis induced by ovariectomy by inhibiting the NF-\u03baB and akt pathways","volume":"10","author":"Zhu","year":"2021","journal-title":"J. Ethnopharmacol."},{"issue":"3","key":"10.1016\/j.bbrc.2025.152539_bib26","first-page":"618","article-title":"Weifuchun ( ) exerts therapeutic effects on gastric fundic gland polyps by promoting ferroptosis","volume":"45","author":"Yue","year":"2025","journal-title":"J. Tradit. Chin. Med."},{"issue":"3","key":"10.1016\/j.bbrc.2025.152539_bib27","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1089\/dna.2017.3992","article-title":"Glaucocalyxin A attenuates the activation of hepatic stellate cells through the TGF-\u03b21\/Smad signaling pathway","volume":"37","author":"Dong","year":"2018","journal-title":"DNA Cell Biol."},{"issue":"24","key":"10.1016\/j.bbrc.2025.152539_bib28","doi-asserted-by":"crossref","first-page":"2221","DOI":"10.1080\/14786419.2014.934235","article-title":"Glaucocalyxin A: a review","volume":"28","author":"Xiang","year":"2014","journal-title":"Nat. Prod. Res."},{"key":"10.1016\/j.bbrc.2025.152539_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2025.108572","article-title":"Interaction of glaucocalyxin a with glutathione and thioredoxin reductase for triple-negative breast cancer treatment","volume":"161","author":"Duan","year":"2025","journal-title":"Bioorg. Chem."},{"issue":"1","key":"10.1016\/j.bbrc.2025.152539_bib30","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1186\/s13018-024-04640-z","article-title":"Glaucocalyxin A delays the progression of OA by inhibiting NF-\u03baB and MAPK signaling pathways","volume":"19","author":"Hong","year":"2024","journal-title":"J. Orthop. Surg. Res."},{"issue":"3","key":"10.1016\/j.bbrc.2025.152539_bib31","doi-asserted-by":"crossref","first-page":"131","DOI":"10.47852\/bonviewMEDIN32021408","article-title":"Integrated bioinformatics approach showed linagliptin as potential drug for prevention of cardiac arrest and cancer","volume":"1","author":"Dhabhai","year":"2024","journal-title":"Medinformatics"},{"issue":"11","key":"10.1016\/j.bbrc.2025.152539_bib32","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.3390\/ph17111485","article-title":"Therapeutic effect of shikimic acid on heat stress-induced myocardial damage: assessment via network pharmacology, molecular docking, molecular dynamics simulation, and in vitro experiments","volume":"5","author":"Gu","year":"2024","journal-title":"Pharmaceuticals"},{"issue":"5","key":"10.1016\/j.bbrc.2025.152539_bib33","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1039\/b604174d","article-title":"Diterpenoids from isodon species and their biological activities","volume":"23","author":"Sun","year":"2006","journal-title":"Nat. Prod. Rep."},{"key":"10.1016\/j.bbrc.2025.152539_bib34","doi-asserted-by":"crossref","DOI":"10.3389\/fgene.2025.1578094","article-title":"Editorial: the role of genes and network pharmacology in new drug discovery","volume":"16","author":"Mao","year":"2025","journal-title":"Front. Genet."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X25012549?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X25012549?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T15:24:27Z","timestamp":1775834667000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X25012549"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":34,"alternative-id":["S0006291X25012549"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2025.152539","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Network pharmacology analysis and biological validation of molecular targets regulated by glaucocalyxin a in periodontitis","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2025.152539","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"152539"}}